show episodes
 
Longevity by Design is a podcast for individuals looking to experience a longer, healthier life. In each episode, Dr. Gil Blander joins a co-host and an industry expert to explore a personalized health journey. The show helps you access science-backed information, unpack complicated concepts, learn what’s on the cutting edge of longevity research and the scientists behind them. Tune into Longevity by Design and see how to add years onto your life...and life onto your years.
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The perfect way for you to stay in touch with the world of content. In each episode, we pick out and pull apart a piece of content that’s caught our eyes and ears, from superb social media campaigns, videos and animation to cracking copywriting. If it’s content that’s clever, we want to tell you about it. Content OD is a digital content agency from Sheffield in the UK.
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show series
 
In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander welcome Dr. Brianna Stubbs, an expert in exogenous ketone metabolism. Dr. Stubbs shares her journey from being a competitive rower to becoming a scientist. She dives into her research on ketone biology and its implications for health and aging. Dr. Stubbs discusses the …
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In this episode of Longevity by Design, host Dr. Gil Blander talks with Dr. Robert Lustig, an emeritus professor of pediatrics at UCSF and a renowned neuroendocrinologist. Dr. Lustig dives into the impact of ultra-processed foods and fructose on metabolism, emphasizing how these contribute to obesity and metabolic diseases. He also discusses his jo…
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In this Longevity by Design Ask Me Anything (AMA) episode with Ashley Reaver, MS, RD, CSSD, and Dr. Gil Blander, the focus is on user questions about optimizing health and longevity. Dr. Blander discusses the rationale behind InsideTracker's shift to a subscription model, emphasizing the importance of continuous engagement for long-term health impr…
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In this episode of Longevity by Design, hosts Ashley Reaver, MS, RD, CSSD, and Dr. Gil Blander sit down with Dr. Gordon Lithgow, a Professor and Vice President for Academic Affairs at the Buck Institute for Research on Aging. Dr. Lithgow's research focuses on understanding the mechanisms of aging and identifying genes and small molecules that can p…
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In this episode of Longevity By Design, co-hosts Ashley Reaver, MS, RD, CSSD, and Dr. Gil Blander welcome renowned professor Dr. Keith Baar. As the head of the Functional Molecular Biology Lab at UC Davis, Dr. Baar has made groundbreaking discoveries about how exercise and nutrition influence the adaptation of muscles, tendons, and ligaments. Durin…
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In this episode of Longevity by Design, host Dr. Gil Blander is joined by Dr. Morten Scheibye-Knudsen, a leading figure in aging research. Dr. Scheibye-Knudsen discusses his groundbreaking research on the role of DNA damage in the aging process and its implications for chronic diseases, aging research, and longevity medicine. The goal of his work i…
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Do you know what senescent (zombie) cells are and how cellular senescence and senolytics impact health? In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander are joined by Dr. James Kirkland from the Mayo Clinic, one of the world's leading figures in aging research. This episode is a deep dive into aging research, cellular…
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This episode of Longevity by Design discusses mental health and suicide risk and prevention. The following topics are discussed: depression, suicide, substance abuse, social isolation, among others also. This episode is intended to raise awareness of mental health issues and suicide risk and prevention. The topics discussed may be distressing or tr…
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Can we find ways to target human aging and extend healthspan? This ambitious premise is at the heart of XPRIZE Healthspan, a 7-year, $101 million global competition with an audacious challenge: to successfully develop a proactive, accessible therapeutic that restores muscle, cognitive, and immune function by a minimum of 10 years, with a goal of 20…
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Aging is inevitable, but can we influence how we age? In this episode of Longevity by Design, hosts Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, interview Dr. Nir Barzilai—the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Resear…
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In this episode of Longevity by Design, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, sit down with Dr. Bartek Nogal from InsideTracker to explore the cutting-edge intersections of exercise, genetics, blood biomarkers, health optimization, and longevity. Dr. Bartek Nogal, with a strong background in biological engineering and genomics, dives int…
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Did you know that your oral health has a profound impact on healthspan and longevity? Do you want to learn about the connections between oral health, healthspan, and longevity and what you can do to improve your oral health to help you live longer and add more healthy years to your life? This episode of Longevity by Design is an Ask Me Anything (AM…
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In this insightful episode of Longevity by Design, hosts Dr. Gil Blander and Ashley Reaver welcome Dr. Tony Wyss-Coray, a distinguished expert in neurology and brain aging. Dr. Wyss-Coray shares his journey from a childhood fascination with nature to becoming a leading figure in neuroscience and immunology. His initial interest in farming evolved i…
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How can you increase NAD+ levels? And do higher NAD+ levels really lead to better metabolic health? What does the research say on their benefits for longevity? These topics and more are discussed in the latest episode of Longevity by Design with Dr. Joe Baur. Dr. Baur, Professor at the Perelman School of Medicine of the University of Pennsylvania, …
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This episode of Longevity by Design features an interview with Dr. Eric Verdin—the CEO of The Buck Institute. The Buck Institute was the first center dedicated to aging research, and many discoveries within the aging field have come out of this research center. For this episode, Dr. Verdin, Dr. Blander, and Ashely Reaver sat down in person to discu…
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Dr. Nick Burd, PhD, is a skeletal muscle physiologist with an expertise in protein metabolism and exercise. In this episode, Dr. Burd discusses the importance of maintaining muscle mass as we age, expressing that “strong is the new healthy.” While adequate protein intake is an important aspect of gaining muscle and maintaining healthspan, many peop…
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In this episode of Longevity By Design, Dr. Gil Blander and Ashley Reaver interview Dr. Sara Gottfried. Dr. Gottfried received her MD from Harvard Medical School and completed residency at UCSF, however she is more likely to prescribe a continuous glucose monitor and personalized nutrition plan to her patients than the latest pharmaceutical. This e…
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Did you know that blood cholesterol levels are influenced by far more than just the foods we eat? Are you eager to know how to assess healthspan using your own body's data? This episode of Longevity by Design is an Ask Me Anything between Dr. Gil Blander and Ashley Reaver. We gathered frequently asked questions from the Longevity by Design audience…
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In this episode of Longevity By Design, Dr. Gil Blander interviews Dr. Bartek Nogal about genetic predispositions to conditions of aging. This episode goes deep into explaining how to improve your healthspan using DNA insights. Dr. Blander and Dr. Nogal talk about bone mineral density, epigenetic age acceleration, cognitive decline, risk of elevate…
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Did you know an estimated 6.7 million Americans aged 65 and older are living with Alzheimer's disease? Alzheimer’s disease is the most common form of dementia, contributing to 60–70% of dementia cases. Being that aging is the primary risk factor for developing dementia, the Longevity By Design team has been eager to discuss dementia on the show. In…
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GLP-1 agonist medications have been a popular topic of discussion recently. While this weight loss drug was designed for obesity, GLP-1 agonists like Ozempic have made their way into Hollywood. This has people questioning their safety and possible health risks, especially in the long run. Are GLP-1 agonists a quick fix for weight loss or a lifetime…
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In this episode of Longevity By Design, Dr. Blander sits down with Dr. Mitch Roslin to discuss insulin resistance. Insulin resistance has been top of mind for Dr. Blander recently, and this conversation offers new insights into how we can prevent insulin resistance through diet and lifestyle. Dr. Roslin parses out the different factors that cause i…
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Hyperbaric oxygen therapy (HBOT) is a medical treatment in which patients breathe pure oxygen at higher than normal atmospheric pressure. This increases the amount of oxygen dissolved in body tissues, enabling tissue rejuvenation and accelerated recovery. Historically, HBOT has been used for chronic wounds like diabetic foot ulcers, radiation injur…
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In 2023, a study was published in the journal Science sharing a breakthrough within the longevity field. This study used synthetic biology to alter the gene networks of yeast cells, and what they found was incredible. They were able to increase the lifespan of yeast cells by 82% compared to control cells. Various media outlets have covered the stud…
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When you hear the word “insulin” what comes to mind first? If your first thought was diabetes, you are not alone. Insulin is most often associated with diabetes, but it plays a key role in many aspects of our health. Did you know that insulin is associated with brain health and cognition? Or that managing insulin levels can aid in weight management…
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What if we told you that sugary foods aren't the only driver of insulin resistance? Many people attribute weight gain solely to a slowed metabolic rate, but the reality is that weight is influenced by dozens of other lifestyle factors. The media often misrepresents the term ‘hormone balance,’ leaving women without adequate advice to address menopau…
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In this episode of Longevity By Design, Dr. Gil Blander welcomes guest Dr. John Oliffe, a renowned expert on men’s mental health. Dr. Blander and Dr. Oliffe discuss the intricacies and challenges regarding mental health faced by men in today’s world, and how when left unaddressed, can threaten men’s longevity. They delve into the complexities of mo…
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In this episode of Longevity By Design, Dr. Gil Blander interviews Dr. Emma Teeling, a leading bat researcher from the University of Dublin. They delve into the extraordinary world of bats, discussing how these mammals hold the key to understanding disease resistance, immunity, and longevity. Dr. Teeling explains the unique immune system of bats an…
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In this episode of Longevity by Design, Dr. Renee Deehan discusses pertinent topics of women's health—and why women's health should matter to all. Hormone levels shift throughout a woman's lifespan, and the symptoms and risks associated with suboptimal hormone levels have an economic burden worth addressing. Tune in to learn how Dr. Deehan integrat…
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In this episode of Longevity By Design, Dr. Leroy Hood and Dr. Nathan Price discuss their approach to scientific wellness—distilling data into a simple, actionable measurement: biological age. Their goal is to leverage technology to compile data from the brain, body, gut microbiome, and more to create a model for scientific wellness. Dr. Leroy Hood…
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In this episode of Longevity By Design, Dr. Rachele Pojednic describes the mechanism behind how exercise improves healthspan—discussing different modes of exercise and how each caters to a key health metric. Muscle integrity declines as we age, and Dr. Pojednic shares why preserving this tissue is critical for healthspan. She encourages listeners t…
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In this episode of Longevity by Design, Dr. Kate Wolin discusses the tactics of behavior change science that can promote sustainable healthy habits. As a behavioral epidemiologist, Dr. Wolin provides actionable advice for health promotion in many contexts. She explains the science of motivation and how leveraging one’s motivation can promote behavi…
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This episode of Longevity by Design discusses groundbreaking research on the use of gene therapies to target common diseases of aging. Dr. Noah Davidsohn leverages genes associated with aging as targets for de-aging cells and reducing the burden of age-related diseases. The research appears promising—Dr. Davidsohn is confident that these findings w…
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During this episode of Longevity by Design, Dr. Joan Mannick explains how mTOR influences the aging process. She explains that this evolutionarily conserved protein is involved in several cellular functions in the body and acts on longevity-promoting pathways like autophagy. Dr. Mannick also discusses the connection between mTOR and the immune syst…
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This episode of Longevity by Design discusses topics related to longevity medicine, including mechanisms of aging, biological aging clocks, organ-specific aging, and factors that impact healthspan. With impressive clinical and research experience, Dr. Maier explains the importance of integrating longevity medicine into general practice as well as t…
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This episode of Longevity by Design is the second of a two-part series in which Dr. Jennifer Garrison discusses women's health and the menopausal transition. In this episode, Dr. Garrison talks about reproductive health, the hormonal fluctuations women experience during their life, and the health implications of menopause. For science-backed ways t…
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This episode of Longevity by Design discusses concepts related to women's health, including the brain-ovary connection, reproductive health, ovarian aging, and the health implications of menopause. Our guest today is Dr. Garrison, a neuroscientist, and expert in reproductive health. Dr. Garrison talks about gender inequalities in research and how h…
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This episode of Longevity by Design is an in-depth discussion on heart rate variability (HRV) and the stress response. Our guest today is Dr. Altini, an HRV expert and data expert. He and Dr. Blander talk through the definition of HRV, how stress impacts the autonomic nervous system, and the many factors that influence HRV. Tune in as Dr. Altini sh…
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This episode of Longevity by Design discusses the research behind biological aging clocks, artificial intelligence, and organ-specific aging with Dr. Alex Zhavoronkov and Deepankar Nayak. In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Alex Zhavoronkov and Deepankar Nayak. Dr. Zh…
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This episode of Longevity by Design discusses topics related to regenerative medicine—senescent cells, biomaterials, arthritis, immunology, and more. In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Jennifer Elisseeff. Dr. Elisseeff holds a PhD in Medical Engineering and has condu…
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This episode of Longevity by Design is all about longevity medicine, diving deep into the topic of longevity clinics, practical tools for using longevity medicine, and how this approach to healthspan differs from traditional methods of care. In this episode of Longevity by Design, our host, Dr. Gil Blander, is joined by Dr. Evelyne Bischof, Chief P…
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In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Robert Pastore. Today’s episode is all about celiac disease—clinical manifestations, challenges in the diagnostic processes, and how this disease is especially relevant to longevity. Along with having celiac himself, Dr. Pastore hol…
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In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Filipe Cabreiro. An expert in the gut microbiome and principal investigator at The Cabreiro Lab, Dr. Cabreiro discusses the latest science on the connection between gut microbial and healthy aging. Join us to learn how to improve mi…
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In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Matt Johnson. Dr. Johnson is the Director of Clinical Research at Dexcom—a leading company in diabetes care through the use of continuous glucose monitoring. With extensive knowledge in diabetes, metabolic health, and exercise physi…
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In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Dudley Lamming, an Associate Professor at the University of Wisconsin-Madison School of Medicine in the Division of Endocrinology, Diabetes, and Metabolism. Tune in as Dr. Lamming discusses his research on protein restriction and fa…
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In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Mitch Roslin, Chief of Bariatric Surgery at Lenox Hill Hospital in New York City. During this conversation with Dr. Mitch Roslin, he talks in detail about the obesity epidemic—he touches on taking a preventative, upstream approach, …
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In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Krista Varady, Professor of Nutrition at the University of Illinois, Chicago. Research on intermittent fasting is largely conducted in cellular and animal models. Dr. Krista Varady is one of few scientists to conduct intermittent fa…
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In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Ronald Krauss, Professor of Medicine at UCSF, and Adjunct Professor of Nutritional Sciences at UC Berkeley. Tune in as Dr. Ronald Krauss discusses the contributing factors to atherosclerosis, the biomarkers most associated with hear…
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In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Roger Fielding, Associate Director of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. Tune in as Dr. Roger Fielding describes how proper nutrition and being physically active build muscle and preven…
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In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Mariette Abrahams, CEO, and Founder of Qina, the first hub for data insights on Personalized Nutrition. Tune in as Mariette Abrahams discusses personalized nutrition and how to turn simple actions into sustainable health changes. Fo…
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