Episode 25 - Alphabet Soup | Overview of Myeloma Treatments

Bloody Minded

RVd, KTd, CyBorD, DVd, EloRd - Looks like the cat got on the keyboard. Oh wait, this is just the myeloma regimens in day therapy today.
Come on a journey as we attempt (mostly successfully) to avoid drug trade names! Let go of your proteasome inhibitions, phenotype your red cells and let us modulate your understanding of what it is to treat myeloma with an alphabet soups worth of drugs. We sincerely apologise to our endocrinology colleagues for how much dexamethasone we use in this episode but also generally.
Timestamps
4:00 - Overview of the treatment journey
9:49 - Steroids - not the bulking kind
13:54 - Immunomodulators - the IMiDs
19:46 - Proteasome inhibitors - Bortezomib, Carflizomib
24:45 - Monoclonal antibodies - Daratumumab, Elotuzumab
28:31 - SINE Inhibitor - Selinexor
29:27 - Antibody-drug conjugates - Belantamab mafodotin
30:27 - CELMoDs - Iberdomide, mezigdomide
31:06 - Standard chemotherapy
33:15 - Autologous stem cell transplant
38:21 - T-cell directed therapy - BiTes, CAR-T
40:57 - Supportive care

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Chapters

1. Episode 25 - Alphabet Soup | Overview of Myeloma Treatments (00:00:00)

2. Overview of the treatment journey (00:04:00)

3. Steroids - not the bulking kind (00:09:49)

4. Immunomodulators - the IMiDs (00:13:54)

5. Proteasome inhibitors - Bortezomib, Carflizomib (00:19:46)

6. Monoclonal antibodies - Daratumumab, Elotuzumab (00:24:45)

7. SINE Inhibitor - Selinexor (00:28:31)

8. Antibody-drug conjugates - Belantamab mafodotin (00:29:27)

9. CELMoDs - Iberdomide, mezigdomide (00:30:27)

10. Standard chemotherapy (00:31:06)

11. Autologous stem cell transplant (00:33:15)

12. T-cell directed therapy - BiTes, CAR-T (00:38:21)

13. Supportive care (00:40:57)