Jamie and Rob want you to listen to your dreams! IT Cosmetics founder and podcast host Jamie Kern Lima joins Rob Lowe to discuss her journey from Denny's waitress to the founder of a billion-dollar cosmetics brand, finding inspiration in dreams, cheering yourself on, not taking rejection personally, and her new podcast, “The Jamie Kern Lima Show.” …

Rob and Casey love talking movies! Casey Affleck joins Rob Lowe to discuss his new film, “The Instigators,” the value of sobriety, the understated genius of Matt Damon, their first movie theater memories, the “Outsiders” audition process, actors as directors (and directors as actors), some excellent advice from Michael Caine, and much more. Got a q…

Season 2 of “Unstable” is now streaming on Netflix! John Owen Lowe and “Unstable” Season 2 showrunner Andrew Gurland join Rob Lowe to discuss the new season of their Netflix show, the increasingly blurry line between Rob and John Owen’s characters and themselves, catching up on “Real Housewives of New Jersey,” the amazing unpredictability of Fred A…

Fred and Rob are so happy to be working together again on their Netflix show “Unstable!” Fred Armisen joins Rob Lowe to discuss the new season of “Unstable” (out August 1st), Fred’s approach to playing Uncle Fester in “Wednesday,” shooting “The Floor” in Ireland, dinner for Mick Jagger, Rob’s field trip to the CERN particle accelerator, starring in…

Rob Lowe welcomes back one of his favorite podcasters and now radio host, Andy Richter! In this episode they get into Andy’s new call-in show on SiriusXM, Howard Stern, how game shows are one of the last universal forms of entertainment, British comedy, and more. Inspired by Walmart, Rob is opening up the Lowe Down Line this summer to answer your q…

Dan and Rob think history is exciting! "Hardcore History" host Dan Carlin joins Rob Lowe to discuss watching history unfold in real-time, why Rob believes 1976 to 1986 was the best time to be alive, whether the United States is an empire in decline, why the presidency of JFK might be even more important than we initially thought, the evolution of t…

Rob and Lynn still consider themselves students of acting! Actress Lynn Whitfield joins Rob Lowe to discuss shooting “The Chi” in Chicago, working with James Brown and Dan Aykroyd for her first-ever film, the story behind her award-winning performance as Josephine Baker, the surprising inspirations for Anthony Hopkins’ performance as Hannibal Lecte…

Jimmy and Rob love milkshakes and mockumentaries! Jimmy Tatro joins Rob Lowe to discuss his new “Real Bros of Simi Valley” movie, the genius of “American Vandal,” Jimmy’s morbid thought during a flight with Don Cheadle and Dave Grohl, getting hit in the crotch by Logan Roy in “Super Troopers 2,” the unique constraints of network television, and muc…

“Yoga with Adriene” host Adriene Mishler and Rob want you to slow down! Adriene joins Rob Lowe to discuss her wildly popular “Yoga with Adriene” YouTube channel, her beloved dog Benji, the benefits of a regular yoga practice, why you should find the time and space to do nothing, how a naked rock star first introduced Rob to yoga, Rob’s pitch for a …

“Crime Junkie" host Ashley Flowers and Rob are talking true crime! Ashley joins Rob Lowe to talk about their shared love for Indiana, the cases they are obsessed with, Ashley’s dream of making a cameo on “Law & Order: SVU,” naming her company after her beloved dog, why they both adore Caitlin Clark, her new show "Crime Junkie AF" on her SiriusXM ch…

Ted and Woody are back together to bring you a brand new podcast from Team Coco! It’s called “Where Everybody Knows Your Name with Ted Danson and Woody Harrelson (Sometimes)" and it’s out right now! They’re talking to guests like Conan O’Brien, Will Arnett, Jane Fonda, Billy Eichner, Kristen Bell, and yours truly! I got to join Ted for an episode a…

At long last, Rob’s son Matthew Lowe is on the show! VC investor, attorney, and fisherman Matthew Lowe joins Rob to discuss golfing with his mom Sheryl Lowe in Hawaii, appearing in “The West Wing” as a kid, watching Dad’s movies as a family, encouraging his father to join “Parks & Rec,” sitting next to Rob in the iconic NFL hat photo, studying for …

Wildlife biologist and outdoor adventurer Forrest Galante joins Rob Lowe to discuss re-discovering animals thought to be extinct, his recent “Shark Week” shoots, the real-life story that inspired “Jaws”, Rob’s recent experience getting stung by a stingray, and much more. Plus, Rob shares his thoughts on the Roast of Tom Brady and his suggestions fo…

Adam and Rob remember the days of woodshop class! Comedian and podcaster Adam Carolla joins Rob Lowe to discuss the odd jobs he did before entering show business, his unconventional first encounter with longtime friend Jimmy Kimmel, betting big on podcasting back in 2009, listening to “Loveline” as a teenager, the value of woodshop class, and his n…

When Rob has questions about the future of technology and artificial intelligence, he goes to Marc Andreessen! Legendary investor and entrepreneur Marc Andreessen joins Rob Lowe to discuss the future of TikTok in the U.S., three major ways that artificial intelligence will improve the lives of everyday people, how a simple photo landed Kenny G in a…

Things get very silly when Thomas and Rob are together. Actor, writer, and comedian Thomas Lennon joins Rob Lowe to discuss the new Netflix film “Unfrosted,” receiving notes from Jerry Seinfeld, Thomas and Rob's ridiculous on-set jokes from the filming of “Monster Trucks,” getting fired gracefully, how studio lot parking spaces reveal your true sta…

Jeff and Rob both love performing drama AND comedy! Jeff Daniels joins Rob Lowe to discuss how working with Jim Carrey on “Dumb and Dumber” taught him fearlessness, committing to his thick accent in Netflix’s “A Man in Full,” his memories of the brilliant James Gandolfini, their experiences performing Aaron Sorkin dialogue, watching Shirley MacLain…

Rob is entering his 60s and committing to a better diet…with the help of the esteemed Dr. Mark Hyman! Dr. Mark Hyman (renowned physician, medical advisor to the Clintons, and the host of “The Doctor's Farmacy” podcast) joins Rob Lowe to discuss the Ozempic revolution, the real key to longevity, the obesity statistic that shocked Rob, what foods to …

Comedian, actor, and podcaster Paul Scheer joins Rob Lowe to discuss celebrity-owned restaurants, the “M*A*S*H” theme song, why the team behind “The League” decided to end the show while they were still on top, Rob’s traumatic childhood talent show memory, the greatest audition story ever, and Paul’s new memoir, “Joyful Recollections of Trauma.” Pr…

Kelly Ripa joins Rob Lowe to discuss getting “knighted” by Disney, the joys of working with her husband, why Rob was one of Kelly’s favorite guest co-hosts, trying out the Oculus headset, Rob’s 60th birthday party, her podcast “Let's Talk Off Camera with Kelly Ripa,” and her big goal to get out of hair and makeup! Got a question for Rob? Call our v…

Katey and Rob looooove talking to other sober people! Actress and musician Katey Sagal joins Rob Lowe to discuss her new podcast with husband Kurt Sutter, the joys of sobriety, the passing of her godfather Norman Lear, being a Keith Richards girl, working with the amazing John Ritter, why “Sons of Anarchy” convinced Rob to go buy a biker jacket, be…

Tig and Rob are silent laughers. Comedian Tig Notaro joins Rob Lowe to discuss their shared obsession with the song “Do They Know It’s Christmas?” by Band Aid, her foolproof method for testing potential TV show titles, her love for drama and despair, her podcast “Handsome,” and her new comedy special, “Hello Again.” Plus, Rob reveals a bit of White…

Rob is a huge admirer of the incredible activist and R&B musician Daryl Davis. He is the first Black author to write a book on the Ku Klux Klan (KKK) based on in-person interviews, and he has convinced dozens of Klansmen to leave and denounce the hate group. Today, Daryl joins Rob to discuss his incredible activism work, the power of conversation, …

Rob Lowe and Ted Sarandos love to quote their favorite movies together! Co-CEO of Netflix (and film fanatic) Ted Sarandos joins Rob Lowe to discuss his early days as a video store manager in Arizona, the little-seen Netflix comedy series that he is obsessed with, how the Netflix algorithm and his own fandom led to the company’s deal with Adam Sandl…

This episode of “Literally” is unlike any other. Rob Lowe is joined by Nando Parrado, one of the 16 survivors of the Uruguayan Air Force Flight 571, which crashed in the Andes mountains in 1972. After spending 72 days trapped in the mountains, Nando, along with his friend and teammate, climbed through the Andes mountains for 10 days to find help. N…