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Some of the world's greatest scientists, doctors and medical researchers share their discoveries and visions onstage at the TED conference, TEDx events and partner events around the world. You can also download these and many other videos free on TED.com, with an interactive English transcript and subtitles in up to 80 languages. TED is a nonprofit devoted to Ideas Worth Spreading.
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The Department of Physics public lecture series. An exciting series of lectures about the research at Oxford Physics take place throughout the academic year. Looking at topics diverse as the creation of the universe to the science of climate change. Features episodes previously published as: (1) 'Oxford Physics Alumni': "Informal interviews with physics alumni at events, lectures and other alumni related activities." (2) 'Physics and Philosophy: Arguments, Experiments and a Few Things in Bet ...
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Artwork
 
The Department of Statistics at Oxford is a world leader in research including computational statistics and statistical methodology, applied probability, bioinformatics and mathematical genetics. In the 2014 Research Excellence Framework (REF), Oxford's Mathematical Sciences submission was ranked overall best in the UK. This is an exciting time for the Department. We have now moved into our new home on St Giles and we are currently settling in. The new building provides improved lecture and ...
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Featuring the video recorded proceedings of events held in conjunction with important scientific symposia, live webcasts and closed meetings featuring the perspectives of renowned clinical investigators, these videos provide an overview of important advances in the management of a number of solid tumors and hematologic cancers.
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CTisus.com is advancing diagnostic imaging and the quality of patient care by educating radiologists, radiology technologists, and other professionals in the principles and practice of CT scanning. This podcast supplements and enhances the cutting-edge materials found on CTisus.com.
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Featuring slide presentations and related discussion from Dr Lipika Goyal, Dr James J Harding, Dr Milind Javle and Dr Robin K (Katie) Kelley, including the following topics: Current Role of Immunotherapeutic Strategies for Advanced Biliary Tract Cancers (BTCs) — Dr Kelley (0:00) Case: A man in his late 60s with advanced distal cholangiocarcinoma tr…
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Featuring perspectives from Dr Pamela Kunz and Dr Simron Singh, including the following topics: Introduction (0:00) Overview (4:04) Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors (NETs) (27:07) Multitarget Tyrosine Kinase Inhibitors for the Treatment of NETs (39:37) Other New Advances in the Management of NETs (50:29) CME informati…
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Featuring perspectives from Dr Tanios Bekaii-Saab and Dr John Strickler, including the following topics: Introduction: Back-to-School Special (0:00) Biomarker Assays in Advanced Gastrointestinal (GI) Cancers (10:12) Sequencing of Treatment for HER2-Positive GI Cancers (28:37) Toxicities Associated with Anti-HER2 Treatment (48:32) Novel Agents and S…
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Featuring slide presentations and related discussion from Dr Pasi A Jänne, Prof Tom John, Dr Zofia Piotrowska and Dr Alexander I Spira, including the following topics: Recent Advances in the Management of Localized and Locally Advanced Non-Small Cell Lung Cancer (NSCLC) with an EGFR Mutation — Prof John (0:00) First-Line Treatment for Advanced NSCL…
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Featuring perspectives from Dr Mrinal Gounder, including the following topics: Epidemiology, classification, genetics and diagnosis of sarcomas (0:00) Contemporary medical treatment of sarcomas (5:29) Targeted therapy for the treatment of sarcomas (9:01) Incidence, pathophysiology, classifications and clinical manifestations of liposarcomas (16:27)…
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Featuring perspectives from Prof Peter Schmid and Dr Sara M Tolaney, including the following topics: Introduction: Pharmacology and Sequencing of Antibody-Drug Conjugates (ADCs) in Metastatic Breast Cancer (mBC) (0:00) Expanding Role of TROP2-Directed ADCs in mBC Management — Dr Tolaney (21:42) Other Targets for ADC Therapy in mBC — Prof Schmid (44…
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Inside the Issue: Integrating Antibody-Drug Conjugates into the Management of HR-Positive and Triple-Negative Metastatic Breast Cancer | Faculty Presentation 2: Other Targets for ADC Therapy in mBC — Professor Peter Schmid, FRCP, MD, PhD CME information and select publicationsBy Dr. Neil Love
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Inside the Issue: Integrating Antibody-Drug Conjugates into the Management of HR-Positive and Triple-Negative Metastatic Breast Cancer | Faculty Presentation 1: Expanding Role of TROP2-Directed Antibody-Drug Conjugates (ADCs) in Metastatic Breast Cancer (mBC) Management — Sara M Tolaney, MD, MPH CME information and select publications…
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Haiyang Kehoe, USGS Seismograms contain information of an earthquake source, its path through the earth, and the local geologic conditions near a recording site. Ground shaking felt on Earth’s surface is modified by each of these contributions–the spatiotemporal evolution of rupture, three-dimensional subsurface structure, and site cond…
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Featuring a slide presentation and related discussion from Dr Michiel van der Heijden, including the following topics: Efficacy and safety data from the Phase III EV-302/KEYNOTE-A39 trial comparing enfortumab vedotin/pembrolizumab to chemotherapy for patients with previously untreated metastatic urothelial bladder cancer (mUBC) (0:00) Principal fin…
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Featuring an interview with Dr Michiel van der Heijden, including the following topics: Underlying biological mechanisms of the bladder cancer immune micro-environment in the context of response to immune checkpoint inhibition (0:00) Treatment patterns and survival outcomes for patients admitted to the intensive care unit due to immune-related adve…
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Featuring a slide presentation and related discussion from Dr Priyanka Sharma, including the following topics: Biomarker Assays in the Identification and Prognostication of Patients with Breast Cancer (0:00) Utility of Circulating Tumor DNA in the Prognostication of Localized Breast Cancer (24:28) Treatment of HR-Positive, HER2-Negative Advanced Br…
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Tara Nye, USGS Models of earthquake ground motion (both simulations and ground-motion models) can be likened to a puzzle with three primary pieces representing the earthquake source, site conditions, and source-to-site path. Early versions of these models were developed using average behavior of earthquakes across a variety of regions and tectonic …
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Featuring an interview with Prof Giuseppe Curigliano, including the following topics: Counseling patients with newly diagnosed metastatic breast cancer (mBC); role of patient-reported outcomes and advocacy (0:00) Individualized selection of up-front therapy for patients with HR-positive, HER2-negative mBC (6:02) Selection and sequencing of treatmen…
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Featuring an interview with Dr Angeles Alvarez Secord, including the following topics: Front-line management of ovarian cancer (0:00) Management of relapsed/refractory ovarian cancer (20:06) Management of microsatellite instability-high/mismatch repair-deficient endometrial cancer (23:20) Management of microsatellite stable/mismatch repair-proficie…
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Inside the Issue: Integrating ALK-Targeted Therapy into the Management of Localized Non-Small Cell Lung Cancer | Faculty Presentation 1: Significance of Biomarker Testing in Localized Non-Small Cell Lung Cancer (NSCLC) and Historical Management Paradigm for ALK-Positive Disease — Professor Solange Peters, MD, PhD CME information and select publicat…
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Inside the Issue: Integrating ALK-Targeted Therapy into the Management of Localized Non-Small Cell Lung Cancer | Faculty Presentation 2: Emerging Role and Practical Application of ALK-Targeted Therapy in Localized NSCLC — Professor Ben Solomon, MBBS, PhD CME information and select publicationsBy Dr. Neil Love
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Featuring perspectives from Prof Solange Peters and Prof Ben Solomon, including the following topics: Introduction (0:00) Significance of Biomarker Testing in Localized Non-Small Cell Lung Cancer (NSCLC) and Historical Management Paradigm for ALK-Positive Disease — Prof Peters (9:17) Emerging Role and Practical Application of ALK-Targeted Therapy i…
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Rashid Shams, University of Southern California Site response in sedimentary basins is partially governed by mechanisms associated with three-dimensional features. This includes the generation of propagating surface waves due to trapped and refracted seismic waves, focusing of seismic energy due to basin shape and size, and resonance of the entire …
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Featuring perspectives from Dr Sara A Hurvitz, including the following topics: Case: A woman in her late 40s who received treatment for triple-negative breast cancer develops lung metastases 2 years later (0:00) Clinical trials investigating TROP2-targeting antibody-drug conjugates (13:28) Identifying and targeting HER2 in HER2 low-expressing disea…
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Featuring perspectives from Dr Melissa Johnson, Dr Ticiana Leal and Dr Manish Patel, including the following topics: Introduction: Two Faces of Lung Cancer Research (0:00) B7-H3-Targeted Antibody-Drug Conjugates for Lung Cancer — Dr Patel (16:14) Potential Role of Tumor Treating Fields in the Management of Metastatic Non-Small Cell Lung Cancer — Dr…
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Amy Williamson, University of California Berkeley Alerts sent through earthquake early warning (EEW) programs provide precious seconds for those alerted to take simple protective actions to mitigate their seismic risk. Programs like ShakeAlert have been providing alerts for felt earthquakes across the west coast of the US for almost 5 years. Earthq…
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Featuring perspectives from Dr Jesús G Berdeja and Dr Thomas Martin, including the following topics: Introduction: Real-World Regulatory Issues in Multiple Myeloma (MM) (0:00) Newly Diagnosed MM (14:30) Novel Agents for Relapsed/Refractory MM (24:58) Chimeric Antigen Receptor T-Cell Therapy and Bispecific Antibodies (44:28) CME information and sele…
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Featuring perspectives from Dr Evan J Lipson, including the following topics: Introduction: Johns Hopkins University (0:00) Metastatic Melanoma (8:21) Nonmetastatic Melanoma and Other Skin Cancers (34:20) CME information and select publicationsBy Dr. Neil Love
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James Biemiller, USGS An unresolved aspect of tsunami generation in great subduction earthquakes is the offshore competition between coseismic deformation mechanisms, such as shallow megathrust slip, slip on one or more splay faults, and off-fault plastic deformation. In this presentation, we first review results from data-constrained 3D dynamic ru…
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Featuring an interview with Dr Joyce O’Shaughnessy, including the following topics: Overview of CDK Inhibition for Metastatic Breast Cancer (0:00) Features of High-Risk, HR-Positive, HER2-Negative Localized Breast Cancer (7:45) Sequencing and Selection of CDK4/6 Inhibitors (23:28) Management of Toxicities Associated with CDK Inhibitors and Promotin…
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Featuring perspectives from Dr Matthew Gubens, including the following topics: Introduction: Risk of Autoimmune Toxicity with Checkpoint Inhibitors (0:00) Immunotherapy in the Neoadjuvant/Adjuvant Setting (7:33) Immunotherapy for Locally Advanced Non-Small Cell Lung Cancer (NSCLC) (15:45) First-Line Immunotherapy for Metastatic NSCLC (24:04) Novel …
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Featuring an interview with Dr Matthew R Smith, including the following topics: Selection and sequencing of androgen-targeting therapies (0:00) Evidence-based selection of treatment for metastatic hormone-sensitive prostate cancer (25:07) New considerations with the use of PARP inhibitors for metastatic castration-resistant prostate cancer (mCRPC) …
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Featuring an interview with Dr Kimberly H Allison, including the following topics: Contemporary practices in pathology and reporting biomarkers of interest (0:00) HER2 testing across numerous solid tumor types (2:47) ER-low reporting category and pathologic interpretation (6:28) PD-1/PD-L1 testing methodology and challenges with bone biopsies (10:5…
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Featuring a slide presentation and related discussion from Dr Kimberly H Allison, including the following topics: Pathological assessment of HER2 and appropriate testing methodologies (0:00) Effect of the DESTINY-Breast04 study on clinical practice (12:32) Relevancy of HER2-ultralow expression and implications of the DESTINY-Breast06 study (22:53) …
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Jaeseok Lee, Brown University Field observations indicate that fault systems are structurally complex, yet fault slip behavior has predominantly been attributed to local fault plane properties, such as friction parameters and roughness. Although relatively unexplored, emerging observations highlight the importance of fault system geometry in the me…
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Featuring perspectives from Dr Dana M Chase, including the following topics: Introduction: ASCO 2024 Review (0:00) Ovarian Cancer (14:29) HER2 as a Therapeutic Target (29:18) Endometrial Cancer (38:55) Cervical Cancer (51:11) CME information and select publicationsBy Dr. Neil Love
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Featuring an interview with Dr Jonathan W Goldman, including the following topics: Contemporary and Future Care for Patients with Nonmetastatic Non-Small Cell Lung Cancer (NSCLC) with an EGFR Mutation (0:00) Evolving First-Line Treatment for Metastatic NSCLC with an EGFR Mutation (21:05) Other Emerging Strategies for Relapsed Metastatic Lung Cancer…
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Thomas Lee, Harvard University Since the first seismograms were recorded in the late 19th century, the seismological community has accumulated millions of ground motion records on both paper and film. While almost all analog seismic recording ended by the late 20th century, replaced by digital media, the still-extant archives of paper and film seis…
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Featuring perspectives from Dr Nikhil I Khushalani and Dr Jason J Luke, including the following topics: Introduction (0:00) Evidence-Based Treatment of Nonmetastatic and Metastatic Melanoma — Dr Luke (2:49) Optimizing the Management of Nonmelanoma Skin Cancers — Dr Khushalani (36:54) CME information and select publications…
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Featuring perspectives from Dr Rana R McKay and Prof Thomas Powles, including the following topics: Introduction (0:00) Management of Metastatic Clear Cell Renal Cell Carcinoma (RCC) — Prof Powles (12:39) Treatment Approaches for Nonmetastatic RCC; Optimal Care of Patients with Non-Clear Cell RCC — Dr McKay (49:27) CME information and select public…
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Ross Maguire, University of Illinois Urbana-Champaign Seismic source parameters – including hypocentral locations and focal mechanism solutions – provide the most direct constraints for understanding tectonic stresses and deformation processes within planetary interiors. The SEIS (Seismic Experiment for Interior Structure) seismometer d…
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Featuring perspectives from Dr Scott Kopetz and Dr John Strickler, including the following topics: Introduction (0:00) Recent Therapeutic Advances in Colorectal Cancer (CRC) — Dr Strickler (1:53) New Developments in Targeted Therapy for Metastatic CRC — Dr Kopetz (35:11) CME information and select publications…
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Featuring perspectives from Dr Joshua Brody, Dr Ian W Flinn and Dr Tycel Phillips, including the following topics: Introduction: CD3 Bispecific Antibodies in the Community Oncology Setting (0:00) Integration of Bispecific Antibody Therapy into the Management of Diffuse Large B-Cell Lymphoma — Dr Phillips (18:13) Current and Future Role of Bispecifi…
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Featuring perspectives from Dr Kevin Kalinsky and Dr Heather McArthur, including the following topics: Introduction (0:00) Case: A woman in her mid 80s with a 2.7-cm residual tumor after neoadjuvant pembrolizumab/chemotherapy for localized triple-negative breast cancer (TNBC) — Ranju Gupta, MD (3:31) Question and Comments: Approach to neoadjuvant t…
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Roland Burgmann, University of California Berkeley Decadal changes in aseismic fault slip rate on partially coupled faults reflect long-term changes in fault loading and/or fault-frictional properties that can be related to earthquake cycle processes. We consider constraints on aseismic fault slip rates from historical alignment array measurements,…
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Featuring perspectives from Dr Rafael Fonseca, Dr María-Victoria Mateos and Dr Elizabeth O’Donnell, moderated by Dr O’Donnell, including the following topics: Introduction (0:00) Treatment Approaches for Newly Diagnosed Multiple Myeloma (MM) — Dr Fonseca (2:05) Role of Chimeric Antigen Receptor T-Cell Therapy and Bispecific Antibodies in the Care o…
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