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Edward Calabrese: The Hormesis Revolution in Biology, Neuroscience, and Medicine
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Professor Ed Calabrese has spent much of his life pouring over tens of thousands of dose – response data from studies in fields ranging from toxicology and radiation biology to cancer, neuroscience, and aging. His work has firmly established the hormesis principle as foundational for evolution and health. In the fields of biology and medicine hormesis is defined as an adaptive response of cells and organisms to a moderate (usually intermittent) stress. Examples include ischemic preconditioning, exercise, dietary energy restriction and exposures to low doses of certain phytochemicals. In this episode Ed and I have a far-reaching conversation on hormesis and its importance for basic neuroscience research, human health, and disease prevention and treatment.
LINKS:
Historical perspective on hormesis, toxicology and radiation biology:
https://www.youtube.com/watch?v=GANStqWcZg4
Articles on hormesis and neuroscience:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096685/pdf/10.1177_1559325818784501.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841445/pdf/nihms946635.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601424/pdf/41514_2017_Article_13.pdf
https://pdf.sciencedirectassets.com/273035/1-s2.0-S0074774220X00079/1-s2.0-S0074774220300556/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEP3%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIQCW5zl1aFc6MtwrtrmNmcVqx%2FWpXKhcwdc4Kat1bZbZpgIgc5XxH8b4%2F5fWHC6q4H6crfVGHpWL97tUlNVINh1dwy8qsgUIFRAFGgwwNTkwMDM1NDY4NjUiDCdQX54o%2F%2FgByMlz5CqPBceL1OeCb1bIvKbdsrfhPfAbNLARt4Wxz7Nt4x%2B%2Fj26zGblNF7oQQqh9Kw4SPPJ%2FLKk7%2BaAr9lTMMfl7XA%2BH2ncHzNQZMcY7iv%2BB%2B0DsvZrb%2FpVqb2kYkx1N9HFrHnUKPecwNS%2FEC4nlyxSW6jpQ5fWbnRkaXyQI0MGf2%2BZrRd0LXbc0zO7c4scL4kj0ytGHZYbw8H%2BVF4spOO0094ZkhOVFV62%2Be%2FsERRLsnEv70YBrllCHGXflcOGUz0e7j5V8gj2GLMRXArnqp8n1KUv2Kf1N9t%2B%2BljoXZLS4g4Jjbz0StSi1CUodJ3cGeaj8rv6kxmdFkfHLeMZanF55M9TZvMx2O1U9s7xk7SyC%2BpdJk1UR2XDetzQQ47tJp6aGZmPjoAGDLsBjQqfCVSDXzpYaxqqBLgPbK6pza9%2FhTlh3H9NmmJFmxmis12knOLU3iD13xyq%2B9%2Bn1%2FKLf%2Fh3DSPribwEuFKnZsmftW3XvlzfOQ3VMwofzssw5AnQ5XcYI0ZBu6vt4dLAHmp2ZWjqu98u8T7yRVStTVKw28677MgOs1z15E0xYaadCk403zPtExD7PjBB4y4ZHg%2BuK4r%2FkZq4SRq4VEVeAzU0Tk4NCM9Qx%2BAYz4dLVLXxV7%2BG%2FbChDiP8Phve1U1UZibv4KgieH7wiAmfepPFnnrTpsjueI1wOGCnHzHCMiWO5QxmK4g7FzvIegXQhlKwgNfsbwTVgnBBroEiezC%2BxHcTmfb%2FqIF4U53oyT6tpk05WpH0%2B%2BvP49wXD%2FymJV8Pnv1ClFssnao62lLGuRGp%2B8LWndtLGhg4%2FNSOmFAzDnpSdkwwqyGLtqWPGJcXKLWh5rSDbeEo%2FX87TccP98Mq8XRtgBSvaBB2yT%2FEwl8afqQY6sQG479723yRQwYkUS%2Bl41lBOXMo4LDAJRG1%2FF3fZAX6M1Rx84YwaPJePMQAgBwXWPggBDklXnaQ6Q%2B2hq6LbW8R8qYdj2E8r6oDlcIqhIxIFL3zTAB48Yrqc6XzXEX26pb8%2FvS3LVbVZm%2Fc8H%2BRpsmbbqgCRh8sKKtpAMJfcAW4EhLdZ%2F0FfzSR4SzHL6DQ3pQpXyfV2BQuYpPo1QXpZRrksamOe0wb3OBfPcuqbnIC9B5I%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20231012T130926Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYZJLXI6FH%2F20231012%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=d6a094c1eab3109f50fa61e6e72c6bf1a65f22ede15f37c1a194d113d90d09c9&hash=6cf4c4c3cccd6602386d9a2e94af8a73b69e4a4de18d0fade6eda8922e2a74a7&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0074774220300556&tid=spdf-32557d0d-d209-4b69-a3ed-2d4918cfe08c&sid=c7cad12d14263147f8386e05119b31fc6efagxrqa&type=client&tsoh=d3d3LXNjaWVuY2VkaXJlY3QtY29tLnByb3h5MS5saWJyYXJ5LmpodS5lZHU%3D&ua=0f105b50520957570754&rr=814f93c60f600cb0&cc=us
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