Improving Diagnostics in Medicine

LabMind

#Science #ARUP Laboratories #University Of Utah

30:20

Eli Beer is a pioneer, social entrepreneur, President and Founder of United Hatzalah of Israel. In thirty years, the organization has grown to more than 6,500 volunteers who unite together to provide immediate, life-saving care to anyone in need - regardless of race or religion. This community EMS force network treats over 730,000 incidents per year, in Israel, as they wait for ambulances and medical attention. Eli’s vision is to bring this life-saving model across the world. In 2015, Beer expanded internationally with the establishment of branches in South America and other countries, including “United Rescue” in Jersey City, USA, where the response time was reduced to just two minutes and thirty-five seconds. Episode Chapters (0:00) intro (1:04) Hatzalah’s reputation for speed (4:48) Hatzalah’s volunteer EMTs and ambucycles (5:50) Entrepreneurism at Hatzalah (8:09) Chutzpah (14:15) Hatzalah’s recruitment (18:31) Volunteers from all walks of life (22:51) Having COVID changed Eli’s perspective (26:00) operating around the world amid antisemitism (28:06) goodbye For video episodes, watch on www.youtube.com/@therudermanfamilyfoundation Stay in touch: X: @JayRuderman | @RudermanFdn LinkedIn: Jay Ruderman | Ruderman Family Foundation Instagram: All About Change Podcast | Ruderman Family Foundation To learn more about the podcast, visit https://allaboutchangepodcast.com/ Looking for more insights into the world of activism? Be sure to check out Jay’s brand new book, Find Your Fight , in which Jay teaches the next generation of activists and advocates how to step up and bring about lasting change. You can find Find Your Fight wherever you buy your books, and you can learn more about it at www.jayruderman.com .…

4 years ago 37:35

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Paul Epner’s more than four-decade career started at Abbott Diagnostics and has involved collaboration with the CDC and a tenure as president of the Clinical Laboratory Management Association (CLMA). He now serves as CEO of the Society to Improve Diagnosis in Medicine (SIDM). Throughout his career, Epner has been a powerful advocate for the role of laboratory professionals. In our special Lab Week interview, we discuss why diagnosis is a team sport, how cross-disciplinary collaboration is fundamental to the critical impact of laboratory medicine, and the overall quality of medical care.

91 episodes

Improving Diagnostics in Medicine

LabMind

22 subscribers

published 4 years ago

MP3•Episode home

91 episodes

#Science #ARUP Laboratories #University Of Utah

All episodes

1
The Laboratory Is a Mystery Machine of Diagnostics 47:09

6 weeks ago47:09

47:09

Every specimen represents a potential mystery, and laboratory professionals often play the role of detectives. For the 2025 Lab Week episode of LabMind, Amanda Openshaw, a genetic counselor at ARUP, shares examples illustrating the importance of good investigative work in the laboratory to discover accurate diagnoses.…

1
Why We Need Better Laboratory Tests for Dementia 25:43

10 weeks ago25:43

25:43

Why hasn’t there been more progress in developing therapies for Alzheimer’s disease and related forms of dementia? One reason has been the lack of specific laboratory tests that can properly diagnose and characterize these diseases. In this interview, Dr. Qinwen Mao from the University of Utah describes how her research team is helping to bring new blood and cerebrospinal fluid biomarkers into clinical practice to step up the fight against these devastating diseases.…

1
An Interview With Dr. Keith Elkins 34:28

16 weeks ago34:28

34:28

As laboratory professionals, we may think we have a good understanding of how physicians use our services. But how often do we ask them for practical feedback? In this interview, family physician Dr. Keith Elkins shares his perspectives on what clinical laboratories and pathologists do well, and what opportunities they may be overlooking to better support frontline clinical care.…

1
Regulating the Safety and Effectiveness of Clinical Laboratory Testing 33:13

22 weeks ago33:13

33:13

Many people in the healthcare profession know that clinical laboratories are under more rigorous regulatory scrutiny than just about any other area of medicine. What they may not know is that the New York State Department of Health (NY DOH) was the pioneer in laboratory regulation, starting long before the implementation of either the FDA Medical Device Amendments or the Clinical Laboratory Improvement Amendments (CLIA) of 1988. In this interview, Beverly Rauch, MS, director of the NY DOH’s Clinical Laboratory Evaluation Program (NY CLEP), describes its process for granting permits, inspecting laboratories, and approving assays, and what the new FDA LDT rule might mean for the program.…

1
Demystifying Data Analysis for the Clinical Lab 31:21

25 weeks ago31:21

31:21

In this age of ChatGPT, artificial intelligence (AI), and machine learning, laboratory professionals might think they need to be experts in sophisticated new technology to glean insights from laboratory data. But as ARUP’s medical director of operational informatics Dr. Jenna Rychert points out in this interview, data analysis doesn’t always have to be complicated to provide meaningful value.…

1
The Human Side of Pathology’s Digital Transformation 41:45

30 weeks ago41:45

41:45

Anatomic pathology is on the verge of its biggest technologic shift in over a century. Making a smooth transition will require leadership to pay as much attention to the human impact as to the technology itself. In this discussion, Dr. Suzanne Dintzis from the University of Washington explains why hospital and department leaders will need to partner with front-line laboratory professionals and pathologists who perform the day-to-day work.…

1
Answering Your Questions About the FDA’s Final Rule on LDTs 43:54

35 weeks ago43:54

43:54

As of September 2024, there remains enormous uncertainty about the FDA’s final rule on laboratory-developed tests (LDTs). Will it hold up in court? Which tests are subject to which requirements? How can laboratories best prepare? In this interview, Dr. Jonathan Genzen, ARUP’s chief medical officer and senior director of governmental affairs, responds to questions sent in by members of the laboratory community.…

1
Creating a More Just, Effective, and Affordable Healthcare System 39:56

39 weeks ago39:56

39:56

Fixing American healthcare will require more than mere tweaks around the edges. Dr. Vikas Saini, president of the Boston-based Lown Institute, believes that it will require a return to medicine’s humanist roots. In this interview he describes some of the ways in which many healthcare organizations prioritize revenue and profit over patients and communities. He also explains why he remains optimistic that Hippocratic principles will ultimately prevail.…

1
What ASCP's Youngest MLS Can Teach Us About Recruiting the Next Generation of Laboratory Scientists 21:48

42 weeks ago21:48

21:48

Clinical laboratories offer great careers, but lack of awareness and other barriers can prevent excellent candidates from pursuing laboratory science professions. In this interview, Isak Schmidley, MLS(ASCP), explains how he first stumbled across medical laboratory science while attending community college in his early teens and then persevered past age stereotypes to land his first hospital laboratory job at the impressive age of 16. He shares advice for laboratory leaders on what his generation expects from employers and tips on how to recruit the next generation.…

1
Preventing Hereditary Cancer Through Genealogy 34:39

45 weeks ago34:39

34:39

Most hereditary cancers, including those associated with BRCA1 mutations and Lynch syndrome, can be prevented through a combination of genetic testing, surveillance, and surgery. Yet only a small minority of eligible individuals currently receive this lifesaving intervention. In this interview, Dr. Brian Shirts, director of the Institute for Public Health Genetics at the University of Washington, discusses a new nonprofit organization that uses family connections to identify individuals at high risk for hereditary cancers and other adult-onset hereditary diseases.…

1
Bringing Pharmacogenomics Into Mainstream Clinical Practice 39:53

49 weeks ago39:53

39:53

Due to genetic variation, patients metabolize and respond to medications in vastly different ways, so why do most drug therapy regimens continue to be one-size-fits-all? In this interview, Dr. Yuan Ji, ARUP’s section chief of Molecular Genetics and Genomics, discusses how currently available genetic tests can be used to improve both the safety and effectiveness of pharmacotherapy.…

1
Building a Professional Community for Laboratory Stewardship 27:46

1 year ago27:46

27:46

Since its founding in 2013 at Seattle Children’s Hospital, PLUGS (Patient-Centered Laboratory Utilization Guidance Services) has brought together laboratory professionals, genetic counselors, clinicians, patients, and insurance companies across the country to improve the application of laboratory tests in clinical practice. In this interview, PLUGS cofounder Dr. Jane Dickerson describes some of the ingredients that have contributed to the program’s remarkable success.…

1
What It Means for a Laboratory to Be Part of the Patient Care Team 42:14

1 year ago42:14

42:14

Dr. Eddie Stenehjem, Vice Chair of Medicine at the University of Colorado, knows a lot about clinical laboratories. As an infectious disease physician and former cochair of Intermountain Healthcare’s laboratory stewardship committee, he has deep respect for the knowledge and dedication that laboratory professionals bring to patient care. In this interview he discusses why clinician-lab collaboration is vital, and how labs can improve communication and relationships with clinical colleagues.…

1
How Will Automation Change Clinical Laboratories? 19:54

1 year ago19:54

19:54

There’s plenty of excitement around laboratory automation. But which tasks are good candidates for automation, and which are poor candidates? What risks need to be managed? And what are the implications of automation for lab professionals? In this interview, Dr. Joseph Rudolf, medical director of ARUP’s Automated Core Laboratory, shares his insights along with some predictions for the future.…

1
Solving Coagulation Mysteries One Patient at a Time 27:59

1 year ago27:59

27:59

Diagnosis involves much more than a number on a lab report. This is particularly true when the patient has disordered bleeding or clotting. In this interview, Dr. Karen Moser from the University of Utah Department of Pathology describes some of the ways she works with her laboratory and clinician colleagues to ensure that patients get the answers and the therapies they need.…

LabMind

1
The Human Side of Quality Management 29:26

1 year ago29:26

29:26

What does it mean to have a quality culture? Technical competence and strict adherence to protocols are certainly part of the story. But so are factors such as workforce engagement and customer service. In this interview, Nancy Ross, assistant director of clinical pathology and quality at Montefiore Medical System and the founder of Improov, a laboratory improvement consulting company, draws on her diverse career experience to argue for a holistic and people-centered approach to quality management.…

LabMind

1
Why Quality Management Is Critical to the Long-Term Success of Healthcare AI 36:21

1 year ago36:21

36:21

A public debate is raging around the regulation of artificial intelligence (AI). One side argues that AI is potentially dangerous and needs to be carefully controlled, whereas the other side argues that any regulation would slow innovation. In this interview, Dr. Ryan Metcalf, section chief of Transfusion Medicine and medical director of Transfusion Service/Blood Bank at ARUP Laboratories, makes a strong case for a safety-first approach to healthcare AI. He also explains why embedding AI development and use within a strong quality management framework could actually lead to more innovation over the long term, even as it prevents patient harm in the short term.…

LabMind

1
How FDA Restrictions on Laboratory-Developed Tests Will Harm Patients and Increase Costs 41:45

2 years ago41:45

41:45

The FDA recently announced a plan to regulate laboratory-developed tests (LDTs) as medical devices. In this interview, Dr. Meghan Delaney from Children’s National Hospital and Dr. Eric Konnick from the University of Washington explain why many tests that are critical to patient care, particularly in the areas of pediatrics, transplantation, and rare diseases, may become unavailable if the rule the FDA has proposed is enacted. Other tests may remain available, but at a significantly increased cost. Dr. Jonathan Genzen, ARUP’s chief medical officer and cohost of this episode, describes how laboratory professionals can provide public feedback to the FDA before the rule takes effect.…

LabMind

1
What the TRUU-Lab Initiative Has Taught Us About Laboratory Test Names 24:46

2 years ago24:46

24:46

Dr. Ila Singh, chief of laboratory medicine at Texas Children’s Hospital, founded the Test Renaming for Understanding and Utilization in the Laboratory (TRUU-Lab) initiative several years ago to tackle challenges related to the nonstandardized and uninformative naming of laboratory tests. In this interview, Dr. Singh describes the surveys her CDC-funded collaborative has conducted with hundreds of physicians and other providers, and she shares insights about how to improve the ordering of tests through more effective naming.…

LabMind

1
Blunt Advice for Navigating a Career in Academic Medicine 31:24

2 years ago31:24

31:24

Individuals pursue careers in academic medicine for many reasons. A love of organizational politics is rarely one of them, but faculty need to understand potential landmines if they are to avoid them. In this interview, Dr. Michael Cohen, a professor emeritus of pathology at Wake Forest University, draws on his experiences serving on faculty and in senior leadership at multiple institutions to explain how to thrive within the paradoxes of academic medicine.…

LabMind

1
Sustainability in Healthcare Organizations 37:36

2 years ago37:36

37:36

Sustainability is a hot topic for American corporations, and health systems are no exception. In this interview, Glen Garrick, system sustainability director for Intermountain Healthcare, explains how his and other healthcare organizations are addressing their environmental, social, and governance responsibilities. He also describes how clinical laboratories can make the most positive impact.…

LabMind

1
Keys to Laboratory Success in the Next Pandemic 40:01

2 years ago40:01

40:01

Three and a half years after the emergence of COVID-19 is a good time to reflect on the capabilities of U.S. laboratories to respond to future pandemics. In this interview, Dr. Marc Couturier, medical director of Emerging Public Health Crises at ARUP Laboratories, explains how the U.S. laboratory sector has improved in its ability to respond quickly to emerging and reemerging infections, but he emphasizes the need to go further. He specifically explains why testing can’t be rapidly scaled up unless there’s tight coordination between public health labs and clinical labs (particularly reference labs and large academic labs).…

LabMind

1
Optimizing Laboratory Testing for Autoimmune Neurologic Disease 33:07

2 years ago33:07

33:07

Laboratory testing can either lead to the correct diagnosis or take a clinician down a blind alley, depending on how carefully the tests are selected and performed. In this interview, a practicing neurologist (Dr. Tammy Smith) and a clinical laboratory immunologist (Dr. Lisa Peterson) explain some of the complexities of laboratory diagnosis of autoimmune neurologic disease, and how to ensure good diagnostic outcomes.…

LabMind

1
Bridging the Cultural Divide Between Nursing and Laboratory Medicine 32:51

2 years ago32:51

32:51

Nurses and laboratory professionals rely on each other to ensure accurate test results, but their relationships are sometimes challenging. As president of St. Alphonsus Medical Center in Nampa, Idaho, as well as a registered nurse with a doctorate degree in nursing practice, Clint Child often mediates when these two professional cultures collide. In this interview he explains why nursing practice is less predictable and requires greater flexibility than laboratory practice. He also shares his perspective on why it’s valuable for hospital leaders to have strong ties to their local communities.…

LabMind

1
Why Different Platforms Can Give Different Results for the Same Test, and What Can Be Done About It 37:07

2 years ago37:07

37:07

Physicians and patients expect laboratory tests to produce the same results, regardless of where they are performed. Unfortunately, that’s not always the case, even for FDA-approved assays. As the current chair of the College of American Pathologists committee for accuracy-based proficiency testing, Dr. Andy Hoofnagle is an authority on this industrywide problem. In this interview, he explains the root causes of inconsistent results across platforms, and how manufacturers, regulators, and professional societies might work together to solve it.…

LabMind

1
Lessons Learned From Automating a Hospital Laboratory 31:40

2 years ago31:40

31:40

The key to successful clinical lab automation doesn’t lie in the instruments or the conveyor belt. It lies in clarifying what the organization most needs to improve (labor efficiency? turnaround time? reliability?) followed by optimizing those factors through modeling and planning. In this interview, Dr. Lauren Pearson, ARUP’s chief medical officer for University of Utah Health, shares lessons she has learned from her recent automation projects.…

LabMind

1
What Laboratory Leaders Aren’t Discussing With Hospital Administrators, But Should Be 25:32

2 years ago25:32

25:32

For her doctoral dissertation, Dr. Susan Edralin dove into the issue of communicating the value contribution of pathology and laboratory medicine to healthcare administrators. What she found in her conversations surprised her. In this interview, she lists some of the misunderstandings regarding laboratory value and describes how lab directors can raise the status of their laboratory operations and expert staff.…

LabMind

1
Understanding the U.S. Patent System 32:15

2 years ago32:15

32:15

You know what a patent is, but do you know what’s patentable in the field of laboratory diagnostics? Or how patent law has changed over the years? In this interview, Dr. Bert Ley, a registered patent agent with decades of experience in the clinical laboratory industry, unpacks some of the mysteries of the U.S. patent system and how it ultimately benefits society.…

LabMind

1
Amplifying the Voice of the Patient 34:07

2 years ago34:07

34:07

Within our current healthcare institutions, patients’ voices are often drowned out by the voices of providers, scientists, and industry. Andrea Downing’s life work is to fix this. As a BRCA1 cancer previvor and a patients’ rights activist, she was a spokesperson for one of the plaintiffs in the U.S. Supreme Court case that ultimately overturned gene patenting. Years later, while moderating an online patient support group, she discovered a major privacy vulnerability in Facebook, which led her into cybersecurity research. In this interview, she chronicles her journey and lays out her vision for patients as cocreators within medicine and medical science.…

LabMind

1
‘Think Different’ About Quality Control 30:10

2 years ago30:10