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ROS1-Alterations and Molecular Testing in Advanced NSCLC
Manage episode 436715992 series 3256997
Content provided by Clinical Care Options, LLC and Clinical Care Options. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Clinical Care Options, LLC and Clinical Care Options or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
In this episode, listen to Alice T. Shaw, MD, PhD, and Jessica J. Lin, MD, share their thoughts on the current understanding of ROS1 rearrangements in non-small-cell lung cancer tumor biology and its implications for molecular testing and treatment selection including:
- ROS1-gene fusions in advanced lung cancer
- ROS1 testing recommendations with DNA NGS, RNA NGS, FISH break apart assay, and IHC
- Comparative specificity of ROS1 and ALK targeting tyrosine kinase inhibitors
- Advantages of RNA- vs DNA-based next-generation sequencing
Program faculty:
Jessica J. Lin, MD
Attending Physician
Massachusetts General Hospital
Associate Professor of Medicine
Harvard Medical School
Boston, Massachusetts
Alice T. Shaw, MD, PhD
Chief, Strategic Partnerships
Attending Physician, Thoracic Oncology
Dana-Farber Cancer Institute
Harvard Medical School
Boston, Massachusetts
Resources:
To download the slides associated with this podcast discussion, please visit the program page
179 episodes
Share
Manage episode 436715992 series 3256997
Content provided by Clinical Care Options, LLC and Clinical Care Options. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Clinical Care Options, LLC and Clinical Care Options or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
In this episode, listen to Alice T. Shaw, MD, PhD, and Jessica J. Lin, MD, share their thoughts on the current understanding of ROS1 rearrangements in non-small-cell lung cancer tumor biology and its implications for molecular testing and treatment selection including:
- ROS1-gene fusions in advanced lung cancer
- ROS1 testing recommendations with DNA NGS, RNA NGS, FISH break apart assay, and IHC
- Comparative specificity of ROS1 and ALK targeting tyrosine kinase inhibitors
- Advantages of RNA- vs DNA-based next-generation sequencing
Program faculty:
Jessica J. Lin, MD
Attending Physician
Massachusetts General Hospital
Associate Professor of Medicine
Harvard Medical School
Boston, Massachusetts
Alice T. Shaw, MD, PhD
Chief, Strategic Partnerships
Attending Physician, Thoracic Oncology
Dana-Farber Cancer Institute
Harvard Medical School
Boston, Massachusetts
Resources:
To download the slides associated with this podcast discussion, please visit the program page
179 episodes
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Similar to CCO Oncology Podcast
PT Inquest is an online journal club. Hosted by Jason Tuori, Megan Graham, and Chris Juneau, the show looks at an article every week and discusses how it applies to current physical therapy practice.
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continue reading
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continue reading
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continue reading
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continue reading
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