#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!

This episode is brought to you by:

Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: https://Qlosi.com/Tim

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Coyote the card game​, which I co-created with Exploding Kittens: https://coyotegame.com

Timestamps:

• [00:00:00] Start.
• [00:00:52] Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
• [00:07:12] My recent adventures in accelerated TMS and bioelectric medicine.
• [00:21:09] The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
• [00:24:23] Aphantasia vs. hyperphantasia, and Joshua Waitzkin's ability to "feel" chess.
• [00:33:12] DORAs for sleep and Alzheimer's prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
• [00:41:21] Dale Bredesen's kitchen-sink approach to dementia and the ketogenic connection.
• [00:46:22] The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
• [00:49:40] Google's full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
• [00:52:50] The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
• [00:58:05] Kevin's three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
• [01:02:05] Holiday gift ideas and recommended reading.
• [01:17:41] The Way App and meditation with Zen master Henry Shukman.
• [01:21:44] Kevin's AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
• [01:26:58] Oboe.fyi: The AI learning platform and my investment philosophy.
• [01:32:09] My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
• [01:38:17] Terry Real's relationship wisdom: Why objective reality has no place in an argument.
• [01:47:18] Dog updates: Molly, a new puppy, and Toaster on rapamycin.
• [01:47:58] Parting thoughts and happy holidays.

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