Best Michael Shaughnessy Podcasts (2024)

1
The Innovation Game: The Market-Driven Approach to Solving Big Science Problems 56:49

18m ago56:49

56:49

TIG (The Innovation Game) is a decentralized science project designed to accelerate algorithmic innovation. It uses a coordination protocol and proof of work to discover the most efficient algorithms for scientific problems. The project originated in 2012 with the goal of addressing the lack of open development and funding for scientific research. …

1
EP 149: Sequencing 33 million samples to support the UK’s COVID-19 response with Tony Cox, CEO of UK Biocentre 34:16

1h ago34:16

34:16

0:00 Intro to The Genetics Podcast 01:00 Welcome to Tony 02:00 What Tony was expecting going into the role of CEO at UK Biocentre, and how the COVID-19 pandemic changed his plans 03:38 Receiving a phone call from the UK government in March 2020 asking the UK Biocentre to stop all of its projects and focus on sequencing COVID-19 samples 05:12 The UK…

1
EP 148: Advancing veteran health through the Million Veteran Program with Dr. Mike Gaziano, professor of medicine at Harvard Medical School 35:13

22h ago35:13

35:13

0:00 Intro 2:00 Mike’s career prior to the Million Veteran Program (MVP), how Mike got to work on MVP, and important milestones in the project's evolution 8:30 Future goals for the Million Veteran Program in expanding and diversifying the research cohort 11:00 The roles of various omics in advancing the project's development 14:30 The most meaningf…

1
Himanshu Tyagi: Sentient's $85m Raise To Build An Alternative to OpenAI Through Monetizable Open Source Models 1:10:04

8d ago1:10:04

1:10:04

Himanshu, a core contributor to Sentient, discusses the vision and mission of the project in this conversation. Sentient aims to create a decentralized alternative to centralized AI, where contributors are rewarded for their contributions and the AI economy is more participatory. The project recently raised $85 million in funding led by Peter Thiel…

1
EP 147: From research to delivering precision medicine in the clinic with Scott Weiss, Professor of Medicine at Harvard University 37:19

27m ago37:19

37:19

0:00 Intro to The Genetics Podcast 01:00 Welcome to Scott 01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD) 04:56 How and why Scott decided to transition into genetics 06:30 The advances in our understanding of the genetics of asthma and COPD over the past 2…

1
EP 146: The biology of aging with Austin Argentieri, Research Fellow at Harvard Medical School, Affiliate Member of the Broad Institute, and Research Fellow at Massachusetts General Hospital 43:05

5d ago43:05

43:05

0:00 Intro to The Genetics Podcast 01:00 Welcome to Austin 01:42 What is aging and how should we think about it? 03:50 Discussion of Austin’s recent breakthrough paper on aging, including the questions he set out to answer, and the outcomes of the research 06:32 How Austin’s work focuses on using large-scale population proteomics data to create acc…

1
EP 145: Navigating rare disease drug development regulations with Daniel O’Connor 39:12

26d ago39:12

39:12

0:00 Intro to The Genetics Podcast 01:00 Welcome to Daniel 02:04 Defining rare disease in the age of personalized medicine 04:57 Key touchpoints with the Medicines and Healthcare products Regulatory Agency (MHRA) when developing a new medicine 09:27 Improvements over the course of Daniel’s career when it comes to incentivizing and making the path t…

1
EP 144: Research Roundup with Dr. Veera: breakthroughs in developmental disorders, Parkinson's, SLE, and Alzheimer's 56:48

26d ago56:48

56:48

0:00 Introduction 1:40 A recurrent de novo mutation in a noncoding region of a small nucleolar RNA gene that has been identified as one of the most common causes of neurodevelopmental disorders This pathogenic variant escaped notice for years because it was not located in a protein coding region of the genome It now shows potential as a target for …

1
EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Scientific Officer at Pheiron 36:17

1M ago36:17

36:17

0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …

1
EP 142: From genome to bedside: How genetics is transforming modern medical practice with Dr. Andrea Gropman 42:45

2M ago42:45

42:45

0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…

1
EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University 43:24

2M ago43:24

43:24

0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…

1
EP 140: The future of Electronic Health Records and data analysis with Ben Goldacre 52:51

2M ago52:51

52:51

0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…

1
The War Between Centralized (OpenAI, Gemini, Anthropic) and Crypto x AI's Open Source Movement with Ben Fielding, Travis Good, Michael Rinko and Pondering Durian 1:55:50

2M ago1:55:50

1:55:50

This episode features a discussion between four AI experts. The conversation explores the advantages and disadvantages of both centralized and decentralized AI and delves into topics such as data concentration, market power, security, and the future of AI. We discuss the potential risks and benefits of each approach and highlight the importance of …

1
EP 139: Rare disease breakthroughs using tRNA with Michelle Werner, CEO of Alltrna and CEO-Partner of Flagship Pioneering 44:42

2M ago44:42

44:42

0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…

1
Smokey The Bera: Berachain Is A Playground for Infinite Economic Games 56:54

2M ago56:54

56:54

Berachain is an EVM-compatible L1 blockchain powered by Proof-of-Liquidity. Users earn the native token, BGT, by providing liquidity to applications on the chain. Join us as we speak to Berachain's cofounder on how the chain works, it's liquidity framework and the roadmap ahead!Smokey's Twitter: https://x.com/SmokeyTheBeraChapters00:00 Introduction…

1
Rossen Yordanov: Azuro’s Role in the Future of Prediction Markets 46:13

2M ago46:13

46:13

Rossen Yardanov, a core contributor to Azuro protocol, discusses the challenges and potential of prediction markets in the crypto space. He explains why prediction markets haven't taken off in the past and how Azuro is addressing these issues. Azuro is focused on making passive liquidity work in prediction markets, allowing anyone to play the role …

1
Michael Rinko and Kevin Kelly: The Liquidity of Attention Drives Markets & Dictates Winners 1:08:22

2M ago1:08:22

1:08:22

The conversation explores the concept of attention as a driving force in the crypto market, particularly in the context of meme coins. It discusses how attention influences demand and behavior, and how it can be a valuable asset in itself. The conversation also touches on the importance of distribution and capturing attention in the success of cryp…

1
Conversation With Professor Randal Milch: The Social And Legal Impact Of The Ashley Madison Data Breach 48:19

2M ago48:19

48:19

Professor Randal Milch, serves as the Faculty Co-Director of the MS in Cybersecurity Risk and Strategy Program at the New York University School of Law. He is also the Co-Chair of the NYU Center for Cybersecurity and a distinguished Fellow at the Reiss Center on Law and Security. He is the former chair of the Board of Equal Justice Works at the New…

1
EP 138: Personalised medicine using microbiome models with Dr. Almut Heinken 40:22

3M ago40:22

40:22

0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…

1
EP 137: Mavis Machirori on promoting equity, diversity, and social justice in genomics research 41:40

3M ago41:40

41:40

0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…

1
EP 136: Developments in ring chromosome 20 research and advocacy with Allison Watson 40:57

3M ago40:57

40:57

0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…

1
EigenLayer's Forkable Token System - Bringing Social Truth Onchain 1:42:20

3M ago1:42:20

1:42:20

Eigenlayer is a protocol for decentralized trust, allowing anyone to build new crypto applications without worrying about the source of trust. It enables other protocols to inherit the security of Ethereum by staking ETH and running the Ethereum protocol correctly. Eigenlayer also introduces the concept of Actively Validated Services (AVS), which c…

1
Arthur Hayes, Kyle Samani and Cindy Leow: Drift Protocol and the Future of DeFi 1:03:46

3M ago1:03:46

1:03:46

In this episode of the Delphi podcast, the co-founders of Drift Protocol, Cindy Leow, along with Arthur Hayes and Kyle Samani, discuss the vision and development of Drift, as well as the future of DeFi. They highlight the importance of censorship resistance and access to financial markets for all individuals, regardless of their location. They also…

1
EP 135: Integration of newborn sequencing programs into healthcare systems with Dr. Ingrid Holm 41:16

3M ago41:16

41:16

0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…

1
EP 134: Prenatal genetic testing and the future of AI in genetic counselling with Kira Dineen, host of DNA Today 40:44

3M ago40:44

40:44

0:00 Introduction 1:00 The backstory of how Kira first started DNA Today in 2012, when she was still in high school! 3:30 Some of Kira’s favourite topics she has discussed on DNA Today, including the legacy of Henrietta Lacks, and the story of a Glee actress with down syndrome 10:00 Kira’s best practices for podcasting, from over 10 years of experi…

1
David Johnston: Morpheus's Fair Launch Attracts $400M in stETH to Build Network of AI Agents 50:56

3M ago50:56

50:56

David Johnston discusses the Morpheus project, which aims to build a free future by providing individuals with their own personal AI. The project attracted significant interest and support through a fair launch, where users could stake their ETH and contribute to the project in exchange for tokens. The Morpheus network acts as a coordination platfo…

1
EP 133: Insights into pharmacogenomics and increasing diversity in genomics research with Dr. Emma Magavern 39:17

3M ago39:17

39:17

0:00 Introduction 2:00 The value of an English Literature degree in designing and analysing research studies in medicine 3:45 Emma’s entrance to pharmacogenomics and her transition from practising physician to genetics research 6:00 How the East London Genes and Health program is increasing representation of diverse populations, namely South Asians…

1
Michael, Ming and Jason of 0G Labs: Building A Modular Chain Specifically for AI 55:55

4M ago55:55

55:55

0G Labs is building the world's first modular AI chain that enables on-chain storage of training data, models, and the entire stack for crypto AI. Their DA layer provides high throughput and scalability, with a performance difference of 50,000 times better and 100 times cheaper than existing solutions. They aim to achieve Web2 parity on-chain for A…

1
EP 132: From mammoths to genome editing, trailblazing genetics with Dr. George Church 47:41

4M ago47:41

47:41

0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…

1
Andrej Radonjic: Grass's Two Million Data Scraping Users Enabling Crypto x AI on Solana 57:27

4M ago57:27

57:27

GRASS (GetGrass.io) is a viral crypto AI project built on Solana that aims to scrape and validate internet data for AI training. The name 'GRASS' was chosen for its memeability and metaphors. The project addresses the scarcity of quality data and the control of web data by a few companies. It also tackles the unfairness of companies scraping data f…

1
Decentralization Unleashed: The Astria Approach to Rollup Sequencing 57:13

4M ago57:13

57:13

Josh, the co-founder of Astria, discusses the journey from data availability layers to building a shared sequencer network. He explains the concept of shared sequencing and its advantages, such as amortizing the cost of engineering and providing a competitive experience for rollup developers. He also addresses the trade-offs and constraints of usin…

1
EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens 44:57

4M ago44:57

44:57

0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…

1
Gui Laliberte and Avichal Garg: Integral's Accounting Suite Driving Backoffice to Zero 1:05:19

4M ago1:05:19

1:05:19

Integral is a financial operations and accounting platform for companies with Web3 assets. It simplifies financial workflows and provides real-time access to financial information. The platform saves businesses time and frustration by automating tasks such as bookkeeping, payroll, and payments. Integral enables companies to manage their crypto asse…

1
EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal 51:56

5M ago51:56

51:56

Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…

1
Tory Green: io.net’s 500,000 GPUs Powering Crypto x AI on Solana 56:30

4M ago56:30

56:30

io.net is a distributed training and inference project built on Solana. They aim to solve the problem of the GPU shortage in the AI industry by building a decentralized network that connects underutilized GPUs from multiple sources. Ionet uses clustering technology to combine GPUs from different geographic locations, allowing for more efficient and…

1
EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy 38:44

4M ago38:44

38:44

0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…

1
Degen Chain and L3s: What's Next 59:16

5M ago59:16

59:16

The conversation explores the concept of Layer 3 (L3) blockchains and their potential impact on the crypto industry. L3s offer unlimited customizations with near-zero gas fees, allowing for limitless creativity and experimentation. The discussion focuses on Degen, a community built on the L3 chain, and its journey from a tipping functionality on Fo…

1
Nous Research: Crypto x AI Masterclass, 30 Million Model Downloads, Bittensor Subnets and Launching a Matrix Style World Simulator 1:15:50

5M ago1:15:50

1:15:50

In this conversation, Jeff from Nous Research discusses their work on open source models and the BitTensor subnet. They address the challenges of ranking models on platforms like Hugging Face and the need for a more reliable and commercially viable model ranking system. Nous Research has developed Nous Hermes, an open source model that can be fine-…

1
EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata 50:18

5M ago50:18

50:18

0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…

1
EP 127: Insights into precision medicine, fatty liver disease, and minimally invasive diagnostic tools with Dr. Mazen Noureddin 39:10

5M ago39:10

39:10

0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…

1
EP 126: Patient-led research for ultra-rare disease drug development with Julia Taravella, Executive Director of Rare Trait Hope Fund 39:41

5M ago39:41

39:41

0:00 Introduction 0:25 Julia’s personal experience with ultra-rare diseases within her family 10:25 The importance of increasing accessibility to genetic testing across populations to learn more about ultra-rare diseases 14:00 The origin story of Rare Trait Hope Fund 23:50 Current research and next steps in developing potential gene therapies for a…

1
ETH Denver Crypto x AI Panel: Casey Caruso, Colin Gagich and Vassilis Tziokas 45:48

5M ago45:48

45:48

Recorded Live at ETH Denver 2024, this conversation explores the intersection of crypto and AI, discussing the need for decentralized AI models and the challenges of achieving this. The participants highlight the importance of keeping AI open and driven by people, rather than organizations. They discuss the potential of blockchain and Web3 technolo…

1
Ethan Sun and Santiago Santos: Bringing Crypto x AI Experiences to Millions with MyShell.AI 1:13:54

5M ago1:13:54

1:13:54

In this episode, Tommy and Santiago interview Ethan Sun, the co-founder of MyShell, a decentralized platform for creating and staking AI native applications. They discuss the evolution of AI over the past decade, the importance of consumer-facing applications, and the potential for AI to enhance daily life. Ethan explains how MyShell empowers creat…

1
EP 125: The future of UK Clinical Trial Policy: Innovation, integration, and game-changing legislation with Lord James O’Shaughnessy 45:23

5M ago45:23

45:23

0:00 Introduction 1:25 How Lord O’Shaughnessy became involved in scientific policy making and his path to writing the UK Commercial Clinical Trials Review. 04:05 How Lord O’Shaughnessy pivoted from education to a focus on life sciences 06:38 The biggest challenges Lord O’Shaughnessy faced during his time as Parliamentary Under Secretary for Health …

1
Orkun Kilic: Technical Dive Into Citrea, Bitcoin's First Zk-Rollup 41:15

6M ago41:15

41:15

In this podcast, we dive deep into the world of Bitcoin scalability solutions with Orkun Kilic, the co-founder and CEO of Chainway Labs, the company behind Citrea - Bitcoin's first zero-knowledge (ZK) rollup. Orkun provides a detailed background on the journey that led to the creation of Citrea, explaining how recent upgrades to Bitcoin's protocol …

1
EP 124: How ReCode Therapeutics is pioneering tissue specific delivery of gene therapies for Primary Ciliary Dyskinesia with John Matthews 42:00

6M ago42:00

42:00

0:00 Introduction 01:10 How growing up in Malawi planted the seeds for John’s career in medicine and transition to therapeutic development 04:35 Why John focuses on rare diseases and conditions such as asthma 06:01 What has changed over the last decade in terms of treating and understanding asthma and the progress that genetics has enabled 07:31 Wh…

1
EP 123: The ethics of newborn genome screening: Actionable insights and beyond with Holly Peay, Senior Research Scientist at the Research Triangle Institute 45:34

6M ago45:34

45:34

0:00 Introduction 0:50 Holly’s background and career so far 03:30 Complex decision-making and multiple risk factors: Family history, genetics, phenotypes and beyond 07:05 Changes within the last decade to help people make complex, sometimes subjective, healthcare decisions 09:20 Impact on people: The RTI’s mission and the Early Check Study 13:45 Ne…

1
Keith Singery: A Conversation with an Extremely Knowledgeable Bittensor Validator 1:21:33

6M ago1:21:33

1:21:33

In this episode, Keith Singery, a prominent validator and thought leader in the Bittensor ecosystem sits down with Tommy and Michael to share his unique perspective on the project's mission to democratize AI and create a decentralized alternative to the centralized models dominating the field. They delve into the intricate dynamics of Bittensor, in…

1
EP 122: Building genome-scale engineered cells for biotechnology with Leslie Mitchell, Co-founder and CEO of Neochromosome 35:55

6M ago35:55

35:55

Summary: 0:00 Introduction 01:01 How Leslie got into the field of synthetic biology and engineering, and her career journey so far 02:45 What Leslie accomplished during her postdoc and recent transformations in the field of genomics 05:57 The impacts of non-coding regions of the genome and the outcome of deletions 08:20 How long it takes to make ch…

1
Keone Hon of Monad: 10,000 TPS & Full EVM Equivalence - A New Era for Ethereum Apps 53:52

6M ago53:52

53:52

In this episode, Keone Hon dives deep on Monad, a high-performance Ethereum-compatible layer 1 blockchain focused on delivering high performance and drastically lower transaction costs. We discuss Monad's key technical innovations like MonadBFT consensus, parallel execution, and a custom database enabling 10,000+ TPS. Keone explains how these break…

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