Nels and Vincent reveal how the protein DHX9 suppresses RNA processing defects caused by invasion of the Alu retroelement into the human genome. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO DHX9 suppresses Alu defects (Nature) Asifa Akhtar on The Latest Thinking This episode is brought to you by Blue Apron. Blue Apron is th ...…

Maitreya Dunham joins Nels and Vincent to explain how her laboratory uses experimental evolution to study yeast flocculation, the community-building cell aggregation trait. Hosts: Nels Elde and Vincent Racaniello Guest: Maitreya Dunham Become a patron of TWiEVO Dunham Laboratory Adaptive Routes to Cell Aggregation in Yeast (Genetics) Making the ...…

Rich Condit joins Nels and Vincent to explain how a vaccinia virus protein customizes ribosomes to favor the translation of viral mRNAs with a stretch of A residues in the 5'-untranslated region. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Rich Condit with Harry Noller (scroll down) Trans-Kingdom mimicry? (Nature) More on ...…

Nels and Vincent explore the role of TSR proteins during colonization of cnidarians by dinoflagellates. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO TSR domain proteins in cnidarian-dinoflagellate symbiosis A. elegantissima image credit Letters read on TWiEVO 20 Science Picks Nels - CRISPR 5 ways Vincent - The Vital Questio ...…

Jonathan Weiner, author of the Pulitzer Prize-winning Beak of the Finch, joins Nels and Vincent to talk about his career and his writing. Hosts: Nels Elde and Vincent Racaniello Guest: Jonathan Weiner Become a patron of TWiEVO Jonathan's Columbia University page Jonathan's author page Science Picks Nels - The Gap by Ira Glass Vincent - EPA remo ...…

Hosts: Nels Elde and Vincent Racaniello Guests: Ni-Chen 'Sylvia' Chang, Waring 'Buck' Trible, and Sean K. McKenzie Buck and Sean join Vincent in New York, while Sylvia is with Nels in Salt Lake City to discuss the first mutant ant ever made: disruption of orco, a gene required for function of odorant receptors, show defects in social behavior a ...…

Hosts: Nels Elde and Vincent Racaniello Guest: Stephen Goff Nels joins Vincent in New York City to speak with Stephen Goff about transmissible clam cancers and the silencing of integrated retroviral genomes. Become a patron of TWiEVO A sixth modality of infectious disease (PLoS Path) Horizontal transmission of clam cancer (Cell) Transmissible b ...…

Hosts: Nels Elde and Vincent Racaniello Nels and Vincent reveal how introns - the parts of pre-mRNAs that are removed by splicing - were generated by DNA transposons in two different picoeukaryotes. Become a patron of TWiEVO Introns from DNA transposons (Nature) Reverse transcription and integration lecture Image: Elde Lab Mobile Studios on loc ...…

Hosts: Nels Elde and Vincent Racaniello Guest: Hopi Hoekstra Nels and Vincent speak with Hopi Hoekstra about her career and the work of her laboratory on developmental mechanisms of stripe patterns in rodents. Become a patron of TWiEVO Hoekstra Laboratory Hopi on Twitter Mechanisms of stripe patterns in rodents (Nature) Image credit Letters rea ...…

Hosts: Nels Elde and Vincent Racaniello Guests: Jessica Brown, Michael Kay, Wayne Potts, June Round, and Janis Weis From the Microbial Pathogenesis Retreat of the University of Utah School of Medicine, held at the Utah Museum of Natural History, Nels and Vincent speak with faculty members about their work on bacteria, fungi, viruses, and mirror ...…

Hosts: Nels Elde and Vincent Racaniello Guest: Corrie Moreau Corrie joins Nels and Vincent to talk about her comparative analysis of the genomes of mutualist ants that nest in plants, and non-symbiotic species. Become a patron of TWiEVO Links for this episode Moreau Laboratory Different rates of evolution in ant-plant mutualisms (Nat Commun) Im ...…

Hosts: Nels Elde and Vincent Racaniello Guest: Josh Drew Josh joins Nels and Vincent to talk about his research on the evolution and conservation of aquatic tropical biodiversity, and the historical ecology of 19th century American Whalers. Become a patron of TWiEVO Links for this episode Drew Laboratory at Columbia University American Whalers ...…

Hosts: Nels Elde and Vincent Racaniello Guest: Nicole King Nicole joins Nels and Vincent to discuss the finding of her laboratory that multicellular development of choanoflagellates, the closest living relatives of animals, is regulated by bacterial lipids. Become a patron of TWiEVO Links for this episode Nicole King on Twitter Choanoflagellate ...…

Hosts: Nels Elde and Vincent Racaniello Nels and Vincent review experiments showing that the replacement of a pale moth with a black one during the industrial revolution was caused by a transposable element. Links for this episode Last experiment of Michael Majerus (Biol Lett) Moth melanism mutation is transposon (Nature) Image credit Letters r ...…

Hosts: Nels Elde and Vincent Racaniello Guest: Jim Bull Nels and Vincent speak with Jim Bull about the results of genetic models which suggest that the evolution of inbreeding in response to lethal gene drive might make population control difficult to achieve. Links for this episode Lethal gene drive selects inbreeding (bioRxiv) Panel endorses ...…

Hosts: Nels Elde and Vincent Racaniello Nels visits Vincent in the MicrobeTV studio in New York and talks about how key genes of the Homo sapiens innate immune response were acquired from Neanderthals. Links for this episode Introgressed Neanderthal haplotype at OAS locus (biorXiv) Genetic time travel (Genetics) Genetic history of Ice Age Europ ...…

Hosts: Nels Elde and Vincent Racaniello Guest: Mike Shapiro Mike joins Nels and Vincent to talk about his work on what controls whether pigeons have scaly or feathered feet, and reveals that the hindlimbs of domestic birds with feathery feet are more like wings at the molecular level. Links for this episode Shapiro Laboratory Shifts in limb ide ...…

Hosts: Nels Elde and Vincent Racaniello Nels and Vincent continue with an emerging sub-theme of TWiEVO - organisms with wings - as they reveal how enhancer shuffling produces diverse butterfly wing patterns. Links for this episode Enhancer shuffling for butterfly wing patterns (PLoS Biol) Batesian mimicry (Wikipedia) Müllerian mimicry (Wikipedi ...…

Hosts: Nels Elde and Vincent Racaniello Guests: Kartik Chandran and Sara Sawyer Sara and Kartik join Nels and Vincent to talk about the filovirus receptor NPC1 regulates Ebolavirus susceptibility in bats. Links for this episode Sara on TWiV #193 Kartik on TWiV #314 NPC1 and bat susceptibility to Ebolaviruses (eLife) Science Picks Nels - Sundanc ...…

Hosts: Nels Elde and Vincent Racaniello Guest: Nitin Phadnis Nitin joins Nels and Vincent to explain how he identified a gene that is responsible for male inviability in hybrids from a cross between two species of fruit flies. Links for this episode Cell cycle regulation gene causes hybrid inviability in fruit fly (Science) Phadnis laboratory P ...…

Hosts: Nels Elde and Vincent Racaniello Nels and Vincent discuss the evolution of recombination in the genomes of birds and yeast. Links for this episode Stable recombination hotspots in birds (Science) Putting the breaks on meiosis (Science) Evolutionary stability of recombination in yeast (Science) Image credit Science Picks Nels - Tardigrade ...…

Hosts: Nels Elde and Vincent Racaniello Nels and Vincent talk about how a cellular enzyme contributes to the very high mutation rate of human immunodeficiency virus type 1. Links for this episode Cell defense enzyme drives high HIV mutation rate (PLoS Biol) High mutation rate of HIV in vivo (PLoS Biol) High viral mutation rates are beneficial ( ...…

Hosts: Nels Elde and Vincent Racaniello Nels and Vincent launch a new podcast on evolution, and start by discussing how the field has changed through recent mergers of evolutionary and experimental biology in the post-genome era. Links for this episode Elde Laboratory Nels on TWiV 234 Mechanistic approaches to the study of evolution (Nat Rev Ge ...…