GDF11 and the Brain with Ceren Ozek

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In this week's episode, Ceren Ozek joins us to discuss how Growth Differentiation Factor 11, GDF11, affects the ageing process in the brain.
As the brain ages, it's cognitive functions also decline, which can have huge effects on quality of life. Identified as a potential longevity factor found in the blood in 2014, GDF11 might have the potential to slow the ageing process in brain areas such as the hippocampus.
This episode discusses the initial parabiosis experiments in young/old mice, the controversy surrounding GDF11's effects on skeletal muscle, the role that the vasculature plays in mediating the effects on the brain, and experimental designs.
Ceren Ozek is a Postdoctoral Fellow in the Rubin lab, within Harvard’s Stem Cell and Regenerative Biology Department. Ceren completed her Ph.D. in Neuroscience at the University of Pennsylvania before coming to Harvard.

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