Megaloblastic Anemia

The Rx Bricks Podcast

Megaloblast. Now there’s a word you don’t hear every day. The root -blast (from the Greek blastos, meaning germ or bud) may be somewhat familiar since we talk about blast cells (very young hematopoietic precursor cells) in hematology. And megalo- (from the Greek megas, meaning large or great) is also used fairly frequently, as in splenomegaly (enlargement of the spleen). So does “megaloblast” just mean a large, immature cell? We’ll answer this question, and many more, in this discussion of megaloblastic anemia.

After listening to this AudioBrick, you should be able to:

• Describe the pathogenesis of megaloblastic anemia.
• List common causes of B12 and folate deficiency and associated nonhematologic symptoms of each.
• List and understand the characteristic complete blood count values in megaloblastic anemia.
• Describe and identify the morphologic changes present in the blood and bone marrow in a patient with megaloblastic anemia.
• Describe the treatment of megaloblastic anemia.

You can also check out the original brick on Megaloblastic Anemia from our Hematology collection, which is available for free.

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