COX-2 Inhibitors to Increase Effectiveness of Emergency Contraception

CEimpact Podcast

Emergency contraception use has an effectiveness of about 70%. Join host, Geoff Wall, as he reviews new literature to see if COX-2 inhibition improves that rate.
The GameChanger
Emergency contraception (EC) is safe and effective but overall efficacy rates could be better. COX-2 inhibitors may enhance the effectiveness of EC but require multiday dosing.
Host
Geoff Wall, PharmD, BCPS, FCCP, BCGP
Professor of Pharmacy Practice, Drake University
Internal Medicine/Critical Care, UnityPoint Health
Reference
Li RHW, Lo SST, Gemzell-Danielsson K, et al. Oral emergency contraception with levonorgestrel plus piroxicam: a randomised double-blind placebo-controlled trial. Lancet. 2023 Sep 9;402(10405):851-858. doi: 10.1016/S0140-6736(23)01240-0. Epub 2023 Aug 16. Erratum in: Lancet. 2023 Sep 9;402(10405):850. PMID: 37597523.
https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(23)01240-0.pdf

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CPE Information

Learning Objectives
Upon successful completion of this knowledge-based activity, participants should be able to:
1. Describe the selection of the particular COX-2 medication used in this study
2. Discuss the implications of the COX-2 augmentation with patients
0.05 CEU/0.5 Hr
UAN: 0107-0000-23-322-H01-P
Initial release date: 10/9/2023
Expiration date: 10/9/2024
Additional CPE details can be found here.

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Chapters

1. COX-2 Inhibitors to Increase Effectiveness of Emergency Contraception (00:00:00)

2. Emergency Contraception With Non-Steroidal Additions (00:00:08)

3. Peroxicam in Emergency Contraception Effectiveness (00:10:40)

4. Enhancing Emergency Contraception Efficacy (00:17:49)