Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation

Alexander Disease Research Update

Albee Messing, Rachel Battaglia, and Tracy Hagemann discuss the following recent publications:

[01:45] A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells

Stem Cell Reports 18, 1701-1720 (2023)

[includes new iPS cell line from an individual with Alexander disease] [full text]
[05:39] Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Journal of Visualized Experiments 18, 55655 (2017)

[includes data on acetylation of lysines in GFAP] [full text]
[10:26] STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease

Cells 12, 978 (2023)

[identification of one of the key mechanisms responsible for the increase in GFAP levels in Alexander disease] [full text]
[22:35] Questions from email: does Alexander disease affect menstrual cycles?
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Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

https://alexander-disease.waisman.wisc.edu/donate/

Chapters

1. Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation (00:00:00)

2. A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells (00:01:46)

3. Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications (00:05:39)

4. STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease (00:10:26)

5. Questions (00:22:35)