MIT's Bob Weinberg is perhaps the world's most prominent cancer researcher. In this episode, Bob emphasizes that true innovation often comes from blending ideas from different fields – a synthesis that transcends the boundaries of one's primary area of research. We discuss the vital role of human interaction, with many scientific breakthroughs comi…

Manu Prakash is a professor of bioengineering at Stanford University, asking biological questions with insights from physics. His most widely known contribution is the FoldScope, a $1-microscope made from paper and a lens – 2 million copies of this have been distributed to would-be scientists around the world. In this episode, Manu emphasizes how s…

Dianne Newman – a molecular microbiologist at CalTech – is a professor both in Biology and Geology. In this episode, she encourages young scientists to pursue questions to which they have a visceral connection, rather than following popular trends. In its search for fundamental truths guided by our inner biases and preferences, Dianne likens scient…

Tina Seelig is Executive Director of the Knight-Hennessy-Scholars at Stanford University. She is widely known for teaching creativity courses and workshops with an entrepreneurial focus. In this episode, Tina emphasizes the importance of living in the problem space longer, taking time to challenge assumptions and reframe questions before rushing to…

Venki Ramakrishnan shared the 2009 Nobel Prize in Chemistry for uncovering the structure of the ribosome. He runs a lab at the MRC Laboratory of Molecular Biology in Cambridge, England. In this episode, Venki emphasizes the importance of enjoying the scientific process itself, not just aiming for major discoveries. He describes his creativity as a …

Jennifer Oyler-Yaniv is a professor working on the immune system at Harvard’s Medical School. In this episode, we discuss with her how she teaches creativity in her course for PhD students. We explore the emotional roller coaster ride of research projects, typically culminating in the point of creative frustration, where we get stuck and are tempte…

Guy Yanai is a painter whose work is displayed in many public and private collections across the US, Europe, and Asia, including, for example, the Tel Aviv Museum of Art. His distinctive painting style blends modernist, abstract tendencies together with references to everyday life and popular culture. Coincidentally, Guy is also Itai’s brother. Tog…

George Church, professor of genetics at Harvard Medical School, leads a large research group at the Wyss Institute for Biologically Inspired Engineering. A pioneer in the fields of personalized genomics and synthetic biology, he has co-founded over 50 biotech companies. In 2017, Time magazine named him one of the 100 most influential people in the …

Prof. Magdalena Zernicka-Goetz directs research labs at both CalTech in the US and the University of Cambridge in England. Magdalena is one of the world’s leading developmental biologists, who has been recognized by the 2023 Ogawa-Yamanaka Stem Cell Prize and Science magazin's People's Vote for Scientific Breakthrough of the Year in 2016. In this e…

Night Science – coming up with novel ways to interpret the physical world – is as old as philosophy. In contrast, Day Science – empirical evidence as the sole argument for truth – was invented only in the 1700s, championed by the groundbreaking work of Isaac Newton. In the April 1st, 2024, episode of the Day Science Podcast, Sir Isaac looks back on…

Bo Xia is a Junior Fellow at Harvard and a Principal Investigator at the Broad Institute. During his PhD with Itai, he suffered a painful tailbone injury that led to an obsession with this vestigial organ and its origins in human evolution. In this out-of-the-ordinary episode, we talk about this specific science project: how did Bo, with Itai’s hel…

Prof. Todd Golub, the Director of the Broad Institute of MIT and Harvard, has made important contributions to cancer research. In this episode, he argues that creativity is the greatest hallmark of a successful scientist, and he tells us about his artist-in-residence program at the Broad. As its director, he aims to hire researchers who look like t…

Sean Carroll is a world-renowned scientist, author, educator, and an Oscar-nominated film producer. Sean sees storytelling as the key to all he does. Similar to how musicians get inspiration by listening to other people’s music, Sean attributes his own creativity to his insatiable habit of reading about other people’s science – that’s how he “ferti…

Nigel Goldenfeld is the Chancellor's Distinguished Professor in Physics at the University of California at San Diego. In this episode, he talks with us about how research is an art form, and how he tries to help graduate students make the transition from being a “classical musician”, where the goal is to faithfully reproduce every note supplied by …

Despite the variety of creative approaches practiced by different scientists, one tried-and-true though often overlooked — trick for generating new ideas stands out. It may sound trivial, yet it is as reliable as it is simple: talk to someone. By talking with other people, we not only pool the information or ideas that each of us individually lacks…

Rich White studies cancer as a professor at Oxford University. Rich is not only a brilliant physician-scientist but also a great friend of Itai Yanai, one of the two Night Science hosts. In this episode, Rich talks about how often the process that led to a particular result can be more interesting than the result itself – something that is true not…

Carolyn Bertozzi is a Professor at Stanford University. In 2022, she was awarded the Nobel Prize in Chemistry. In this episode we talk about how the process of science is unstructured, so you don’t know when and where the next idea is going to come – sometimes even at the supermarket checkout line. For Carolyn, science is a long game, where one per…

Stephen Quake is a Stanford University professor and the Head of Science at the Chan Zuckerberg Initiative (CZI). Among his many inventions are DNA sequencing methods for non-invasive prenatal testing. In this episode, Steve tells us about his tricks for the creative scientific process, including the surprising usefulness of jetlag, the role of gen…

John Mattick is Professor of RNA Biology at the University of New South Wales in Sydney, Australia. For decades, he has been on a mission to show that the large portions of the human genome that many scientists consider useless "junk" instead have important regulatory functions. In this episode, he tells us that his creative process involves always…

Peter J. Ratcliffe shared the 2019 Nobel Prize in Physiology or Medicine for his work on oxygen sensing in animal cells. He directs research institutes in London and Oxford. In this episode, he reveals the interplay between dissociation – daydreaming – and interaction with colleagues as a major source of his scientific creativity. He emphasizes tha…

Christina Curtis is a Professor of Medicine and the Director of Artificial Intelligence and Cancer Genomics at Stanford University’s Cancer Institute. Among her many achievements is the conception of the “Big Bang Theory” of tumor biology. In this episode, she tells us how not being biased by assumptions of what we know has been very helpful in her…

Daniel Dennett, Professor at Tufts University, may be the most important living philosopher, tackling the biggest questions around: what is consciousness, do we have free will, how does evolutionary adaptation occur? In this episode, Dan tells us about some of his ‘intuition pumps’ - tools that are as indispensable for thinking as hammers and saws …

Howard Stone is a Professor of Engineering at Princeton. His research explores how fluid dynamics can help to understand diverse systems, from bacterial biofilms to the earth’s interior. In this episode, Howard explains how a lot of important, low-hanging fruit are at the interface between disciplines. Howard is most creative when he debates phenom…

Prisca Liberali is a senior group leader at the Friedrich Miescher Institute for Biomedical Research in Switzerland. In this episode, Prisca tells us how her creative thinking thrives on recursive thinking – going deeper and deeper into a problem from different angles. Prisca also deliberately uses carefully chosen conferences to discuss and to dev…

Tom Mullaney is a Professor of History at Stanford University and the Kluge Chair in Technology and Society at the Library of Congress, and Chris Rea is a Professor of Asian Studies at the University of British Columbia. In 2022, Tom and Chris published the book ‘Where Research Begins: Choosing a Research Project That Matters to You (and the World)…

Bonnie Bassler is the Chair of the Molecular Biology Department at Princeton. In this episode, Bonnie talks about her passion for scientific inquiry, creativity, mentorship, and how the journey of discovery is about asking the right questions, distinguishing between what you can do and what you should do, and about embracing the unexpected. In our …

Yukiko Yamashita is a biology professor at MIT and an investigator at the Howard Hughes Medical Institute. Yukiko’s research is amazingly broad, perhaps because she often only realizes at the end of a project which question she was asking by what she had been doing, as she explains in this episode. She likens research to solving 5000-piece jigsaw p…

Can you think of another big company CEO that does basic science? Stephen Wolfram is the CEO of Wolfram Research – the company that developed Mathematica and Wolfram Alpha – but most fundamentally he has a deep commitment to figuring out the nature of reality. Stephen wrote the landmark ‘A new kind of science’ in 2002 and in his current ‘physics pr…

Laurence Hurst is a professor of Evolutionary Genetics and the founding Director of the Milner Centre for Evolution at The University of Bath. Martin actually learned biology from Laurence as a postdoc, and he still likes to quote Laurence’s favorite question after the departmental seminars: “Why is this interesting?” In this episode, Laurence expl…

Edith Heard is a Professor at the Collège de France and the Director General of Europe’s “CERN for biologists”, the European Molecular Biology Lab (EMBL). In this episode, Edith explains how she gets ideas when she’s out of her comfort zone and being challenged, and how in her youth she would go to the piano whenever her brain needed time to solve …

Ewan Birney is the deputy director general of the European Molecular Biology Lab (EMBL) and co-director of the European Bioinformatics Institute. In his research, Ewan combines his training in biochemistry with computer science, which made him one of the heroes of the human genome project. In this episode, he describes that an “emotional” understan…

Paola Arlotta is a developmental neurobiologist and a professor at Harvard. She studies how the most complex organ in the human body (in the world? in the universe maybe?) comes to be: the brain (!). How does it develop from just a bunch of cells? Paola is also the Chair of her Department of Stem Cell and Regenerative Biology, where she takes parti…

In this special, we talk about podcasting with the two hosts of the Big Biology Podcast (https://www.bigbiology.org), Marty Martin – professor of disease ecology at the University of South Florida – and Art Woods – professor of physiological ecology at the University of Montana. We had a great time discussing our respective podcast experiences, tra…

What was the creative process of Alfred Russel Wallace? In this séance, we channel the legendary self-taught evolutionary biologist, founder of the field of biogeography, and co-discoverer of natural selection. Mr. Wallace (as he insists to be called) told us how he did night science by candlelight during long and lonely nights on his travels in th…

Isaac (Zak) Kohane is the Chair of the Department of Biomedical Informatics at Harvard Medical School. In this episode, Zak talks with us about how medicine, at its core, is information processing. But in medical data science, one has to understand and to model the dynamics of two orthogonal systems: the patient’s physiology and the dynamics of the…

Jim Collins is Professor of Biological Engineering at MIT. In this episode, he talks with us about his radical switch of fields in the early 2000’s, when he essentially founded the field of synthetic biology. Jim’s creative process includes ‘storing content’ about a particular problem; committing a portion of each day to reflect on it, even if this…

Caroline Bartman is a Postdoctoral Fellow in Princeton’s Chemistry Department, and she is about to start her own lab at the University of Pennsylvania. Caroline’s research focuses on how our metabolism changes in response to cancer and to viral infections. In this episode, Caroline explains how she has developed to become a creative scientist. She …

Albert-László Barabási is a distinguished professor at Northeastern University in Boston. In this episode, he tells us how he established the field of network science. He explains the expert’s fallacy and why it’s time to move to another field once you become afraid to break things. He tells about his strategies to select research projects with his…

Doing science reminds Stuart Firestein of an old saying: “It’s very difficult to find a black cat in a dark room. Especially when there is no cat.” Before studying biology and becoming a professor at Columbia University in New York, Stuart worked for many years in the theater. In this episode, he talks about how he doesn’t miss the creativity or th…

Professor Galit Lahav is the Chair of the Systems Biology Department at Harvard Medical School, where she creates an environment that is collaborative, stimulating, and interdisciplinary. In this episode, Galit tells us how her creative process consists of incubation and interaction. She stresses the importance of being vulnerable for creativity to…

Eric Topol is a cardiologist, scientist, and author. Many twitter users will know Eric from his voice-of-reason tweets related to the covid pandemic. While Eric’s exceptionally broad scientific work includes genetics and clinical trials, his main focus is on the ways in which artificial intelligence may change medicine as we know it. Creativity in …

Aviv Regev is what anyone would call a true science hero. She is not only a pioneer of single-cell genomics and systems biology, but also a great mentor. In 2020, she moved from her professorship at MIT and the Broad Institute to the biotech company Genentech, where she is Executive Vice President and Head of Research and Early Development. We talk…

Cassandra Extavour is a Professor of developmental and evolutionary biology at Harvard University, and she is an Investigator at the prestigious Howard Hughes Medical Institute. Cassandra’s pioneering research focuses on how germ cells – those immortal cells that form the next generation – are specified in different animals. Cassandra is a champion…

Daniel Kahneman won the Nobel Prize for Economics – as a psychologist. His fundamental work in behavioral economics revealed our cognitive biases, such as loss aversion – the fact that we react much more strongly to losses than to gains. Danny’s popular science book “Thinking, Fast and Slow” is a highly influential bestseller; Itai and Martin consi…

Peer Bork is a legendary scientist, and these days he’s also the Director of Scientific Activities at the European Molecular Biology Lab (EMBL) in Heidelberg. Among his many accolades, Peer was recently honored by the International Society for Computational Biology for "Tremendous contributions to bioinformatics on a plethora of fronts within the f…

Edward Tufte (ET) is widely-considered as the guru of data visualisation. He has taught the world about how data is to be communicated. He is best known for his 5 books on data visualisation, which have had an immeasurable influence on how to reveal the story told by data, combining layers of information into clear visual representations. In this e…

Shafi Goldwasser received the Turing Award – the “Nobel Prize of Computing” – in 2012. She needs no introduction to anyone working in computer science or cryptology, a field she essentially founded as a theoretical discipline. Shafi is a professor at both MIT and the Weizmann Institute in Israel, as well as being the director of the Simons Institut…

Uri Alon, a professor at the Weizmann Institute of Science in Israel, is best known for his contributions to systems biology. But Uri is also famous for his very joyful and playful attitude to science, which is memorable for anyone who’s ever heard him speak (or sing). Uri’s research is exceptionally broad in terms of the fields he covers, which is…

Agnel Sfeir is a leading scientist in the Memorial Sloan Kettering Cancer Center in New York, who studies fundamental aspects of the biology of the cell. Agnel revels in asking seemingly simple questions that get to the heart of the unknown in biology. In this conversation, she told us how she immerses herself in the project together with her team,…

Nikolaus Rajewsky is the founding director of the Berlin Institute for Medical Systems Biology. After studying Physics, he moved into systems biology, studying the role of RNA in gene regulation. In this episode, Nikolaus talks about how his training as a physicist enlightens his approach to biological problems. He also studied piano at the Folkwan…