Left Ventricular Remodeling in Twin Pregnancy

AJP-Heart and Circulatory Physiology Podcast

In our latest episode, Associate Editor Dr. Amanda LeBlanc (University of Louisville) interviews author Prof. Pietro Modesti (University of Florence) and expert Dr. Alexandre da Silva (University of Mississippi Medical Center) about the new study by Pellegrino et al. that investigated the pattern of intraventricular hemodynamic forces associated with left ventricular function in women with uncomplicated twin pregnancy. The authors found that, in twin pregnancy, hemodynamic forces misalignment in the first trimester precedes a slight temporary decrease in left ventricular systolic function in the second trimester. In the third trimester, a rightward shift of the end diastolic pressure relationship (EDPR) was, in fact, associated with a realignment of hemodynamic forces and normalization of ventricular contractility indices. Why is twin pregnancy an ideal physiological condition to study increased ventricular workload over time? Listen to this insightful conversation and find out.

Alessio Pellegrino, Loira Toncelli, Lucia Pasquini, Giulia Masini, Federico Mecacci, Gianni Pedrizzetti, and Pietro Amedeo Modesti Left ventricular remodeling in twin pregnancy, noninvasively assessed using hemodynamic forces and pressure-volume relation analysis: prospective, cohort study Am J Physiol Heart Circ Physiol, published January 23, 2024. DOI: 10.1152/ajpheart.00699.2023