Updates on new data and best practices in the care of patients with cancer across a wide variety of solid tumors and hematologic malignancies from Clinical Care Options. Gain practical clinical insights and strategies and earn CME/CE credit for selected episodes.
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Welcome to Talking To Charlie - the home of real life experiences from those directly or indirectly affected by cancer, plus the many other challenges that life can sometimes throw at us - www.talkingtocharlie.com
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Life is messy, so a dash of chaos is enough to set you over the edge. You're not alone. There's a lot of things in life to experience, and I'm fairly certain I've had my share. I'm a single mom who works full-time, raising two boys, one on the spectrum, and in between all that I managed to find myself on the PTSA board, starting a nonprofit, and doing piles of laundry. Prior to this madness I had to deal with fighting Non-Hodgkin's lymphoma. I'm currently working on weight loss, meditation, ...
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Welcome to the Power Pod, a space to elevate your life and help you feel more powerful. My name is Alexa and I am the host of this podcast and #1 best selling author of Power to Persevere: Inspiring Stories to Help You Get Through Challenging Moments. My goal is to help improve your life through wellness tips and motivation, and support you on your journey through life. Make sure you stay tuned for new episodes weekly. Connect with me on Instagram @alexacuc and alexacuc.com
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1
Congress to Clinic: Expert Takeaways on Emerging Data for MPNs
28:35
28:35
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28:35
In this episode, listen to Dr Brady L. Stein share his clinical insights and takeaways on new data for myeloproliferative neoplasms (MPNs) presented at the 2024 ASCO Annual Meeting and the EHA 2024 Congress including: Long-term survival adjusted for treatment crossover in patients with myelofibrosis (MF) treated with momelotinib vs danazol in the M…
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1
CELMoDs: Spotlight on Therapeutic Approaches Targeting Protein Degradation Pathways
24:23
24:23
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24:23
In this podcast episode, Julio C. Chavez, MD, MS, and Alan Skarbnik, MD, discuss the emerging role of CELMoDs in NHL care, including: Rationale for targeting CELMoDs in NHL Mechanism of action of CELMoDs Key studies and available efficacy and safety data with investigational CELMoDs in NHL Key ongoing clinical trials of CELMoDs in NHL Strategies to…
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1
Experts Discuss the Role of CDK4/6 Inhibitors in HR+/HER2- Breast Cancer
24:30
24:30
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In this episode, Dr Joyce O’Shaughnessy moderates a discussion with Dr Sara Hurvitz and Dr Erica Mayer answering audience questions on the latest data on incorporating CDK4/6 inhibitors into treatment plans for patients with HR+/HER2- breast cancer. Topics in this podcast include: Evidence from the monarchE and NATALEE trials of adjuvant abemacicli…
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1
A cancer survivor and thriver - kicking breast cancer into touch at 28 w/ Lucy Horan
55:38
55:38
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55:38
In this episode, Charlie is joined by Lucy who was diagnosed with Stage 4 breast cancer at the age of 28. Living a seamlessly normal life, her world was turned upside down when she discovered a small lump above her left breast on Christmas Eve last year. Fast forward 6 months and Lucy tells of her remarkable story and how she now finds herself with…
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1
Congress to Clinic: Expert Takeaways on Emerging Data for AML
25:21
25:21
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25:21
In this episode, listen to Professor Eunice S. Wang, MD, share her clinical insights and takeaways on new data for acute myeloid leukemia (AML) presented at the 2024 ASCO annual meeting and the EHA 2024 Congress including: Data from the prospective, single-center phase Ib/II study of FLAG-IDA plus venetoclax in newly diagnosed or relapsed/refractor…
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1
Congress to Clinic: Expert Takeaways on Emerging Data for MDS
19:19
19:19
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19:19
In this episode, listen to Professor Courtney DiNardo, MD, MSCE, share her clinical highlights and clinical takeaways on new data for myelodysplastic syndromes (MDS) presented at the 2024 ASCO annual meeting and the EHA 2024 Congress including: COMMANDS trial of luspatercept in transfusion-dependent, erythropoietin stimulating agent–naive, very low…
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1
Living with my wife's terminal breast cancer diagnosis w/ Hadley Green
36:53
36:53
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36:53
In this episode, Charlie is joined by Hadley whose wife has been diagnosed with terminal breast cancer following 6 months of failed chemotherapy. As a successful businessman and father of 3 teenage children, he's had to learn to manage his emotions and mental health for the benefit of all those around him and in particular his wife, Lydia. As they …
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1
Using Spirituality and Science to Facilitate Food Freedom/ Getting in Touch with Hunger Cues/ Power of Protein with Sloane Elizabeth
35:53
35:53
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Topics include: Body image, food, post-puberty Perfectionism, self-worth Breaking out of control/ finding what feels unsafe Deep healing in the subconscious mind Addressing hunger cues Veganism and protein Releasing weight Miami recsFollow Sloane on Instagram: @sloaneelizabeth
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1
How to be Confident in Career by Changing Your Thoughts - Neural Network - Affirmations - Meditation Pep Talk
13:46
13:46
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13:46
Share this with whoever might need it - this one is a request for a dear friend (a bonus meditation pep talk)! Starts at 1:56My name is Alexa and I am the host of this podcast and #1 best-selling author of Power to Persevere: Inspiring Stories to Help You Get Through Challenging Moments. My goal is to help improve your life through wellness tips an…
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1
Reduce Inflammation/ Life After Hodgkin Lymphoma w/ Cancer Survivor and Health Coach Madison Pollack
48:07
48:07
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48:07
The transformation from cancer, career changes, health coaching, overcoming fears, and reducing inflammation with Madison Pollack. We talk about meal prepping, mindset, go-to salads, fitness, and more.Madison's Instagram: https://www.instagram.com/cancersurvivor_nutritioncoach/?hl=enMadison's podcast: https://podcasts.apple.com/us/podcast/cancer-ac…
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1
Keeping Your Head Up and Fostering Strength With Matthew @MattyBowels Ulcerative Colitis Awareness & My Cancer Experience with Hodgkin's Lymphoma AYA Cancer Survivor
1:11:18
1:11:18
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Matt dives into his experience with UC and the following topics/ themes: Having a second chance at life Surviving life weighing 101 - 111 lbs as a 5'7 male Colonoscopy/ j-pouch surgery and complications Maintaining a positive mindset Advocating for your health Finding the right medical team Power of prayer and synchronicities Fostering friendships …
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1
3 Small Habits to Boost Your Energy (walking and fashion/ tips living in NYC)
15:57
15:57
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15:57
Three simple hacks to help you light UP & make the world a better place.My name is Alexa and I am the host of this podcast and #1 best-selling author of Power to Persevere: Inspiring Stories to Help You Get Through Challenging Moments. My goal is to help improve your life through wellness tips and motivation, and support you on your journey through…
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1
Poverty to Abundance and Entrepreneurship Through Law of Attraction with Sabrina @betteryoubysabrina
32:26
32:26
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32:26
Sabrina, Spiritual Mindset Mentor and Coach, and I have a discussion on creating reality. Tune in to learn how to work with Sabrina."Following your intuition is like walking through thick fog."From poverty to abundanceVictim mindsetBlacking out from drinkingChanging your environmentJournalingChronic anxiety and depressionListening to your intuition…
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Pivoting Through Entrepreneurial Ventures and Using Social Media to Grow Your Network at 23 with Creative Kate Hannan @sheconnectsclub @katesheconnects
37:21
37:21
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Kate’s bubbly personality and passion for connection are contagious. Tune in to hear topics including: Partnerships with Seek and Lemon 8 Businesses by Kate: She Connects, 99 Angels, Daisy Denim, Fleur, Male Stylist NYC life & fashion influence Meeting and Connecting with like-minded people How to create an event Finding power in creativity and art…
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(2/2) The Importance of Human Connection in Marketing and Business, Dealing with Rejection, and Learning From Your Challenges w/ Danielle Becker @leftysrightmind
25:12
25:12
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Part two is here! Topics include: Importance of human connection What is sourcing? Overcoming challenges and embracing the unknown How to deal with rejection Favorite collaborations Ralph Lauren Fashion Week, Marie Claire Habits and Lifestyle ZodiacsAnswering Questions:✨Advice for aspiring artists/ entrepreneurs:- How do you find yourself as an art…
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(1/2) Growing Your Creative Agency and Turning Your Passion into a Business w/ Danielle Becker @leftysrightmind
21:32
21:32
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Meet Danielle, CEO and Founder of Lefty’s Right Mind, a bespoke creative studio. IG: @leftysrightmindTopics include: Starting a career at Aeropostale, Hanes, Champion, Nike, Walmart Discovering your identity through motherhood and balancing careerLefty’s Right Mind is a full-service, bespoke atelier that brings a client’s vision to life through cre…
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Should I Quit my 9-5? Should You Get into Real Estate? The Arts? Finding Your Foundation Mentally and Physically and Entrepreneurship in Copenhagen w/ Henriette Einevoll Husby @businesshenriette
34:36
34:36
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Topics include: Dancing, Real estate, Entrepreneurship Master’s Degree in Strategy and Leadership Expanding in the US market Life in NYC Reaching out and being bold when networking The power of social media Quitting your 9-5 Budgeting your income entrepreneurship Dealing with rejection https://www.instagram.com/businesshenriette/https://www.busines…
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1
Thriving in Your 20s - Approach Health Through a Place of Love and Curiosity, Dietetics, Hormonal Balance, Blood Sugar Regulation with Ava Nouri
49:41
49:41
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49:41
Topics include: Approach health through a place of love and curiosity The intentionality of food choices from a place of love, gratitude, and intention Is meat actually bad for you? Thoughts on veganism Normalizing your blood sugar to prevent hanger What a balanced meal looks like Protein powder - whey versus pea Heme versus non-here iron Build the…
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1
Experiences With Oral SERDs for HR+/HER2- Metastatic Breast Cancer
25:55
25:55
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In this episode, Manali Bhave, MD; Annalise Labatut, PharmD, BCOP; and nurse practitioner Jamie L. Carroll, CNP, APRN, MSN, begin by discussing the landmark EMERALD study that led to FDA approval of elacestrant, the first oral selective estrogen receptor degrader (SERD) for treatment of hormone receptor–positive/HER2-negative metastatic breast canc…
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1
Applying the Latest Evidence and NCCN Guideline Recommendations in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
47:23
47:23
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47:23
In this episode, Danielle M. Brander, MD; Deborah Stephens, DO; and Brian Hill, MD, PhD, discuss key aspects of the NCCN CLL guidelines and share strategies for applying these recommendations in your clinical practice to optimize treatment and outcomes. The greater discussion addresses: Optimal selection of therapy for treatment-naive CLL, includin…
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1
Part 2: Our child's cancer diagnosis and parenting w/ Alice Richardson
38:49
38:49
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38:49
In this episode, Charlie is joined by Hazy's mother Alice, following the previous episode with her husband, Paddy. Having had a very candid and somewhat emotional discussion with Paddy about Hazy's diagnosis, her subsequent treatment and the magical moment when she rang the bell in Great Ormond Street Hospital. Charlie & Alice now discuss what life…
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Part 1: Our child's cancer diagnosis and parenting w/ Paddy Richardson
44:15
44:15
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44:15
In this episode, Charlie is joined by his very good friend Paddy Richardson. Paddy is a successful businessman and married father of three. Rewind nine years and Paddy and his wife Alice, received the news that no parent would ever wish to get, that their child had cancer. Their youngest daughter Hazel, only 18 months old at the time was diagnosed …
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1
My experience with Hodgkin's Lymphoma: Q&A w/ Charlie Mitchell
37:47
37:47
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In this episode, Charlie changes places as the host of his own show and becomes the guest. Following a few requests suggesting listeners wanted to learn more about Charlie's own diagnosis and experience, that is exactly what the focus and premise of this episode is. His previous guest, James Benzing takes on the hosting duties and they take a more …
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1
Homologous Recombination Repair (HRR) Testing and Targeted Therapy in Prostate Cancer
48:15
48:15
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In this episode, Colin C. Pritchard, MD, PhD, a pathologist, and Heather H. Cheng, MD, PhD, a medical oncologist, discuss optimal biomarker testing to guide treatment decisions in advanced prostate cancer, with topics including: Rationale for targeting PARP in prostate cancer with ARI combinations Study design nuances and findings from key randomiz…
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1
Real-world Perspectives on Novel HER2-Targeted and TROP-2–Directed Therapies in Advanced Breast Cancer
36:29
36:29
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In this podcast episode, Sara M. Tolaney, MD, MPH, and Melinda Telli, MD, delve into the critical aspects of the current therapeutic landscape for patients with unresectable or metastatic HER2-low, hormone receptor–positive, and triple-negative breast cancer, including: Challenges with the pathologic testing for HER2-low expression Optimal treatmen…
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1
Can trauma lead to a cancer diagnosis? w/ James Benzing
47:58
47:58
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In this latest episode, Charlie is joined by James Benzing, his therapist and now good friend. In the previous episode, Charlie's guest Lucy Smail was adamant that her cancer diagnosis all stemmed from the trauma she experienced upon learning of her sons paralysis. Her body shut down and became overridden with cortisol and various other symptoms. W…
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1
Confronting a terminal colon cancer diagnosis w/ Lucy Smail
52:13
52:13
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52:13
In this episode, Charlie is joined by Lucy, who was diagnosed with Stage 4 Colon Cancer and told she had just 5 months to live. After the initial shock and not to be disheartened, she started to do her own research in an attempt to overcome her prognosis. Reading up on all the alternative medicines, self-healing techniques and practices out there s…
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Your nutrition choices and cancer w/ Andrew Finlay, Wild View Retreat
42:47
42:47
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42:47
In this episode, Charlie is joined by his good friend Andrew Finlay. Andrew is a leading nutritionist, as well as the Owner of the hugely successful well-being retreat, Wild View Retreat in Portugal. But he didn't get there by chance. He had to circumnavigate certain life changing events and scenarios before finding his purpose and focusing on a ne…
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1
The cancer landscape and Hodgkin lymphoma w/ Professor George Follows
41:10
41:10
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41:10
In this episode, Charlie is joined by his own oncologist Professor George Follows and they discuss various aspects of cancer, as well as having a heart-to-heart about their own experiences together. George is one of the countries leading haematologists and as well as holding a number of key appointments at regional and national level, he also has a…
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Hi and welcome to Talking to Charlie. I’m your host Charlie and this is my podcast. Hoping to extend a hand if you like, to all those who have been directly or indirectly affected by cancer in their lives. I’ll be inviting guests from all walks of life including oncologists, patients, parents of patients, nutritionists, psychologists and celebritie…
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1
Current Considerations for Adverse Event Management With HER3-Directed Agents
12:33
12:33
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The third and final episode in a 3-part series covers the safety profile of and considerations for managing adverse events associated with HER3-targeted antibody–drug conjugates, including patritumab deruxtecan (HER3-DXd) and others, in the setting of lung cancer. Presenters in this series include: Rebecca S. Heist, MD, MPH Associate Professor of M…
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Unpacking the Potential of HER3-Targeted Therapy in NSCLC
15:24
15:24
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This second episode in a 3-part series on HER3-targeted agents in NSCLC covers current clinical trials with HER3-targeted therapy, including: Recent data on patritumab deruxtecan (HER3-DXd) in the HERTHENA-Lung01 trial The EGFRxHER3 bispecific antibodies BL-B01D1 and izalontamab The HER2xHER3 bispecific antibody zenocutuzumab The HER3-targeted anti…
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1
Recent Advances in ADCs and Rationale for HER3 as a Target in Lung Cancer
8:54
8:54
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This first episode in a 3-part series tackles the role of HER3 in cancer, specifically in NSCLC, and how HER3 can be effectively targeted with ADCs. Presenters in this series include: Rebecca S. Heist, MD, MPH Associate Professor of Medicine Harvard Medical School Medical Oncology Massachusetts General Hospital Boston, Massachusetts Helena Yu, MD A…
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1
Expert Insight on Seminal New Clinical Trial Data Presented at the 2023 IGCS Conference Informing Treatment for Endometrial, Ovarian, and Cervical Cancers
30:29
30:29
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30:29
In this episode, Brian Slomovitz, MD, MS, FACOG, and Keiichi Fujiwara, MD, PhD, share their thoughts and opinions on seminal data presented at the 2023 IGCS annual meeting for endometrial, ovarian, and cervical cancers, including: Phase III NRG GY018 trial of carboplatin and paclitaxel with or without pembrolizumab followed by pembrolizumab or plac…
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1
Novel Emerging Investigational Treatment Strategies for Patients With Myelofibrosis
19:33
19:33
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In this episode, Jacqueline S. Garcia, MD, discusses novel agents and strategies in clinical trial development for treating patients with myelofibrosis, including: Navitoclax (BCL-XL/BCL-2 inhibitor) Pelabresib (BET inhibitor) Imetelstat (telomerase inhibitor) Luspatercept (erythroid maturation agent) Additional strategies Presenter: Jacqueline S. …
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1
A Year in Review and a Look to the Future: BTKi in CLL and MCL
27:33
27:33
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27:33
In this episode, Ana Marin-Niebla, MD, PhD, and Stephan Stilgenbauer, MD, discuss key trial data on the use of BTK inhibitors in CLL and MCL throughout the past year, how these studies have impacted their practice, and what data they are looking forward to in the near future. The discussion includes analyses of: SHINE: First-Line Ibrutinib + Bendam…
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Expert Insight on Key Updates and New Clinical Trial Data From the ESMO 2023 Congress Informing Treatment for Endometrial, Ovarian, and Cervical Cancers
33:18
33:18
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33:18
In this episode, Isabelle Ray-Coquard, MD, PhD, and Ana Oaknin, MD, PhD, provide expert insights on new clinical trial data presented at the 2023 ESMO annual congress for endometrial, ovarian, and cervical cancers, including: Results from the double-blind, randomized, placebo-controlled phase III AtTEnd trial of atezolizumab plus carboplatin/paclit…
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1
Expert Insights and Considerations for Precision Care With HER3-Targeted Agents in NSCLC and Breast Cancer
38:51
38:51
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38:51
In this episode, Aakash Desai, MD; Narjust Florez, MD; and Paolo Tarantino, MD, discuss the biologic rationale and clinical development of agents targeting HER3 for the treatment of breast and lung cancers. The potential niche for HER3-targeted agents in these treatment landscapes is considered, with consideration of acquired resistance to previous…
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1
Improving Care for Black Patients With Endometrial Cancer
26:58
26:58
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26:58
In this episode, Dr Leslie Boyd and Adrienne Moore, a patient advocate and endometrial cancer survivor, discuss how healthcare professionals can partner with Black patients to improve the diagnosis and management of endometrial cancer (EC). Topics include: Data on racial disparities in EC survival Importance of listening to Black patients to better…
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1
Spurts of Excellence: What It's Like Running a Business with Family with Caroline and Lizzy Tierney with @daughters.lessons
36:17
36:17
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Expert Insight on Key Updates and New Clinical Trial Data From the ESGO 2023 Congress Informing Treatment for Cervical, Ovarian, and Endometrial Cancers
24:54
24:54
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24:54
In this episode, Domenica Lorusso, MD, PhD, and Alexandra Leary, MD, PhD, provide expert insights on key updates and new clinical trial data presented at the ESGO 2023 Congress for cervical, endometrial, and ovarian cancers, including: Long-Term Follow Up From Phase III SIENDO Study of Selinexor vs Pbo Maintenance in Patients With TP53wt Advanced/R…
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1
New Evidence With BTK Inhibitor Therapy in CLL and MCL From SOHO 2023
20:58
20:58
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20:58
In this episode, Catherine C. Coombs, MD, MS, and Toby Eyre, MBChB, MD, discuss key trials presented at SOHO 2023 evaluating the use of BTK inhibitors in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). The discussion includes analyses of: Matching-adjusted indirect comparison of 3 randomized phase III trials of ibrutinib for rela…
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Send to a friend to boost their energy, help them find their proud moment, and stop living on autopilot. I share a little story about how I have felt proud of all that I have personally experienced in life the past few years: overcoming survivor guilt after chemotherapy, accepting life, and looking at every experience as a blessing. My name is Alex…
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New Evidence With BTK Inhibitor Therapy in MCL From ICML 2023
14:39
14:39
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14:39
In this episode, Catherine C. Coombs, MD, and Toby Eyre, MBChB, MD, discuss key trials presented at ICML 2023 evaluating the use of BTK inhibitors in mantle cell lymphoma (MCL). The discussion includes analyses of: Phase II trial of acalabrutinib with rituximab for older patients with untreated MCL BRUIN: updated results of pirtobrutinib in covalen…
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1
JUST DO IT! How to motivate yourself in your 20s...
16:25
16:25
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16:25
A must-listen if you are struggling on where to start and NEED motivation <3 My name is Alexa and I am the host of this podcast and #1 best-selling author of Power to Persevere: Inspiring Stories to Help You Get Through Challenging Moments. My goal is to help improve your life through wellness tips and motivation, and support you on your journey th…
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New Evidence With BTK Inhibitor Therapy in CLL From EHA 2023
27:03
27:03
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27:03
In this episode, Catherine C. Coombs, MD, MS, and Toby Eyre, MBChB, MD, discuss key trials presented at EHA 2023 evaluating the use of BTK inhibitors in chronic lymphocytic leukemia (CLL). The discussion includes analyses of: CLL12: final results of the phase III trial of ibrutinib vs placebo in asymptomatic, treatment-naive CLL SEQUOIA: extended f…
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COPING WITH YOUR 20s: Career, Dating, Friends, Moving, WE TELL IT ALL featuring Enara and us laughing
35:34
35:34
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Enara and I discuss the following: Three things we learned in our 20s Listening to your gut Self-validation Honoring your present (trusting your path) We also answer 3 questions and give tips from our audience! How to make friends/ relationships How to cope with stress What to do when your friends are in different life stages…
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*MEDITATION* to Help Achieve Goals (Affirmations, Visualization, 15 minutes)
14:56
14:56
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This meditation will help you condition your body to reach your highest goals and declare a large milestone you want to achieve. In order to tap into your desires, you need to tune into your body and clear all that is blocking you, get clear on the future person you want to embody, and energetically create the match to get there closer. We use thes…
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Expert Insight on Key Updates and New Clinical Trial Data From the 2023 ASCO Annual Meeting, Informing Treatment for Cervical, Ovarian, and Endometrial Cancers
46:02
46:02
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In this episode, Kathleen Moore, MD, MS, and Nicoletta Colombo, MD, PhD, provide expert insights on key updates and new clinical trial data presented at the 2023 ASCO Annual Meeting for cervical, endometrial, and ovarian cancers, including: ENGOT-EN6-NSGO/GOG-3031/RUBY: phase III study of dostarlimab plus chemotherapy followed by dostarlimab mainte…
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How to Find Your Beauty - (great episode for female cancer patients!!!)
20:11
20:11
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20:11
I give some mind, body, and soul tips on finding your inner beauty and walk through my chemo story a little. 10:45 - how to find your beautyYouTube: https://youtu.be/y6wNL9DvXzYMy name is Alexa and I am the host of this podcast and #1 best-selling author of Power to Persevere: Inspiring Stories to Help You Get Through Challenging Moments. My goal i…
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