There are many reasons why we’re in an “A.I. spring” after multiple “A.I. winters” — but how then do we tease apart what’s real vs. what’s hype when it comes to the (legitimate!) excitement about artificial intelligence and machine learning? Especially when it comes to the latest story of computers beating games, which has played a critical rol ...…

In this hallway-style podcast conversation, O'Reilly Media founder Tim O'Reilly and a16z partner Benedict Evans discuss how we make sense of the most recent wave of new technologies --- technologies that are perhaps more transformative than any we've seen before -- and how we think about the capabilities they might have that we haven't yet even ...…

We’ve already talked quite a bit about the Algorithms, Machines, and People lab at U.C. Berkeley (AMPLab) — all about making sense of big data — so what happens when the entire world moves towards artificial intelligence — and the need to make intelligent decisions on that data? That’s where the new RISElab (Real-time Intelligence Secure Execut ...…

Head of the largest bioengineering lab in the world, former chairman of the FDA and one of the few recipients of the National Medals of Science and of Technology and Innovation, Bob Langer's work has spanned multiple fields and settings and has been applied across numerous fields, from pharmaceutical to chemical, biotechnology to medical device ...…

with Chris Dixon and Fred EhrsamWe’ve already talked about why bitcoin matters. But as the set of cryptocurrencies — and networks and “tokens” enabled by the underlying blockchain — grow (Ethereum being one of the fastest-growing ones), where do we go from here? How do we tease apart the signal from the noise, given all the buzz and critiques o ...…

with David Mack, Joseph Okpaku, and Matt SpenceHow should startups engage with policymakers, build their own government relations (GR) function (whether in house or with consultants), and just begin to figure out their GR playbook? Let alone explain their moves -- not just externally, but internally too? "We really viewed our first mission as e ...…

In this episode, Wei Luo, founding COO of DeepMap -- who build HD maps for autonomous vehicles -- and David Rumsey, founder of the David Rumsey Map Collection (one of the largest paper private map collections in the world, now at Stanford University, and *the* largest digital online private collection in the world, at 80,000 + maps) talk with a ...…

with Juan Benet and Chris DixonThe story of how innovation happens is a long one — from government funding early basic research, to the heyday of corporate R&D like Bell Labs, to startups as experiments before product-market fit. Through all that, we’ve ended up with “unprecedented superpowers” distributed through the internet, and people build ...…

Bob Sutton's book The No Asshole Rule was all about how to foster company cultures that don't tolerate asshole behavior. But sometimes, dealing with an asshole is unavoidable -- in life or at work. So what are the best tactics to both protect yourself and to stop the asshole behavior? This is the subject that Sutton tackles in his new book, The ...…

with Russ Roberts, Noah Smith, and Sonal ChokshiBeyond the overly simplistic framing of trade as “good” or “bad” — by politicians, by Econ 101 — why is the topic of trade (or rather, economies and people adjusting to trade) so damn hard? A big part of it has to do with not seeing the human side of trade, let alone the big picture across time an ...…

We tend to talk about tech and parenting through devices and artifacts -- screen time, to code or not to code -- but actually, there's a bigger, macro picture at play there: game theory, economic incentives, culture, and more. So in this back-to-school episode of the a16z Podcast, two economists -- Kevin Zollman, game theorist and philosopher a ...…

with Clayton Christensen, Marc Andreessen, and Steven LevyIn business, mistakes of omission may be just as bad as (if not worse than) mistakes of commission -- simply because of the loss in potential upside: new companies, new products, new opportunities for growth. Or even in the ability to respond to the disruption coming to one's industry an ...…

"Young hungry and scrappy" is how Hamilton described his country, and it's how many -- including the guests on this episode -- describe startups... or more precisely, the mindset that engineers in startups need to balance both creativity and efficiency. But what happens as those startups scale, accrue technical debt, standardize their framework ...…

What is "infrastructure" actually? In the 19th and 20th century, that usually meant the transportation systems supporting roadways, airports, trains... but we don't even really know yet what it might potentially mean in the age of rapidly changing technology, autonomous vehicles, drones, and self-driving cars. In this episode, a16z's Matthew Co ...…

with Ben Horowitz, Scott Kupor, and Caroline Moon“The only unforgivable sin in business is to run out of cash” [so said Harold Geneen], yet startup CEOs “always act on leading indicators of good news, and lagging indicators of bad news” [according to Andy Grove]; after all, it requires a certain stubborn, headstrong optimism to start a company. ...…

What do disease diagnostics, language learning, and image recognition have in common? All depend on the organization of collective intelligence: data ontologies. In this episode of the a16z Podcast, guests Luis von Ahn, founder of reCaptcha and Duolingo, Jay Komarneni, founder of HumanDX, a16z General Partner Vijay Pande, and a16z Partner Malin ...…

with Graham Allison and Matthew Colford"When a rising power threatens to displace a ruling power, shit happens." It's true of people, it's true of companies, and it's even more true of countries. It's also the fundamental insight captured by ancient Greek historian Thucydides in his History of The Pelopennesian War. But where he was describing ...…

What happens when companies grow exponentially in a short amount of time -- to their organization, their product planning, their behavior towards change itself? In this "hallway conversation", a16z partners Steven Sinofsky and Benedict Evans discuss the business tactics and strategies behind four of the largest tech companies -- Google, Apple, ...…

with Anne Mitchell, Lars Dalgaard, and Scott Kupor"Orthogonal thinking" but "shared core values" -- that's what makes an ideal board... especially when it comes to "independents", i.e., board members who aren't also investors. But how do you get the most out of those independent directors, who are often in the minority? How do you bring in the ...…

with Jimmy Soni, Rob Goodman, and Steven SinofskyModern technology owes much to the introduction of the binary digit or "bit", first proposed by Claude Shannon in "A Mathematical Theory of Communication”, a paper published in 1948. The bit would go on to transform analog to digital, making Shannon the father of the information age. His contempo ...…

There are the things that you carefully plan when it comes to an IPO -- the who (the bankers, the desired institutional investors); the what (the pricing, the allocations); and the when (are we ready? is this a good public business?). But then there are the things that you don't plan: like the worst financial crisis since the Great Depression.. ...…

Here’s what we know: There’s a pair (father and son) of Russian scientists trying to resurrect (or rather, "rewild") an Ice Age (aka Pleistocene era) biome (grassland) complete with (gene edited, lab-grown) woolly mammoths (derived from elephants). In Arctic Siberia (though, not at the one station there that Amazon Prime delivers to!).Here's wh ...…

In the age of virality, what does it actually mean to be popular? When does popularity -- or good product design, for that matter -- cross over from desire and engagement... to addiction? Journalist and editor Derek Thompson, author of Hit Makers: The Science of Popularity in an Age of Distraction -- and NYU professor Adam Alter, author of Irre ...…

This episode of the a16z Podcast takes us on a quick tour through the themes of economics/historian/journalist Marc Levinson's books -- from An Extraordinary Time, on the end of the postwar boom and the return of the ordinary economy; to The Great A&P, on retail and the struggle for small business in America; all the way through to The Box, on ...…

A funny thing happened on the way to quantum computing: Unlike other major shifts in classic computing before it, it begins -- not ends -- with The Cloud. That's because quantum computers today are more like "physics experiments in a can" that most companies can't use yet -- unless you use software, not just as cloud infrastructure for accessin ...…

Is a network -- whether a crowd or blockchain-based entity -- going to replace the firm anytime soon? Not yet, argue Andrew McAfee and Erik Brynjolfsson in the new book Machine, Platform, Crowd. But that title is a bit misleading, because the real questions most companies and people wrestle with are more "machine vs. mind", "platform vs. produc ...…

What is lobbying, really? Is it “white", "heavy-set" men "playing golf" and making arrangements in "smoke-filled back rooms”? It's not like that anymore, according to two lobbyists who join this episode of the a16z Podcast to pull back the curtain on this practice… and share what’s changed: Heather Podesta, founder of Invariant (and a lawyer by ...…

"We're always fighting the last war" -- that's a phrase historians like to use because policymakers and others tend to be so focused on the threats they already know, and our mindsets and organizational structures are oriented to respond that way as well. And in the "situation room" of nation states (including the intelligence briefing war room ...…

Nearly every cybersecurity discussion/presentation follows this formula: We don’t know what we’re doing; the bad guys are getting smarter; our defenses are getting worse; everything's more connected than ever; we’re heading towards a digital . But even though security itself has obviously changed in many ways and not in others, we — as an indus ...…

When individuals gain the abilities that only nation states once had, how do we put cyber threats in perspective for policymakers -- without unduly "inflating" the threats? As it is, security is an intense and important topic, so our job is to be scared -- and prepared -- but what's the scope of the actual threats, how do we talk about them, an ...…

"Slow down, cowboys" -- that's what Senator Kamala Harris (D-California) said when prosecutors in her office wanted to bring a case against companies that let apps download someone's entire address book, because surely that's a complete violation of privacy?! The issue was a perfect example of the perfect storm playing out right now between exi ...…

When people think of modernizing government, they tend to think of new IT, of improved procurement, of new infrastructure ... rather than social services like foster care or food stamps. But how can we actually help improve daily lives -- less in the abstract and more concretely -- by applying tools and lessons from consumer tech to help put fo ...…

Rules, guidelines, regulations, and “laws” are all sometimes used interchangeably — but what’s legal and what isn’t is far more complex when it comes to policy, especially when politics (and technology) enters the picture. Take encryption for instance: The debate has gone beyond the “Crypto Wars” of yore to a war of attrition playing out today ...…

Every industry (for-profit, non-profit, government, private-sector) has been touched by tech, with most trying to lead the charge in order to stay ahead. But museums and memorials, by definition, lag rather than lead there. How is that changing as visitors increasingly expect to be a part of a dialogue, not just a monologue limited to a single ...…

There's feedback and there's guidance; there's praise and there's criticism. All of it is important to do better work, but to develop a better and more productive workplace and relationships -- especially given how much time we spend at work! -- the way we give and receive feedback really matters. "One of the great things about having a great b ...…

Turnabout is fair play: That's true in politics, and it's true at Andreessen Horowitz given our internal (and very opinionated!) culture of debate -- where we often agree to disagree, or more often, disagree to agree. So in this special "turnabout" episode of the a16z Podcast, co-founder Marc Andreessen (who is most often in the hot seat being ...…

Discussions and headlines around tech policy tend to be dominated by what the President and the White House (aka the executive branch of the government) and what the Senate and House of Representatives (aka the legislative branch) are saying and doing. But it’s the judicial branch — the courts — that often gets the final say on key technology p ...…

There’s an interesting paradox when it comes to the U.S. government and tech: Either they’re an inventor, early adopter, and buyer of emerging new tech … or they’re a very late adopter (as in the case of government officials using Blackberries vs. iPhones). But when it comes to the blockchain, they’re trying to get ahead of and stay on top of t ...…

When it comes to spycraft — or rather, “tradecraft,” as they say in the biz — what do the movies get right, and what do they get wrong? In this episode of the a16z Podcast, Michael Morell — former Deputy Director and twice-Acting Director of the CIA — talks all things tradecraft and tech with a16z partners Matt Spence and Hanne Tidnam.What it i ...…

In this lively conversation -- from our recent annual tech and policy summit in Washington, D.C. -- Axios' Dan Primack interviews a16z co-founder Marc Andreessen about the two major narratives dominating discussions about the tech industry right now: the industry is building stupid stuff; and tech is “evil” (or at least has an outsized impact, ...…

Moore's Law -- putting more and more transistors on a chip -- accelerated the computing industry by so many orders of magnitude, it has (and continues to) achieve seemingly impossible feats. However, we're now resorting to brute-force hacks to keep pushing it beyond its limits and are getting closer to the point of diminishing returns (especial ...…

A board veteran who has sat on both sides of the table, CEO of PagerDuty Jennifer Tejada shares what you gain from board membership (vs. being only an operator). How does being a board member change you as a CEO, and vice versa?Recorded as part of our annual Director's College held at Stanford University in April 2017, Tejada (in conversation w ...…

It’s the end of the beginning — not the beginning of the end — for wearables, argue the guests in this episode of the a16z Podcast. Especially as we move from the first, to the next, generation of wearable devices: not just activity trackers and watches but VR/AR gear, “hearables”, continuous glucose monitors, and more. The quantified self move ...…

The first thing that comes to mind when treating health problems is the need to take a pill (or other pharmaceutical) of some kind. But could a digital therapeutic -- a software-based intervention -- not only complement, but possibly even replace pills? In this episode of the a16z Podcast, CEO of Omada Health Sean Duffy and a16z bio fund genera ...…

In this hallway-style episode of the podcast, a16z partners Connie Chan and Kyle Russell discuss recent announcements at Facebook's annual developer conference, F8, in the context of trends such as: messaging and QR codes; brain computer interfaces; augmented reality and social VR; and, bots (again). As online platforms built on "real" identity ...…

Is it real or science fiction to dream of being able to treat… getting old? In this episode, we discuss with Dr. Thomas Rando from Stanford (who directs the Glenn Center for the Biology of Aging), Kristen Fortney, CEO of BioAge, and a16z’s general partner Vijay Pande where we are in the field of “geroscience” — the idea of studying, well, aging ...…

A crisis is an opportunity to change one's culture, to model scenarios and set up a crisis plan/process, to become a better company. But it's also a bit like therapy, from the act of asking probing questions to get at the facts ... to dealing with emotions and conflicting agendas.In this hallway-style conversation with a16z's Margit Wennmachers ...…

Here’s what we know about open source: Developers are the new buyers. Community matters. And there will never be another Red Hat (i.e., a successful “open core” business model … nor do we necessarily think there should be).Yet open source is real, and it’s here to stay. So how then do companies build a viable business model on top of open sourc ...…

The culture of open source has changed across generations, from previous ones that had to fight for the brave new way -- to the current "GitHub generation" that not only accepts open source, but expects it as the default. Which makes sense given that open source powers so much of the software world today... and by the way, that's not just tech ...…

Most of us have probably heard of bitcoin and ethereum -- but did you know there were 15 new cryptocurrencies launched this past month alone? How then do we know which protocols to invest in -- not just as a developer or user, but as an investor? Because, let's face it, open source software and services need resources not just to survive but th ...…