58. Mythbusting Cidal vs Static with Microbe Mail

ID:IOTS - Infectious Disease Insight Of Two Specialists

Jame and Callum were delighted to be invited as guests to the podcast Microbe Mail by host Vindana (Vin) Chibabhai. Check out the Microbe Mail podcast:
https://microbemail.captivate.fm/ @microbemail
We discuss how bactericidal and bacteriostatic are defined, what the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) are and why this isn't as simple as it first seems. We then discuss specific clinical situations and where bactercidal vs static have been compared.
Links/papers mentioned in this episode:
The basics of beta lactamases
Wald-Dickler N, Holtom P, Spellberg B. Busting the Myth of ‘Static vs Cidal’: A Systemic Literature Review. Clin Infect Dis. 2018 17;66(9):1470–4.
Use of bacteriostatic agents in Neutropenic fever:
The RCT referred to in the abstract is here:
Jaksic B, Martinelli G, Oteyza JP, Hartman CS, Leonard LB, Tack KJ. Efficacy and Safety of Linezolid Compared with Vancomycin in a Randomized, Double-Blind Study of Febrile Neutropenic Patients with Cancer. Clinical Infectious Diseases. 2006 Mar 1;42(5):597–607

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Chapters

1. Bactericidal vs. Bacterostatic Antibiotics (00:00:00)

2. Myths About Antibiotics Debunked (00:14:17)

3. Comparing Static and Saddle Antibiotics (00:26:57)

4. Debunking Antibiotic Myths (00:37:30)