New Era of Highly Targeted Drugs Originating from the Dark Genome: Dr. Samir Ounzain, HAYA Therapeutics
Manage episode 421897412 series 3469528
Can the Dark Genome have the answer to any disease?
And if you are wondering, what is the dark genome, you are not alone. And it is absolutely fascinating.
Some scientists believe that the dark matter of the genome – previously called junk genome – might have the answer to many, many diseases.
With the potential to cure them completely.
Today we are speaking about heart fibrosis and also:
- the richness of the regulatory genome
- its function: as a kind of software for the human body
- RNA therapies that are targeted, non-toxic, fast in development
- an absolutely new approach to drugs
Dr. Samir Ounzain is the CEO of HAYA Therapeutics. A molecular biologist who’s researched dark genome and its roles for over 15 years. While a postdoc at Lausanne University Hospital (CHUV), he discovered hundreds of long-non-coding RNAs.
HAYA Therapeutics selected one of them, called Wisper, to develop a highly targeted drug to address cardiovascular disease. That's for starters. They already work on lung fibrosis, cancer microenvironment, liver, pancreas, and kidney. They are based in both Lausanne and San Diego.
https://www.hayatx.com/
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The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
Chapters
1. Dr. Samir Ounzain and HAYA Therapeutics (00:00:00)
2. Over 90% of Human Genome is Called Dark Genome (00:01:14)
3. What is the Dark Genome (00:07:12)
4. What is Epigenetics (00:08:12)
5. Why Are Humans Different from a Fly (00:11:41)
6. Most of Chronic Diseases Are Found in Dark Genome (00:17:56)
7. Types of RNA: Messenger RNA, Non-Coding RNA (00:20:17)
8. Building the Atlas of Cardiovascular Disease Dark Genome (00:26:40)
9. Fibrosis and the RNA Called Wisper (00:30:30)
10. How Can RNAs Be Used As Medicine (00:38:33)
11. Pre-Clinical Results in Heart Fibrosis: When You Block Wisper RNA (00:42:37)
12. Start of Studies in Humans of First in Biology Drugs (00:45:22)
13. HAYA's Atlas of Dark Genome and Search Engine (00:47:21)
14. HAYA in both Switzerland and the US (00:51:28)
15. Thank You, Follow HAYA (00:58:34)
16. Follow X-Health.show, Disclaimer (00:59:42)
66 episodes