A podcast discussing current research in the field of Genomics
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Interviews and discussions about the best in Catholic literture past and present.
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Darragh Wynne and Eleanor O' Brien bring you weekly updates on how they're getting on going Carbon Neutral this Lent and what they're learning from the whole experience.
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Transposons and epigenetic priming of enhancers within early human embryo development with Dr Christopher Todd
1:26:40
1:26:40
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1:26:40
In today's episode I spoke again to Dr Christopher Todd from the Babraham institute. Chris is a postdoctoral researcher in Wolf Reiks lab who talked to me about transposable elements and epigenetic priming of enhancers with human embryonic development. Chris gave a great talk at GREECS 2022 where he discussed his research and I absolutely loved his…
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Neuroscience meets epigenetics - Doctor Ben Rein
1:27:07
1:27:07
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1:27:07
TGL made it to 2022! On todays episode, I spoke to Dr Benjamin Rein, a neuroscientist all the way from Stanford. We speak all about Bens experience of science communication on social media, Ben uses Tik Tok & instagram to make awesome short videos on scientific papers and topics and has gained a following of +600,000 on tik tok! He also talks all a…
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Spatial transcriptomics with Dr Patrick CN Martin
1:17:27
1:17:27
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1:17:27
In today's episode I spoke again to Dr Patrick CN Martin from the Biotech research and innovation centre at the University of Copenhagen, about spatial transcriptomics. Patrick is a post doctoral researcher who has been working on ST and more specifically, this pre print which we also took a deep dive into, on todays episode! Patricks new tool, nam…
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Epigenetics & fertility with Alka Gupta
1:11:46
1:11:46
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1:11:46
This week I spoke to Alka Gupta. Alka has just finished up her PhD and begun her postdoctoral position at UCSC in the Sharma Lab where she is now working on epigenetic inheritance. Today we spoke about her PhD research in which she was looking at the role of microRNAs in male infertility. We learnt about Sertoli cells, spermatogenesis and shrinking…
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Biomarkers in genomics with Dr Paul Okunieff
54:59
54:59
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54:59
Today I speak to Dr Paul Okunieff , founder and consultant of Diacarta. DiaCarta is a leading translational genomics and personalized diagnostics company based in California. DiaCarta provides highly sensitive and advanced technologies aiming to change the landscape of precision medicine and molecular diagnostics by impacting healthcare treatment p…
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The dark matter of the genome with Sudarshan Pinglay
1:09:23
1:09:23
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1:09:23
On todays episode, I speak to Sudarshan Pinglay, a PhD student from NYU medical center. Sudarshan is involved in the dark matter project- we talk about the dark matter of the genome, where introns, repetitive and regulatory elements reside. Sudarshan works specifically on the HOXA locus. The Hox family of genes pattern the head to tail axis in the …
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The immune system: B cells and Epigenetics with Dr Hamish King
1:14:31
1:14:31
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1:14:31
In todays episode, I speak to Dr Hamish King, a Sir Henry Wellcome Fellow affiliated with the Blizard Institute at Queen Mary University of London. Hamish is interested in how errors in gene regulation lead to changes in the behaviour and function of B cells, an important cell type in our immune system that makes antibodies to fight and remember in…
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Epigenetic biomarkers of exposure to tobacco smoke : A biosocial approach with Alexandria Andrayas
1:02:21
1:02:21
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1:02:21
Welcome to Episode 29 of The Genomics Lab! On today's episode we talk to Alexandria Andrayas who is a PhD candidate in the Soc-B Centre for doctoral training which is a new and unique programme in biosocial research. The programme is funded by the Economic and Social Research Council and the Biotechnology & Biological Sciences Research Council. It …
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Dissecting the binding mechanisms of Transcription Factors to DNA with Dr Patrick CN Martin
1:10:52
1:10:52
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1:10:52
Welcome to Episode 28 of The Genomics Lab! On today's episode we talk to Dr.Patrick CN Martin who is a postdoctoral researcher at the University of Copenhagen. He completed his PhD in Dr Radu Zabets lab in 2020 where he investigated the binding mechanisms of transcription factors to DNA. His research involved development of an R package, ChIPAnalys…
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Remote control of gene expression: enhancers and the 4D genome with Professor Wendy Bickmore
1:16:42
1:16:42
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1:16:42
This week we are honoured to host Professor Wendy Bickmore, the Director of the MRC Human Genetics unit at the University of Edinburgh. Wendys research laboratory focuses on trying to better understand the 3D organisation of the genome, and how this controls how the genome functions during normal development. They are further interested in how this…
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Rattlesnakes and Population Genomics with Kat Ivey
1:11:04
1:11:04
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1:11:04
Welcome back! Today we are talking to Kathleen Ivey, a PhD student from the University of Texas at Arlington in the Castoe Lab. Kat talks to us all about her journey to her PhD, with a background in vet tech & herpetology. Kat now focuses on population genomics, with a particular interest in Rattlesnakes. She tells us all about being out in the fie…
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Making connections between epigenetics and evolution with Dr Peter Sarkies
1:21:20
1:21:20
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1:21:20
Welcome back for another episode! This week we chat to Dr Peter Sarkies from Imperial College London / MRC LMS! Peter is a senior lecturer running his own laboratory which aims to make connections between epigenetic gene regulation and evolution. Peter talks to us all about his research involving investigation of a wide range of epigenetic pathways…
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Epigenetic regulation in neurodegenerative diseases with Dr Sarah Marzi
1:06:30
1:06:30
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1:06:30
On todays episode, we talk to Dr Sarah Marzi from Imperial College London all about her work into the epigenetic regulation in neurodegenerative diseases like Alzheimers and Parkinsons. Sarah tells us about her journey into this field and describes what exactly neurodegenerative diseases are?! She also talks to us about her contributions to the fie…
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This week we took a slight detour away from our normal topic of conversation (Genomics) and immersed ourselves into the world of DNA nanotechnology with Dr Andrew J Lee, the centre manager of the Bragg Centre for materials research. Andy is a weaver of DNA and nanoscale filmaker in the Bioelectronics group. He develops nanostructures that are self …
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Non-CG Methylation and its Role in Development with Dr Ozren Bogdanovic
59:35
59:35
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59:35
Our second guest from the Garvan Institute of Medical Research in Sydney, is DrOzren Bogdanovic. We are so privileged to talk today to Ozren about his work in developmental epigenetics which covers how DNA methylation participates in diverse developmental processes, and how deposition and removal of the methylation mark impacts upon embryonic and g…
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The association between socioeconomic factors, the methylome and heart failure with Dr Mark Pepin and Dr Adam Wende
1:07:02
1:07:02
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1:07:02
On todays episode we speak to Dr Adam Wende and Dr Mark Pepin! We discuss their recent publication which has been all over twitter recently! During the research, they identified an association between socioeconomic factors, the methylome, & heart failure. We discuss all of the motivations, methodological techniques and interesting findings from the…
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Extrachromosomal circular DNA, chromosome evolution & circular DNA in human disease with the Regenberg Lab (Dr Birgitte Regenberg and Dr Sam Keating)
1:10:37
1:10:37
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1:10:37
In today's episode we speak to Dr Birgitte Regenberg and Dr Sam Keating from the Regenberg Lab, University of Copenhagen, about extrachromosomal circular DNA and it's significance in human disease. Circular DNA originates from chromosomes but differs from linear chromosomes as they mostly don’t have centromeres - so if a gene is trapped on a circle…
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Single Cell Technology Development and Spatial Omics with Dr Cátia Moutinho
1:10:38
1:10:38
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1:10:38
We've reached episode 20!!! In celebration of our twentieth episode, we are speaking today to Dr Cátia Moutinho about single cell sequencing and spatial omics - two up and coming techniques that everyone seems to be talking about at the moment. Cátia is Group Leader of the Single Cell Technology Development in the Garvan Institute in Sydney, Austra…
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The importance of DNA damage in all areas of disease and the potential for personally tailored oncological treatments based on the analysis of DNA damage using machine learning, with Dr Anna Poetsch
1:09:35
1:09:35
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1:09:35
This week we speak to Anna Postsch. Anna is a group leader at the biotechnology center at the University Dresden! Her group employs computational techniques and machine learning approaches to assess and model DNA damage and repair processes, mutagenesis and genome editing to develop clinical applications. We also had some interesting conversations …
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Cancer epigenetics & the role of Ybx1 in fine tuning PRC2 activity to control embryonic brain development with Dr Myron Evans
1:07:12
1:07:12
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On this weeks episode we are discussing Cancer and developmental biology in genomics with Dr Myron Evans! Myron is currently a post doctoral research fellow at St Judes Childrens research hospital in Memphis, Tennesse! Myron discusses with us his journey into cancer biology and shares a unique perspective of life working at a research hospital. He …
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The role of Yq-linked genes in fertility and offspring sex ratio with Dr Peter Ellis
1:17:25
1:17:25
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1:17:25
We're back after the Easter Break with an extremely interesting episode with Dr Peter Ellis from the School of Biosciences at the University of Kent! Dr.Ellis is a Lecturer in Molecular Genetics and Reproduction at the University of Kent. His research thus far has involved the identification of novel genes on the mouse Y chromosome that affect sper…
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DNA methylation & epigenetic reprogramming during development with Dr Maxim Greenberg
1:13:50
1:13:50
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1:13:50
Join us today as we speak to Dr Maxim Greenberg, located at the Institut Jacques Monod in the heart of Paris. IJM is one of the premier institutes for fundamental research in the life sciences in France. Maxim's lab aims to better understand the epigenetic consequences of DNA methylation during a specific window of development which occurs in the f…
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The Role of Mitochondrial Quality Control Pathways in Familial and Non-Familial Variants of Disease, with David Tumbarello
1:09:29
1:09:29
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Join us today as we speak to Dr David Tumbarello, from the University of Southampton, as he talks to us about his dynamic and varied academic career that has taken him from New York, to Southampton, stopping off at a number of places in between!! David's lab currently focuses on understanding the cellular mechanisms and molecular machinery required…
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Evolutionary genomics- exploring the genomic basis of biological adaptations and transitions with Dr Jordi Paps Montserrat
1:10:31
1:10:31
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1:10:31
In today's episode, we speak to Dr Jordi Paps-Montserrat, lecturer in the School of Biological Sciences at the University of Bristol. Jordi did his PhD at the University of Barcelona, before completing his post-doc at the University of Oxford. We talk with Jordi today about his work on evolutionary genomics, and how we can elucidate biological adap…
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Genomic analysis of the Ashanti Dwarf pig of Ghana and Sustainable agricultural production utilising genomic tools with Sethlina Naa Dodua Aryee
1:08:50
1:08:50
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1:08:50
Join us today as we speak to an inspirational Woman in STEM, Sethlina Naa Dodua Aryee, raised in Ghana, who moved to the University of Cambridge to complete her PhD in sustainable food production through the use of genomic and bioinformatic tools - a global issue that she has been passionate about for her whole life. Sethlina speaks to us today abo…
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Celebrating Women in STEM for International Women's Day, with Dr Louise Beard and Dr Michelle Taylor: Bonus Ep2
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1:02:42
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In order to celebrate International Women's Day 2021, we have picked two inspirational role models at our University and invited them to speak to us about their experiences of being a woman in science. We learn about their varied and exciting careers, and then we discuss all of our personal experiences of being a woman in science - from how we were…
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CTCF binding, nucleosome positioning and 3D chromatin organization with Dr Christopher Clarkson
1:07:32
1:07:32
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In today's episode, we are excited to be talking to Dr Christopher Clarkson, currently based at UCL, where he has just started a post-doctoral research position. In 2020, Dr. Clarkson completed his PhD at the University of Essex where he investigated changes of nucleosome positioning and 3D chromatin organization! In today's episode, we discuss how…
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Designer Babies, Disseminating Science, and Dinosaurs with Professor Darren Griffin
1:13:47
1:13:47
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In today's episode, we are privileged to be speaking to Professor Darren Griffin, who is currently based at the University of Kent, where he is the director of the Centre for Interdisciplinary Studies of Reproduction, and Professor of Genetics. Darren is President of the International Chromosome and Genome Society, and is a world leader in the fiel…
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Running a genomics core facility and discussing careers in genomics - Nicky Hales
51:34
51:34
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51:34
Don't miss today's episode, as we are joined by Nicky Hales, who runs a Genomics Core Facility in Texas! This episode is a little different to usual, as we are focusing more on a genomics based career path, and excitingly, it's a career path we did not know much about - so it was a real learning curve to talk to Nicky. Nicky explains to us how she …
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Social media in academia and networking as a PhD student - Joseph Festa and Brad Richardson (Bonus Ep1)
1:09:53
1:09:53
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Something a little different - our first BONUS episode. Today we talk to Brad and Joe about our experience of using social media as a networking an science communications tool. Brad and Joe briefly introduce their research (for once, not genomics......) and we then discuss the pros and cons of a number of social media platforms, as well as the powe…
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Using explainable AI to understand the enhancer histone modification code - Jareth Wolfe
58:42
58:42
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58:42
Welcome to Episode 5 of The Genomics Lab! On today's episode we talk to Jareth Wolfe who is a final year PhD student at the University of Essex. We talk to Jareth today about his work on using explainable artificial intelligence models in order to identify enhancers in DNA. Jareth explores the link between histone modifications and enhancers, expla…
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Epigenetic biomarkers of exposure to tobacco smoke : A biosocial approach - Alexandria Andrayas
59:18
59:18
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59:18
Welcome to Episode 6 of The Genomics Lab! On today's episode we talk to Alexandria Andrayas who is a PhD candidate in the Soc-B Centre for doctoral training which is a new and unique programme in biosocial research. The programme is funded by the Economic and Social Research Council and the Biotechnology & Biological Sciences Research Council. It c…
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Identifying genetic variants for inherited retinal disease - Laura Whelan
56:49
56:49
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56:49
Welcome to Episode 3 of The Genomics Lab! On today's episode we talk to Laura Whelan, who is a PhD researcher at the School of Genetics & Microbiology at the Trinity College Dublin. Laura is part of the Target 5000 programme; the first large-scale study to apply next generation sequencing to the Irish inherited retinal diseases (IRD) patient popula…
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How neuroepigenetics can help us to better understand spinal cord injury -Jess Chadwick
49:05
49:05
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49:05
Welcome to Episode 1 of The Genomics Lab! On today's episode we talk to Jess Chadwick who is a third year PhD researcher at Imperial College London. She is doing her PhD in molecular neuroscience, investigating the molecular mechanisms of axonal regeneration after spinal cord injury. Jess talks to us about how axonal injury in the spinal cord usual…
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ARK Watson sits down with Chris Sparks to talk about maintaining faith in a world that is increasingly anti-Catholic. How do we respond when people bring the many moral issues in the Church today?
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Catholic Reads found ARK Watson sits down for a chat with author Annette Young.
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With Lent over and storm Hannah approaching, Darragh and Eleanor reflect on the whole experience with more giddiness and frankness than ever before...
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Darragh and Eleanor discuss the environmental impact of the fashion industry and share some great news!
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Darragh and Eleanor return with news of tree planting, an update on their footprints and some more info about food!
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Courtney Guest Kim interviews John O'Neil about his book The Fisherman's Tomb.
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ARK Watson interviews Eleanor Bourgh Nicholson, author of A Bloody Habit.
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ARK Watson reviews The Joining by J.H. Dierking
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S. Leigh Hall reviews The Table by Dennis Lambert
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Lori Wilson's review of A Distant Prospect by Annette Young.
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M.S. Ocampo reviews 10 Steps to Girlfriend Status by Cynthia Toney.
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Eric Postma interviews Declan Finn about his vampire series Honor at Stake.
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S. Leigh Hall reviews Woman - My Confession by Marianne Collins.
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Catholic Reads founder ARK Watson reviews Vigil by Russell Newquist.
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S. Leigh Hall reviews Roland West Loner by Theresa Linden.
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