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Welcome to ThinkBetweenWorlds, Where we take you to different worlds and think about things way more than any sane person should. Starring: David Kennedy-Farner and Derek Dillon. Guest Starring: Madison Sneddon and Nick Mata Support this podcast: https://podcasters.spotify.com/pod/show/thinkbetweenworlds/support
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A podcast from The Tennessee Holler (www.TNHoller.com), a user-supported site lifting up progressive voices and fearlessly shining a light on injustices throughout Tennessee.
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Weekly conversations with C-Suite leaders offering insights into how they attained success and overcame challenges.
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Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com
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Various forms of divination, Tarot, Astrology, etc, in tandem with magical walks of all paths. From ceremonial magic to quick and dirty spell work. Managing to keep it light while still taking ourselves seriously. We will also discuss Paranormal investigations, and supernatural experiences. No matter where you live you can book blue for a reading at www.bluejunetarot.com Support this podcast: https://podcasters.spotify.com/pod/show/mysticwitch/support
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EP 154: Pioneering early disease detection through wearable devices and regular monitoring with Dr. Mike Snyder
41:03
41:03
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0:00 Introduction 1:00 Overview of Mike’s background and contributions to genomics and preventative medicine, as well as how he first became interested in deep data collection for health monitoring 4:20 The use of various tools, including smartwatches, blood tests, genetic testing, and more, to create a comprehensive view of an individual’s health …
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EP 153: How genomics is re-writing the taxonomy of disease with Lon Cardon, President and CEO of The Jackson Laboratory
40:25
40:25
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Lon 01:51 Lon’s involvement in the very first GWAS and what drew him to large-scale genomics research 03:32 Was moving away from candidate genes towards GWAS and data sharing initially a controversial idea? 05:25 What Lon believes has driven collaboration and data sharing within research communiti…
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EP 152: Unlocking the secrets of gene regulation with Nadav Ahituv, Director of the Institute of Human Genetics at UCSF
42:40
42:40
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01:15 - Introductions 02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career 04:56 - Our current understanding of non-coding genome grammar 07:40 - Is there a missing piece to the common variant, common disease paradigm? 10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs) 12:…
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Marsha Won't Debate Gloria (with David Plazas of the Tennessean)
20:39
20:39
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The Tennessean's David Plazas joins to talk about why Marsha won't debate Gloria, and why the Tennessean won't hold the debate with an empty podium anyway. (They should, so we might)
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EP 151: Understanding cell ageing and its role in disease with Marco Quarta Co-founder and CEO of Rubedo Life Sciences
42:36
42:36
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Marco 02:00 The areas Marco focused on during his academic career and what motivated him to found his first company 03:18 How our understanding of ageing has changed over the past two decades and some of the current big questions in ageing biology 06:01 How to get a clearer picture of the ageing p…
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MEMPHIS MAYOR PAUL YOUNG (on why he opposes the city council's lawsuit)
22:24
22:24
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Memphis Mayor Paul Young joins to explain why he thinks the city council should drop its lawsuit over gun law referendums, which he calls "futile" - after state Republicans threatened to withhold tax revenue to block them
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EP 150: Cracking the biological code of aging with Martin Borch Jensen, Co-Founder and Chief Scientific Officer at Gordian Biotechnology
44:21
44:21
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Martin 01:35 How a particularly large Indian meal resulted in a book about intermittent fasting and the biology of ageing 05:10 The biological mechanisms behind intermittent fasting, and whether it’s been established to extend life expectancy in humans. 10:13 What we know (and what we don’t) about…
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EP 149: Sequencing 33 million samples to support the UK’s COVID-19 response with Tony Cox, CEO of UK Biocentre
34:16
34:16
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Tony 02:00 What Tony was expecting going into the role of CEO at UK Biocentre, and how the COVID-19 pandemic changed his plans 03:38 Receiving a phone call from the UK government in March 2020 asking the UK Biocentre to stop all of its projects and focus on sequencing COVID-19 samples 05:12 The UK…
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REP. JUSTIN J. PEARSON on Memphis vs. The State (again)
18:15
18:15
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Pearson joins to talk about state Republicans attacking Memphis again over gun safety referendums, and Kanew calls on Mark Green to release his unredacted army discharge papers.
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EP 148: Advancing veteran health through the Million Veteran Program with Dr. Mike Gaziano, professor of medicine at Harvard Medical School
35:13
35:13
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0:00 Intro 2:00 Mike’s career prior to the Million Veteran Program (MVP), how Mike got to work on MVP, and important milestones in the project's evolution 8:30 Future goals for the Million Veteran Program in expanding and diversifying the research cohort 11:00 The roles of various omics in advancing the project's development 14:30 The most meaningf…
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Kanew asks folks to help us pressure the media to have a Gloria-Marsha debate and not settle for back to back interviews, threatening to have an empty podium if she doesn't show up. USE THIS LINK TO EMAIL THEM! Then we point out that Project 2025 is Project 2024 in Tennessee, and that's what's on the ballot.…
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EP 147: From research to delivering precision medicine in the clinic with Scott Weiss, Professor of Medicine at Harvard University
37:19
37:19
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Scott 01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD) 04:56 How and why Scott decided to transition into genetics 06:30 The advances in our understanding of the genetics of asthma and COPD over the past 2…
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EP 146: The biology of aging with Austin Argentieri, Research Fellow at Harvard Medical School, Affiliate Member of the Broad Institute, and Research Fellow at Massachusetts General Hospital
43:05
43:05
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Austin 01:42 What is aging and how should we think about it? 03:50 Discussion of Austin’s recent breakthrough paper on aging, including the questions he set out to answer, and the outcomes of the research 06:32 How Austin’s work focuses on using large-scale population proteomics data to create acc…
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Gloria joins to talk about her primary victory. Help her campaign HERE.
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EP 145: Navigating rare disease drug development regulations with Daniel O’Connor
39:12
39:12
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Daniel 02:04 Defining rare disease in the age of personalized medicine 04:57 Key touchpoints with the Medicines and Healthcare products Regulatory Agency (MHRA) when developing a new medicine 09:27 Improvements over the course of Daniel’s career when it comes to incentivizing and making the path t…
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EP 144: Research Roundup with Dr. Veera: breakthroughs in developmental disorders, Parkinson's, SLE, and Alzheimer's
56:48
56:48
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0:00 Introduction 1:40 A recurrent de novo mutation in a noncoding region of a small nucleolar RNA gene that has been identified as one of the most common causes of neurodevelopmental disorders This pathogenic variant escaped notice for years because it was not located in a protein coding region of the genome It now shows potential as a target for …
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EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Scientific Officer at Pheiron
36:17
36:17
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …
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EP 142: From genome to bedside: How genetics is transforming modern medical practice with Dr. Andrea Gropman
42:45
42:45
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0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…
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LUIS MATA, state house candidate (Rutherford County)
38:32
38:32
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Luis Mata, running for state house against Mike Sparks - who won't admit the Civil War was fought over slavery - joins to talk about his campaign. More info HERE.
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EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University
43:24
43:24
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…
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GLORIA JOHNSON on Hargett's Voter Suppression Letters
15:54
15:54
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U.S. Senate candidate GLORIA JOHNSON joins to talk about the 14,000+ voter intimidation letters send by Secretary of Voter Suppression Tre Hargett and his henchman Mark Goins.
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EP 140: The future of Electronic Health Records and data analysis with Ben Goldacre
52:51
52:51
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0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…
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CHERI BROWN, state house candidate (Murfreesboro)
18:28
18:28
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Cheri Brown joins to talk about her campaign to unseat Charlie Baum in Murfreesboro. Check out her campaign HERE.
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EP 139: Rare disease breakthroughs using tRNA with Michelle Werner, CEO of Alltrna and CEO-Partner of Flagship Pioneering
44:42
44:42
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0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…
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SHAUNDELLE BROOKS, state house candidate (Nashville)
11:52
11:52
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Shaundelle Brooks, who lost her son Akilah DaSilva in the Waffle House shooting, joins to talk about her campaign for house in Nashville. More on the campaign here.
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ALISON BEALE, state house candidate (Hendersonville)
27:51
27:51
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Alison Beale current mom, former teacher, joins to talk about her campaign for state house against Johnny Garrett. Check out her campaign HERE.
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Lauren Windsor joins to talk about her undercover recordings of Justice Alito and his wife. Moer on her site.
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KURT KOSACK, state house candidate (Brentwood)
20:22
20:22
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Kurt Kosack joins to talk about his campaign to replace Gino "Bully" Bulso in Brentwood.
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Preserve Cheatham County Vs. The TVA (with Tracy O'Neill)
17:11
17:11
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Tracy O'Neill of "Preserve Cheatham County" joins to talk about their fight against the Tennessee Valley Authority, which is poised to put a methane gas plant in their community against their wishes.
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JESSE HUSETH, state house candidate (Memphis)
19:22
19:22
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Jesse Huseth joins to talk about his campaign to replace John Gillespie (who lied to the family of Tyre Nichols) in the state House. More on his campaign HERE.
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EP 138: Personalised medicine using microbiome models with Dr. Almut Heinken
40:22
40:22
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0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…
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The hilarious duo that goes to Trump rallies and asks the tough questions will be in Nashville Thursday night at Zanies. Get your tix here.
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David Dayen of The Prospect joins to talk about corporate price gouging and what is really behind it. Read their articles here.
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EP 137: Mavis Machirori on promoting equity, diversity, and social justice in genomics research
41:40
41:40
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0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…
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CLAIRE JONES, State House Candidate (Brentwood)
16:49
16:49
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Clair Jones is a hospice nurse and mom running to replace Gino "Bully" Bulso. More on her campaign HERE.
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MEGAN BARRY, Candidate for Congress (TN-7)
15:23
15:23
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The former mayor of Nashville joins us to talk about her current bid for congress in TN-7, challenging "extreme" Mark Green. More about her campaign here.
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A New Vandy poll shows the Tennessee Republican supermajority is out of touch with Tennessee voters on many key issues, and that most of Tennessee is "pro-choice".
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EP 136: Developments in ring chromosome 20 research and advocacy with Allison Watson
40:57
40:57
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0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…
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Maryam Abolfazli, Candidate for Congress (TN-5)
15:33
15:33
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Maryam Abolfazli is running against Andy Ogles aka "Pinocchiogles" in TN-5. Learn more about her campaign HERE
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EP 135: Integration of newborn sequencing programs into healthcare systems with Dr. Ingrid Holm
41:16
41:16
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0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…
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EP 134: Prenatal genetic testing and the future of AI in genetic counselling with Kira Dineen, host of DNA Today
40:44
40:44
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0:00 Introduction 1:00 The backstory of how Kira first started DNA Today in 2012, when she was still in high school! 3:30 Some of Kira’s favourite topics she has discussed on DNA Today, including the legacy of Henrietta Lacks, and the story of a Glee actress with down syndrome 10:00 Kira’s best practices for podcasting, from over 10 years of experi…
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NOAH NORDSTROM, State House Candidate (Memphis)
15:22
15:22
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Noah Nordstrom, a public school teacher in Memphis challenging voucher scam bill sponsor Rep. Mark White, joins us to talk about his campaign for state house. Check out his campaign site here.
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EP 133: Insights into pharmacogenomics and increasing diversity in genomics research with Dr. Emma Magavern
39:17
39:17
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0:00 Introduction 2:00 The value of an English Literature degree in designing and analysing research studies in medicine 3:45 Emma’s entrance to pharmacogenomics and her transition from practising physician to genetics research 6:00 How the East London Genes and Health program is increasing representation of diverse populations, namely South Asians…
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EP 132: From mammoths to genome editing, trailblazing genetics with Dr. George Church
47:41
47:41
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0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…
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EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens
44:57
44:57
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0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…
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EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal
51:56
51:56
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Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…
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EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy
38:44
38:44
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0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…
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EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata
50:18
50:18
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0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…
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Eli Motycka, the Nashville Scene reporter arrested at Vandy while covering a pro-Palestine protest, joins to talk about the "chilling effect".
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EP 127: Insights into precision medicine, fatty liver disease, and minimally invasive diagnostic tools with Dr. Mazen Noureddin
39:10
39:10
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0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…
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