))
Here at Drug Discovery World (DDW) we've been publishing articles written by leading experts in the Drug Discovery, Pharmaceutical, and BioPharmaceutical industries for over 20 years. DDW has grown as a quarterly business review of drug discovery and development, and now we've created this podcast to allow you to listen to our articles on the go. In our journal and this podcast, we cover topics surrounding: drug discovery; drug development; business; chemistry; enabling technologies; informa ...
…
continue reading
Sounds of Science is a monthly podcast about beginnings: how a molecule becomes a drug, how a rodent elucidates a disease pathway, how a horseshoe crab morphs into an infection fighter. The podcast is produced by Eureka, the scientific blog of Charles River, a contract research organization for drug discovery and development. Tune in and begin the journey.
…
continue reading
Lisa Sharp, Project Coordinator for Charles River, joins us to discuss her COVID lockdown experience. Right at the beginning of the pandemic, just weeks apart, both she and her husband were diagnosed with cancer. Sadly, he didn't make it. While Lisa and their daughter faced the worst, she decided to make big changes to her life and career. Listen n…
…
continue reading
The latest episode of the DDW Highlights podcast is now available. The publication of DDW’s latest eBook on immunotherapy has coincided with some interesting developments in this therapy area, particularly monoclonal antibodies, including two new regulatory approvals. You can listen here, or find The Drug Discovery World Podcast on Spotify, Google …
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. This week we have seen a number of developments related to cell therapies, particularly CAR-T cell therapies, beyond their traditional use i…
…
continue reading
1
The consistency and value of immunotherapy
24:35
24:35
Play later
Play later
Lists
Like
Liked
24:35
This is the latest episode of the free DDW narrated podcast, titled “How technology is impacting drug discovery”, which covers two articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: Immunotherapy offers survival extension for brain tumour patients and The evolution of assays for immuno-oncology research. The first a…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. This week, DDW has opened registrations for its webinar ‘The latest advancements driving neuroscience drug discovery research’, so our news …
…
continue reading
Imagine you’re exploring the great outdoors when, out of nowhere, you feel the fangs of a snake – a poisonous snake – breaking through your skin. Medical care is nowhere in sight, so you’re left with the terrifying prospect of venom slowly infecting your body’s critical functions. This is the reality that roughly five million people face annually. …
…
continue reading
In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Dr Friso Postma, Vice President of AI Drug Discovery at BioXcel Therapeutics. Thanks to BioXcel's AI platform, …
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. With the release of clinical study results that led some media titles to ask if semaglutide could be a ‘fountain of youth’, this week our ne…
…
continue reading
I am joined by Dr. Kacey Ronaldson-Bouchard from Columbia University, who is an expert on linking organs on a chip together to form models of human systems. Can these models replace animals? Can they save time and money in drug development and safety testing? Find out now when you listen to this podcast!…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. With the launch of an international clinical trial investigating BioNTech’s mRNA lung cancer vaccine announced this week, our news highlight…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. It’s been a busy week for medical regulatory agencies, with a number of key decisions made on therapies for graft-versus-host-disease, neuro…
…
continue reading
1
How technology is impacting drug discovery
17:31
17:31
Play later
Play later
Lists
Like
Liked
17:31
This is the latest episode of the free DDW narrated podcast, titled "How technology is impacting drug discovery", which covers two articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: AI is critical to solving new complexities in drug discovery and The push towards lab automation in biopharma. In the first article, An…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The chosen news highlights this week all feature advances in drug development in oncology indications and reflect the breadth of therapeutic…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The news highlights this week all centre around significant US Food and Drug Administration (FDA) regulatory decisions, including new approv…
…
continue reading
1
Ep. 75: Porcine Kidneys for Human Transplant
22:05
22:05
Play later
Play later
Lists
Like
Liked
22:05
Mike Curtis, president and CEO of eGenesis, and transplant surgeon Dr. Leonardo Riella join me to discuss the ongoing research into pig kidney to human transplants. How can a porcine kidney be genetically modified to be safe for a human? Listen now to find out more.By Charles River
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. GLP-1 receptor agonists have dominated the headlines this week, with data revealed on new potential beneficial effects of treatment with sem…
…
continue reading
1
Innovation drivers and opportunities for drug discovery
32:04
32:04
Play later
Play later
Lists
Like
Liked
32:04
This is the latest episode of the free DDW narrated podcast, titled "Innovation drivers and opportunities for drug discovery", which covers three articles written Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: Optimising AAV capsid purification through improved analytics How transcriptomics is driving drug discovery Scandinavia: Ins…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. There have been some interesting developments in neuroscience this week. Perhaps most note-worthy, shingles vaccines Shingrix has been shown…
…
continue reading
1
Where is the global innovation and the opportunity in CGTs?
33:06
33:06
Play later
Play later
Lists
Like
Liked
33:06
This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers five articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: The promise and growth of cell and gene therapies No sign of stopping: The rise of cell and gene therapy Expert view: What's next…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The chosen news stories this week all feature therapies that could have significant impact on the future treatment of cancer, particularly h…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. Clinical trial news has caught our attention this week. Despite the revelation from Phesi that a third of clinical trials fail at Phase II, …
…
continue reading
1
Shining a spotlight on cancer research developments
11:00
11:00
Play later
Play later
Lists
Like
Liked
11:00
This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers two articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: The ‘dark matter’ behind cancer and Could this ‘Goldilocks’ drug be a non-toxic way to treat breast cancer? In the first article, …
…
continue reading
Felicia Samuel has worked for Charles River for years, but recently the work she contributes to has taken on a new meaning. Her daughter will be part of a clinical trial to receive one of the brand new sickle cell treatments, with the potential to drastically change her own and her family's lives. She joins me to discuss the details of this amazing…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The last few days have seen some interesting developments related to gene editing, including the discovery of a new mechanism for genetic pr…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. This week has seen some exciting advances in neuroscience drug discovery, including Phase II clinical trials for two potentially game-changi…
…
continue reading
1
How to utilise clinical trials in drug discovery
29:44
29:44
Play later
Play later
Lists
Like
Liked
29:44
This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers three articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: Medicinal cannabis: Why more clinical trials and better access is needed, What are the opportunities for decentralised clinical …
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. It’s been another busy week in the world of cell therapy, with the first use of CAR-T therapy for stiff-person syndrome, a study debunking t…
…
continue reading
1
Why drug repurposing is so significant for drug discovery
25:21
25:21
Play later
Play later
Lists
Like
Liked
25:21
This is the latest episode of the free DDW narrated podcast, titled “Why drug repurposing is so significant for drug discovery” which covers three written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: AI use in repurposing drugs for Covid-19 and RRx-001: Jack of all trades, master of…many. In the first article, Imran Haque, VP …
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. With a lead story on the restoration of congenital hearing loss following gene therapy, the news highlights selection this week focuses on c…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. With the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting concluding this week, the headline news has all focused on breakth…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The selected news highlights this week report breakthrough findings from early phase research and development, mainly preclinical studies an…
…
continue reading
What if we could replace mouse model control groups with a virtual equivalent? What would that mean for drug development in terms of cost, time, and animal model reduction? To answer, I am joined by Charles River associate director Laura Lotfi and Guillemette Duchateau-Nguyen from F. Hoffmann-La Roche Ltd, Pharmaceutical Sciences - Roche Innovation…
…
continue reading
1
The future climate and landscape for drug discovery
20:37
20:37
Play later
Play later
Lists
Like
Liked
20:37
This is the latest episode of the free DDW narrated podcast, titled “The future climate and landscape for drug discovery” which covers three written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: Pharma’s important climate and What will the 2023 drug discovery landscape look like? In the first article, DDW Editor Reece Armstrong…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. From a weight loss drug that prevents heart attacks and a gene therapy that restores hearing, to a vaccine that can treat viruses that don’t…
…
continue reading
In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Tien Lee, CEO of Aardvark Therapeutics, a San Diego-based biotech company in Phase II studies of its drug, ARD-…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. A leading news story this week has been the announcement of positive Phase II results of a head and neck cancer trial, but there have been a…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The ongoing innovation and development in the drug discovery sector relies on a number of moving parts, one of which is financial support an…
…
continue reading
1
Ep. 72: Artificial Intelligence in Cell and Gene Therapy
27:04
27:04
Play later
Play later
Lists
Like
Liked
27:04
Alex Sargent, Director of Process Development at Charles River in our Cell and Gene Therapy department, joins me to discuss the work he and his partner put into developing an algorithm to make his job faster and easier. How can you train a computer to accurately sift through the mountains of data generated in drug development? Listen now to find ou…
…
continue reading
1
Selective Translation Regulator Inhibitors: Depriving cancer of what it needs
17:51
17:51
Play later
Play later
Lists
Like
Liked
17:51
In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Steve Worland, CEO of eFFECTOR. eFFECTOR is a company targeting three distinct targets central to the eIF4F tra…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The leading news story this week has been the launch of a new clinical trial in the UK for a melanoma personalised mRNA cancer vaccine, but …
…
continue reading
1
A look behind the scenes of the drug discovery industry
34:23
34:23
Play later
Play later
Lists
Like
Liked
34:23
This is the latest episode of the free DDW narrated podcast, titled “A look behind the scenes of the drug discovery industry” which covers three written for Volume 23 – Issue 4, Fall 2022 of DDW. They are called: Going paperless – the move to electronic lab notebooks, New horizon for cancer innovation, and A personal touch: the role of bioprinting …
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The headline news this week all concerns clinical trials for new drugs that could have a significant impact on future patient treatment, inc…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The cancer research news has been coming thick and fast from the American Association of Cancer Research (AACR) Annual Meeting in San Diego …
…
continue reading
1
Ep. 71: Cellular Agriculture - Lab Grown Meat of the Future
31:28
31:28
Play later
Play later
Lists
Like
Liked
31:28
There have been many articles recently about cellular agriculture, or lab-grown meat products. But what happens when a company takes a practical approach to this science fiction concept? Joining me are Charles River's Steven Miklasz from our Biologics Testing Solutions team; and Ramsey Foty, Scientific Director for Fork & Good, a cultivated meat co…
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. In another busy week for drug discovery and development, we have seen the FDA approval of a monoclonal antibody for emergency use in Covid-1…
…
continue reading
1
Flow cytometry for drug discovery research
32:57
32:57
Play later
Play later
Lists
Like
Liked
32:57
This is the latest episode of the free DDW narrated podcast, titled “Flow cytometry for drug discovery research” which covers three written for Volume 23 – Issue 4, Fall 2022 of DDW. They are called: Flow cytometry technologies and cancer associated fibroblasts and Leveraging flow cytometry in drug discovery. In the first article, Dr Amber Miller, …
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. Following the recent AD/PD 2024 conference, which took place on 5-9 March in Lisbon, Portugal, there have been a number of key announcements…
…
continue reading
1
Exploring the potential of a new class of drug candidates
14:06
14:06
Play later
Play later
Lists
Like
Liked
14:06
In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Ahmed Mousa, CEO of Vicore Pharma. Vicore Pharma is exploring the potential of a new class of drug candidates, …
…
continue reading
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. It was antibodies hitting the headlines this week, with the discovery of antibodies with potential against a new influenza target, the launc…
…
continue reading
1
Ep. 70: Benjamin Oakes and the Promise of CRISPR
28:49
28:49
Play later
Play later
Lists
Like
Liked
28:49
This month I am joined by Benjamin Oakes, scientist, entrepreneur, and co-founder of Scribe Therapeutics. He studied at UC Berkeley, working in the Doudna Lab and Savage Lab during the earliest days of CRISPR. We discuss his personal vision for the future of CRISPR, encouraging advances in the field, and the first ever drug approval for a CRISPR ba…
…
continue reading
