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Transformation in Trials

Sam Parnell & Ivanna Rosendal

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A podcast about the transformations in clinical trial. As life science companies are pressured to deliver novel drugs faster, data, processes, applications, roles and change itself is changing. We speak to people in the industry that experience these transformations up close and make sense of how the pressure can become a catalyst for transformation.
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Maneuvering Monday

Ivanna Rosendal & Anne Katrine Carlsson Sejr

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In this podcast, we invite you to follow the fictional story of Marie as she maneuvers the organizational culture and dysfunctions in the company Zebra Apps. Once a week, we invite guest experts to discuss what happens in the episode, and provide tools and insights into what Marie could do. Let's maneuver Mondays together!
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The Circle

Faisal Kamal

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Where MedTech and Sci-Fi Collide! In The Circle Podcast we welcome you into the world of innovators & leaders from the Medical and Health Technology space. Through the projectionlens of Sci-Fi stories, prepare to meet, the who's who in the Medicon Valley... Circle! ---------------------- Hosted by Faisal Kamal Faisal holds a Masters Degree in Pharmaceutical Science from Copenhagen University, where he has acted as an external lecturer. Faisal is an experienced Regulatory Affairs professional ...
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What does Star Trek have to do with medical device safety? More than you think. 🚀⚕️ In this episode of The Circle Podcast, we journey from the starship Enterprise to the heart of modern MedTech — exploring how imagination, engineering discipline, and global safety standards like IEC 60601 shape the future of healthcare.Join host Faisal Kamal and sp…
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Send us a text What if millions of electronic health records could transform how we understand medicine? In this thought-provoking conversation with Dr. Manfred Stapff, physician and real-world evidence pioneer, we uncover how anonymized patient data is revolutionizing healthcare research. Dr. Stapff reveals how the 21st Century Cures Act dramatica…
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Send us a text Cloud computing is transforming biotech by offering purpose-built infrastructure that supports AI-driven drug discovery and development while meeting strict regulatory requirements. Dr. Ilya Burkov explains how Nebius provides full-stack solutions that democratize access to powerful technology, enabling researchers to achieve breakth…
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Send us a text Dominik Lysek, CEO of PharmaTrail, explains how blockchain technology can solve trust issues in clinical trials by providing an incorruptible audit trail that verifies data integrity. This solution could significantly accelerate the time required for regulatory approvals, partnerships, and acquisitions, ultimately getting treatments …
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Send us a text Dr. Shervin Molayem shares his journey of innovation in dentistry, starting with his discovery of a connection between periodontal disease and COVID-19 severity that became the world's most-read dental article of 2020. He discusses groundbreaking technologies including AI-powered diagnostic tools and a revolutionary non-surgical trea…
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Send us a text Chris Wood discusses how early diagnostics of lung cancer through artificial intelligence and medical imaging can lead to better survival rates through early intervention. • Lung cancer takes more lives than breast, prostate and colon cancer combined, with approximately 70% of cases caught at late stages • The National Lung Screening…
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Send us a text Building high-performing teams in life sciences requires understanding how neurodiversity can be an advantage and designing work systems that enable different brain types to collaborate effectively. • A high-performing team continues to function when everything around it has fallen apart • Star players can become crutches that mask u…
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Send us a text Sebastian Andruszczak, Chief Growth Officer at Holisticon (part of the Nexer Group), brings fresh perspective to the conversation around generative AI adoption in pharmaceutical companies. Drawing from his unique background in sales, marketing, and technology, Sebastian cuts through the hype to address fundamental challenges that pre…
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Send us a text Why do we wait until we're severely unwell before seeking help? In this thought-provoking episode, I'm joined by Eva Papadopoulou, a mental health professional and expert in digital and AI-enabled healthcare solutions, to explore the transformative potential of preventative mental healthcare. Eva reveals the stark reality of our curr…
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Send us a text Rob Freistat, President of Uncommon Cures, discusses how clinical trials are transforming to accelerate drug development and ensure patients receive treatments faster, particularly in the rare disease space. • Current market uncertainty and investment challenges in biotech, especially for rare disease research • Approximately two-thi…
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Send us a text Jonathan Hill takes us on a fascinating journey through the cutting-edge world of DNA sequencing and its revolutionary potential for early disease detection. As both an academic professor at Brigham Young University and co-founder of Wasatch BioLabs, Hill shares how third-generation sequencing technologies are transforming our abilit…
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Send us a text Vectors are the unsung heroes of cell and gene therapy—molecular couriers that transport therapeutic genes into human cells to treat disease. But as Alan Griffith, Head of Global Operations at Vector Builder reveals, creating these sophisticated delivery vehicles is far more complex than most realize. Drawing from over a decade of ex…
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Send us a text The untapped potential of electronic health records has long been recognized in clinical research, but extracting meaningful insights from this treasure trove of data has remained an elusive challenge—until now. Vish Srivastava, founder of Century Health, reveals how artificial intelligence is revolutionizing real-world evidence by u…
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Send us a text Join us for a conversation with guest Shelli Pavone, co-founder of Inlightened, to uncover the untapped potential of diversity in clinical trials. Discover how historical mistrust, structural barriers, and exclusion criteria continue to hinder diverse patient recruitment. Shelli sheds light on the transformative impact inclusive tria…
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Send us a text In this episode we dive into Brain-Computer Interface (BCI) technology, where the brain's faint signals are harnessed to create life-changing applications. Andreas Forsland and Greg Johns emphasize the importance of community-driven innovation, guided by the Brainiac Council—a unique assembly of patients, caregivers, and experts. Thi…
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Send us a text This episode reveals alarming statistics about patient access to clinical trials, highlighting that only 3% of patients currently have access to participate. Our guest, Jill Pellegrino, CEO of Auto Recruitment, shares innovative strategies to engage the other 90% of the patient population and discusses the importance of digital adver…
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Send us a text Why has SAS been the cornerstone of clinical trials for decades, and what is causing the shift to R now? Join us on "Transformation in Trials" as we explore this pivotal transition with Sunil Gupta, a seasoned programmer who has navigated both worlds. Sunil elaborates on SAS's long-standing dominance due to its robust programming cap…
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Send us a text Prepare to transform your understanding of vendor oversight in clinical trials as we welcome Jessica Cordes, a senior consultant and trainer at the Clinical Excellence Consultancy. Jessica brings her wealth of experience to highlight the intricate responsibilities that sponsors must navigate when outsourcing tasks. Our conversation p…
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Send us a text In this final episode of Maneuvering Monday the podcast, AK and Ivanna wrap up everything and share the next steps for our book project. There is a bit of heavy breathing (sorry!) as we discuss Natalie and her trajectory, and how she ends up finally connecting with her purpose and passion after having suffered from 'The Peter Princip…
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Send us a text Our very last guest on the podcast, Cecil 'Gary' Rupp, is an expert in leadership, business transformation, and Lean-Agile frameworks. With both executive management and management consulting experience, Gary brings a unique perspective to what our friends in Zebra Apps need to be doing to save their own future. Value stream mapping …
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Send us a text Richard himself makes an appearance in the meeting, where a group of Zebra employees investigate scenarios for the company's survival. The tension builds as it becomes clear that Zebra Apps will not make it for much longer with its current setup. But then what? What do you think Marie should do? Join the conversation on our LinkedIn …
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Send us a text To kick off the final chapter of Marie's story, we are lucky to be accompanied by Sofie Henriksen, who is a leader within strategy in a digital innovation agency. Sofie brings her insightful perspectives to the table as we intersect how personalities, actions, and behaviors are understood and worked with in the context of Zebra Apps.…
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Send us a text Marie and the engineers talk to an advisory board of parents and teachers to get feedback on ASLO, and share the concerning results with Natalie and the leadership team, who finally seem to listen. Natalie, who used to be a teacher herself, decides to take things into her own hands. The engineers start setting shared objectives for e…
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Send us a text In the final commentary episode of chapter 5, we are happy to welcome Katja Schipperheijn, internationally awarded author, learning influencer, futurist and keynote speaker on learning, innovation and being human in a digital world. With years of experience from the EdTech company, Katja is the perfect match to guide Zebra Apps at th…
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Send us a text In the final part of chapter 5, things start to get real when Marie learns from Willie that Natalie purchased spare parts from Russia for Zebra Apps' physical data center, and that she likely traveled there together with Frank and Andrea. She also learns that every time the engineers create new features for ASLO, they increase their …
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Send us a text In this commentary episode, we are pleased to talk to Paul Hargreaves, CEO of Cotswold Fayre & Flourish and renowned author of the books Forces For Good and The Fourth Bottom Line about purpose-driven and compassionate leadership. We wish Zebra Apps had a CEO like Paul. And not just as Chief Executive Officer, but Chief Empowerment O…
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Send us a text Marie interviews the engineers to map out who work on the different aspects of ASLO. She learns that they belong to two teams, and uses an animal metaphor to convince Jenni to reorganize the engineering department to fix the quality issues, and to start funding the teams in a way that ensures continuous improvement. Marie meets up wi…
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Send us a text In the first part of chapter 5, we have invited guest expert Michelle Leedy, who is an organization effectiveness, design and transformation business leader, passionate about creating value and positive impact through authentic leadership. Michelle brings more than 20 years experience in consulting and leadership roles across multipl…
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Send us a text In this first section of chapter 5, the UX Designer Jason makes a comeback at Zebra Apps. A mysterious meeting is taking place with attendance by the full leadership team and a white-bearded man. And Marie's colleague and employee Erik once again urges her to use her informal power and influence to help the engineers fix their dysfun…
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Send us a text How do you navigate the complexities of manufacturing cell and gene therapies that are tailored to individual patients? Find out as we sit down with Dr. Bruce Levine from the University of Pennsylvania to unpack the intricacies of clinical research in this groundbreaking field. From the unique emphasis on chemistry, manufacturing, an…
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Send us a text What if re-engaging with your purpose could revolutionize your job satisfaction and mental health? Join us for our conversation with Jill Donahue, a leader in life sciences whose personal journey through psychology, behavioral science, and a profound personal tragedy has fueled her mission to improve communication and trust within th…
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Send us a text When nine out of ten clinical trials don't cross the finish line, it's time to ask tough questions and seek innovative answers. That's exactly the journey we embark on with Vinodh Balaraman from KolateAI in our latest podcast episode. Together, we unravel the complex knot of challenges that lead to clinical trial failures, from flawe…
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Send us a text Navigating the tumultuous sea of inflammatory bowel disease (IBD) is no small feat, and Ariadna Maso of Sanno Health is our compass on this voyage. As the mastermind behind a company that's reshaping how we understand and manage gut health, Ari shares her intimate understanding of the patient's struggle, from the stinging uncertainty…
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Send us a text This week we sit down with Erini Schlosser, CEO of Dyania Health, and chart the pioneering advancements in large language models within healthcare. This episode promises to reveal how the shift from simple entity recognition to sophisticated reasoning models has revolutionized drug discovery and the curation of electronic medical rec…
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Send us a text Uncover how the seamless fusion of wearables with patient data is revolutionizing clinical trials in our latest conversation with Wessam Sonbol, the Founder and CEO of Delve Health. We navigate the transformation from cumbersome paper reporting to the sophisticated use of Patient Reported Outcomes and the continuous insights wearable…
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Send us a text Unlock the secrets of clinical trial design with industry experts Pierre Colin and Boaz Adler as they join us for a deep dive into the early-stage planning that shapes the future of pharmaceuticals. They provide a look at the collaboration between clinicians, statisticians, and regulatory experts that's critical for determining the r…
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Send us a text Embark on a journey through the dynamic landscape of clinical trial outsourcing with Jason Gubb, the co-founder of ClinOps Clarity and Emergent Teams. As we navigate the historical shift from predominantly in-house operations to the intricate web of external partnerships, Jason sheds light on the critical decision-making processes th…
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Send us a text In this conversation with Sam Whitaker, we delve into the pivotal issues faced by underrepresented groups—particularly those from lower-income backgrounds—highlighting the disparity in current demographics and the consequences it bears on the reliability of drug efficacy and safety data for diverse populations. We go beyond the surfa…
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Send us a text This week we speak to Boaz Adler from Cytel's Software Division. This episode promises to illuminate the intricacies of trial design through the lens of Monte Carlo simulation, revealing how this potent approach crafts trials resilient to a myriad of scenarios. Boaz delves into the pivotal roles of interim monitoring and strategic ma…
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Send us a text Ever wondered why the life sciences industry is stuck in redundant vendor qualification processes? Picture an organization where quality is designed rather than inspected. Yes, it's possible and we're about to paint that picture for you in this stimulating conversation with our guests, Dele Babalola and Rani Naik. They've got their f…
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Send us a text Get ready to learn about clinical trials operations from an expert. This episode is an opportunity to learn all about the essential aspects of managing such trials and the core role of contract research organizations (CROs) in the process. We have the privilege of introducing Becky Baggett, Associate Vice President of Project Deliver…
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Send us a text Ever wondered what goes into designing a modern, adaptable, and inclusive lab space? Join us as we uncover the intricacies of laboratory planning with architect and lab planning leader, Marilee Lloyd. Marilee takes us behind the scenes of designing new research labs, divulging the importance of flexibility, adaptability, and the use …
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Send us a text In the last commentary episode of chapter 4, we talk to Mary Lemmer, who is not only the founder of the company Improve, but also a keynote speaker, conference session facilitator, longtime entrepreneur, writer/author, and improv comedian. The story episode is full of attempts to solve the team communication and culture problems that…
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Send us a text Ever wondered about the science behind a simple cough? What if we told you that a cough is not as simple as it seems and AI technology could revolutionize how we perceive it? Come along as we host Dr. Peter Small, acoustic epidemiologist and Chief Medical Officer of Hyfe, who enlightens us on the complexity of measuring coughs in cli…
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Send us a text Marie and Mark are interviewing for the CFO position, and Marie learns from the employees in the Finance department that they are not wishing for a specialist manager, but a leader to represent them in the management team. Natalie suggests the VP of Sales, Jaque, which disappoints Mark. Jason returns to Zebra Apps, and Paul bakes cin…
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Send us a text Join us in a conversation with Nechama Katan, as we investigate the world of generative AI in life sciences, a realm where technology meets business, and where Nechama, an expert in innovative data in the clinical space of life sciences, will guide us. We're taking a deep dive into the ever-evolving realm of technology in life scienc…
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