Macrodosing is a twice weekly macrodose of knowledge on topics ranging anywhere from your favorite conspiracy theory to deep dives on historical events. With PFT Commenter and Arian Foster at the helm of their cast of characters, the only criteria for this podcast is that we tickle your brain. You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/macrodosing
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Is it possible to feel safe at work? Neurobiology expert Rajkumari Neogy absolutely thinks so. Join us for conversations that will blow your mind as we explore what it takes to foster inclusive leadership and cultivate resonant cultures in the workplace.
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With the convergence of data, computing power, and new methods, computational biology is at its most exciting moment. At PSI, we're asking the leading researchers in the field to discover where we're headed for, and which exciting pathways will take us there. Whether you're just thinking of starting your research career or have been computing stuff for decades, come and join the conversation!
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Could Arian Compete In The Olympics? | Jun 25, 2024
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On today’s episode we check in on Big T live from Omaha, plus, the guys get into Kendrick Lamar, the Trump vs. Biden debate coming up this week, the Paris Olympics, Boeing executives and much more. Enjoy! You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit …
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Episode 14 - Syma Khalid: New ways to fight bacteria, the bacterial envelope, and kindness & openness in academia
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Send us a Text Message. In the fourteenth episode, Syma Khalid and I talk about the challenges we're faced with when trying to understand the environment of the bacterial cell envelope, and the outer membrane in particular. We discuss how the lessons taken from the computational study of these structures can inform the design of future antibacteria…
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Are Reptilians Living Among Us? | Jun 20, 2024
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On today’s episode we dive deep into the enigmatic world of Reptilian conspiracies. From the origins of the theory to the key figures who propagate it, we unravel the layers of this fascinating and controversial belief. Join us as we explore the claims that a hidden reptilian elite controls the world, examine the evidence presented by conspiracy th…
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PFT Got Robbed and Didn’t Even Know It | Jun 18, 2024
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On today's episode we get into PFT and Big T's teed off. Plus, Jersey Jerry joins us to answer your voicemails. Enjoy!(00:05:38) PFTeed off (Gym membership) (00:19:56) Chuck Schumer’s meat (00:28:32) Jerry joins (00:43:32) Teed off (Concerts) (01:06:10) Voicemails You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime …
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Episode 13 - Daniel Zuckerman: Trajectory ensembles, writing books, and learning biology through physics
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Send us a Text Message. In the thirteenth episode, Daniel Zuckerman and I talk about textbooks on statistical biophysics and a physics-based vision of biology, a few of which he himself authored. Daniel reveals that his passion for clarity in writing comes from his early humanities background, and makes a case for how well-thought and physically mo…
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How Can Leaders Think Creatively? w/ Culturati CEO Eugene Sepulveda
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By championing creative thinking, leaders cultivate a space where ideas flourish, collaboration thrives, and the extraordinary becomes possible, paving the way for sustainable success and growth. "Yet we don't program time for leaders to be creative," says Eugene Sepulveda. "When can they let their mind relax and daydream? The best organizations cr…
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Exploring the Life and Legacy of Sigmund Freud | Jun 13, 2024
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In this episode, we delve into the fascinating life and enduring legacy of Sigmund Freud, the father of psychoanalysis. Join us as we explore Freud's early years and academic journey, uncovering the experiences and influences that shaped his groundbreaking work. We'll discuss his most influential theories, including the concepts of the unconscious …
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Episode 12 - Vlad Cojocaru: Simulating transcriptional regulation, returning to our home countries, and the scales of the genome
27:12
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Send us a Text Message. In the twelfth episode, Vlad Cojocaru and I discuss how the simulation field can integrate further layers of complexity in modeling transcription control and genome organization in humans. Vlad shares his insights on the computational biology of transcription factors, including DNA-mediated allostery and pioneer transcriptio…
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San Diego Recap + The Worst Day of Big T’s Life | June 10, 2024
1:33:51
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On today’s episode we recap our trip to San Diego including Arian’s first pitch, Big T getting drunk and much more. Plus, we discuss Dan Hurley and The Lakers, Gregg Berhalter & USA Soccer and answer your voicemails.(00:01:55) San Diego Recap(00:25:49) Dan Hurley + The Lakers(00:31:00) Gregg Berhalter & USA Soccer (00:45:23) Voicemails You can find…
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Exploring The Conspiracy Behind The Lincoln Assassination | Jun 6, 2024
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In this episode, we delve into the intricate web of conspiracy theories surrounding the assassination of President Abraham Lincoln. Join us as we explore the events leading up to that fateful night at Ford's Theatre, the key figures involved, and the numerous theories that suggest a broader plot beyond John Wilkes Booth's infamous act. Was it merel…
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Trump's Legal Battles: Discussing the Convictions | Jun 4, 2024
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In this jam-packed episode, we dive into some of the most talked-about news stories making headlines. First, we provide an update on the man caught driving with a suspended license while attending his Zoom court hearing. Next, we explore the bizarre and escalating incidents of orcas attacking boats, examining the possible reasons behind this unusua…
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Viewing Homelessness Through a Human Lens w/ Social Worker Ariane Porras
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The homelessness crisis in the United States is at an all-time high, with 653,000 people experiencing homelessness on any given night, the highest number since 2007. Homelessness involves complex factors such as mental health, economic instability, and inadequate social support. Yet recently, a Supreme Court case debated whether sleeping on the str…
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Inside the World of Political Coups | May 30, 2024
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In this episode, we delve into the tumultuous world of political coups, exploring their causes, mechanics, and impacts on modern history. From the dramatic overthrows of governments to the intricate power plays behind the scenes, we examine how coups have shaped nations and altered the course of political landscapes. Join us as we unpack notable co…
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Episode 11 - Justin Lemkul: Providing technical help online, sharing expertise, and polarization in nucleic acids
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Send us a Text Message. In the eleventh episode, Justin Lemkul and I talk about the motivations and challenges behind providing technical help on online forums and mailing lists. Justin shares his story of becoming a prolific technical advisor for the Gromacs community, which evolves into a discussion about automatability, the role of expertise in …
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Solving Riddles With Jersey Jerry | May 28th, 2024
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Answering your voicemails(00:04:02) Apple Music top albums (00:13:35) Riddles(00:23:48) Harrison Butker(00:30:14) P. Diddy(00:32:48) Favorite song ever written (00:48:11) What would you name a horse(00:51:48) Picking up girls at the gym (01:08:13) Hitting on girls at the gym(01:10:54) Riddles You can find every episode of this show on Apple Podcast…
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Inside Private Equity: Power, Controversy, and Sports | May 23, 2024
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In this episode, we dive deep into the world of private equity, unraveling what it is and how it operates. We'll explore the controversies and criticisms surrounding this often-misunderstood sector, from its impact on companies to the broader economic implications. Additionally, we'll examine private equity's growing influence in professional sport…
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Episode 10 - Ariane Nunes-Alves: Kinetics in drug design, molecular crowding, and the social life of a PI
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Send us a Text Message. In the tenth episode, Ariane Nunes-Alves and I talk about a kinetics-centric view of drug design, making the case that modeling kinetics in atomistic simulation is an important frontier that, despite clear biomedical relevance, is rarely explicitly addressed either in model parameterization or with the latest AI methods. We …
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Our Reaction to the Scottie Scheffler Arrest | May 21, 2024
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On today's Nanodose, the guys dive into the unexpected story of Scottie Scheffler's arrest, examine the latest news on Iran’s president, debate the merits of tennis versus pickleball, and share their thoughts on some notorious bad preachers. Plus, there's a lot more in store, so tune in for an episode packed with lively discussions and unexpected t…
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Is DEI Headed for Extinction? w/ Cindy Owyoung
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In the past few years, DEI efforts in the U.S. have hit some setbacks. Political divides have deepened, with some states passing laws that limit conversations about race and gender, and the Supreme Court ruling against affirmative action in the workplace. "I've been here before," says Cindy Owyoung, who has been at the forefront of DEI for over 20 …
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Mermaids and Psychedelics: Diving into Myth and Mind (ft. Jake Plummer) | May 16, 2024
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Dive into the mystical and mind-bending world of mermaids and psychedelics in today’s episode with our special guest, former NFL quarterback Jake Plummer. We explore ancient myths and modern tales of these enchanting sea beings, delving into their symbolic connections to our subconscious minds. Join us as we discuss the intriguing intersections of …
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Episode 9 - Michele Vendruscolo: Preventing protein misfolding, fostering public engagement of scientists, and AI tools in drug design
31:21
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Send us a Text Message. In the ninth episode, Michele Vendruscolo and I discuss the current state of research on misfolding diseases, typically associated with excessive protein aggregation and formation of insoluble amyloids. Michele presents an optimistic perspective in which the convergence of recent clinical and software developments opens up n…
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Large Explains Roaring Kitty’s Meme Stocks | May 14, 2024
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In today’s episode we get into the world of meme stocks and the internet phenomenon that turned Wall Street on its head. Large joins us to unravel the incredible story of Roaring Kitty, the YouTube and Reddit persona who became a key figure in the GameStop stock saga. Plus, we get into the Miss USA controversy, Ashley Biden’s diary, and voicemails.…
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Join us as we delve deep into the secretive world of DARPA, the Defense Advanced Research Projects Agency. Uncover the fascinating history of this enigmatic organization, from its inception in response to the Soviet Union's launch of Sputnik to its groundbreaking innovations that have shaped the modern world.Explore DARPA's most noteworthy inventio…
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Joe Biden Has 24 Hours To Respond | May 7, 2024
1:59:57
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On today’s dynamic episode, we dive deep into the latest developments in the rap world, starting with the ongoing saga between Drake and Kendrick Lamar. Get the latest updates on their lyrical feud and how it's shaping the landscape of modern hip-hop. Plus, Big T hops in on the rap beef and gives us a diss track aimed at none other than Joe Biden.S…
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Unraveling the OJ Simpson Trial + A Send Off To Billy Football | Thu May 2, 2024
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In today’s episode, we get into the infamous OJ Simpson Trial, exploring its intricate details, shocking twists, and enduring cultural impact. Join us as we unravel the complexities of the case, from the murder of Nicole Brown Simpson and Ron Goldman to the dramatic courtroom proceedings that captivated the nation. We examine the evidence, the lega…
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Big T Goes Off About The Falcons Draft Pick | Macrodosing - April 30, 2024
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In this week's episode, we dive into all things happening in the news. First up, we dissect the shocking controversy surrounding South Dakota Governor Kristi Noem's defense of her controversial act. Then, join us as we explore the saga of Arian's attempt to cancel his LA Fitness membership—spoiler alert: he is NOT happy with them. Plus, Big T break…
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A Journey Through the History of Sports Drafts | Macrodosing - Apr 25, 2024
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On today’s episode we dive into the captivating history of sports drafts. From humble beginnings to multi-billion dollar industries, we explore how drafts have evolved across various sports, shaping the landscape of competition and player recruitment. Discover the stories behind iconic draft moments, the strategies employed by teams and leagues, an…
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Arian Is Back in Chicago! | Nanodosing - Apr 23, 2024
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On today’s episode everyone is back and Arian is IN STUDIO in Chicago!! We get into Taylor Swift’s new album, Arian’s problem with people traveling first class, NBA contracts and how the game has changed over the years, Zach Wilson to the Broncos and the new NFL uniforms. Plus, Hank joins the show to chat with Arian about our continued conversation…
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A Hard Look at White Supremacy w/ Jill Nagle
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White supremacy isn’t just in the history books; it’s baked into our daily lives, from the shows we watch to the ways we work, often without us even noticing. "It's the water that we swim in. And we don't know because we're the fish," says Jill Nagle. Jill has written multiple books, created a somatic counseling approach called Wisdom of the Body, …
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The Rise of Cyber Warfare (ft. Jersey Jerry)
1:53:46
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In today's episode, we’re joined by Jersey Jerry to discuss the intricate world of cyber security and cyber warfare. Join us as we explore the evolving landscape of digital threats, from ransomware attacks to state-sponsored cyber espionage. Learn how governments, businesses, and individuals can protect their digital assets and stay ahead in the on…
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Episode 8½ - My commentary: Wrapping up the first season
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Send us a Text Message. In this episode, I'm attempting to string together the most common threads brought up by my guests in the first eight interviews on the podcast. Reflecting on these conversations, I'm suggesting some grand challenges for the field in the years to come.By Miłosz Wieczór
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Secret Food Formulas (Part 2) | Nanodosing - April 16, 2024
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On today’s episode we continue the conversation on secret food formulas. We get into the secretive realms of renowned brands like Krispy Kreme, Dr. Pepper, Hershey's Chocolate, Heinz Ketchup, and more.From the irresistible melt-in-your-mouth sweetness of Krispy Kreme's original glazed donuts to the unique blend of 23 flavors in Dr. Pepper, discover…
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Inside the World of Secret Food Formulas | Apr 11, 2024
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Step into the world of culinary alchemy as we explore the fascinating realm of secret food formulas. In this episode, we talk about some of the most iconic and closely guarded recipes in the food industry, including the formula behind Coca-Cola's signature taste and the legendary blend of herbs and spices that defines KFC's finger-licking good chic…
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Episode 8 - Rossen Apostolov: Managing scientific collaboration, the biggest project of European biophysics, and seeding schools of thought
27:13
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Send us a Text Message. In the eight episode, Rossen Apostolov and I depart from the standard format to talk about the core concepts behind BioExcel, the European Center of Excellence for computational biology. We discuss their main objectives and challenges, from working with code to organizing schools and webinars, talk about the challenges of su…
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Billy Recaps His Fox News Experience | Apr 9, 2024
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On today’s episode we recap Billy’s Fox News appearance. Plus we get into the women’s basketball National Championship game, the solar eclipse, Big T’s teed off, PMT’s gambling turtle and much more. Enjoy! (00:04:10) Billy on Fox News (00:27:55) Donald Trump Truth Social(00:29:28) Women’s Basketball (00:41:55) Solar Eclipse (00:51:25) Big T’s Inter…
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What Do You Do in Times of Despair? w/ Author & Professor Dr. Shariff Abdullah
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At a time of crisis at home and abroad, we find ourselves in a state of unprecedented disharmony. "But that doesn't mean we're going to act," says Dr. Shariff Abdullah, with a reminder that "the call to action may make you very uncomfortable." Shariff has devoted much of his life to the work of inclusivity and societal transformation. His award-win…
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On today’s episode we dive into the world of rap beefs. From the gritty streets of the Bronx to the glitzy stages of today's global rap scene, we look at the highs and lows of one of the most fascinating aspects of hip-hop culture.Explore the origins of rap beefs, from friendly competition to full-blown feuds, as we examine how rivalries between ar…
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Explaining The Kendrick Lamar and Drake Beef
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In today’s episode, Arian explains the heated rivalry between two of hip-hop's biggest names: Kendrick Lamar and Drake. From subtle disses in lyrics to public call-outs, we analyze the origins and evolution of this longstanding feud. Plus, we also cover a wide range of intriguing topics, including the antics of April Fools' Day, Donnie's update (in…
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Episode 7 - Aleksei Aksimentiev: Nanobiotechnology, the importance of mentoring, and engineering serendipity
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Send us a Text Message. In the seventh episode, Aleksei Aksimentiev and I delve into the intersection of physics, biology, and nanotechnology, exploring the innovative world of nanopores and biomolecular sequencing. Aleksei shares his journey from particle physics in Ukraine to leading-edge research in the US, and underscores how on the unpredictab…
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Digesting 'Super Size Me': 20 Years Later
2:35:11
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In this episode, we delve into the groundbreaking 2004 documentary 'Super Size Me' directed by Morgan Spurlock. We revisit the eye-opening journey where Spurlock puts his own body on the line to investigate the effects of consuming nothing but McDonald's for 30 days. From shocking health revelations to societal critiques, 'Super Size Me' ignited a …
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Episode 6 - Giulia Palermo: Reimagining scientific creativity, the RNA revolution, and truly multiscale systems
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Send us a Text Message. In the sixth episode, Giulia Palermo and I discuss the challenges of studying truly multiscale biomolecular systems, such as the CRISPR/Cas9 complex she famously got involved with. While such problems can take us way out of our comfort zones, they also provide us with clear pathways to innovative and transformative science, …
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On today’s episode PFT, Big T and Billy get into PFT’s JMU game experience and additional college basketball discussion. Plus, the guys talk about what’s happening in the news, including, a terrorist attack in Moscow, the Department of Justice, Shohei Ohtani’s gambling allegations, Donald Trump’s Judgment and much more. Enjoy!(00:02:31) PFT at the …
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How to Build Face Recognition Software Ethically w/ Paravision's CEO, Doug Aley
1:01:21
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Face recognition technology is becoming a part of our daily lives in simple yet impactful ways. Unlocking your phone with a glance, tagging friends on social media, or verifying your identity at the airport are all examples of face recognition at work. Alongside its many practical benefits, there is a growing focus on addressing ethical concerns, e…
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The Conspiracy of Free Energy Suppression
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On today’s episode we dive deep into the controversial topic of free energy suppression. Join us as we uncover the intriguing history and alleged suppression of revolutionary energy technologies that could potentially change the world as we know it. From Nikola Tesla's pioneering work to modern inventors claiming to have discovered limitless energy…
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Episode 5 - Paul Robustelli: The dissolving barrier between industry and academia, embracing our artistic side, and new models of funding
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Send us a Text Message. In the fifth episode, Paul Robustelli and I discuss how the once very sharp boundary between academia and industry has been becoming increasingly porous, and what implications it will have for future careers in science. Paul shares his experiences and observations about the competing models of funding scientific research, an…
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Billy Sets The Record Straight On His Run For Congress
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On today’s episode the guys are back with a TON of different topics. We start off hearing from Billy and his adventures in Iceland and he sets the records straight (kinda of) on whether or not he’s still running for Congress. Plus we get into Kate Middleton and the Royal family, St. Patrick’s Day in Chicago recap, Lebron James’ new podcast, Dine 2,…
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Dave Portnoy Discusses His Run For Boston Mayor
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In today's episode we delve into the world of celebrities and non-politicians who have thrown their hats into the political ring. We bring on Dave Portnoy, founder of Barstool Sports, as our guest, as he shares insights from his past mayoral run in Boston and offers a unique perspective on the intersection of fame and politics.But that's not all— B…
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Episode 4 - Modesto Orozco: Computations driving experiments, opening simulation data, and integrating knowledge across sources and scales
24:18
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Send us a Text Message. In the fourth episode, Modesto Orozco and I talk about the rough path to the predictive power modern computational science has achieved in biology, and the immense possibilities it opens to today's computational biologists working across the scales of space and time. Modesto also reflects on why sharing simulation data is cr…
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Kirk Cousins Is Going To Be Half A Billionaire
1:45:23
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On today’s episode the guys are back to get into a whole slew of current events. We discuss 311 day, The Oscars, a Cannibal Gang leader named ‘Barbecue’ in Haiti, Jake Paul vs. Mike Tyson’s fight announcement, Tennessee basketball, breaking NFL trade news and much more. Enjoy! (00:00:52) 311 Band (00:14:05) Cannibal Gang leader named ‘Barbecue’ in …
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A DEIB+ Strategy for High Growth w/ Indeed's Misty Gaither, VP of DEIB+
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Amid ongoing debates about the efficacy of Diversity, Equity, Inclusion, and Belonging (DEIB+) initiatives, Indeed stands out as an example of how high-growth organizations can integrate these principles effectively. With over 10,000 employees across more than 60 countries, Indeed not only prioritizes DEIB+ as a strategic and moral imperative but a…
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