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Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com
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Artwork

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Looking Inside

Rory Mitchell

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"Looking Inside" is partly based on a spiritual exercise known as 'hitbodedut' in which one has personal private conversations with God in order to see their true self as God sees them. It involves looking inside ourselves, asking probing questions to unveil the truth - of why we act, speak, and think the way we do, and being bold in taking the necessary steps to improve ourselves, and our relationships with both God and man. My hope is that this podcast will help you find the courage to loo ...
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The Ready Set Blow Podcast is brought to you each and every Wednesday by Randy Valerio. Randy is a LA-based comedian and podcaster originally hailing from Queens, New York. He tries to make sense of his life and the world around him every week on the podcast by sharing crazy ideas, news, stories, and his adventures with his guests and the listeners.
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Listen to H.K. Domino give his unbiased, unfiltered, unapologetic opinion on everything from Politics to Porn to Pop culture. Nothing is off limits or too taboo. Follow the podcast on Instagram: @Domino_Effect_Podcast Follow on X: @DominoEffectPod @HK_Domino
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There’s never been a musical theatre game show… until now. In The Great Broadway Game Show Competition teams of Broadway stars face off against each other, and the audience, to identify show tunes and win money for charity, all while sharing intimate stories and memories from their lives and careers. Who do you think knows more about musicals? Who can remember all the lyrics to the most obscure songs on Broadway? Tune in and play along with host Todd Graff as he puts everyone’s knowledge to ...
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show series
 
Randy welcomes the always funny Xander Beltran back to the podcast. The two talk about the end of the Olympics and novel sports the USA would be good at. Randy discusses his dislike of bidets. The boys shift gears and talk about performing comedy at music shows. Xander discusses performing while on various substances. Xander then tells the tale of …
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Tony 02:00 What Tony was expecting going into the role of CEO at UK Biocentre, and how the COVID-19 pandemic changed his plans 03:38 Receiving a phone call from the UK government in March 2020 asking the UK Biocentre to stop all of its projects and focus on sequencing COVID-19 samples 05:12 The UK…
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All the way from the land down under, Rory Lowe is in LA and graces the podcast with his presence. The boys open the show talking about how out of control tipping has gotten in the US. Rory talks about losing his belonging 3 times on his trip to America. Randy asks about the multicolor Monopoly money Australia uses as its currency. Randy talks abou…
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0:00 Intro 2:00 Mike’s career prior to the Million Veteran Program (MVP), how Mike got to work on MVP, and important milestones in the project's evolution 8:30 Future goals for the Million Veteran Program in expanding and diversifying the research cohort 11:00 The roles of various omics in advancing the project's development 14:30 The most meaningf…
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The hilarious Dustin Chafin joins the podcast this week. Randy kicks off the show asking what it’s like performing in arenas opening for the great Nate Bargatze. Dustin shares tips on how work clean. He tells the tale of the time he got into a fight during a comedy set. The boys discuss the choice to not have kids. Dustin talks about his time in th…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Scott 01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD) 04:56 How and why Scott decided to transition into genetics 06:30 The advances in our understanding of the genetics of asthma and COPD over the past 2…
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Randy welcomes the lovely Jen Murphy to the show. Jen opens the show telling Randy about her theater days. Randy laments that he’s not as charismatic and sweet as Jen. The two talk about getting older and dating younger people. Randy dispenses a little bad relationship advice. He talks about balancing a day job with comedy and trying to keep the dr…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Austin 01:42 What is aging and how should we think about it? 03:50 Discussion of Austin’s recent breakthrough paper on aging, including the questions he set out to answer, and the outcomes of the research 06:32 How Austin’s work focuses on using large-scale population proteomics data to create acc…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Daniel 02:04 Defining rare disease in the age of personalized medicine 04:57 Key touchpoints with the Medicines and Healthcare products Regulatory Agency (MHRA) when developing a new medicine 09:27 Improvements over the course of Daniel’s career when it comes to incentivizing and making the path t…
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Listener-favorite Nacya Marriero is back on the podcast this week. Nacya opens the show talking about the difficulty of finding a job and employers judging a book by its cover. Randy suggests Nacya get into “FinDom” work. Nacya shares with Randy some of the things that men do to give her the “ick”. The two talk about situations Nacya found herself …
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Riley Lassin was back in LA and dropped by the show. They open the podcast following up on Riley’s vaginismus condition and the “homework” her doctors gave her. This leads to a conversation about “self-love”. The two talk about the differences between men and women when it comes to getting intimate. Riley talks about cat-calling in the streets of N…
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0:00 Introduction 1:40 A recurrent de novo mutation in a noncoding region of a small nucleolar RNA gene that has been identified as one of the most common causes of neurodevelopmental disorders This pathogenic variant escaped notice for years because it was not located in a protein coding region of the genome It now shows potential as a target for …
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Randy welcomes Tommy Mitchell back to the podcast. The boys open the show discussing Tommy’s college experience as a college lacrosse player. Tommy tells Randy about taking tap dancing lessons during the pandemic. Randy talks about how vulnerability is good, but men have gotten too soft. The fellas talk about growing up in the 90s and how times hav…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …
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Handren Seavey is back on the show this week. The boys open the show discussing the politics of the war in Ukraine. Randy has a theory about the only way Trump could possibly lose his supporters. The guys shift gears and talk about funny accidents. Handren tells Randy about the joys of being a parent. This leads to a convo about advances in genetic…
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0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…
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Randy welcomes back Boston legend Don Zollo to the podcast. Don opens the show talking about a bizarre Tinder date. Randy asks Don if there is any comic more “Boston” than him. The fellas talk about their recent mushroom trip at the SplitRock Farm & Retreat and Don’s inexplicable issues with new music. The two talk about learning strange facts abou…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…
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0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…
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Podcast-favorite Jeff Zenisek returns to the studio for Men’s Mental Health Month! Jeff opens the show talking about his love for Chet Hanks. The boys pitch a novel reality TV show idea. They discuss the economics of the OnlyFans marketplace. Randy backtracks and gets Jeff’s origin story and finds out what he did for day jobs before comedy. The boy…
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LA comedian and mystery-man, Fanto, joins Randy on this episode of the podcast. The guys open the show discussing what LA was like in the 90s. Fanto gives Randy a history lesson on Armenia, Eastern Europe, Russia and the former Soviet Union. The boys get into a political discussion and Fanto shares his thoughts on the security of US elections and t…
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0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…
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Randy welcomes the very funny Jay Washington to the podcast. They open the show talking about the Netflix is a Joke Comedy Festival and the smashing success Jay’s show at the festival was. Randy asks Jay about his upcoming cruise ship shows and they discuss the rules against the talent and staff hooking up with guests on the boat. The boys shift ge…
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0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…
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New York based Comedian Brandon Trusso is in studio for this episode of the podcast. Brandon opens the show talking about his journey to sobriety. Randy asks about his vice of choice and how he was able to overcome his addiction. They move on and talk about the awesome shows Brandon runs at the Grisly Pear in NYC. The boys discuss working in sales …
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0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…
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Chase Abel joins Randy back in studio in LA. The boys are fresh off a big Chinese buffet lunch, so they open the show talking about their favorite dishes. Randy starts a discussion about crimes of passion. The fellas move on to discuss the current protests and unrest on college campuses. Chase talks about his plan, or lack thereof, to payback his s…
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0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…
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The very funny Riley Lassin joins Randy on the show this week. The two open the show by discussing their start in comedy. They talk about how hard work and perseverance usually beats talent. The show takes a long and hilarious detour when Riley shares her struggle dealing with a medical condition called vaginismus. She goes on to discuss how she fi…
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0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…
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Randy welcomes the hilarious Shapel Lacey to the podcast. The boys open the show talking about their favorite game shows from their youth. This leads to a conversation about 80s and 90s action movies. Randy moves on to talk about surviving in the wilderness and how intimidating wild animals are. Shapel wonders aloud about living a simpler, hunter-g…
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0:00 Introduction 1:00 The backstory of how Kira first started DNA Today in 2012, when she was still in high school! 3:30 Some of Kira’s favourite topics she has discussed on DNA Today, including the legacy of Henrietta Lacks, and the story of a Glee actress with down syndrome 10:00 Kira’s best practices for podcasting, from over 10 years of experi…
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George Dulcich, comedian and podcast editor extraordinaire, is back on the podcast. George opens the show talking about doing Croatian-themed comedy shows. Randy talks about closing multi-million dollar deals at his day job while touring with Jeff Dye and Josh Nelson. Randy asks the boys if they would prefer an Asian or Eastern European mail-order …
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Back again for the first time...again. The greatest battle in hip-hop history as brought me back out to give my 2 cents. The first hour is getting reaclamated to podding alone. A lot of ranting with random incoherent thoughts but cut me some slack! I'm doing my best! 🥲 but the second hour is a discussion with my Canadian comrade waving his hometown…
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0:00 Introduction 2:00 The value of an English Literature degree in designing and analysing research studies in medicine 3:45 Emma’s entrance to pharmacogenomics and her transition from practising physician to genetics research 6:00 How the East London Genes and Health program is increasing representation of diverse populations, namely South Asians…
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Randy welcomes bonafide adult industry star Sophia Locke to the show. The two open the show talking about how an internet meme of Sophia called “Italian Gangbang” got them acquainted. Sophia talks about how she got into the industry, took some time off for a relationship and then returned to the industry. Randy asks Sophia how Only Fans and similar…
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0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…
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Florida’s-own Nate Roscoe is back on the podcast. The fellas open the show talking about positive stereotypes. Randy asks Nate who he’s got in the upcoming World War 3. Nate talks about his short time in the military, how poorly soldiers are actually treated and his dislike of Americans fighting in foreign wars. The boys move on and discuss the asc…
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0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…
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Randy has the very funny and talented Dean Gonzalez back on the show. Dean reviews his first year in LA. Randy asks Dean what he misses most about Miami. The fellas get into a deep conversation about their goals in comedy and show business. Dean pumps Randy up and gives him some advice on not being too humble, telling Randy it's not clout chasing t…
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Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…
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Xander Beltran is back on the show this week. The boys kick off talking about Xander’s YouTube comedy special. Super-producer Mike Nell tells the fellas about the Dune 2 phenomenon, which leads to a discussion about going to the movies. Xander talks about all the random terrible jobs he used to have. Randy asks Xander to rank his favorite sauces. X…
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0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…
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Miami-based comedian Mac Lawson joins Randy in studio this week. Mac shares how people on social media convinced her to get her starts in comedy. Randy asks Mac about being an OF creator and not actually sharing scandalous pics. The two debate why showing a nipple is considered adult content, but the rest of the boob is not. Randy asks Mac about be…
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0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…
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Randy welcomes comedian Joe Bartnick back to the show on St. Patrick's Day. The open up talking about their mutual love of drinking. The fellas discuss having to go to parties and having to talk to boring people. Randy talks about the cancellation of historical figures. The boys talk about working strange towns on the road. Somehow, the gents have …
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0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…
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This week Randy is joined by his buddy and fellow comic Vinny Fasline. They open the show talking about getting work done and looking good in Hollywood. Randy ask Vinny about his recovery from a brain tumor and getting a Make-a-Wish. The boys talk about the victim mentality and people getting offended on social media. Vinny talk about dating instag…
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0:00 Introduction 0:25 Julia’s personal experience with ultra-rare diseases within her family 10:25 The importance of increasing accessibility to genetic testing across populations to learn more about ultra-rare diseases 14:00 The origin story of Rare Trait Hope Fund 23:50 Current research and next steps in developing potential gene therapies for a…
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Randy welcomes first-timer Mandy Martino to the show. They open up talking about Shane Gillis hosting SNL. Randy enlightens Mandy on great trash TV shows. Mandy tells him about some of the fun stories from her new podcast 'Weirdly Obessed'. They move on to talk about relationships and Randy asks Mandy what her biggest pet peeves are in a relationsh…
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