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Homologous Recombination Repair (HRR) Testing and Targeted Therapy in Prostate Cancer
Manage episode 409274058 series 3256997
Content provided by Clinical Care Options, LLC and Clinical Care Options. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Clinical Care Options, LLC and Clinical Care Options or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
In this episode, Colin C. Pritchard, MD, PhD, a pathologist, and Heather H. Cheng, MD, PhD, a medical oncologist, discuss optimal biomarker testing to guide treatment decisions in advanced prostate cancer, with topics including:
- Rationale for targeting PARP in prostate cancer with ARI combinations
- Study design nuances and findings from key randomized phase III clinical trials evaluating combination therapy with a PARP inhibitor and ARI, including PROpel, MAGNITUDE, and TALAPRO-2
- FDA approvals of combination therapy with a PARP inhibitor and ARI, including a comparison of populations based on mutations
- Optimal biomarker testing for gene mutations in homologous recombination and mismatch repair pathways
- Tips for optimal coordination between pathology and medical oncology
Presenters:
Heather H. Cheng, MD, PhD
Associate Professor
Department of Medicine
Division of Hematology and Oncology
Attending Physician
Department of Genitourinary Medical Oncology
Fred Hutchinson Cancer Center
Seattle, Washington
Colin C. Pritchard, MD, PhD
Co-Director
Genetics and Solid Tumors Laboratory
University of Washington Medical Center
Professor
Department of Laboratory Medicine and Pathology
University of Washington
Seattle, Washington
Content based on an online CME program supported by an independent educational grant from Pfizer, Inc.
Link to full program:
https://bit.ly/3PFagxb
179 episodes
Share
Manage episode 409274058 series 3256997
Content provided by Clinical Care Options, LLC and Clinical Care Options. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Clinical Care Options, LLC and Clinical Care Options or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
In this episode, Colin C. Pritchard, MD, PhD, a pathologist, and Heather H. Cheng, MD, PhD, a medical oncologist, discuss optimal biomarker testing to guide treatment decisions in advanced prostate cancer, with topics including:
- Rationale for targeting PARP in prostate cancer with ARI combinations
- Study design nuances and findings from key randomized phase III clinical trials evaluating combination therapy with a PARP inhibitor and ARI, including PROpel, MAGNITUDE, and TALAPRO-2
- FDA approvals of combination therapy with a PARP inhibitor and ARI, including a comparison of populations based on mutations
- Optimal biomarker testing for gene mutations in homologous recombination and mismatch repair pathways
- Tips for optimal coordination between pathology and medical oncology
Presenters:
Heather H. Cheng, MD, PhD
Associate Professor
Department of Medicine
Division of Hematology and Oncology
Attending Physician
Department of Genitourinary Medical Oncology
Fred Hutchinson Cancer Center
Seattle, Washington
Colin C. Pritchard, MD, PhD
Co-Director
Genetics and Solid Tumors Laboratory
University of Washington Medical Center
Professor
Department of Laboratory Medicine and Pathology
University of Washington
Seattle, Washington
Content based on an online CME program supported by an independent educational grant from Pfizer, Inc.
Link to full program:
https://bit.ly/3PFagxb
179 episodes
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Similar to CCO Oncology Podcast
PT Inquest is an online journal club. Hosted by Jason Tuori, Megan Graham, and Chris Juneau, the show looks at an article every week and discusses how it applies to current physical therapy practice.
…
continue reading
Emergency Medicine Cases – Where the Experts Keep You in the Know. For show notes, quizzes, videos and more learning tools please visit emergencymedicinecases.com
…
continue reading
Seeking a healthier emotional life? It’s time to bring a trained psychologist and mental health expert along for the ride. Dr. Monica Johnson explains the why behind complex emotions, helps you form better relationships, and guides you down the path of self-understanding.
…
continue reading
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…
continue reading
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…
continue reading
What Drives You, with over 70 million downloads and 1,350 episodes, gets to the root causes of personal transformation. Join elite athlete, personal development guide, serial entrepreneur, author, and father of nine Kevin Miller as he conducts deep dives with our world's greatest transformational luminaries to gain clarity on what we want and our motives for wanting it. This brings us into alignment so we can drive further and faster with less effort, and most importantly, enjoy the ride on ...
…
continue reading
How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
…
continue reading
We are often distracted in life and never really dive deep into the real foundation of self improvement, goal achieving, and wellbeing. - Join our team of experts every week as we discuss the real facets of manhood. Topics like: How to develop more self esteem, self love, deeper relationships. How to improve our wellbeing, mental toughness, resilience, and productivity. How to develop critical skills, become better leaders, expand our careers/business, create financial security and contribut ...
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