DrBeen#85: mRNA Vaccines Produce Off-Target Proteins

FLCCC Alliance

What are the off-target proteins produced by mRNA vaccines? Can these proteins cause harm? What is the mechanism of their production? Let's review.

An article on University of Cambridge contains this statement, "Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics."

DrBeen: Medical Education Online

https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance

https://covid19criticalcare.com/

URL list from Friday, Dec. 15, 2023

Long Story Short With Dr. Been - FLCCC | Front Line COVID-19 Critical Care Alliance

https://covid19criticalcare.com/courses/long-story-short-with-dr-been/

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses | University of Cambridge

https://www.cam.ac.uk/research/news/researchers-redesign-future-mrna-therapeutics-to-prevent-potentially-harmful-immune-responses

N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting | Nature

https://www.nature.com/articles/s41586-023-06800-3

Interferon gamma - Wikipedia

https://en.wikipedia.org/wiki/Interferon_gamma

The Shape and Structure of Proteins - Molecular Biology of the Cell - NCBI Bookshelf

https://www.ncbi.nlm.nih.gov/books/NBK26830/#:~:text=A%20protein%20molecule%20is%20made,one%20molecule%20to%20the%20next

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Ribosomes, Transcription, Translation | Learn Science at Scitable

https://www.nature.com/scitable/topicpage/ribosomes-transcription-and-translation-14120660/#:~:text=Recall%20that%20mRNA%20molecules%20are,protein%20as%20it%20is%20synthesized

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Genetic code - Wikipedia

https://en.wikipedia.org/wiki/Genetic_code

DNA and RNA codon tables - Wikipedia

https://en.wikipedia.org/wiki/DNA_and_RNA_codon_tables

Pseudouridine - Wikipedia

https://en.wikipedia.org/wiki/Pseudouridine

Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines | ACS Central Science

https://pubs.acs.org/doi/10.1021/acscentsci.1c00197

Ribonucleotide - Wikipedia

https://en.wikipedia.org/wiki/Ribonucleotide#:~:text=In%20biochemistry%2C%20a%20ribonucleotide%20is,monomeric%20building%20blocks%20for%20RNA

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Translation: DNA to mRNA to Protein | Learn Science at Scitable

https://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393/#:~:text=The%20process%20of%20translation%20can,transcription%20as%20well%20as%20tRNA.&text=The%20genes%20in%20DNA%20encode,the%20functions%20necessary%20for%20life

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Frontiers | On programmed ribosomal frameshifting: the alternative proteomes

https://www.frontiersin.org/articles/10.3389/fgene.2012.00242/full#:~:text=Frameshifting%20is%20a%20process%20whereby,downstream%20(%E2%88%921%20frameshift)

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