Episode 30. Management of High-Risk Myeloma

Blood Cancer Talks

Content provided by Rajshekhar Chakraborty and Ashwin Kishtagari, Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Rajshekhar Chakraborty and Ashwin Kishtagari, Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

1y ago 1:08:29

MP3•Episode home

In this episode, we discuss with Dr. Martin Kaiser how to identify and manage newly diagnosed high-risk multiple myeloma in the current era of effective frontline therapies. Here are the key studies that we touched upon:

1. Phase II OPTIMUM (MUKnine) trial in ultra-high-risk myeloma and PCL:

https://pubmed.ncbi.nlm.nih.gov/37315268/

2. Meta-analysis of >2500 patients with chromosome 1q21 abnormalities:

https://pubmed.ncbi.nlm.nih.gov/34092058/

3. Predicting ultra-high risk myeloma by molecular profiling (including SKY92 GEP signature):

https://pubmed.ncbi.nlm.nih.gov/32157174/

4. French data on adverse prognostic impact of del(1p32):

https://pubmed.ncbi.nlm.nih.gov/36375118/

5. S1211 study: The first high-risk enrichment RCT in myeloma (VRD vs Elo-VRD):

https://pubmed.ncbi.nlm.nih.gov/33357482/

6. Outcome of “double-hit” patients in MASTER and Dara-VRD arm of GRIFFIN trial:

https://ashpublications.org/blood/article/140/Supplement%201/10144/488521

7. Impact of Auto-Transplant on decreasing MRD burden in high-risk myeloma (including double-hits):

https://pubmed.ncbi.nlm.nih.gov/35731911/

8. Preliminary results from GMMG-CONCEPT trial in high-risk myeloma:

https://pubmed.ncbi.nlm.nih.gov/34732857/

51 episodes

#Fitness #Medicine #Rajshekhar Chakraborty and Ashwin Kishtagari #Ashwin Kishtagari #Rajshekhar Chakraborty #Hematology #Cancer #Podcasting Education #Edward Cliff