Unlock the latest breakthroughs in thrombosis diagnosis and management with CLOT Conversations - the must-listen podcast for healthcare professionals. Join hosts Dr Jameel Abdulrehman, a Hematologist with specialization in Thrombosis and Hemostasis at the University Health Network in Toronto, and David Airdrie, the Executive Director of Thrombosis Canada, as they delve into new research and explore the evolving field of thrombosis in 15 to 30 minute easily digestible episodes. Learn from the ...
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The official podcast feed of MDedge Hematology-Oncology, part of the Medscape Professional Network. On Thursdays, Dr. David Henry interviews key opinion leaders and rising stars in hematology and oncology. The information in this podcast is provided for informational and educational purposes only.
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ANNEXA-4 G.I. Sub-analysis - Dr Deborah Siegal
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23:56
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Dr Deborah Siegal joins us for a discussion on the recent paper, The Efficacy and Safety of Andexanet Alfa in Patients With Acute Gastrointestinal Bleeding While Taking Factor Xa Inhibitors: An ANNEXA-4 Sub-analysis. In this wide-ranging discussion she reviews the results of the sub-analysis and the need for anticoagulant reversal for acute GI blee…
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ISTH 2023 COVID Guideline Update - Schulman & Sholzberg
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32:51
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This episode of CLOT Conversations features Dr Sam Schulman (Hamilton) and Dr Michelle Sholzberg (Toronto) discussing the 2023 ISTH update of the 2022 ISTH guidelines for antithrombotic treatment in COVID-19 of which they were two of the co-authors. While COVID-19 is no longer considered a global emergency, healthcare professionals continue to see …
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Pharmacokinetics of DOACS after Bariatric Surgery - Gunka & Mithoowani
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20:06
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This podcast episode features Dr. Barbara Gunka and Dr. Siraj Mithoowani discussing their research on how bariatric surgery affects direct oral anticoagulants (DOACs). Bariatric surgery is increasingly used to fight obesity-related health problems. However, these patients often need DOACs to prevent blood clots due to surgery and obesity. The conce…
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Spot The Clot in Cancer-associated Thrombosis - Dr Laurie Sardo & Julia Bayadinova, NP
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21:55
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This podcast features an interview with Laurie Sardo and Julia Bayadinova, experts on Cancer-associated Thrombosis, from Hamilton Ontario, authors of a series of publications in the Canadian Oncology Nursing Journal on Cancer-associated Thrombosis, called Spot the Clot. Laurie Sardo is a Nurse Practitioner in the Thrombosis Service, Department of H…
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Exploring Drug-Drug Interactions in Cancer Patients - Dr Tzu-Fei Wang
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26:22
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In Season 2, Episode 2 of CLOT Conversations from Thrombosis Canada, Dr. Tzu-Fei Wang, an associate professor and hematologist, discusses a recent study titled "The prevalence of relevant drug-drug interactions and associated clinical outcomes in patients with cancer-associated thrombosis on concurrent anticoagulation and anticancer or supportive c…
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Post-thrombotic Syndrome and the TILE Study
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28:46
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The CLOT Conversation Hosts (Dr Jameel Abdulrehman and Dr Maha Othman) discuss Post-Thrombotic Syndrome and the TILE study with two of the authors of the recently published paper, Tinzaparin Lead-in to Prevent the Post-Thrombotic syndrome study protocol, Dr Jean-Phillippe Galanaud and Dr Ilia Makedonov. In the interview the authors discuss the late…
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ISTH Interview - Dr Gregoire Le Gal interviews Dr Vicky Mai
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Dr Vicky Mai presented multiple times at the ISTH 2023. Dr Le Gal talks to her about the research that she presented and the implications. The first study that she presented was a systematic review with metaanalysis on thrombolysis in intermediate high and high risk PE. The second one was an abstract on a sub analysis of the PREDICTORS study which …
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Dr Abdulrehman interviews three researchers working in Canada who presented work at ISTH 2023 in Montreal. Dr Menal Huroy, reviews her poster on The Impact of GI Surgeries on peak plasma anti-Xa Direct Oral Anticoagulant levels, Dr Adam Suleman discusses his research on The Risk iof VTE in Primary CNS Lymphoma: A Systematic Review and Dr Ismail Ras…
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Statins & Post-thrombotic Syndrome - The Evidence
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Join us for an in-depth conversation with Dr Lucia Caiano and Dr Tzu-Fei Wang, two of the authors of a review exploring the potential role of statins in preventing post-thrombotic syndrome (PTS), a frequent long-term complication of deep vein thrombosis (DVT). They dive into their systematic review and meta-analysis, discussing the intriguing findi…
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The HIGHLOW Study with Dr Saskia Middeldorp & Dr Hanke Wiegers
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20:33
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In this episode of CLOT Conversations we interview Dr Saskia Middeldorp and Dr Hanke Wiegers, authors of the groundbreaking Highlow study. This open-label, multicenter, randomized controlled trial aimed to determine the optimal dose of low-molecular-weight heparin (LMWH) for pregnant and postpartum women with a history of venous thromboembolism (VT…
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Thrombotic & Bleeding Outcomes following AC interruption in NVAF and Ca with Dr Joseph Shaw & Dr Tzu-Fei Wang
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25:45
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Don't miss our latest podcast interview with Dr Joseph Shaw and Dr Tzu-Fei Wang who discuss insights from their single-center retrospective cohort study, which included 264 patients with nonvalvular AF and Cancer undergoing 302 periprocedural interruptions. Learn about the primary endpoints, which were the 30-day risks of arterial thromboembolism a…
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DOACs vs VKAs in thrombotic APS - Dr Jean Connors & Dr Behnood Bikdeli
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20:29
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In this interview, two of the authors of the paper Direct oral anticoagulants vs vitamin-K antagonists in thrombotic antiphospholipid syndrome: meta-analysis of randomized controlled trials, Dr Jean Connors and Dr Benhood Bikdeli, provide listeners with an overview of their systematic review and meta-analysis that evaluated the efficacy and safety …
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Antithrombotic Stewardship with Dr Maral Koolian & Ryan Kerzner
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36:33
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Are you curious about how to improve the safety and effectiveness of anticoagulant prescriptions for hospitalized patients? Join us for an exclusive interview with two of the authors (Dr Maral Koolian and Pharmacist Ryan Kerzner ) of a groundbreaking study on anticoagulation stewardship program at the Montreal Jewish General Hospital. Our guests wi…
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Diagnosis & Mgmt of SCPCD with Dr M Othman & Dr L Brandao
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31:39
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In this episode we interview two of the authors of a recent paper, Diagnosis and management of severe congenital protein C deficiency (SCPCD): Communication from the SSC of the ISTH, Dr Maha Othman and Dr Leonardo Brandao on this paper from the Journal of Thrombosis and Haemostasis. 2022;20:1735–1743. Severe congenital protein C deficiency (SCPCD) …
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Br J Haem VTE & COC Review and Meta-analysis Abdulrehman & Skeith
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Two of the co-authors (Dr Jameel Abdulrehman and Dr Leslie Skeith) of the recently published review and meta-analysis, "Recurrence after stopping anticoagulants in women with combined oral contraceptive-associated venous thromboembolism: A systematic review and meta-analysis" (https://doi.org/10.1111/bjh.18331) discuss the clinical relevance of the…
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2022 CHEST Perioperative Guidelines with Dr J Douketis
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21:00
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In this episode we will be discussing a recent paper published in CHEST entitled Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline with lead author Dr Jim Douketis. Dr. Douketis is Staff Physician in General Internal Medicine and Clinical Thromboembolism at St. Joseph’s Healthcar…
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mRNA COVID Vaccines & VTE with M Nicholson and N Chan
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26:54
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In this episode have a conversation with Dr Matthew Nicholson and Dr Noel Chan on their recent publication from Blood Review entitled No apparent association between mRNA COVID-19 vaccination and venous thromboembolism (https://www.sciencedirect.com/science/article/pii/S0268960X22000443) which was co-authored by Dr Hadi Goubran and Dr Deborah Siega…
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ISTH 2022 Day 4 Highlights with Thrombosis Canada
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This episode recorded at the ISTH2022 meeting in London features interviews with Dr Rita Selby and Dr James Douketis with Dr Jameel Abdulrehman. Support the show https://thrombosiscanada.ca Take a look at our healthcare professional and patient resources, videos and publications on thrombosis from the expert members of Thrombosis Canada…
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ISTH 2022 Day 3 Highlights with Thrombosis Canada
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Thrombosis Canada members Mark Crowther and Taylor Drury join host Jameel Abdulrehman in a discussion on some highlights from the 2022 ISTH meeting in London. Support the show https://thrombosiscanada.ca Take a look at our healthcare professional and patient resources, videos and publications on thrombosis from the expert members of Thrombosis Cana…
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ISTH 2022 Day 2 Highlights with Thrombosis Canada
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Thrombosis Canada members Jameel Abdulrehman, Tsu-Fei Wang, Marc Carrier, Joseph Shaw and Yan Xu discuss their highlights from day 2 of the ISTH 2022 program. Support the show https://thrombosiscanada.ca Take a look at our healthcare professional and patient resources, videos and publications on thrombosis from the expert members of Thrombosis Cana…
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ISTH2022 Day 1 with Jameel Abdulrehman and Maha Othman
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9:23
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The 2022 International Society on Thrombosis and Haemostasis (ISTH) annual meeting is the first fully in-person meeting since the start of the pandemic in 2020. A number of Thrombosis Canada members are attending sessions throughout the program and we have invited those who can, to share their insights from the sessions that they think are key with…
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CCS 2022 PAD Guidelines with Dr Sonia Anand and Dr Eric Kaplovitch
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45:08
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In this episode we discuss a recent paper published in The Canadian Journal of Cardiology entitled Canadian Cardiovascular Society 2022 Guidelines for Peripheral Arterial Disease and co-authored by a national team of Canadian expertsWe are joined today by the two of the authors, Dr Sonia Anand and Dr. Eric KaplovitchDr. Sonia Anand is Professor of …
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New GI Guidelines on Management of GI Bleeds with Alan Barkun & Jim Douketis
36:11
36:11
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In this episode we discuss a recent paper published jointly in The American Journal of Gastroenterology and the Journal of the Canadian Association of Gastroenterology entitled American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastro…
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The RAPID Trial - a discussion with Dr Michelle Sholzberg
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24:08
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In this episode have a conversation with Dr Michelle Sholzberg on her recent publication from the British Medical Journal entitled Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinica…
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Risk of VTE Recurrence with Subsegmental PE not anticoagulated
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18:21
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Welcome to Episode 6 of CLOT Conversations from Thrombosis Canada. In this episode Dr Jameel Abdulrehman and David Airdrie are joined by Dr Gregoire Le Gal and Dr Marc Carrier, two of the authors of a recently published paper on the entitled Risk for Recurrent Venous Thromboembolism in Patients With Subsegmental Pulmonary Embolism Managed Without A…
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POISE-3 Tranexamic Acid in Noncardiac Surgery
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Welcome to Episode 5 of CLOT Conversations from Thrombosis Canada. In this episode Dr Jameel Abdulrehman and David Airdrie are joined by Dr PJ Devereaux and Dr M Marcucci, two of the authors of a recently published paper on the POISE-3 study entitled Tranexamic Acid in Patients Undergoing Noncardiac Surgery. The paper was published in the New Engla…
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Anti-seizure & Anticoagulant medications & interactions
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This is Episode 4 of CLOT Conversations from Thrombosis Canada. In this episode Dr Jameel Abdulrehman and David Airdrie are joined by Dr Vinai Bhagirath and Dr Sam Schulman, two of the authors of a recently published paper entitled Carbamazepine, phenytoin, and oral anticoagulants: Drug-drug interaction and clinical events in a retrospective cohort…
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Evaluation of definitions of OAC-associated major bleeding
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22:33
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In this episode Dr Jameel Abdulrehman and David Airdrie are joined by Dr Yan Xu, one of the authors of a recently published review paper entitled Evaluation of definitions for oral anticoagulant-associated major bleeding: A population-based cohort study, co-authored by Yan Xu, Tara Gomes, Philip S. Wells, Priscila Pequeno, Ana Johnson, and Michelle…
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Canadian Cancer-associated Thrombosis Algorithm Update 2021
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In this episode we are joined by Dr Vicky Tagalakis and Dr Marc Carrier, two of the authors of a recently published review paper entitled Treatment Algorithm in Cancer-Associated Thrombosis: Updated Canadian Expert Consensus. The paper was published in Current Oncology (Curr. Oncol. 2021, 28, 5434–5451. https://www.mdpi.com/1718-7729/28/6/453). The…
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Episode 1: Interview with Dr Sameer Parpia and Dr Kerstin De Wit
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19:19
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Welcome to Episode 1 of CLOT Conversations from Thrombosis Canada. In this episode Dr Jameel Abdulrehman and David Airdrie are joined by Dr Sameer Parpia and Dr Kerstin De Wit, two of the authors of a recently published paper entitled Diagnosis of deep vein thrombosis with D-dimer adjusted to clinical probability: prospective diagnostic management …
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An introduction to CLOT Conversations a new podcast for healthcare professionals with interviews and discussions on advances in thrombosis management. Support the show https://thrombosiscanada.ca Take a look at our healthcare professional and patient resources, videos and publications on thrombosis from the expert members of Thrombosis Canada…
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Existing biosimilars are safe, effective alternatives to their reference biologics, and are increasingly being incorporated into oncology treatment guidelines. Technological advances that have emerged in the years since biologic agents entered the market allow for the careful assessment of “critical clinical attributes” of biosimilar agents. This h…
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Advanced bladder cancer: Dr. Arjun Balar talks treatment strategies in a changing field
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Systemic treatment for advanced urothelial cancer is quickly evolving. On this week’s podcast, Arjun Balar, MD, director of the genitourinary medical oncology program at New York University discusses his approach amid changing times with guest host Alan Lyss, MD, a community-based medical oncologist and clinical researcher in the St. Louis area bef…
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Gene therapies in hemophilia with Dr. Glenn Pierce
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24:10
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A “very basic” type of gene therapy could potentially cure hemophilia, but a major hurdle has been the lack of an effective mode of delivery. Recent strides in using adeno-associated virus (AAV) vectors are changing that, and Glenn Pierce, MD, World Federation of Hemophilia Vice President, Medical, predicts approvals in the next 12-18 months. Dr. P…
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Thrombosis and thrombocytopenia caused by COVID-19 vaccines: How to identify and treat VITT, VIPIT, or TTS
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At least 17 cases of thrombosis and thrombocytopenia have been reported in patients who received the Johnson & Johnson COVID-19 vaccine in the United States. Such events have been reported in patients who received the AstraZeneca vaccine as well. In this episode, Adam C. Cuker, MD, of the University of Pennsylvania, Philadelphia, tells host David H…
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Toward more personalized treatment in prostate cancer: The CCR score predicts metastasis and guides treatment decisions after radiation
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28:23
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The combined clinical cell-cycle risk (CCR) score uses clinical and genetic factors to assess the risk of metastasis after radiation therapy in patients with prostate cancer. The CCR score has proven accurate in studies and can guide post-radiation treatment decisions in practice, according to Jonathan D. Tward, MD, PhD, of the University of Utah, …
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Changing perspectives: Dr. Michael Weiner recounts his experiences as an oncologist who became a cancer patient and then a caregiver
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Pediatric oncologists are used to dealing with emotional, heart-wrenching situations, but oncology took on a new dimension for Michael Weiner, MD, when both he and his daughter were diagnosed with cancer. Dr. Weiner, a pediatric oncologist at Columbia University, New York, describes his roles as oncologist, patient, and caregiver to host David H. H…
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Optimizing CAR T-cell therapies in lymphoma: Improving response, fighting cytokine release syndrome, and identifying mechanisms of resistance
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Studies have shown that chimeric antigen receptor (CAR) T-cell therapies produce responses in patients with relapsed/refractory B-cell lymphomas, but researchers continue to look for ways to improve efficacy, decrease toxicity, and overcome treatment resistance. Leslie Kean, MD, PhD, of Boston Children’s Hospital, discusses some of this research wi…
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Trends in genetic testing for breast and ovarian cancer: Undertesting and racial/ethnic disparities persist
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Researchers have tracked the evolution of genetic germline testing in women with breast or ovarian cancer in recent years and reported the results in the Journal of Clinical Oncology. Study author Allison W. Kurian, MD, of Stanford (Calif.) University, describes the group’s findings (https://bit.ly/31RaSGR) to guest host Alan Lyss, MD, subprincipal…
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Improving cancer screening in the COVID era: Drive By Flu-FIT allows for socially distanced colorectal cancer screening
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A program called Drive By Flu-FIT has allowed for socially distanced colorectal cancer (CRC) screening during the COVID-19 pandemic. Armenta Washington, senior research coordinator at the University of Pennsylvania, describes the program to guest host Alan Lyss, MD, subprincipal investigator emeritus for Heartland Cancer Research NCORP, in this epi…
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Unpacking von Willebrand disease guidelines: Dr. Paula James talks diagnosis and pre-procedure prophylaxis
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Earlier this year, clinical practice guidelines for the diagnosis and management of von Willebrand disease (VWD) were published in Blood Advances. The guidelines (https://bit.ly/2OIfKLE) are a collaborative effort from the American Society of Hematology, the International Society on Thrombosis and Haemostasis, the National Hemophilia Foundation, an…
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FDA approvals in hematology and oncology, Part II: New oral formulations, RET and MET inhibitors, and CAR T-cell therapies
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We continue our review of drugs recently approved by the Food and Drug Administration (FDA) in the hematology/oncology space. In part 1 of our review, David M. Mintzer, MD, of Pennsylvania Hospital, highlighted 11 therapies, including newly-approved treatments and new indications for older drugs. Part 1 was published Feb. 18 (https://bit.ly/38JR782…
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How I treat CLL and MCL: From ‘watch and wait’ to BCL2 and BTK inhibitors, CAR T-cell therapy, and transplant
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Treatments for chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) have advanced in recent years, with more new developments on the horizon. James Gerson, MD, of the University of Pennsylvania, Philadelphia, reviewed some of these advances and future directions while describing how he would treat three patients. Host David H. Henry, M…
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COVID-19 vaccination in cancer patients: Who should be vaccinated and when?
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When should cancer patients receive a COVID-19 vaccine? The National Comprehensive Cancer Network (NCCN) has issued recommendations to provide guidance on the topic. Guideline author Steven Pergam, MD, of Fred Hutchinson Cancer Research Center, Seattle, explains NCCN’s recommendations to host David H. Henry, MD, in this episode. Prioritization Prio…
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Managing pain in sickle cell crisis with Dr. Ifeyinwa Osunkwo
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Ifeyinwa (Ify) Osunkwo, MD, MPH, joins us to talk about her approach to pain management in patients suffering from sickle cell crisis as well as the cognitive and behavioral effects of long-term opioid use in these patients. She and our host David H. Henry, MD, cover these topics and more in this episode. Dr. Osunkwo is a professor of medicine at A…
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FDA approvals in hematology and oncology: Novel agents and new tricks for old drugs
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23:25
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In this episode, we review drugs recently approved by the Food and Drug Administration in the hematology/oncology space. David M. Mintzer, MD, of Pennsylvania Hospital, joins host David H. Henry, MD, to highlight some first-time approvals and new indications for older drugs. Approvals in 2020 Pembrolizumab (Keytruda) was approved for a range of new…
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NCI-MATCH trial reveals actionable mutations and matches cancer patients to targeted therapies
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The NCI-MATCH trial was designed to reveal mutations in underexplored cancer types, allowing researchers to match patients to appropriate targeted therapies. Study investigator Alice P. Chen, MD, from the National Cancer Institute, reviews the goals and results of NCI-MATCH with host David H. Henry, MD, in this episode. Trial details NCI-MATCH has …
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COVID-19 vaccine 101: Dr. Drew Weissman discusses mechanisms, efficacy, and vaccinating patients with cancer or HIV
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How do the various COVID-19 vaccines work, and when should patients be vaccinated? We tackle these topics and more in this episode. Our host David H. Henry, MD, is joined by Drew Weissman, MD, PhD, a professor at the University of Pennsylvania, Philadelphia. Dr. Weissman codeveloped the messenger RNA (mRNA) technology being used in the COVID-19 vac…
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Barriers to clinical trial enrollment for patients with gynecologic cancers: Why patients don’t participate and how to improve enrollment
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The greatest barrier to clinical trial enrollment is patients not knowing an appropriate trial exists, according to a survey of gynecologic cancer survivors. The most common reason survey respondents gave for not enrolling in clinical trials was that their medical team didn't tell them about any trials. Annie Ellis and Mary (Dicey) Jackson Scroggin…
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Convalescent plasma for COVID-19, race linked to cancer-associated thrombosis risk, iron deficiency common in pregnancy, and more from ‘Best of ASH’
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New studies have shed additional light on how convalescent plasma may affect patients with COVID-19, how blood type impacts bleeding risk, the effects of race on cancer-associated thrombosis, and iron deficiency in pregnancy. These studies were presented as part of the “Best of ASH” session at the 2020 annual meeting of the American Society of Hema…
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