TWiV 1126: Clinical update with Dr. Daniel Griffin

This Week in Virology

In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high HLA-DQA2 expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin use prevented severe COVID-19, the benefit of administering nirmatrelvir and ritonavir after 5 days, convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if fecal microbiota transplants aid in recovery from COVID-19, and the definition of characteristics and clinical patterns for the diagnosis of long COVID.

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Links for this episode

• CDC ACIP for RSV (CDC)
• This respiratory virus season everyone age 75 and older receive the RSV vaccine (CDC Newsroom)
• Revised RSV vaccine recommendations (CIDRAP)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Local and systemic response dynamics to SARS-CoV-2 infection (Nature)
• Drink more coffee, reduces risk for SARS-C0V-2 infection (Cell & Bioscience)
• Cannabis, tobacco…smoking in general NOT good for preventing COVID-19 (JAMA Network OPEN)
• Do older versions of the COVID-19 vaccine still provide any protection (JAMA Internal Medicine)
• Where to get pemgarda (Pemgarda)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Adjuvant statin therapy reduces SARS-CoV-2 mortality (American Journal of Medicine)
• Nirmatrelvir and ritonavir beyond 5 days of symptom onset improved the multiple organ dysfunction in severe COVID-19 patient (BMC Infectious Disease)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Faecal microbtiota transplantation cures sleep disturbance in post-acute COVID-19 syndrome (Clinical Gastroenterology and Hepatology)
• Long COVID defined by patient phenotype (CIDRAP)
• Three distinct symptom-based post-COVID condition phenotypes (JID)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1126
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [e-mail]