Updates on new data and best practices in the care of patients with cancer across a wide variety of solid tumors and hematologic malignancies from Clinical Care Options. Gain practical clinical insights and strategies and earn CME/CE credit for selected episodes.
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America's first radio talk show dedicated to overcoming chronic pain. Hear exclusive interviews and personal stories from celebrity guests. No one is immune to pain, but together we can overcome it.
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ROS1-Alterations and Molecular Testing in Advanced NSCLC
16:28
16:28
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16:28
In this episode, listen to Alice T. Shaw, MD, PhD, and Jessica J. Lin, MD, share their thoughts on the current understanding of ROS1 rearrangements in non-small-cell lung cancer tumor biology and its implications for molecular testing and treatment selection including: ROS1-gene fusions in advanced lung cancer ROS1 testing recommendations with DNA …
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Midyear Highlights of Key Data From 2024 Gynecologic Cancer Conferences Informing Treatment of Ovarian, Endometrial, and Cervical Cancers
49:32
49:32
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49:32
In this episode, listen to Floor J. Backes, MD, and Angeles Alvarez Secord, MD, MHSc, share their clinical insights and takeaways on new data presented for endometrial, ovarian, and cervical cancers presented at the 2024 annual meetings of the Society of Gynecologic Oncology and American Society of Clinical Oncology including: RUBY Part 1 Subgroup …
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Next-Generation Therapeutics for HR+/HER2- Breast Cancer: Spotlight on SERDs
34:45
34:45
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34:45
In this episode, Dr Virginia Kaklamani moderates a discussion with Dr Aditya Bardia and Dr Sarah Sammons answering audience questions on the latest data on the use of oral SERDs therapy, including how to incorporate this new class of therapy into treatment plans for patients with HR+/HER2- breast cancer. Presenters: Virginia Kaklamani, MD, DSc Prof…
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1
Current Clinical Practice and NCCN Guidelines for CLL/SLL
31:33
31:33
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31:33
In this podcast episode, Farrukh Awan, MD, Jeremy S. Abramson, MD, MMSc, and Shuo Ma, MD, PhD, discuss real-world patient cases and how to align current clinical practice with the NCCN guidelines for CLL/SLL, including: Prognostic variables when deciding between regimens Role of MRD in CLL Results from the phase II CAPTIVATE trial Choosing among th…
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1
Congress to Clinic: Expert Takeaways on Emerging Data for MPNs
28:35
28:35
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28:35
In this episode, listen to Dr Brady L. Stein share his clinical insights and takeaways on new data for myeloproliferative neoplasms (MPNs) presented at the 2024 ASCO Annual Meeting and the EHA 2024 Congress including: Long-term survival adjusted for treatment crossover in patients with myelofibrosis (MF) treated with momelotinib vs danazol in the M…
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CELMoDs: Spotlight on Therapeutic Approaches Targeting Protein Degradation Pathways
24:23
24:23
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24:23
In this podcast episode, Julio C. Chavez, MD, MS, and Alan Skarbnik, MD, discuss the emerging role of CELMoDs in NHL care, including: Rationale for targeting CELMoDs in NHL Mechanism of action of CELMoDs Key studies and available efficacy and safety data with investigational CELMoDs in NHL Key ongoing clinical trials of CELMoDs in NHL Strategies to…
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Experts Discuss the Role of CDK4/6 Inhibitors in HR+/HER2- Breast Cancer
24:30
24:30
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In this episode, Dr Joyce O’Shaughnessy moderates a discussion with Dr Sara Hurvitz and Dr Erica Mayer answering audience questions on the latest data on incorporating CDK4/6 inhibitors into treatment plans for patients with HR+/HER2- breast cancer. Topics in this podcast include: Evidence from the monarchE and NATALEE trials of adjuvant abemacicli…
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Congress to Clinic: Expert Takeaways on Emerging Data for AML
25:21
25:21
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25:21
In this episode, listen to Professor Eunice S. Wang, MD, share her clinical insights and takeaways on new data for acute myeloid leukemia (AML) presented at the 2024 ASCO annual meeting and the EHA 2024 Congress including: Data from the prospective, single-center phase Ib/II study of FLAG-IDA plus venetoclax in newly diagnosed or relapsed/refractor…
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Congress to Clinic: Expert Takeaways on Emerging Data for MDS
19:19
19:19
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19:19
In this episode, listen to Professor Courtney DiNardo, MD, MSCE, share her clinical highlights and clinical takeaways on new data for myelodysplastic syndromes (MDS) presented at the 2024 ASCO annual meeting and the EHA 2024 Congress including: COMMANDS trial of luspatercept in transfusion-dependent, erythropoietin stimulating agent–naive, very low…
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Experiences With Oral SERDs for HR+/HER2- Metastatic Breast Cancer
25:55
25:55
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25:55
In this episode, Manali Bhave, MD; Annalise Labatut, PharmD, BCOP; and nurse practitioner Jamie L. Carroll, CNP, APRN, MSN, begin by discussing the landmark EMERALD study that led to FDA approval of elacestrant, the first oral selective estrogen receptor degrader (SERD) for treatment of hormone receptor–positive/HER2-negative metastatic breast canc…
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Applying the Latest Evidence and NCCN Guideline Recommendations in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
47:23
47:23
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47:23
In this episode, Danielle M. Brander, MD; Deborah Stephens, DO; and Brian Hill, MD, PhD, discuss key aspects of the NCCN CLL guidelines and share strategies for applying these recommendations in your clinical practice to optimize treatment and outcomes. The greater discussion addresses: Optimal selection of therapy for treatment-naive CLL, includin…
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Homologous Recombination Repair (HRR) Testing and Targeted Therapy in Prostate Cancer
48:15
48:15
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48:15
In this episode, Colin C. Pritchard, MD, PhD, a pathologist, and Heather H. Cheng, MD, PhD, a medical oncologist, discuss optimal biomarker testing to guide treatment decisions in advanced prostate cancer, with topics including: Rationale for targeting PARP in prostate cancer with ARI combinations Study design nuances and findings from key randomiz…
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Real-world Perspectives on Novel HER2-Targeted and TROP-2–Directed Therapies in Advanced Breast Cancer
36:29
36:29
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In this podcast episode, Sara M. Tolaney, MD, MPH, and Melinda Telli, MD, delve into the critical aspects of the current therapeutic landscape for patients with unresectable or metastatic HER2-low, hormone receptor–positive, and triple-negative breast cancer, including: Challenges with the pathologic testing for HER2-low expression Optimal treatmen…
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Leukemia is a medical term for cancer of the blood cells. Acute Myeloid Leukemia, known as AML is the most common acute leukemia in adults. AML is rapidly lethal if untreated, but overall survival has improved for those under age 65 from just 8 months in the late 1970s to 46 months in 2014. We’ll have […]…
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Leukemia is a medical term for cancer of the blood cells. Acute Myeloid Leukemia, known as AML is the most common acute leukemia in adults. AML is rapidly lethal if untreated, but overall survival has improved for those under age 65 from just 8 months in the late 1970s to 46 months in 2014. We’ll have […]…
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When we experience pain, it begins as an acute process. It might be an ankle sprain, arm fracture, or due to surgery. In fact, chronic postsurgical pain affects up to 50% of adults. Guidelines suggest using multimodal analgesia to manage acute pain. Seglentis, a unique oral medication is available that combines tramadol, a weak opioid […]…
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When we experience pain, it begins as an acute process. It might be an ankle sprain, arm fracture, or due to surgery. In fact, chronic postsurgical pain affects up to 50% of adults. Guidelines suggest using multimodal analgesia to manage acute pain. Seglentis, a unique oral medication is available that combines tramadol, a weak opioid […]…
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Current Considerations for Adverse Event Management With HER3-Directed Agents
12:33
12:33
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The third and final episode in a 3-part series covers the safety profile of and considerations for managing adverse events associated with HER3-targeted antibody–drug conjugates, including patritumab deruxtecan (HER3-DXd) and others, in the setting of lung cancer. Presenters in this series include: Rebecca S. Heist, MD, MPH Associate Professor of M…
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Unpacking the Potential of HER3-Targeted Therapy in NSCLC
15:24
15:24
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This second episode in a 3-part series on HER3-targeted agents in NSCLC covers current clinical trials with HER3-targeted therapy, including: Recent data on patritumab deruxtecan (HER3-DXd) in the HERTHENA-Lung01 trial The EGFRxHER3 bispecific antibodies BL-B01D1 and izalontamab The HER2xHER3 bispecific antibody zenocutuzumab The HER3-targeted anti…
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Recent Advances in ADCs and Rationale for HER3 as a Target in Lung Cancer
8:54
8:54
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This first episode in a 3-part series tackles the role of HER3 in cancer, specifically in NSCLC, and how HER3 can be effectively targeted with ADCs. Presenters in this series include: Rebecca S. Heist, MD, MPH Associate Professor of Medicine Harvard Medical School Medical Oncology Massachusetts General Hospital Boston, Massachusetts Helena Yu, MD A…
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Expert Insight on Seminal New Clinical Trial Data Presented at the 2023 IGCS Conference Informing Treatment for Endometrial, Ovarian, and Cervical Cancers
30:29
30:29
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30:29
In this episode, Brian Slomovitz, MD, MS, FACOG, and Keiichi Fujiwara, MD, PhD, share their thoughts and opinions on seminal data presented at the 2023 IGCS annual meeting for endometrial, ovarian, and cervical cancers, including: Phase III NRG GY018 trial of carboplatin and paclitaxel with or without pembrolizumab followed by pembrolizumab or plac…
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Novel Emerging Investigational Treatment Strategies for Patients With Myelofibrosis
19:33
19:33
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19:33
In this episode, Jacqueline S. Garcia, MD, discusses novel agents and strategies in clinical trial development for treating patients with myelofibrosis, including: Navitoclax (BCL-XL/BCL-2 inhibitor) Pelabresib (BET inhibitor) Imetelstat (telomerase inhibitor) Luspatercept (erythroid maturation agent) Additional strategies Presenter: Jacqueline S. …
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A Year in Review and a Look to the Future: BTKi in CLL and MCL
27:33
27:33
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27:33
In this episode, Ana Marin-Niebla, MD, PhD, and Stephan Stilgenbauer, MD, discuss key trial data on the use of BTK inhibitors in CLL and MCL throughout the past year, how these studies have impacted their practice, and what data they are looking forward to in the near future. The discussion includes analyses of: SHINE: First-Line Ibrutinib + Bendam…
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Expert Insight on Key Updates and New Clinical Trial Data From the ESMO 2023 Congress Informing Treatment for Endometrial, Ovarian, and Cervical Cancers
33:18
33:18
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33:18
In this episode, Isabelle Ray-Coquard, MD, PhD, and Ana Oaknin, MD, PhD, provide expert insights on new clinical trial data presented at the 2023 ESMO annual congress for endometrial, ovarian, and cervical cancers, including: Results from the double-blind, randomized, placebo-controlled phase III AtTEnd trial of atezolizumab plus carboplatin/paclit…
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Expert Insights and Considerations for Precision Care With HER3-Targeted Agents in NSCLC and Breast Cancer
38:51
38:51
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38:51
In this episode, Aakash Desai, MD; Narjust Florez, MD; and Paolo Tarantino, MD, discuss the biologic rationale and clinical development of agents targeting HER3 for the treatment of breast and lung cancers. The potential niche for HER3-targeted agents in these treatment landscapes is considered, with consideration of acquired resistance to previous…
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Improving Care for Black Patients With Endometrial Cancer
26:58
26:58
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26:58
In this episode, Dr Leslie Boyd and Adrienne Moore, a patient advocate and endometrial cancer survivor, discuss how healthcare professionals can partner with Black patients to improve the diagnosis and management of endometrial cancer (EC). Topics include: Data on racial disparities in EC survival Importance of listening to Black patients to better…
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Expert Insight on Key Updates and New Clinical Trial Data From the ESGO 2023 Congress Informing Treatment for Cervical, Ovarian, and Endometrial Cancers
24:54
24:54
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24:54
In this episode, Domenica Lorusso, MD, PhD, and Alexandra Leary, MD, PhD, provide expert insights on key updates and new clinical trial data presented at the ESGO 2023 Congress for cervical, endometrial, and ovarian cancers, including: Long-Term Follow Up From Phase III SIENDO Study of Selinexor vs Pbo Maintenance in Patients With TP53wt Advanced/R…
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New Evidence With BTK Inhibitor Therapy in CLL and MCL From SOHO 2023
20:58
20:58
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20:58
In this episode, Catherine C. Coombs, MD, MS, and Toby Eyre, MBChB, MD, discuss key trials presented at SOHO 2023 evaluating the use of BTK inhibitors in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). The discussion includes analyses of: Matching-adjusted indirect comparison of 3 randomized phase III trials of ibrutinib for rela…
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New Evidence With BTK Inhibitor Therapy in MCL From ICML 2023
14:39
14:39
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14:39
In this episode, Catherine C. Coombs, MD, and Toby Eyre, MBChB, MD, discuss key trials presented at ICML 2023 evaluating the use of BTK inhibitors in mantle cell lymphoma (MCL). The discussion includes analyses of: Phase II trial of acalabrutinib with rituximab for older patients with untreated MCL BRUIN: updated results of pirtobrutinib in covalen…
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New Evidence With BTK Inhibitor Therapy in CLL From EHA 2023
27:03
27:03
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27:03
In this episode, Catherine C. Coombs, MD, MS, and Toby Eyre, MBChB, MD, discuss key trials presented at EHA 2023 evaluating the use of BTK inhibitors in chronic lymphocytic leukemia (CLL). The discussion includes analyses of: CLL12: final results of the phase III trial of ibrutinib vs placebo in asymptomatic, treatment-naive CLL SEQUOIA: extended f…
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Expert Insight on Key Updates and New Clinical Trial Data From the 2023 ASCO Annual Meeting, Informing Treatment for Cervical, Ovarian, and Endometrial Cancers
46:02
46:02
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46:02
In this episode, Kathleen Moore, MD, MS, and Nicoletta Colombo, MD, PhD, provide expert insights on key updates and new clinical trial data presented at the 2023 ASCO Annual Meeting for cervical, endometrial, and ovarian cancers, including: ENGOT-EN6-NSGO/GOG-3031/RUBY: phase III study of dostarlimab plus chemotherapy followed by dostarlimab mainte…
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Expert Insight on New Data From SGO 2023 Informing Treatment for Endometrial, Cervical, and Ovarian Cancers
31:38
31:38
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31:38
In this episode, David Scott Miller, MD, FACOG, FACS, and Linda Duska, MD, MPH, provide expert insights on practice-changing data and other new findings presented at SGO 2023 in endometrial, cervical, and ovarian cancers, including: NRG GY018: randomized phase III study evaluating standard of care of carboplatin plus paclitaxel with or without pemb…
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Practical Insights on Using BCMA-Targeted Therapies in Multiple Myeloma
32:21
32:21
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32:21
In this episode, Suzanne Lentzsch, MD, Ph.D., and Joseph Mikhael, MD, MEd, FRCPC, FACP, discuss the role of BCMA-targeted therapies in the management of patients with multiple myeloma, including their experiences and challenges with implementing recent data. This overview will include a discussion of: Considerations with administration, including a…
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Contemporary Approaches to Treating Myelofibrosis: A Conversation Between Experts
15:58
15:58
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15:58
In this episode, John Mascarenhas, MD, and Ruben A. Mesa, MD, FACP, discuss current best practices and emerging approaches for treating patients with myelofibrosis, including: Overall approach to treatment Use of JAK inhibitors for treating myelofibrosis Treating patients with low platelets Defining JAK inhibitor failure Unmet needs in treatment an…
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BRCA Testing and Adjuvant Therapy in Early Breast Cancer: Experiences and Challenges
25:05
25:05
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25:05
In this episode, Banu Arun, MD; Allison Butts, PharmD, BCOP; and Marissa Marti-Smith, MSN, APRN, AGNP-C, AOCNP, discuss the role of BRCA testing and adjuvant olaparib in early breast cancer, including their experiences and challenges with implementing recent data. This overview will include discussion of: Data supporting the use of adjuvant PARP in…
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Experts Discuss Claudin 18.2: A New Target for Precision Care of Gastric and Gastroesophageal Cancers
15:48
15:48
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In this podcast episode, Samuel Klempner, MD, and Gregory Botta, MD, PhD, provide expert commentary on the rationale and development of novel agents under investigation for targeting claudin 18.2 in gastric and gastroesophageal cancers, with topics including: Expression patterns and function of the claudin family of proteins in normal gastric tissu…
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Chronic low back pain can be due to degeneration of the multifidus muscles. We now have a neurostimulator designed to activate the multifudus muscles and control pain – ReActiv8. John McFarland describes how this device has helped him return to an active life at age 75. Dr. Chris Gilligan, Chief of the Division of Pain Medicine […]…
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Chronic low back pain can be due to degeneration of the multifidus muscles. We now have a neurostimulator designed to activate the multifudus muscles and control pain – ReActiv8. John McFarland describes how this device has helped him return to an active life at age 75. Dr. Chris Gilligan, Chief of the Division of Pain Medicine […]…
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The American Academy of Pain Medicine (AAPM) hosts the one of a kind, AAPM-MIT Hacking Medicine Innovation Challenge. Companies from around the world apply for the chance to pitch their ideas and solutions in a “shark tank” style competition. We feature two of the winners of the 2022 challenge: Sana Health with its visual and auditory […]…
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Treatment Considerations for Patients With Essential Thrombocythemia: A Conversation Between Experts
21:28
21:28
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In this podcast episode, Prithviraj Bose, MD, and Andrew Kuykendall, MD, discuss their contemporary approaches to the treatment of patients with essential thrombocythemia. The topics covered include: When to use cytoreduction therapies and which therapies to use in low-risk patients Type 1 and type 2 CALR mutations and addressing patient concerns w…
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FAQs on the Use of Asparaginase Therapy in Young and Older Adults With Acute Lymphoblastic Leukemia
26:12
26:12
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In this episode, Daniel J. DeAngelo, MD, PhD; Kjeld Schmiegelow, MD, DMSci; and Emily Curran, MD, answer key questions asked by the audience during a live satellite symposium at the 2022 American Society of Hematology Annual Meeting on optimizing pediatric or pediatric-inspired regimens containing asparaginase for the treatment of young and older a…
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Experts Answer Questions on Personalized Management of Patients With Myelodysplastic Syndromes
21:59
21:59
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21:59
In this podcast, Rami Komrokji, MD; María Díez Campelo, MD, PhD; and Amer Zeidan, MBBS, MHS answer questions from an audience of healthcare professionals on topics related to personalized management of myelodysplastic syndromes including: Practical use of the Molecular International Prognostic Scoring System Mutational targets and other treatments …
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Experts Answer Questions on the Management of Patients With T-Cell Lymphomas
16:27
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In this podcast episode, Steven M. Horwitz, MD; Pamela B. Allen, MD, MSc; and Kerry Savage, MD, MSc, answer questions from an audience of healthcare professionals on topics related to the management of T-cell lymphomas, including: Use of brentuximab vedotin in ≤1% CD-30‒expressing lymphomas Strategies with JAK inhibition and epigenetic agents Allog…
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