The Impact of Exercise on Blood Biomarkers and InsideTracker’s New DNA Healthspan Report with Dr. Bartek Nogal

Longevity by Design

In this episode of Longevity by Design, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, sit down with Dr. Bartek Nogal from InsideTracker to explore the cutting-edge intersections of exercise, genetics, blood biomarkers, health optimization, and longevity. Dr. Bartek Nogal, with a strong background in biological engineering and genomics, dives into how personalized health data can shape our understanding of aging and wellness. He discusses InsideTracker's new innovative approach to using DNA analysis for tailoring health interventions, emphasizing the importance of actionable guidance for optimizing blood biomarkers and extending healthspan and longevity.

Dr. Bartek Nogal shares compelling insights into the latest findings from InsideTracker's peer-reviewed published study on the effect of running on blood biomarkers and metabolic health, along with the influence of genetics—highlighting the power of exercise combined with the added value genetics provide for even greater personal health optimization. Dr. Nogal also discusses InsideTracker’s new innovative DNA healthspan report and the enhanced information and deeper insights it provides.

The conversation is a deep dive into how technology bridges the gap between scientific research and everyday health practices, offering listeners a roadmap to a longer, healthier life. Listeners will leave with a clear understanding of the power of exercise on blood biomarkers and genomics for personal health and practical tips for leveraging their genetic information to make even better-informed lifestyle choices. This episode is a testament to the evolving landscape of health and science, where the fusion of data, technology, and personalized insights paves the way for a future of optimized health and longevity.
Listen to all episodes of Longevity by Design at https://info.insidetracker.com/longevitybydesign
Episode timestamps:

• Introduction: 00:00-02:32
• What led Dr. Bartek Nogal to become a scientist: 02:33-03:27
• Dr. Bartek Nogal’s career at InsideTracker: 03:28-04:02
• InsideTracker’s peer-reviewed study: Dose response of running on blood biomarkers of wellness in generally healthy individuals (https://pubmed.ncbi.nlm.nih.gov/37967046/): 04:03-06:46
• What is principal component analysis (PCA), and what were the findings using PCA: 06:47-07:56
• What is the effect of running blood biomarkers? What is the effect of the amount of running on blood biomarkers?: 07:57-09:27
• What was the effect of running on BMI (body mass index): 09:28-10:44
• What is Mendelian randomization, and what is the relationship of genetics with exercise and blood biomarkers? : 10:45-12:40
• What is the influence of genes on the relationship between exercise and diet: 12:41-13:33
• What are the strengths of Mendelian randomization for understanding the influence of genetics: 13:34-17:05
• What were the key findings from InsideTracker’s study on the effect of running on blood biomarkers 17:06-18:56
• What is InsideTracker’s new DNA report? What was the motivation for developing this new DNA healthspan report: 18:57-20:31
• What additional information and insights does InsideTracker’s new DNA report and scores provide: 20:32-28:41
• How much do genes or lifestyle influence blood biomarkers and risk of developing diseases: 28:42-32:24
• How to use InsideTracker’s new DNA and healthspan scores to optimize blood biomarkers and health: 32:25-34:28
• What is the future of genetics research: 34:29-36:36
• What is the future of genetic testing at InsideTracker: 36

Chapters

1. Introduction (00:00:00)

2. What led Dr. Bartek Nogal to become a scientist (00:02:33)

3. Dr. Bartek Nogal’s career at InsideTracker (00:03:28)

4. InsideTracker’s peer-reviewed published study: Dose response of running on blood biomarkers of wellness in generally healthy individuals (https://pubmed.ncbi.nlm.nih.gov/37967046/) (00:04:03)

5. What is principal component analysis (PCA), and what were the findings using PCA (00:06:47)

6. What is the effect of running blood biomarkers? What is the effect of the amount of running on blood biomarkers? (00:07:57)

7. What was the effect of running on BMI (body mass index)? (00:09:28)

8. What is Mendelian randomization, and what is the relationship of genetics with exercise and blood biomarkers? (00:10:45)

9. What is the influence of genes on the relationship between exercise and diet? (00:12:41)

10. What are the strengths of Mendelian randomization for understanding the influence of genetics? (00:13:34)

11. What were the key findings from InsideTracker’s study on the effect of running on blood biomarkers? (00:17:06)

12. What is InsideTracker’s new DNA report? What was the motivation for developing this new DNA healthspan report? (00:18:57)

13. What additional information and insights does InsideTracker’s new DNA report and scores provide? (00:20:32)

14. How much do genes or lifestyle influence blood biomarkers and risk of developing diseases? (00:28:42)

15. How to use InsideTracker’s new DNA and healthspan scores to optimize blood biomarkers and health (00:32:25)

16. What is the future of genetics research? (00:34:29)

17. What is the future of genetic testing at InsideTracker? (00:36:37)

18. Dr. Bartek Nogal’s top tip for improving health (00:38:20)