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Reviving Retigabine for Tinnitus - Thanos Tzounopoulos, PhD
Manage episode 262751661 series 2516991
Content provided by Tinnitus Hub. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Tinnitus Hub or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
A drug to quieten your tinnitus. It’s what most people struggling with tinnitus desire. We had the pleasure of interviewing Thanos Tzounopoulos, PhD, director of the Pittsburgh Hearing Research Center, on his work to develop just such a drug.
His work builds on the previously somewhat successful off-label tinnitus drug Retigabine. That drug was taken off the market due to severe side effects. Thanos is now attempting to re-develop it, without the side effects, and better targeted at the source of the neural hyperactivity perceived as tinnitus.
In this episode, we speak extensively about Thanos’ theory of how tinnitus is generated in the brain and the role of (broken) potassium channels in this. He explains all the trial and error that went into re-developing the drug and speaks about the upcoming phases of research needed before the drug can come to market.
Become a Tinnitus Talk Podcast Patron at https://moretinnitustalk.com for bonus content, video interviews, Ask an Expert series, and more!
24 episodes
Share
Manage episode 262751661 series 2516991
Content provided by Tinnitus Hub. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Tinnitus Hub or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
A drug to quieten your tinnitus. It’s what most people struggling with tinnitus desire. We had the pleasure of interviewing Thanos Tzounopoulos, PhD, director of the Pittsburgh Hearing Research Center, on his work to develop just such a drug.
His work builds on the previously somewhat successful off-label tinnitus drug Retigabine. That drug was taken off the market due to severe side effects. Thanos is now attempting to re-develop it, without the side effects, and better targeted at the source of the neural hyperactivity perceived as tinnitus.
In this episode, we speak extensively about Thanos’ theory of how tinnitus is generated in the brain and the role of (broken) potassium channels in this. He explains all the trial and error that went into re-developing the drug and speaks about the upcoming phases of research needed before the drug can come to market.
Become a Tinnitus Talk Podcast Patron at https://moretinnitustalk.com for bonus content, video interviews, Ask an Expert series, and more!
24 episodes
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Similar to Tinnitus Talk
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continue reading
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continue reading
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continue reading
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continue reading
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