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#49 Manish Butte, MD PhD: All about immunology, especially T cells

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Manage episode 299235119 series 2943299
Content provided by Gillian Ehrlich. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Gillian Ehrlich or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

Dr Manish Butte, MD PhD, is a pediatrician & Division Chief of Immunology, Allergy & Rheumatology, and is also a surprisingly down-to-Earth kind of guy. In this show, he causally lays it all out there from the perspective of a scientist and compassionate clinician who works at the edges of what we know regarding genetics and rare diseases to give us a view of the whole playing field of immunology, including allergy, autoimmunity and infection (especially the post-infectious drive towards autoimmunity). We discuss Lyme, EBV (Epstein Barr Virus) and the ways in which the B cells & T cells function to mount, address & recede from their battle stations (did you know regulatory T cells even a part of the initial cytotoxic T cell response to infection?). Dr Butte then dives into the mechanobiology components of T cell activation (did you know stiff vs soft, aka swollen/edematous tissues vs non-traumatized tissue, trigger different T cell responses?) with some fascinating conjecture about the interaction between hypermobile tissues & T cell activity. We seem to end the conversation with a deep discussion about IVIG (IV immunoglobulin G) and rituximab which address aberrant antibodies but then truly finish with some discussion about the importance of immunogenetics and COVID antibody & T-cell evaluations. All in all, a fabulous show for which we are grateful for Dr Butte's generous participation.

  continue reading

86 episodes

Artwork
iconShare
 
Manage episode 299235119 series 2943299
Content provided by Gillian Ehrlich. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Gillian Ehrlich or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

Dr Manish Butte, MD PhD, is a pediatrician & Division Chief of Immunology, Allergy & Rheumatology, and is also a surprisingly down-to-Earth kind of guy. In this show, he causally lays it all out there from the perspective of a scientist and compassionate clinician who works at the edges of what we know regarding genetics and rare diseases to give us a view of the whole playing field of immunology, including allergy, autoimmunity and infection (especially the post-infectious drive towards autoimmunity). We discuss Lyme, EBV (Epstein Barr Virus) and the ways in which the B cells & T cells function to mount, address & recede from their battle stations (did you know regulatory T cells even a part of the initial cytotoxic T cell response to infection?). Dr Butte then dives into the mechanobiology components of T cell activation (did you know stiff vs soft, aka swollen/edematous tissues vs non-traumatized tissue, trigger different T cell responses?) with some fascinating conjecture about the interaction between hypermobile tissues & T cell activity. We seem to end the conversation with a deep discussion about IVIG (IV immunoglobulin G) and rituximab which address aberrant antibodies but then truly finish with some discussion about the importance of immunogenetics and COVID antibody & T-cell evaluations. All in all, a fabulous show for which we are grateful for Dr Butte's generous participation.

  continue reading

86 episodes

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