Got Guts: Initiation and severity of experimental pancreatitis are modified by phosphate
Manage episode 353687710 series 3332773
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Get to know author Dr. Rodger Liddle (Duke University) in this latest podcast as he goes over his recently published manuscript "Initiation and severity of experimental pancreatitis are modified by phosphate" with Editor in Chief Professor Mark Frey.
New and Noteworthy-Impaired ATP synthesis disrupts acinar cell homeostasis and is an early step in pancreatitis. We report that reduced phosphate availability impairs mitochondrial function and worsens pancreatic injury. Phosphate supplementation improves mitochondrial function and protects against experimental pancreatitis, raising the possibility that phosphate supplementation may be useful in treating pancreatitis.
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