Host Francesca Amiker sits down with directors Joe and Anthony Russo, producer Angela Russo-Otstot, stars Millie Bobby Brown and Chris Pratt, and more to uncover how family was the key to building the emotional core of The Electric State . From the Russos’ own experiences growing up in a large Italian family to the film’s central relationship between Michelle and her robot brother Kid Cosmo, family relationships both on and off of the set were the key to bringing The Electric State to life. Listen to more from Netflix Podcasts . State Secrets: Inside the Making of The Electric State is produced by Netflix and Treefort Media.…
How can echocardiographers improve the accuracy and confidence of hypertrophic cardiomyopathy diagnosis? In this episode of In the Thick of It , sonographers Amy Dillenbeck and Brad Mehl explore the essential role of echocardiography in evaluating HCM, sharing best practices for optimizing imaging techniques, Doppler assessment, and contrast use. They discuss the most common challenges in detecting HCM, how to train sonographers to recognize subtle diagnostic clues, and strategies to avoid misinterpretation. Whether you're a seasoned clinician or new to HCM imaging, this episode offers valuable insights into refining echocardiographic evaluation for better patient outcomes. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
How do we determine which hypertrophic cardiomyopathy patients are at the highest risk for sudden cardiac death? In this episode of In the Thick of It , Dr. Steve Ommen and Dr. Mark Link take a deep dive into the role of non-sustained ventricular tachycardia (NSVT) in risk assessment and ICD decision-making. They discuss how age, VT duration, and other clinical factors influence risk stratification, as well as the evolving guidelines on ICD placement. The conversation also covers the latest advancements in device technology and the nuances of selecting the right ICD for each patient. Don’t miss this essential discussion on refining risk assessment and improving outcomes in HCM care. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
How can late gadolinium enhancement (LGE) on cardiac MRI help predict sudden cardiac death risk in hypertrophic cardiomyopathy? In this episode of In the Thick of It , Dr. Christopher Kramer and Dr. Raymond Chan explore the clinical significance of LGE, from its role in ICD decision-making to the challenges of scar quantification. They discuss how to differentiate true myocardial scar from artifacts, the evolving guidelines on LGE thresholds, and the implications of advanced imaging techniques for HCM management. Tune in for expert insights on integrating LGE into risk assessment and optimizing patient care. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
How do hypertrophic cardiomyopathy and aortic valve disease intersect, and what makes managing these patients so challenging? In this episode of In the Thick of It , Dr. Srihari Naidu and Dr. Megan Coylewright explore the complexities of aortic valve replacement (TAVR) in patients with HCM. What challenges arise when HCM patients undergo aortic valve replacement, and how can these risks be mitigated? They discuss the risks of left ventricular outflow tract obstruction, strategies to optimize patient outcomes, and the importance of distinguishing HCM from other conditions like amyloidosis. Tune in to learn about the role of advanced imaging, careful patient selection, and multidisciplinary heart teams in managing these overlapping conditions effectively. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
How has genetic testing transformed the understanding and care of hypertrophic cardiomyopathy? In this episode of In the Thick of It , Dr. Victoria Parikh and genetic counselor Tia Moscarello from the Stanford Center for Inherited Cardiovascular Disease explore the powerful role of genetics in HCM diagnosis, family screening, and treatment. They discuss groundbreaking advancements like gene therapy, precision medicine, and the evolving understanding of variants of uncertain significance (VUS). Tune in to learn how genetic insights are driving early detection, personalized therapies, and even potential cures for HCM, offering hope for patients and their families. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
What are left ventricular apical aneurysms, and why do they pose such a high risk in hypertrophic cardiomyopathy patients? In this episode of In the Thick of It , Dr. Ethan Rowin and Dr. Jeffrey Geske delve into this rare but critical HCM phenotype. They discuss how to accurately define and detect apical aneurysms, the importance of advanced imaging techniques like contrast echocardiography and cardiac MRI, and the elevated risks of sudden cardiac death and stroke these patients face. This insightful conversation also provides insights into the evolving guidelines for ICD placement and the nuanced role of aneurysm size in risk stratification. Don’t miss this deep dive into one of HCM’s most challenging presentations. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
Why is early detection of hypertrophic cardiomyopathy in children so critical for effective treatment? In this episode of In the Thick of It, Dr. Matthew Martinez sits down with pediatric cardiologist Dr. Tess Saarel to explore the unique challenges of managing HCM in young patients. They discuss the importance of personalized risk assessments, the role of genetics in tailoring care, and the collaborative efforts needed to improve outcomes in pediatric HCM. Join them for an insightful conversation on the evolving landscape of pediatric cardiology in HCM care. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
What makes managing common conditions like hypertension and sleep apnea uniquely challenging in hypertrophic cardiomyopathy patients? In this episode of In the Thick of It, Dr. Michael Ayers and Dr. Robyn Bryde tackle the complexities of treating comorbidities such as obesity and type 2 diabetes within the context of HCM. They delve into how obstructive physiology impacts treatment choices and share key considerations for surgical clearance, all aimed at optimizing patient outcomes. Tune in for practical insights into managing the multifaceted health needs of HCM patients. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
What does it take for healthcare providers to meet the unique needs of HCM patients experiencing AFib? In this episode, Dr. Ethan Rowin and Dr. Jose Joglar delve into the critical topic of atrial fibrillation (AFib) in patients with hypertrophic cardiomyopathy (HCM). They discuss the heightened risk of stroke associated with AFib, the necessity for prompt anticoagulation, and the complexities of maintaining rhythm control. Tune in to gain pivotal insights into effective treatment strategies, including anti-arrhythmic medications and left atrial appendage closure devices, and discover the importance of comprehensive care and lifestyle management to improve outcomes for HCM patients facing AFib. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
In today’s episode of In the Thick Of It, Dr. Anna Woo is joined by Dr. Sharon Cresci for a conversation on hypertrophic cardiomyopathy and its genetic implications. What role does genetic testing play in identifying familial variants and whether inheriting a pathogenic variant will lead to disease? Learn about the importance of genetic testing, lifelong serial screening, collaborative treatment approaches, and the processes of educating patients and families about HCM. Tune in as these experts provide insights on vigilance, follow-up care, and informed decision-making in HCM management. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
On today's episode of 'In The Thick of It', Dr. Benjamin Van Boxtel welcomes Dr. Daniel Swistel and Dr. Joseph Dearani to discuss Septal Myectomy and mitral valve repair. Why is personalized patient care crucial when managing hypertrophic cardiomyopathy? Tune in as these specialists explore the importance of customized procedures, teamwork across disciplines, ongoing education, and staying abreast of the latest technological advancements in the field. Dr. Swistel and Dr. Dearani also explain the significance of comprehensive evaluations and specialist collaboration in treating HCM. But what obstacles do they encounter in their multidisciplinary efforts? Check out today's episode to discover their approaches to these challenges, and to learn how the latest surgical innovations are transforming treatment options for HCM and beyond. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
On this episode of 'In The Thick of It', Dr. Steve Ommen joins Dr. Matthew Martinez to explain the latest changes and updates to the HCM guidelines. What is the importance of personalized patient care, shared decision-making, and lifestyle adjustments for HCM patients? Find out as Dr. Martinez and Dr. Ommen discuss risk assessment methodologies, effective management strategies for atrial fibrillation, and the evolving landscape of emerging medical therapies for HCM. These seasoned experts also dissect critical information from the new guidelines while drawing attention to key similarities and differences compared to prior guidelines. What impact do these new guidelines have on individuals affected by HCM across all age brackets? Join Dr. Martinez and Dr. Ommen as they explain how these updates aim to align clinical practices with the latest evidence, ensuring personalized and effective management of HCM. Season 2 of In the Thick of It is brought to you by the HCM Society , is supported by sponsorship from Cytokinetics , and is produced by Earfluence .…
When should we make the critical decision to start Cardiac Myosin therapy in NYHA Class II HCM patients? Today, Dr. Patrycja Galazka is joined by Dr. Sara Saberi, Assistant Associate Professor in Cardiovascular Medicine and co-director of the Inherited Cardiomyopathy Program at the Frankel Cardiovascular Center. Together, we dive into the intricate world of Cardiac Myosin Inhibitors, addressing this vital question. In the ever-changing landscape of HCM management, this episode offers a beacon of clarity. Whether you're a healthcare professional dedicated to improving patient outcomes or someone personally navigating the challenges of HCM, our conversation provides essential insights. Join us for a discussion that could reshape your approach to HCM care. In the Thick of It is brought to you by the HCM Society and is produced by Earfluence .…
How do you envision the role of gene therapy in shaping the future of cardiac care? In today’s episode, your host, Dr. Sharlene Day , engages in an enlightening conversation with Dr. Carolyn Ho , delving into the transformative world of gene therapy. Together, they navigate the complexities of gene therapy's fundamental concepts and potential applications in treating genetic cardiomyopathies and arrhythmia syndromes. Remember, understanding the potential of gene therapy is just the beginning. Collectively, we can pave the way for transformative advancements in treating genetic heart conditions by staying informed and engaged. In the Thick of It is brought to you by the HCM Society and is produced by Earfluence .…
Are the symptoms of nonobstructive hypertrophic cardiomyopathy (nHCM) holding patients back from living their fullest lives? Join Dr. Melissa Lyle and Dr. Michelle Kittleson as they unravel the mysteries of nHCM symptoms like congestion, angina, and exercise intolerance. How can we better manage these symptoms and pave the way for improved quality of life? Tune in as they explore innovative solutions, from advanced therapies to cutting-edge gene editing technologies like CRISPR, in the quest for better patient outcomes. Let's uncover the path to empowerment for nHCM patients together. In the Thick of It is brought to you by the HCM Society , and is produced by Earfluence .…
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