How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
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Mini Episode: Fundamentals: Testings Tests, Addictions vs Dependence, How Do We Alter Drug Absorption, What Do Drugs Do?
MP3•Episode home
Manage episode 337597531 series 3382933
Content provided by Ryan Feldman and Ryan Feldman PharmD DABAT. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Ryan Feldman and Ryan Feldman PharmD DABAT or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Concepts in this episode
- testing our tests
- Sensitivity: Rate of Positive test in those who have the disease
- Specificity: Rate of negative test in those without the disease
- Positive predictive value: True positive/ True Positive + False Positive
- Negative predictive value: True negative/True negative + False negative
- (PK) Bioavailablity = Amount of drug available to be used by the body
- Oral Bioavailablity= Dose- Fraction excreted unchanged- Fraction metabolized in gut- Fraction metabolized by liver
- How drugs interact with the body (PD)
- Agonist- stimulates receptor
- Partial agonist- Activation of receptor with ceiling effect, never achieves maximal activation
- Antagonist- Prevents receptor activation
- Inverse agonist- induces an opposite effect as an agonist after binding receptor
- Addiction vs dependance
- Addiction- Relationship between user and substance
- A few definitions but frequently involving consequences in life from use and loss of control over use of substance
- Dependence- Physiologic changes in body due to chronic use
- Down regulation of stimulated receptors
- Physiologic basis for tolerance and withdrawal
- Addiction- Relationship between user and substance
54 episodes
MP3•Episode home
Manage episode 337597531 series 3382933
Content provided by Ryan Feldman and Ryan Feldman PharmD DABAT. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Ryan Feldman and Ryan Feldman PharmD DABAT or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Concepts in this episode
- testing our tests
- Sensitivity: Rate of Positive test in those who have the disease
- Specificity: Rate of negative test in those without the disease
- Positive predictive value: True positive/ True Positive + False Positive
- Negative predictive value: True negative/True negative + False negative
- (PK) Bioavailablity = Amount of drug available to be used by the body
- Oral Bioavailablity= Dose- Fraction excreted unchanged- Fraction metabolized in gut- Fraction metabolized by liver
- How drugs interact with the body (PD)
- Agonist- stimulates receptor
- Partial agonist- Activation of receptor with ceiling effect, never achieves maximal activation
- Antagonist- Prevents receptor activation
- Inverse agonist- induces an opposite effect as an agonist after binding receptor
- Addiction vs dependance
- Addiction- Relationship between user and substance
- A few definitions but frequently involving consequences in life from use and loss of control over use of substance
- Dependence- Physiologic changes in body due to chronic use
- Down regulation of stimulated receptors
- Physiologic basis for tolerance and withdrawal
- Addiction- Relationship between user and substance
54 episodes
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