Updates on new data and best practices in the care of patients with cancer across a wide variety of solid tumors and hematologic malignancies from Clinical Care Options. Gain practical clinical insights and strategies and earn CME/CE credit for selected episodes.
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This is a podcast on latest advances in the understanding and management of blood cancers. Here, we will bring a wide range of experts within hematologic malignancies to discuss various topics in depth. Host: Raj Chakraborty, MD from Columbia University, New York, Ashwin Kishtagari, MD, from Vanderbilt University, Nashville, and Edward Cliff, MD, from Harvard University, Boston Tweet your suggestions and feedback to @rajshekharucms @AshKishtagari @Eddie_Cliff @BloodCancerTalk
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The Beyond the Pearls podcast, based on the Morning Report series from Elsevier, has been adapted for audio in collaboration with series editor, Dr. Raj Dasgupta, InsideTheBoards, and the volume editors of the Morning Report series’ five volumes covering Internal Medicine, Obstetrics and Gynecology, Pediatrics, Psychiatry, and Surgery. Like the books in the series, the podcast uses an in-depth case dissection format and aims to deliver practical, concise and easy to digest information that i ...
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Today's Episode Charlee reviews chapter 12 from the Pediatric Morning Report book. A 12-month-old female presents for a well-child care visit. The mother is concerned that the patient is a “picky eater.” She was exclusively breast-fed until she was 6 months old and then switched to formula with the introduction of solids. At 12 months of age, the m…
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Next-Generation Therapeutics for HR+/HER2- Breast Cancer: Spotlight on SERDs
34:45
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In this episode, Dr Virginia Kaklamani moderates a discussion with Dr Aditya Bardia and Dr Sarah Sammons answering audience questions on the latest data on the use of oral SERDs therapy, including how to incorporate this new class of therapy into treatment plans for patients with HR+/HER2- breast cancer. Presenters: Virginia Kaklamani, MD, DSc Prof…
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Episode 48. Management of Polycythemia Vera with Dr. Aaron Gerds
57:09
57:09
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In this episode, we discussed the diagnosis and management of polycythemia vera with Dr. Aaron T. Gerds. Here are the shownotes with the key studies discussed: 1. MIPS PV scoring system https://pubmed.ncbi.nlm.nih.gov/31945802/ 2. REVEAL study https://ashpublications.org/blood/article/143/16/1646/506717/Association-between-elevated-white-blood-cell…
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Current Clinical Practice and NCCN Guidelines for CLL/SLL
31:33
31:33
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In this podcast episode, Farrukh Awan, MD, Jeremy S. Abramson, MD, MMSc, and Shuo Ma, MD, PhD, discuss real-world patient cases and how to align current clinical practice with the NCCN guidelines for CLL/SLL, including: Prognostic variables when deciding between regimens Role of MRD in CLL Results from the phase II CAPTIVATE trial Choosing among th…
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PEDS: Hemolytic disease of the fetus and newborn due to Rh(D) alloimmunization
24:16
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Today's Episode Charlee reviews chapter 10 from the Pediatric Morning Report book. The obstetric service is monitoring a 33-year-old G9P2071 pregnant female with a history of a prior pregnancy ending in intrauterine fetal demise at 8 months of gestation. A prenatal ultrasound performed at 29 weeks of gestation shows worsening anemia, as evidenced b…
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Congress to Clinic: Expert Takeaways on Emerging Data for MPNs
28:35
28:35
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In this episode, listen to Dr Brady L. Stein share his clinical insights and takeaways on new data for myeloproliferative neoplasms (MPNs) presented at the 2024 ASCO Annual Meeting and the EHA 2024 Congress including: Long-term survival adjusted for treatment crossover in patients with myelofibrosis (MF) treated with momelotinib vs danazol in the M…
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CELMoDs: Spotlight on Therapeutic Approaches Targeting Protein Degradation Pathways
24:23
24:23
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In this podcast episode, Julio C. Chavez, MD, MS, and Alan Skarbnik, MD, discuss the emerging role of CELMoDs in NHL care, including: Rationale for targeting CELMoDs in NHL Mechanism of action of CELMoDs Key studies and available efficacy and safety data with investigational CELMoDs in NHL Key ongoing clinical trials of CELMoDs in NHL Strategies to…
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Today's Episode Charlee reviews chapter 7 from the Pediatric Morning Report book. A 13-month-old male presents with 10 days of fever, fussiness, and cough. The patient was seen multiple times by his primary care physician, but thus far no source of fever has been found. Today's Host Charlee Quarless is a 3rd year medical student at Ross University.…
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Experts Discuss the Role of CDK4/6 Inhibitors in HR+/HER2- Breast Cancer
24:30
24:30
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In this episode, Dr Joyce O’Shaughnessy moderates a discussion with Dr Sara Hurvitz and Dr Erica Mayer answering audience questions on the latest data on incorporating CDK4/6 inhibitors into treatment plans for patients with HR+/HER2- breast cancer. Topics in this podcast include: Evidence from the monarchE and NATALEE trials of adjuvant abemacicli…
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Congress to Clinic: Expert Takeaways on Emerging Data for AML
25:21
25:21
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In this episode, listen to Professor Eunice S. Wang, MD, share her clinical insights and takeaways on new data for acute myeloid leukemia (AML) presented at the 2024 ASCO annual meeting and the EHA 2024 Congress including: Data from the prospective, single-center phase Ib/II study of FLAG-IDA plus venetoclax in newly diagnosed or relapsed/refractor…
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Episode 47. ASCO/EHA 2024 Lymphoma Updates with Dr. Gloria Iacoboni
47:48
47:48
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In this episode, we reviewed the hottest updates in lymphoma from ASCO and EHA 2024, held in Chicago and Madrid respectively, with Dr. Gloria Iacoboni, a haematologist from University Hospital Vall d'Hebron, in Barcelona, Spain. Here are the key abstracts we discussed: 1. STARGLO: Glofit-GEMOX vs R-GEMOX in relapsed/refractory DLBCL https://library…
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Congress to Clinic: Expert Takeaways on Emerging Data for MDS
19:19
19:19
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In this episode, listen to Professor Courtney DiNardo, MD, MSCE, share her clinical highlights and clinical takeaways on new data for myelodysplastic syndromes (MDS) presented at the 2024 ASCO annual meeting and the EHA 2024 Congress including: COMMANDS trial of luspatercept in transfusion-dependent, erythropoietin stimulating agent–naive, very low…
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Today's Episode Alexandra reviews chapter 15 from the Psychiatry Morning Report book. A 53-year-old female comes into the clinic reporting problems with sleep for the past 5 months. She tells you that she has been using over-the-counter sleep aids but has not found them helpful. Even though they help her fall asleep, she wakes up multiple times eve…
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PSYCHIATRY: Obsessive-Compulsive Disorder
15:37
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Today's Episode Alexandra reviews chapter 9 from the Psychiatry Morning Report book. A 25-year-old female presents to the outpatient psychiatry office for emetophobia (a fear of vomiting). She reports her symptoms have been going on for “as long as I can remember.” She describes that even thinking about vomiting will make her feel nauseated. She av…
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Today's Episode Alexandra reviews chapter 2 from the Psychiatry Morning Report book. A 34-year-old male with a history of hypertension and anxiety presents to the emergency department (ED) accompanied by his wife. He complains of abdominal pain from an injury to the right upper quadrant of his abdomen secondary to a pellet gunshot. He is tachycardi…
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PEDS: Pulmonary Atresia with Intact Ventricular Septum
22:29
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Today's Episode Charlee reviews chapter 5 from the Pediatric Morning Report book. A girl is born at 35 weeks and 3 days gestation to a 26-year-old mother. Minimal prenatal care was given prior to delivery. She is born under considerable distress and is apneic on delivery. The child is noted to be cyanotic, with pulse oximetry measuring oxygen satur…
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Episode 46. Updates in Myeloma MRD with Dr. Ben Derman and Dr. Manni Mohyuddin
57:48
57:48
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In this episode, we dive into updates in Minimal Residual Disease (MRD) in multiple myeloma, along with the FDA ODAC meeting in April 2024 to decide on MRD as a surrogate endpoint for accelerated approval. Our guests are Dr. Benjamin Derman and Dr. Manni Mohyuddin. Here are the key papers we discussed: 1. Recording of FDA ODAC meeting: https://www.…
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Today's Episode Charlee reviews chapter 3 from the Pediatric Morning Report book. A 15-year-old female presents with pain, trismus, and neck stiffness for approximately 5 days. She is able to eat but has pain with chewing and swallowing. She also has right ear pain and a diffuse headache. She has otherwise not had any sore throat, cough, or hoarsen…
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Today's Episode Charlee reviews chapter 1 from the Pediatric Morning Report book. A 20-month-old child presents with 8 weeks of right leg pain and limping. She otherwise has had no fever, bleeding, or other joint pain. Today's Host Charlee Quarless is a 3rd year medical student at Ross University. About Dr. Raj Dr Raj is a quadruple board certified…
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Episode 45. Updates in Primary Myelofibrosis with Dr. Ayalew Tefferi
1:00:53
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In this episode, we discuss updates in primary myelofibrosis with Dr. Ayalew Tefferi from the Mayo Clinic. The key studies and trials discussed are as follows: · GIPSS: Genetically inspired prognostic scoring system that is exclusively based on genetic markers. § https://www.nature.com/articles/s41375-018-0107-z · MIPSS70+ Version 2.0: Mutation and…
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Today's Episode This is the last part of Raj's 8 part hypersomnia series, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TN…
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Today's Episode This is part seven of Raj's 8 part hypersomnia series, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT s…
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Experiences With Oral SERDs for HR+/HER2- Metastatic Breast Cancer
25:55
25:55
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In this episode, Manali Bhave, MD; Annalise Labatut, PharmD, BCOP; and nurse practitioner Jamie L. Carroll, CNP, APRN, MSN, begin by discussing the landmark EMERALD study that led to FDA approval of elacestrant, the first oral selective estrogen receptor degrader (SERD) for treatment of hormone receptor–positive/HER2-negative metastatic breast canc…
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Today's Episode This is part six of Raj's 8 part hypersomnia series, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT ser…
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Applying the Latest Evidence and NCCN Guideline Recommendations in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
47:23
47:23
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In this episode, Danielle M. Brander, MD; Deborah Stephens, DO; and Brian Hill, MD, PhD, discuss key aspects of the NCCN CLL guidelines and share strategies for applying these recommendations in your clinical practice to optimize treatment and outcomes. The greater discussion addresses: Optimal selection of therapy for treatment-naive CLL, includin…
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Today's Episode This is part five of Raj's 8 part hypersomnia series, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT se…
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Episode 44. Maintenance Therapy in Multiple Myeloma with Dr. Hira Mian and Dr. Manni Mohyuddin
52:58
52:58
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In this episode, we dive into the data on maintenance therapy in multiple myeloma with Dr. Hira Mian and Dr. Manni Mohyuddin. Here are the key studies we discussed: 1. Meta-analysis of individual patient-level data from CALGB, IFM, and Italian maintenance RCTs (lenalidomide vs placebo or observation): https://pubmed.ncbi.nlm.nih.gov/28742454/ 2. My…
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Today's Episode This is part four of Raj's 8 part hypersomnia series, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT se…
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Episode 43. Essential Thrombocythemia with Dr. Raajit Rampal
35:28
35:28
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In this episode, we discuss the diagnosis and management of Essential Thrombocythemia with Dr. Raajit Rampal. Here are the shownotes: 1. IPSET (revised) system, risk categories are defined by the presence of a prior thrombosis, age, and JAK2 mutation status: · Very low risk: No prior thrombosis, age ≤60 years, JAK2-unmutated · Low risk: No prior th…
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Today's Episode This is part three of Raj's 8 part hypersomnia series, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT s…
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Today's Episode This is part two of Raj's 8 part hypersomnia series, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT ser…
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Today's Episode This is part one of Raj's 8 part hypersomnia series, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT ser…
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Homologous Recombination Repair (HRR) Testing and Targeted Therapy in Prostate Cancer
48:15
48:15
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In this episode, Colin C. Pritchard, MD, PhD, a pathologist, and Heather H. Cheng, MD, PhD, a medical oncologist, discuss optimal biomarker testing to guide treatment decisions in advanced prostate cancer, with topics including: Rationale for targeting PARP in prostate cancer with ARI combinations Study design nuances and findings from key randomiz…
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Today's Episode This is the second part of Raj's lecture, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing…
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Episode 42. CAR T-cell Therapy in Early Relapsed Myeloma with Dr. Samer Al Hadidi
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54:49
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In this episode, we talked about overall survival data from CARTITUDE-4 and KarMMa-3 that was presented at FDA ODAC meeting with Dr. Samer Al Hadidi from University of Arkansas Myeloma Center. RCTs of BCMA CAR T-cell Therapy in Early Relapsed Multiple Myeloma: a) KarMMa-3 (ide-cel): https://pubmed.ncbi.nlm.nih.gov/36762851/ b) CARTITUDE-4 (cilta-ce…
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Today's Episode This is the first part of Raj's lecture, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing …
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Real-world Perspectives on Novel HER2-Targeted and TROP-2–Directed Therapies in Advanced Breast Cancer
36:29
36:29
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In this podcast episode, Sara M. Tolaney, MD, MPH, and Melinda Telli, MD, delve into the critical aspects of the current therapeutic landscape for patients with unresectable or metastatic HER2-low, hormone receptor–positive, and triple-negative breast cancer, including: Challenges with the pathologic testing for HER2-low expression Optimal treatmen…
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Episode 41. Career Development as a Clinician-Investigator with Dr. Ayalew Tefferi
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47:22
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In this episode, we discuss mentorship and career development as a clinician-investigator with Dr. Ayalew Tefferi from the Mayo Clinic.By Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff
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Today's Episode This is the second part of Raj's lecture, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing…
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Today's Episode This is the first part of Raj's lecture, originally recorded for American Physician Institute. This episode may reference supplemental material not provided here. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing …
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Episode 40. Management of Newly Diagnosed AL Amyloidosis with Dr. Angela Dispenzieri
52:34
52:34
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In this episode we discuss the management of newly diagnosed AL amyloidosis with Dr. Angela Dispenzieri from the Mayo Clinic. Here are the key articles discussed: 1. Optimal use of tissue biopsy in AL amyloidosis: https://pubmed.ncbi.nlm.nih.gov/28271734/ 2. Mayo 2004 staging: https://pubmed.ncbi.nlm.nih.gov/15365071/ 3. Mayo 2012 staging: https://…
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Episode 39. ASH 2023 Leukemia and Myeloid Neoplasm Recap with Dr. Anand Patel
55:14
55:14
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In this episode, we discuss top abstracts in the myeloid space from the American Society of Hematology 2023 meeting with Dr. Anand Patel. Here are the abstracts that were discussed: 1. TRANSFORM-1: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, International Phase 3 Study of Navitoclax in Combination with Ruxolitinib Versus Ruxolitini…
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Updates in Asthma and COPD for the IM Boards (Part 4)
20:57
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This lecture was originally recorded for American Physician Institute and may reference supplemental material not provided here. Learn more about your ad choices. Visit megaphone.fm/adchoicesBy Raj Dasgupta & MedPrepToGo
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Updates in Asthma and COPD for the IM Boards (Part 3)
14:03
14:03
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This lecture was originally recorded for American Physician Institute and may reference supplemental material not provided here. Learn more about your ad choices. Visit megaphone.fm/adchoicesBy Raj Dasgupta & MedPrepToGo
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Updates in Asthma and COPD for the IM Boards (Part 2)
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This lecture was originally recorded for American Physician Institute and may reference supplemental material not provided here. Learn more about your ad choices. Visit megaphone.fm/adchoicesBy Raj Dasgupta & MedPrepToGo
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Episode 38. GVHD Prophylaxis in Allo-Transplant with Dr. Shernan Holtan
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52:10
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In this episode, we talk about GVHD prophylaxis, including recent data on post-transplant cyclophosphamide and abatacept with Dr. Shernan Holtan from the University of Minnesota. Here are the key trials we discussed: 1. BMT CTN 1203 trial: Three prophylaxis regimens (tacrolimus, mycophenolate mofetil, and cyclophosphamide; tacrolimus, methotrexate,…
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Updates in Asthma and COPD for the IM Boards (Part 1)
23:18
23:18
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This lecture was originally recorded for American Physician Institute and may reference supplemental material not provided here. Learn more about your ad choices. Visit megaphone.fm/adchoicesBy Raj Dasgupta & MedPrepToGo
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Today's Episode This is the 5th and final part of the "No Time To Sleep" series, originally recorded for American Physician Institute. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing the Cure with Ann Curry, a regular on the TV…
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Today's Episode This is part 4 of the "No Time To Sleep" series, originally recorded for American Physician Institute. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing the Cure with Ann Curry, a regular on the TV Show The Doctor…
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Today's Episode This is part 3 of the "No Time To Sleep" series, originally recorded for American Physician Institute. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing the Cure with Ann Curry, a regular on the TV Show The Doctor…
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