What you need to know about today’s top cardiovascular trials in five minutes flat. Join Dr C Michael Gibson for brief interviews with the principal investigators
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Investigating Innovative Cardiovascular Research at the Intersection of Academic Theory and Clinical Practice. Podcasts are also available on most podcast services including Apple, Google and Pocket Cast
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At Patient Pulse, we aim to improve understanding of difficult topics in cardiology and medicine. Easy enough for the layman, but detailed enough for someone who wants to know more about their condition or that of a loved one. Also available on Apple Podcasts, Google Podcasts and most other services. Subscribe to have new podcasts sent directly to your player.
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Coronary Inflammation, Heart Attack Risk and use of CT angiography With Dr Stefan Neubauer
9:27
9:27
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Prof. Stefan Neubauer and Dr. Thomas Nero discuss two recent papers on the utility of coronary inflammation imaging on CT coronary angiography and how that translates to increased heart events. Beyond cholesterol, coronary inflammation is being revealed to be a significant risk factor with future treatments under development. Prof. Neubauer is the …
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Coronary Inflammation Imaging with FAI Score on CT angiography with Prof. Stefan Neubauer
45:30
45:30
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Send us a Text Message. Prof. Stefan Neubauer and Dr. Thomas Nero discuss two recent papers on the utility of coronary inflammation imaging on CT coronary angiography with Fat Attenuation Index (FAI)FAI score. The ORFAN study demonstrated a 20 fold increased risk in CV event rates with low vs high FAI score and a 10 fold increased event rate in pat…
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How to Read and Understand Clinical Trials with Dr C. Michael Gibson
10:33
10:33
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Dr Nero and Dr Gibson discuss how to understand the information when looking at clinical trial data. Is it meaningful for a patient? Did the trail population match the patient's risks and medical problems? The also discuss the importance of Shared Decision Making and the use of Absolute Risk Reduction and Number Needed To Treat when interpreting th…
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Trial Statistics, Trial Design and AI with Dr. C Michael Gibson
34:28
34:28
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Send us a Text Message. Dr Gibson and Dr Nero discuss the oft maligned issue of medical statistics. Their discussion covers the pros and cons of traditional Cox proportional hazards regression models and Kaplan-Meier curves and newer techniques including win ratios. They then dip their toes into AI. A great overview by one of our leading clinical t…
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Improving Cardiac Health, A Fireside Chat with Jeff Scott and Dr Thomas Nero
1:01:10
1:01:10
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Jeff Scott, CEO of Section 810 communication, interviews Dr. Nero on ways to improve cardiac health. The cover a wide range of topics, from diet and exercise to medical therapy and advanced testing. Some future research topics are also discussed. Section 810 Communications is a training and development company based in Greenwich, CT. The interview …
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Deep Dive into Lp(a) with Dr Steven Nissen Part 2 of 2
48:10
48:10
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Send us a Text Message. This episode is a deep dive into Lipoprotein a with Dr Steven Nissen from the Cleveland Clinic. He and Dr Nero discuss the genetics of Lp(a), its pathophysiology, current treatment strategies and research into lowering Lp(a) levels. This is a fascinating conversation that also discusses the role of coronary inflammation in t…
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Dr Steven Nissen and Dr Thomas Nero discuss the importance of Lipoprotein a -aka Lp(a)- and its clinical importance as a special type of LDL cholesterol which dramatically increases your cardiovascular risk. They also covers why it important to get it tested at least once and what you can do to lower your risk of heart attack if you have it. If you…
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Lp(a): a basic clinical approach with Dr. Steven Nissen Part 1 of 2
11:00
11:00
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Send us a Text Message. Dr Steven Nissen from the Cleveland Clinic discuses with Dr. Thomas Nero the basic clinical approach to Lp(a) with need for routine testing and a few simple case studies. In the second (longer podcast) they take a deep deep dive into Lp(a) genetic, pathophysiology and the current research trials.…
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Coronary Artery Disease in the Endurance Athlete with Dr Aaron Baggish
41:40
41:40
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Send us a Text Message. Dr Thomas Nero speaks with Dr Aaron Baggish about coronary artery disease in the endurance athlete (and non-athlete as well!) They discuss cardiovascular testing in Masters athletes including ETT, coronary calcium scoring and CT angiography as well as risk factor identification, inflammation, physical & emotional stress and …
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Exercise and Coronary Artery Disease With Dr Aaron Baggish
14:16
14:16
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Dr Nero discusses coronary artery disease and exercise with Dr. Aaron Baggish. Dr Baggish was the founder of the Cardiovascular Performance Program at the Mass General Hospital and is one of the best known sports cardiologists in the world. They discuss the importance of exercise, coronary artery disease in the endurance athlete and current cardiov…
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Treatment of Atrial Fibrillation with Dr John Mandrola
12:28
12:28
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Dr. Thomas Nero interviews Dr. John Mandrola on his approach to treating atrial fibrillation. In addition to a nuts and bolts approach they discuss how to assess risk and shared decision making.By Thomas Nero, MD
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Atrial Fibrillation and Clinical Trials with Dr John Mandrola
48:30
48:30
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48:30
Send us a Text Message. Dr Mandrola discusses recent trail data with Dr. Thomas Nero including the results from Artesia, NOAH Afnet 6, Frail AF, Azalea and Oceanic-AF. They also discuss Left Atrial Appendage Occlusion and utility of wearable devices. Finally, a shout out to Dr. Andre Foy and his work on multi-morbidity and its role in clinical tria…
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Coronary Calcium Score and CT Coronary Angiography with Dr. Mathew Budoff
24:35
24:35
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Send us a Text Message. Dr. Thomas Nero speaks with Dr. Mathew Budoff about Coronary Calcium Scoring, CT Coronary Angiography and cardiovascular outcomes. The discussion goes beyond basic risk factor enhancement, highlighting its role to help evaluate disease progression, power future clinical trials and determine efficacy of therapy. Along the way…
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Coronary Calcium Scores and CT Angiograms with Dr. Mathew Budoff
8:36
8:36
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Dr Mathew Budoff discusses the importance of Coronary Artery Calcium Scoring and CT Coronary Angiography to prevent and treat heart disease with Dr. Thomas Nero. In addition they discuss new goals for treating cholesterol based on the CAC. If you enjoy this podcast you can also listen to a longer, in depth discussion on FUTURE PULSE CARDIOLOGY.…
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African American Heart Study with Dr Elizabeth Ofili and Iyana Liburd
17:38
17:38
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Dr. Ofili and Iyana discuss their experience with the African American Heart Study and why it is so important to be involved.By Thomas Nero, MD
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Dr Elizabeth Ofili and The African American Heart Study
34:24
34:24
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Send us a Text Message. Dr. Elizabeth Ofili discusses the African American Heart Study with Dr. Thomas Nero. They also discuss her work at the NIH and the African American Heart Failure Trial and the role of community based pragmatic clinical trials.By Thomas Nero MD FACC
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Anticoagulation, Thombin Generation and Factor XI inhibition in ACS and Atrial Fibrillation with Dr C. Michael Gibson
30:16
30:16
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30:16
Send us a Text Message. Dr. Thomas Nero discusses current therapy with Factor X inhibitors, the new research with Factor XI inhibition and specifically the enrolling Milvexian clinical trials with Dr. C Micahel Gibson. In addition they discuss, the addition of these medications along wiht anti-platelet therapy, Lp(a) and other interesting current a…
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Blood Thinners in Atrial Fibrillaiton and Coronary Atery Disease with Dr.Michael Gibson
14:14
14:14
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Dr Gibson from Harvard's Baim Institue discusses anticoagulants for atrial fibrillation and coronary artery disease with Dr. Thomas Nero. The also discuss the concern about bleeding with current medical therapy and future options for patients.By Thomas Nero, MD
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Diabetes and Cardiovascular Disease, SGLT2 inhibitors and GLP1 receptor agonists with Dr. Peter Toth
45:58
45:58
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Send us a Text Message. Dr. Thomas Nero speaks with Dr Peter Toth about the dramatic change occuring in diabtetes management and its effect on cardiovascular disease. Starting with the biochemestry of diabetes and its effects at the cellular level, the discussion goes on to speak about the role SGLT2 inhibitors and GLP1 receptor agonists play in DM…
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Weight Loss and CV Outcomes with Ozempic, Munjaro and Similar Drugs with Dr. Peter Toth
7:22
7:22
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Dr Peter Toth discusses with Dr. Thomas Nero the new classes of diabetes medications, SGLT2 inhibitors (eg Jardiance) and GLP1 receptor agonists (eg Ozempic and Munjaro.) These drugs have been in the news due to an impressive effect on weight reduction, but they also improve cardiovascular outcomes in diabetic and non-diabetic patients.…
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Lipids, Lipid Sub-fractionations and Inflammation, Putting It All Together with Dr Peter Toth
34:58
34:58
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Send us a Text Message. Dr. Thomas Nero speaks with Dr. Peter Toth about the complex biology of lipids and atherosclerosis. In this episode Dr Toth dives into LDL goals, therapies for attenuating non-LDL risk, vascular biology and the where are research studies lead us in choosing therapies.By Thomas Nero MD FACC
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Reducing Heart Attack Risk with Dr. Peter Toth
7:47
7:47
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In this brief discussion, Dr. Toth discusses the current recommendations on decreasing cardiovascular risk and where we are headed to decrease your risk of a heart attack.By Thomas Nero, MD
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Inflammation, Coronary Artery Disease and hs-CRP with Dr Paul Ridker
12:19
12:19
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Coronary inflammation is the final pathway for the development of coronary artery disease. Dr. Paul Ridker discusses the role of inflammation, hs-CRP and therapies with Dr. Thomas Nero.By Thomas Nero, MD
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Inflammation and Coronary Artery Disease with Dr Paul Ridker
40:52
40:52
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40:52
Send us a Text Message. Dr Paul Ridker discusses his paper on residual inflammatory risk that was recently published in the Lancet with Dr. Thomas Nero. He discusses the pathology of inflammation as part of atherosclerosis, utilization of hs-CRP in clinical trials and in daily practice as well as current therapeutic options and ongoing investigatio…
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Evolve MI and Pragmatic Clinical Trials with Dr. Christopher Cannon
9:30
9:30
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Dr Christopher Cannon discusses the EVOLVE-MI trial to decrease cholesterol with Evolocumab early after Myocardial Infarction as well as the rational for a less intensive way to study patients with open label, pragmatic clinical trials.By Thomas Nero, MD
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Pragmatic Clinical Trials and EVOLVE-MI with Dr Christopher Cannon
21:01
21:01
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Send us a Text Message. Dr Christopher Cannon discusses the potential of Pragmatic Clinical Trials in our research armamentarium with Dr. Thomas Nero. They review the EVOLVE-MI trial for Early use of Evolocumab after Myocardial Infarction in detail and highlight the potential for future research.By Thomas Nero MD FACC
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Spontaneous Coronary Artery Dissection (SCAD) with Dr. Sharonne Hayes Part 2
23:42
23:42
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Send us a Text Message. Dr Sharoanne Hayes and Dr. Thomas Nero continue their discussion of SCAD focusing on genetics, trial design and the role of online registries as well as the holistic treatment of the SCAD patient. This is part two of two.By Thomas Nero MD FACC
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Spontaneous Coronary Artery Dissection (SCAD) with Dr. Sharonne Hayes Part 1
26:13
26:13
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Send us a Text Message. Dr Sharonne Hayes of the May Clinic discusses SCAD with Dr. Thomas Nero. Initially focusing on the new treatment paradigms, their wide ranging discussion covers etiology, pathophysiology and potential future therapeutic options. Tis is the first of a two part podcast.By Thomas Nero MD FACC
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1
Spontaneous Coronary Artery Dissection and Heart Disease in Women
16:24
16:24
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Dr Kebrina Bartley discuses Spontaneous Coronary Artery Dissection (SCAD) and Heart Disease in Women with Dr Sharonne Hayes, Professor of Medicine at the Mayo Clinic. Their wide ranging conversation discuses SCAD, the difference between SCAD and atherosclerotic heart disease and approaching the female patient who presents with chest pain. The also …
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Dr. Kabrina Bartley interviews Dr. Thomas Nero on ways patients can improve their outcomes by understanding their medical issues and becoming more involved with their care. These a a few very simple steps anyone can doBy Thomas Nero, MD
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Evaluation of Coronary Inflammation with CT angiography and Fat Attenuation Indexing
28:00
28:00
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28:00
Send us a Text Message. Dr. Nero discusses evaluation of coronary artery disease and coronary inflammaiton with Dr. Cheerag Shirodaria from the University of Oxford. Dr. Shirodaria along with Prof. Charalambos Antonidies at Caristo Diagnostics have developed a ground breaking technology that allows us to evaluate not just the severity of a coronary…
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1
Evaluation of Coronary Artery Disease and Inflammation
8:15
8:15
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Dr. Nero discusses with ways to evaluate coronary artery disease with Dr. Cheerag Shirodaria from Oxford. Dr. Shirodaria and his team at Caristo Diagnostics have developed a ground breaking technology that allows us to evaluate not just the severity of a coronary artery lesion, but also how inflamed it is and how likely it is to cause a heart attac…
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Legal Aspects of FDA approval and implications for clinical research
23:13
23:13
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Send us a Text Message. Prof. Christine Coughlin of Wake Forest School of Law speaks with Dr. Thomas Nero on the FDA approval process, emergency use authorization, Right to Try Legislation and the implications for clinical research, diversity and health care equity. Prof. Coughlin holds positions in the College of Medicine as well as the Law school…
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Cholesterol Management and Statin Associated Muscle Symptoms
16:56
16:56
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Dr. Kebrina Bartley discusses cholesterol management with Dr. Thomas Nero. They go over the important roll that statins play in coronary artery disease prevention especially in association with diet and exercise. The also discuss other options for lowering cholesterol and briefly discuss the approach to treating patients who feel that they may be h…
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If you REALLY want to understand what your doctor is telling you and how she came to the decisions that she did, then you have to know a little bit about medical statistics. In this episode, we will go over how we make a diagnosis with testing, how to measure benefit of a treatment in relative vs absolute risk reduction , and how to "judge" a study…
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Understanding cholesterol is an important part of understanding your risk of heart disease and stroke. Your total cholesterol is made up of LDL (The bad cholesterol), HDL (the good cholesterol) and Triglycerides (which are also bad). Since it is made up of both bad and good parts, total cholesterol can be misleading. In this episode we introduce, N…
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At Patients First, we aim to improve understanding of difficult topics in cardiology and medicine in general. Easy enough for the layman, but detailed enough for someone who wants to know more about their condition or that of a loved one. This first episode introduces the topic of outcomes based research and evidence based medicine. It also discuss…
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Coronary Artery Disease in the Athlete with Dr Paul Thompson
23:31
23:31
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Send us a Text Message. Although exercise usually provides a cardiovascular benefit, there is some data that points to an increase in event rates in extreme endurance athletes. In this episode, Dr. Thomas Nero and Dr. Paul Thompson discuss the surprising findings regarding coronary calcium, cardiac troponins and atrial fibrillation in the endurance…
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Statin Associated Muscle Symptoms with Dr Thomas Nero and Dr Paul Thompson
22:41
22:41
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22:41
Send us a Text Message. Dr Nero and Dr Thomposn discuss Statin Associated Muscle Symptoms (SAMS) and the results of the STOMP and SAMSON trials. In addition, they discuss statins and athletic training, options for the statin intolerant patient and research regarding further investigation of the ranitadine receptor among other topics…
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CAD, Lipid Sub-fractionation and Lp(a) with Dr Paul Thompson
20:43
20:43
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Send us a Text Message. Our inaugural podcast is a discussion between Dr. Paul Thompson, Chief of Cardiology, Emeritus, at Hartford Hospital and Professor of Medicine, Emeritus, at University of Connecticut and Dr. Thomas Nero, Director of Cardiovascular Research at CAFC about coronary artery disease, lipid sub-fractionation and the role of lipopro…
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Send us a Text Message. I’m Dr Thomas Nero. At Future Pulse our goal is to investigate the future of cardiovascular research and promote that discussion. What is the next step and how will this trickle down to our clinical practice? What’s exciting and new in our field and why should we be interested. We will also look at the other side of the equa…
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Trials and PIs with Dr Michael Gibson #17: DANPACE with Dr Jens C Nielsen
3:12
3:12
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What you need to know about today’s top cardiovascular trials in five minutes flat. Join Dr C Michael Gibson for brief interviews with the principal investigators
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Trials and PIs with Dr Michael Gibson #16: ANTIPAF with Dr Andreas Goette
5:41
5:41
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What you need to know about today’s top cardiovascular trials in five minutes flat. Join Dr C Michael Gibson for brief interviews with the principal investigators
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Trials and PIs with Dr Michael Gibson #15: AVERROES with Dr Stuart J Connolly
5:41
5:41
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What you need to know about today’s top cardiovascular trials in five minutes flat. Join Dr C Michael Gibson for brief interviews with the principal investigators
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Trials and PIs with Dr Michael Gibson #14: FUTURA OASIS 8 with Dr Sanjit Jolly
5:06
5:06
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What you need to know about today’s top cardiovascular trials in five minutes flat. Join Dr C Michael Gibson for brief interviews with the principal investigators
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Trials and PIs with Dr Michael Gibson #13: RESPONSE with Dr Ron J Peters
4:17
4:17
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What you need to know about today’s top cardiovascular trials in five minutes flat. Join Dr C Michael Gibson for brief interviews with the principal investigators
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Trials and PIs with Dr Michael Gibson #12: Double-blind, placebo-controlled phase 2 studies of E5555 in Japanese patients with ACS and CAD with Dr Shinya Goto
3:56
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What you need to know about today’s top cardiovascular trials in five minutes flat. Join Dr C Michael Gibson for brief interviews with the principal investigators
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Trials and PIs with Dr Michael Gibson #11: ART with Dr David P Taggart
6:22
6:22
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What you need to know about today’s top cardiovascular trials in five minutes flat. Join Dr C Michael Gibson for brief interviews with the principal investigators
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Trials and PIs with Dr Michael Gibson #10: HEBE III with Dr A Voors
6:11
6:11
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What you need to know about today’s top cardiovascular trials in five minutes flat. Join Dr C Michael Gibson for brief interviews with the principal investigators
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Trials and PIs with Dr Michael Gibson #9: PCI: State of the art with Dr Sunil Rao
3:33
3:33
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What you need to know about today’s top cardiovascular trials in five minutes flat. Join Dr C Michael Gibson for brief interviews with the principal investigators
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