Podcasts of the American Journal of Physiology-Gastrointestinal and Liver Physiology
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Unraveling Appetite: The Microbiota-Brain Connection Across the Lifespan
10:16
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10:16In this episode, coauthors Gabriela Ribeiro, Marta P. Silvestre, Harriët Schellekens, and Cristina Cuesta-Marti discuss their recent review published in AJP-Gastrointestinal and Liver Physiology, titled "A menu for microbes: unraveling appetite regulation and weight dynamics through the microbiota-brain connection across the lifespan." Appetite reg…
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Unraveling Fabry Disease: Lyso-Gb3’s Role in Gut Physiology
12:22
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12:22In this episode, coauthors Cecilia Delprete, Friederike Uhlig, Marco Caprini, and Niall P. Hyland dive into their latest research titled "Characterization of Fabry disease-associated lyso-Gb3 on mouse colonic ion transport and motility." Fabry disease (FD) is a rare genetic disorder with wide-ranging effects across the body, including the gastroint…
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Got Guts: A Chance to Put Liver Biopsy Back to Its Former Glory?
6:37
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6:37In this episode, coauthors Camilla Venturin and Luca Fabris delve into their editorial titled "Machine Learning Application to Histology for the Study of Cholangiopathies (BiliQML): A Chance to Put Liver Biopsy Back to Its Former Glory?" The episode explores groundbreaking research by Dominick Hellen and colleagues on the limitations of current his…
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"Got Guts" The Micro Version: Pacing Inhibits Slow Wave Dysrhythmias in the Intestine
7:25
7:25
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7:25In this podcast coauthors Nipuni D. Nagahawatte and Leo K. Cheng discuss their research titled "High-energy pacing inhibits slow-wave dysrhythmias in the small intestine." Glucagon was infused in pigs to induce hyperglycemia and the resulting slow-wave response in the intact jejunum was defined in high resolution for the first time. Subsequently, w…
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"Got Guts" Special Episode: The GI and Liver Section at the 2025 American Physiology Summit
20:09
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20:09In this episode, AJP GI and Liver Physiology's Editor-in-Chief Mark Frey and Nicholas Zachos representative of the Gastrointestinal and Liver Physiology Section provide an exclusive preview of the GI programming at the upcoming APS Summit. They walk listeners through the exciting lineup of sessions, symposia, and featured topics designed to ignite …
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"Got Guts" The Micro Version: Electromechanical Coupling of the In-Vivo Pylorus
13:02
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13:02Join coauthors Sam Simmonds, Ashton Matthee, and Timothy R. Angeli-Gordon as they delve into their recently published research, "Electromechanical Coupling and Anatomy of the In Vivo Gastroduodenal Junction." In this episode, they explore cutting-edge techniques like electrical mapping, impedance planimetry, and histological analysis to investigate…
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"Got Guts" The Micro Version: Effect of amniotic fluid on the esophageal epithelium
7:50
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7:50Join coauthors Mark Rochman and Marc E. Rothenberg as they explore their recently published paper, "Amniotic Fluid Modifies Esophageal Epithelium Differentiation and Inflammatory Responses." In this engaging episode, they discuss how the interaction between amniotic fluid and the esophageal epithelium during pregnancy impacts epithelial differentia…
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"Got Guts" The Micro Version: The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology
7:20
7:20
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7:20Join coauthor Chloe Edmonds in this insightful episode as she delves into her recently published paper, "The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology." Chloe explores how simulating gastroesophageal reflux in an infant pig model reveals significant alterations in pharyngeal swallowing dynamics. Dis…
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"Got Guts" The Micro Version: Autoimmune liver disease and hormonal responses
5:56
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5:56In this episode, coauthors Anne-Sofie H. Jensen and Nicolai J. Wewer Albrechtsen discuss the recently published research titled "Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease." The authors reveal that patients with autoimmune liver disease, even in the absence of overt diab…
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"Got Guts" The Micro Version: Inhibitory neurotransmission in the internal anal sphincter
8:43
8:43
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8:43Coauthor Caroline A. Cobine dives into the fascinating world of internal anal sphincter biology in the latest episode of "Gut Guts." The research uncovers direct and indirect neural pathways that modulate intracellular calcium activity in interstitial cells of Cajal, shedding light on their role in smooth muscle cell function. Article Citation: Mod…
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"Got Guts" The Micro Version: Mechanical Stress-induced Connective Tissue Growth Factor and Intestinal Fibrosis
8:25
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8:25In this episode of "Gut Guts" coauthor Xuan-Zheng Shi discusses new research on intestinal fibrosis in Crohn’s-like colitis. The study found that mechanical stress causes a protein called CTGF to increase, leading to fibrosis. In a rat model, easing the mechanical stress reduced connective tissue growth factor (CTGF) and lessened fibrosis. This sug…
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"Got Guts" The Micro Version: Characterization of Rat Gastric Slow Wave Activity
8:29
8:29
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8:29Tune in to our latest podcast episode where Peng Du, Omkar N. Athavale, and Madeleine R. Di Natale dive into the fascinating world of gastric slow-wave conduction. They discuss their recent article titled "Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal st…
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"Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis
4:39
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4:39In this episode of "Got Guts" The Micro Version, Jill P. Smith highlights the recently published research titled "Implicating the cholecystokinin B receptor in liver stem cell oncogenesis." This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of t…
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"Got Guts" The Micro Version: Corticotropin-Releasing Hormone Effects on Gastric Function
6:26
6:26
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6:26In this podcast, I-Hsuan Huang highlights the recently published paper titled "Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study." The aim of this research was to investigate the effects of peripheral corticotropin-releasing hormone infusion on…
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"Got Guts" The Micro Version: Effects of L. Casei-Fermented Milk on Mice with DSS Colitis
7:07
7:07
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7:07Coauthors Mélanie G. Gareau and Maria L. Marco delve into the findings of their latest research titled "Milk and Lacticaseibacillus paracasei BL23 effects on intestinal responses in a murine model of colitis." This study marked the first exploration into sex-dependent responses to probiotic Lacticaseibacillus paracasei and milk, as well as the pote…
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"Got Guts" The Micro Version: Characterize Mouse Glutamatergic Myenteric Neurons
6:22
6:22
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6:22In this episode, Jia Liu and Bin Feng highlight the recently published research titled "Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons." In this research, the authors reveal that VGLUT2-positive enteric neurons (EN), although constituting a small fraction of total EN, are homogeneously expressed i…
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”Got Guts” The Micro Version: Gastric Neuromuscular Transmission
5:29
5:29
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5:29In this episode of the Got Guts podcast series Madeleine R. Di Natale of the University of Melbourne discusses the recently published manuscript titled "Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach." This study provides a detailed mapping of nerve transmission to the circular muscle of th…
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”Got Guts” The Micro Version: Gene expression and microbiome composition in EsoCaSR-/-mice
7:28
7:28
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7:28In this episode of the Got Guts Podcast series, Solange M. Abdulnour-Nakhoul of Tulane University, discusses the recently published manuscript titled "Alterations in gene expression and microbiome composition upon calcium sensing receptor deletion in the mouse esophagus." In this research Abdulnour-Nakhoul et al. highlight why calcium sensing recep…
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"Got Guts" Special Episode: The GI and Liver Section at the 2024 American Physiology Summit
11:26
11:26
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11:26Listen as Editor in Chief of AJPGI and Liver Physiology, Mark Frey and the Chair of the Gastrointestinal & Liver Section, Pradeep Dudeja discuss what they are looking forward at the 2024 American Physiology Summit, April 4-7th. Registration Deadline for American Physiology Summit is March 11, 2024. Click here for more info on the American Journal o…
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”Got Guts” The Micro Version: Pf Inhibits Inflammation-Induced Epithelial Break-Down
5:16
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5:16In this episode Marine Mantel of Nantes Université discusses the recently published research in AJP-GI and Liver Physiology titled "Propionibacterium freudenreichii CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening." NEW & NOTEWORTHY Propionibacterium freudenreichii reduces dextran sodium sulfate (DSS)-indu…
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”Got Guts” The Micro Version: IL-4Rα Signaling in Esophageal Smooth Muscle
6:22
6:22
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6:22In this episode author, Melissa Nelson of Baylor University Medical Center, discusses the recently published manuscript titled "Th2 Cytokine Signaling through IL-4Rα Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle." New and Noteworthy: Nelson et al. have found that Th2 cytokines increase eotaxin-3 secretion and tension i…
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”Got Guts” The Micro Version: Order of Events after Keratin 8 Sequential Downregulation
6:26
6:26
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6:26In this podcast, authors Maria A. Ilomäki and Lauri Polari (both at Åbo Akademi University) discuss their recently published research titled “Defining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation.” New and Noteworthy: Understanding the order in whic…
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”Got Guts” The Micro Version: Effects of in utero fluoxetine exposure on the GI tract
4:10
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4:10In this episode authors Katherine L. Prowse,, and Elyanne M. Ratcliffe of McMaster University, discuss their recently published article titled “Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring.” NEW & NOTEWORTHY There is increasing recognition of the relevance of in utero and early postnatal exposures in the…
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”Got Guts” The Micro Version: Colon ion transporter gene expression during cirrhosis
8:29
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8:29Diego Alvarez de la Rosa of the University of La Laguna discusses the recently published manuscript titled “Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression.” NEW & NOTEWORTHY Liver cirrhosis progression significantly alters ion transporter subunit expression in the rat distal c…
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”Got Guts” The Micro Version: Maternal influenza infection and offspring gut immunity
7:40
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7:40In this podcast lead author Dr. Stella Liong of RMIT University, discusses the recently published manuscript titled “Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice.” NEW & NOTEWORTHY Influenza A virus (IAV) infection during pregnancy is associated with changes in gut-as…
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”Got Guts” the Micro Version with Kalidas Ramamoorthy
5:09
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5:09First author, Dr. Kalidas Ramamoorthy of the University of California, Irvine discusses the recently published paper titled “miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells.” NEW & NOTEWORTHY This study shows that the expression and function of mit…
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”Got Guts” the Micro Version with Steven Hutchens and Somshuvra Mukhopadhyay
6:30
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6:30In this podcast Steven Hutchens and Dr. Somshuvra Mukhopadhyay of the University of Texas at Austin discuss the recently published research titled "Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure." NEW & NOTEWORTHY This article shows that, in contrast with expectations from…
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”Got Guts” the Micro Version with Jihane N. Benhammou
8:42
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8:42In this episode, Dr. Jihane N. Benhammou of UCLA discusses the recently published article titled "Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton." NEW & NOTEWORTHY Statins are widely used for the treatment of cardiovascular diseases. Recently, their use has been…
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”Got Guts” the Micro Version with Francisco Pascual and Samuel Camilli
5:19
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5:19In this podcast coauthors Francisco Pascual, and Samuel Camilli of Morsani College of Medicine, University of South Florida discuss the recently published Perspectives titled "Mind-body connection: metabolite 4-ethylphenyl linked to anxiety behavior and oligodendrocyte modification in autism spectrum disorder." Article Citation: Mind-body connectio…
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”Got Guts” the Micro Version with Theo A.T.G. van Kempen and Gavin M. Boerboom
7:45
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7:45In this podcast Prof. Theo A.T.G. van Kempen of North Carolina State University and Dr. Gavin M. Boerboom of Trouw Nutrition discuss their recently published perspectives paper titled "Is the intestinal mucous layer a natural deep eutectic solvent-based digestion matrix?" Article Citation: Is the intestinal mucous layer a natural deep eutectic solv…
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”Got Guts” the Micro Version with Jessica A. Breznik
8:55
8:55
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8:55In this podcast first author Dr. Jessica A. Breznik of McMaster University, discusses the recently published manuscript titled "Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor." NEW & NOTEWORTHY We found that diet-induce…
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”Got Guts” the Micro Version with Gene Lamanilao
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4:57In this micro podcast Dr. Gene G. Lamanilao The University of Tennessee Health Science Center, College of Medicine gives the listeners an overview the recently published manuscript titled "Key hepatoprotective roles of mitochondria in liver regeneration." Treatment of advanced liver disease using surgical modalities is possible due to the liver’s i…
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Got Guts: Small Intestine Neuroendocrine Tumor: Its cell-of-origin has a curious fate of tumorigenesis
33:41
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33:41Take a listen to our latest podcast with coauthor Dr. Yoshi Sei as he discusses the recently published manuscript "Tissue- and cell-specific properties of enterochromaffin cells affect the fate of tumorigenesis toward nonendocrine adenocarcinoma of the small intestine" with Editor in Chief Professor Mark Frey. Small intestinal neuroendocrine tumors…
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Got Guts: The 411 of GI and Liver Section at American Physiology Summit 2023
21:09
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21:09Take a listen to our latest podcast where the magnificent Dr. Karen Edelblum, chair of the GI and Liver Section discusses what's happening at our first ever American Physiology Summit, April 20-23rd in Long Beach California. Registration Deadline for American Physiology Summit is March 31, 2023 Click here for more info on American Physiology Gastro…
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Got Guts: Initiation and severity of experimental pancreatitis are modified by phosphate
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28:30Get to know author Dr. Rodger Liddle (Duke University) in this latest podcast as he goes over his recently published manuscript "Initiation and severity of experimental pancreatitis are modified by phosphate" with Editor in Chief Professor Mark Frey. New and Noteworthy-Impaired ATP synthesis disrupts acinar cell homeostasis and is an early step in …
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Got Guts: Unravelling the NF-kappa B enigma in the gut
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35:31In this podcast authors Prof D. Mark Pritchard and Dr. Carrie Duckworth of the University of Liverpool, discuss their recently published manuscript “Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa” with Editor-in-Chief Prof. Mark Frey. Novel transcriptomic analysis of murine proximal i…
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Got Guts: Plasticity of Human Barrett’s Organoids
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27:58In our latest podcast senior author Dr. Rhonda Souza discusses her latest published research “A Human Barrett's Esophagus Organoid System Reveals Epithelial-Mesenchymal Plasticity Induced by Acid and Bile Salts” with Editor-in-Chief Prof. Mark Frey. Using Barrett's esophagus (BE) biopsies, the authors established organoids recapitulating key BE fea…
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Got Guts: Aryl hydrocarbon receptor (AhR) function is required for optimal interleukin-22 signaling in colonic epithelial stem cells
27:39
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27:39In this podcast, coauthors Dr. Huajun Han, and Prof. Robert S. Chapkin of Texas A&M University, discuss their recently published research "Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3" with Editor-in-Chief Prof. Mark Frey. Data from their preclinical orthogonal models …
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Got Guts: Lifting the Lid on Diarrheal Diseases
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26:45In today’s episode Dr. Stephen Keely from the Royal College of Surgeons in Ireland and Prof Kim Barrett of the University of California, Davis talk about their recent review article “Mechanisms of Secretory Diarrhea” with Prof Mark Frey. They discuss why it is we need to talk more about diarrheal diseases, lift the lid on the complex cellular and m…
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In a rapidly evolving era of single cell technologies, the authors of "Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis" explain the mechanism of an amplification loop during liver fibrosis. By deciphering how stiffness macro and microscopic heterogeneity promote differential gene expression in hepatic stellate…
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Got Guts: HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia
25:34
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25:34Get to know senior author Dr. Liara M. Gonzalez of North Carolina State University as she discusses the recently published paper entitled "HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia" with EIC Prof. Mark Frey. This paper supports that rISCs are resistant to ischemic injury and likely an im…
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Got Guts: A new approach to treat gastrointestinal motility disorders
25:11
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25:11Looking for a new pharmacological approach to treat gastrointestinal motility disorders? In this podcast authors Dr. Daniel Poole and Dr. Simona Carbone of Monash University discuss their recent paper, where they investigated the therapeutic potential of a positive allosteric modulator to enhance endogenous delta-opioid receptor signaling in the gu…
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Unraveling the mysteries of stem cells in inflammatory bowel disease
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26:36Three investigators at Children's Hospital Los Angeles, Nandini Girish, Dr. Cambrian Liu, and Dr. Brent Polk, talk about their recent work to visualize the fates and functions of epithelial stem cells in models of inflammatory bowel disease with Editor-in-Chief Professor Mark Frey. The investigators discuss their diverse backgrounds, reveal how the…
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Got Guts: Behind the science with an Organoid Diva
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15:02Many times we read a manuscript but don’t really get to know the amazing author behind the great science. Behind those black typewritten letters that spell a scientists name lies a person that is usually creative, intelligent, quirky, and fun. This is certainly the case with the author of “Use of human tissue stem cell-derived organoid cultures to …
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Welcome to AJP- Gastrointestinal Liver’s Physiology’s Podcast series, Got Guts? Our first episode is a joint effort with Dr. Pradeep Dudeja, Chair of the GI and Liver Section and Dr. Karen Edelblum, Chair of GI and Liver Program Committee with host Editor-In-Chief, Professor Mark Frey. In this podcast we will be talking about all things Experimenta…
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