”Got Guts” The Micro Version: IL-4Rα Signaling in Esophageal Smooth Muscle

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

In this episode author, Melissa Nelson of Baylor University Medical Center, discusses the recently published manuscript titled "Th2 Cytokine Signaling through IL-4Rα Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle."

New and Noteworthy:

Nelson et al. have found that Th2 cytokines increase eotaxin-3 secretion and tension in esophageal smooth muscle (ESM) cells via IL-4Rα signaling. Unlike esophageal epithelial cells, ESM cells do not express H+,K+ATPase, and omeprazole does not inhibit their cytokine-stimulated eotaxin-3 secretion or tension. An IL-4Rα blocking antibody reduces both eotaxin-3 secretion and tension induced by Th2 cytokines in ESM cells, suggesting that an agent such as dupilumab might be preferred for EoE patients with esophageal muscle involvement.

Article Citation:

Th2 Cytokine Signaling through IL-4Rα Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle Melissa R. Nelson, Xi Zhang, Eitan Podgaetz, Xuan Wang, Qiuyang Zhang, Zui Pan, Stuart Jon Spechler, and Rhonda F. Souza

American Journal of Physiology-Gastrointestinal and Liver Physiology 0 0:0