The FRAIL AF Study

CEimpact Podcast

Multiple studies highlight the benefits of direct oral anticoagulants (DOACS) with lower incidence of side effects and non-inferiority to warfarin. Join host, Geoff Wall, and guest, Mathew Boyd, as they discuss the FRAILE AF study and whether warfarin may be the best bet in older adults.
The GameChanger:
DOACs are recommended by nearly all relevant major medical guidelines as the anticoagulant of choice in atrial fibrillation. A new study has found that in frail elderly patients, warfarin may be associated with fewer bleeding episodes.
Host
Geoff Wall, PharmD, BCPS, FCCP, BCGP
Professor of Pharmacy Practice, Drake University
Internal Medicine/Critical Care, UnityPoint Health
Guest
Mathew Boyd, PharmD
Clinical Pharmacist
Unity Point
Reference
Joosten LPT, van Doorn S, van de Ven PM,et al. Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial. Circulation. 2023 Aug 27. doi: 10.1161/CIRCULATIONAHA.123.066485. Epub ahead of print. PMID: 37634130.
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.066485

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CPE Information

Learning Objectives
Upon successful completion of this knowledge-based activity, participants should be able to:
1. Describe the design and results of the FRAIL AF study
2. Apply the results of the Groningen Frailty Index to a specific patient
0.05 CEU/0.5 Hr
UAN: 0107-0000-23-302-H01-P
Initial release date: 9/25/2023
Expiration date: 9/25/2024
Additional CPE details can be found here.

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Chapters

1. The FRAIL AF Study (00:00:00)

2. The Frail FAF Study (00:00:08)

3. Increased Bleeding in Fragile Patients (00:11:30)

4. Considerations for Choosing DOACs or Warfarin (00:17:53)