Commentary and discussion on featured articles in AJP - Heart and Circulatory Physiology
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Life Lines is a general interest monthly science podcast of The American Physiological Society. Visit us online at www.lifelines.tv.
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The Out of the Blue podcast takes you out of the pages of the American Journal of Respiratory and Critical Care Medicine and into the minds of the most brilliant researchers in the fields of respiratory, critical care, and sleep medicine.
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Acute Intranasal Insulin Increases MSNA in Healthy Adults
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What is the impact of central insulin on muscle sympathetic nerve activity (MSNA) and vascular conductance in the absence of peripheral insulin delivery? Listen as Associate Editor Dr. Jason Carter (Baylor University) interviews authors Neil McMillan and Dr. Jackie Limberg (both at University of Missouri), along with expert Dr. Manda Keller-Ross (U…
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Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Electrophysiology and Experimental Reproducibility
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14:20
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Sometimes experimental results are serendipitous. Listen as Associate Editor Dr. Crystal Ripplinger (University of California, Davis) talks with authors Dr. Nikki Posnack and Devon Guerrelli (both at Children’s National Hospital and The George Washington University School of Engineering and Applied Science), along with expert Dr. Silvia Marchiano (…
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Serum Estradiol and Cardiovascular Health Among Transgender and Nonbinary Adults Using Gender Affirming Estrogen Therapy
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Hormone modulation therapy is a growing area of research in cardiovascular science related to a number of factors, such as menopause and andropause, cancers in hormone-producing organs, as well as gender-affirming hormone therapy. So how do scientists and clinicians measure, monitor, and balance applications of hormone therapy? In our latest podcas…
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IL-33 Supplementation Improves RUPP Pathophysiology
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While decreased IL-33 signaling has been associated with preeclampsia, the mechanisms linking this signaling pathway to disease pathophysiology are not well understood. In this episode, Associate Editor Dr. Amanda LeBlanc (University of Louisville) interviews author Dr. Denise Cornelius (University of Mississippi Medical Center) and expert Dr. Stel…
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In this episode, Associate Editor Dr. Jonathan Kirk (Loyola University Chicago) interviews author Dr. Ed Lesnefsky (Richmond Department of Veterans Affairs Medical Center and Virginia Commonwealth University) and expert Dr. Chi Fung Lee (Oklahoma Medical Research Foundation) about the new Methods and Resources article by Chen et al. published in ou…
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Guidelines on Use of Sex and Gender in Cardiovascular Research
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In our latest episode, Consulting Editor Dr. Kristine DeLeon-Pennell (Medical University of South Carolina) interviews fellow co-authors Dr. Charlotte Usselman (McGill University), Dr. Judy Regensteiner (University of Colorado Anschutz Medical Campus), Dr. Kerrie Moreau (University of Colorado Anschutz Medical Campus), Dr. Austin Robinson (Indiana …
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After a yearlong hiatus, Behind the Bench is back, listeners! In this episode, we welcome back our B2B co-hosts Dr. Charlotte Usselman and Dr. Tommy Martin, who get the story behind the story from the one and only Dr. DeWayne Townsend, corresponding author of the recently published study by Stevens et al. Trust me, you are going to love listening t…
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Left Ventricular Remodeling in Twin Pregnancy
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In our latest episode, Associate Editor Dr. Amanda LeBlanc (University of Louisville) interviews author Prof. Pietro Modesti (University of Florence) and expert Dr. Alexandre da Silva (University of Mississippi Medical Center) about the new study by Pellegrino et al. that investigated the pattern of intraventricular hemodynamic forces associated wi…
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Reducing Thrombotic Risks in Video Gamers
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43:05
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Ready Player One? In our latest episode, Dr. Keith Brunt (Dalhousie University) interviews lead author Dr. Joanne DiFrancisco-Donoghue (New York Institute of Technology) and expert Dr. Saurabh Thosar (Oregon Health and Science University Hospital) about a new article published in the AJP-Heart and Circ Call for Papers on Exercise, Physical Activity…
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Impact of Maternal Diet on Offspring Blood Flow
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What is the relationship between cardiovascular developmental programming and the risk of stroke later in life? Listen as Guest Editor Dr. Helen E. Collins (University of Louisville) interviews author Dr. Nafisa Jadavji (Midwestern University) and expert Dr. Deanne Hryciw (Griffith University) about the latest research by Pull et al. looking at und…
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Given that there appears to be variation in significant risk to the cardiovascular system following SARS-CoV2 infection with regard to age and sex, the latest study by Rouhana et al. provides a foundation for studying sex differences with a preclinical model of infection to the direct exposure to SARS-CoV-2 and the impact on the myocardium of ferre…
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Preload and Calcium Handling in Muscular Dystrophy
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28:13
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What does a mouse heart have to do with an M&M candy (the regular kind, not the peanut variety)? In our latest episode, Associate Editor Dr. Crystal Ripplinger (University of California, Davis) interviews author Dr. Tim Domeier (University of Missouri) and expert Dr. DeWayne Townsend (University of Minnesota) about the recent study by Haffner et al…
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Coronary Endothelial Function, HIV, and Aging
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20:49
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People living with HIV have an increased risk of developing cardiovascular disease, including coronary artery disease. Until now, it has been unclear why. In this episode, Guest Editor Dr. Ashley Walker (University of Oregon) interviews author Dr. Efthymios Ziogos (Johns Hopkins Medicine) and expert Dr. Jennifer Williams (McMaster University) about…
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Estimating Cardiac Output During Incremental Exercise
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What does it sound like when a young researcher meets one of his science heroes for the first time? Listen to this episode of The AJP-Heart and Circ Podcast to find out. Associate Editor Dr. Keith Brunt (Dalhousie University) interviews author Dr. Holger Burchert (University of Basel) and leading expert Dr. William Stringer (Lundquist Institute at …
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Hot Yoga and Sodium-Induced Endothelial Dysfunction
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Come for the yoga metaphors, stay for the science. In this episode, Associate Editor Dr. Keith Brunt (Dalhousie University) interviews author Dr. Stacy Hunter (Texas State University) and expert Dr. Annet Kirabo (Vanderbilt University) about the new study by Hunter et al., which examined the impact of hot yoga on sodium-induced pressor responses an…
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Soluble Prorenin Receptor and Vascular Damage
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What is the impact of female sex hormones on obesity, diabetes, and vascular dysfunction? In this episode, Deputy Editor Dr. Zam Kassiri (University of Alberta) interviews authors Dr. Bruna Visniauskas and Dr. Minolfa Prieto (both at Tulane University School of Medicine), along with expert Dr. Glen Pyle (IMPART Network at Dalhousie Medicine) about …
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Pre-operative COVID19 and Cardiovascular Complications
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When is it safe to have surgery after COVID? Listen as Associate Editor Dr. Jason Carter (Baylor University) interviews lead author Dr. Anai Kothari (Medical College of Wisconsin) and leading expert Dr. Michael Joyner (Mayo Clinic) about the groundbreaking new research study by SenthilKumar et al. that evaluated how pre-operative COVID infection mi…
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How the American Physiological Society can Promote Black Physiologists
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What does being a good ally look like? In a new Perspective, authors Dr. Karla Haack (Merck), Dr. Austin Robinson (Auburn University), Dr. Dexter Lee (Howard University College of Medicine), Dr. Keisa Mathis (University of North Texas Health Science Center), and Dr. Junie Paula Warrington (University of Mississippi Medical Center) discuss how the A…
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How can researchers capture the most accurate demographic data possible on intake surveys for human participant studies? Listen as author and moderator Dr. Karla Haack (Merck) interviews co-authors Dr. Jesse Moreira (Boston University) and Dr. Troy Roepke (Rutgers, The State University of New Jersey) about their recent Perspective regarding how res…
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Efficacy of Growth Hormone-Releasing Hormone-Agonist in a Cardiometabolic HFpEF Model
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Heart failure with preserved ejection fraction (HFpEF) is, in many ways, a fascinating tale of modern cardiovascular medicine that, according to lead author Dr. Joshua Hare (University of Miami Miller School of Medicine), has taught cardiovascular researchers and clinicians a lot of humility. Understanding HFpEF in a variety of animal models has le…
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APS’ Chief Science Officer Dennis Brown, PhD, recently spoke to astronaut and APS member Jessica Meir, PhD, about her work on the International Space Station. As part of the interview, we asked her for lessons that #StationLife can teach us about living in isolation. Listen to her recommendations and read the full interview in the July issue of The…
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Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction
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By American Thoracic Society
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Perspectives on Burnout from Pulmonary, Critical Care, and Sleep Medicine Division Directors
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29:08
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Dr. Michael Lanspa sits down with Dr. Seppo Rinne to discuss burnoutfrom the perspectives of pulmonary, critical care, and sleep medicinedivision directors.By American Thoracic Society
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Join our podcast hosts Nitin Seam MD and John Fleetham MD as they share their thoughts on some of the most interesting papers related to pulmonary, critical care and sleep medicine published in the AJRCCM in 2019.By American Thoracic Society
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Supra-Physiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients
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Dr. Michael Lanspa sits down with Dr. Edward Palmer to discuss the paper The Association Between Supra-Physiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients: A Multi-Centre Observational Cohort Study.By American Thoracic Society
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BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications
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26:44
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Dr. Maor Sauler is joined by Drs. Nathaniel Weathington and Brian Modena to discuss the article BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications.By American Thoracic Society
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Diagnosis and Treatment of Adults with Community-acquired Pneumonia
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Dr. John Fleetham is joined by Drs. Metlay and Waterer to discuss the American Thoracic Society and Infectious Diseases Society of America's official clinical practice guideline on diagnosing and treating adults with CAP.By American Thoracic Society
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Evaluation and Management of Obesity Hypoventilation Syndrome
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41:19
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Dr. John Fleetham is joined by Dr. Babak Mokhlesi to discuss the recently published ATS Guideline on the evaluation and treatment of OHS.By American Thoracic Society
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Dr. Jadwiga Wedzicha, editor-in-chief of the American Journal of Respiratory and Critical Care Medicine, joins Nitin Seam to discuss several important papers from 5/1/19 Blue Journal.By American Thoracic Society
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Long-term Outcome After Prolonged Mechanical Ventilation: A Long-Term Acute-Care Hospital Study
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Dr. Trish Kritek is joined by Drs. Jubran and Nava to discuss the paper Long-term Outcome After Prolonged Mechanical Ventilation: A Long-Term Acute-Care Hospital StudyBy American Thoracic Society
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Symptom Subtypes of OSA Predict Incidence of Cardiovascular Outcome
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35:05
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Dr. John Fleetham is joined by Drs. Diego Mazzotti and Henry Yaggi to discuss the paper "Symptom Subtypes of Obstructive Sleep Apnea Predict Incidence of Cardiovascular Outcomes".By American Thoracic Society
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The Combination of Atomoxetine and Oxybutynin Greatly Reduces OSA Severity
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23:10
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Dr. John Fleetham is joined by Luigi Taranto Montemurro, MD, Andrew Wellman, MD, PhD, and Seva Polotsky, MD, PhD to discuss the impact the combination of Atomoxetine and Oxybutynin has on reducing the severity of obstructive sleep apnea.By American Thoracic Society
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Dr. Nitin Seam discusses important papers from the special 2/15/19 AJRCCM asthma issue with deputy editor Dr. Fernando D. Martinez and associate editor Dr. Leonardo Fabbri.By American Thoracic Society
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Management of Malignant Pleural Effusion Clinical Practice Guideline
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57:42
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David Feller Kopman and Daniel Sterman join Nitin Seam to discuss the recent Clinical Practice Guideline on Management of Malignant Pleural Effusions published in the 10/1/18 American Journal of Respiratory and Critical Care Medicine.By American Thoracic Society
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Determinants of Intensive Care Unit Telemedicine Effectiveness: An Ethnographic Study
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31:45
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Dr. Trish Kritek sits down with Dr. Jeremy Kahn to discuss what organizational factors may impact the clinical effectiveness of ICU telemedicine programs.By American Thoracic Society
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Nitin Seam, Trish Kritek and John Fleetham review their favorite podcasts discussions of important articles in AJRCCM in 2018.By American Thoracic Society
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Prenatal Household Air Pollution is Associated with Impaired Infant Lung Function
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24:45
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Dr. John Fleetham is joined by Drs. Alison Lee and John Balmes to discuss the article "Prenatal Household Air Pollution is Associated with Impaired Infant Lung Function with Sex-Specific Effects: Evidence from GRAPHS, a Cluster Randomized Cookstove IntervBy American Thoracic Society
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Mortality Changes Associated with Mandated Public Reporting for Sepsis
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33:56
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Trish Kritek is joined by Dr. Mitchell Levy to discuss his article Mortality Changes Associated with Mandated Public Reporting for Sepsis: The Results of the New York State InitiativeBy American Thoracic Society
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Diagnosis of IPF Clinical Practice Guideline Part 2
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In Part 2 of this discussion of the 2018 ATS/ERS/JRS/ALAT Guideline, we discuss the approach to invasive procedures in suspected IPF and unanswered questions/directions of future research in IPF.By American Thoracic Society
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Diagnosis of IPF Clinical Practice Guideline: Part 1
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30:33
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Dr. Nitin Seam moderates a discussion of the 2018 ATS/ERS/JRS/ALAT Guideline with authors Ganesh Raghu and Kevin Wilson. Part 1 discusses the history, how the guideline questions were formulated and the non-invasive workup.By American Thoracic Society
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Alternatives to CPAP When Treating Obstructive Sleep Apnea
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22:49
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Dr. Fleetham is joined by Drs. Julia Chapman and Sanjay Patel to discuss their respective article and editorial on alternatives to CPAP and the role Armodafinil could possibly play.By American Thoracic Society
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Effect of Supplemental Oxygen on Blood Pressure in Obstructive Sleep Apnea
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20:47
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John Fleetham is joined by Chris Turnbull, lead author of the paper Effect of Supplemental Oxygen on Blood Pressure in Obstructive Sleep Apnea (SOX): A Randomised, CPAP Withdrawal Trial.By American Thoracic Society
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Nitric Oxide Decreases Acute Kidney Injury and Stage 3 Chronic Kidney Disease after Cardiac Surgery
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34:51
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Drs. Lorenzo Berra and Mark Gladwin join Nitin Seam to discuss an interesting trial looking at the effect of inhaled nitric oxide on hemolysis and renal failure post cardiac surgeryBy American Thoracic Society
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Reclassifying Acute Respirators Syndromey Distres
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29:10
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Dr. Trish Kritek is joined by Drs. Luciano Gattinoni and Taylor Thompson to discuss Gattinonis article on the topic.By American Thoracic Society
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Do Endobronchial Valves Improve Outcome in Heterogeneous Emphysema?
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39:16
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Drs. Gerard Criner and Gaetan Deslee join Nitin Seam to discuss the results of the multi-center LIBERATE trial, the first endobronchial valve study to follow patients for 12 months.By American Thoracic Society
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Phenotyping Pharyngeal Pathophysiology using Polysomnography in Patients with OSA
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29:59
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Dr. Fleetham discusses phenotyping using polysomnography in patients with COPD with Drs. Scott Sands and David RappoportBy American Thoracic Society
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The Conference Issue with AJRCCM Editor Jadwiga Wedzicha
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21:47
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Dr. Wedzicha joins Nitin Seam to give her perspective on 3 important papers from the conference issue of the blue journal and to discuss some current and future articles of interest.By American Thoracic Society
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Research Priorities in Pathophysiology for SDB in patients with COPD
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24:00
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Drs. Atul Malhotra and Safwan Badr join Dr. Fleetham to discuss the article Research priorities in pathophysiology for sleep-disordered breathing (SDB)in patients with chronic obstructive pulmonary disease (COPD)By American Thoracic Society
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Can Nocturnal Dexmedetomidine Prevent ICU Delirium?
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Nitin Seam discusses this phase II trial published in the Blue Journal with lead study author Dr. Yohanna Skorbik and Dr. Tim GirardBy American Thoracic Society
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Efficacy of Cisatracurium Compared to Vecuronium in Patients with or at Risk for ARDS
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23:55
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Dr. Trish Kritek is joined by Dr. Marc Moss to discuss the findings and implications of the article An Observational Study of the Efficacy of Cisatracurium Compared to Vecuronium in Patients with or at Risk for ARDS.By American Thoracic Society
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