Best Nucleic Podcasts (2024)

1
Therapeutic nucleic acids – a CDMO’s view on mRNA 32:04

1d ago32:04

32:04

While some of us knew a good bit about mRNA prior to 2020, we all got a crash course on mRNA technology and its prophylactic and therapeutic potential as a result of the COVID pandemic and subsequent SARS CoV-2 vaccine development. In fact, most of us have now received at least one mRNA vaccine at this point. Our guest for this episode, Dr. Christi…

1
Episode 19 - Alex MacKerell: Simple physics, missing experimental data, and model compatibility 26:14

3d ago26:14

26:14

Send us a text In episode 19, Alex and I discuss the history and future of developments in the CHARMM family of force fields, and whether Alex believes there is more physics that we need to include in our classical energy functions to work around our current challenges in biomolecular modeling. Throughout the conversation, he's advocated for a prag…

1
Episode 18 - Erik Lindahl: Finding simple and novel ideas, starting an experimental lab, and ligand-gated ion channels 36:58

10d ago36:58

36:58

Send us a text In Episode 18, Erik Lindahl reminds us that despite our dependence on computational power and advanced technology, real breakthroughs are often waiting for those who have the patience to think carefully, come up with eye-opening ideas, and follow their sense of purpose. We discuss the different ways to be smart in science, highlighti…

1
Episode 17 - Caroline Lynn Kamerlin: Deep interdisciplinarity, enzyme promiscuity, and science in society 40:30

17d ago40:30

40:30

Send us a text In episode seventeen, Caroline Lynn Kamerlin talks about the art of asking bold and impactful scientific questions, as well as how to engage in truly interdisciplinary research, something she sees as a consequence of her formal background in natural philosophy. We talk about the emerging concepts around enzyme promiscuity, how this v…

1
A molecular thermometer for the future 35:29

29d ago35:29

35:29

There are all sorts of molecular tests to tell if you’re infected with something specific, but what do you use when you’re not sure what you might have? You might use a thermometer as a first step, but wouldn’t it be nice if that thermometer was a bit more high tech? In this episode we meet Dr. Nick Meyerson, CEO and co-founder of Darwin Bioscience…

1
Episode 16½ - End-of-season 2 commentary 19:23

2M ago19:23

19:23

Send us a textBy Miłosz Wieczór

1
Directed evolution – A PETase project 32:58

2M ago32:58

32:58

Plastics are a modern miracle of science that have helped deliver both convenience and life-saving solutions. However, we must now grapple with the challenge of immense amounts of plastics in our waste streams and environment. How do we best deconstruct plastics to reusable or more bio-friendly molecules? This is the exact challenge being addressed…

1
Episode 16 - Janusz Bujnicki: Structural modeling, RNA modifications, and advising policy-makers on science 28:51

2M ago28:51

28:51

Send us a text In the sixteenth episode, Janusz Bujnicki tells me about his early switch to bioinformatics, a stroke of serendipity that defined his future career, and how he later managed to reincorporate both biophysics and experimental biology into his research agenda. We talk about the current state of the field of RNA structural prediction, an…

1
Episode 15 - Paulo CT Souza: Developing a universal coarse-grained force field, and approaching the science of molecular complexity 26:41

3M ago26:41

26:41

Send us a text In the fifteenth episode, Paulo Souza and I discuss the challenges inherent in managing a project of such a scope, and the philosophy behind the systematic way in which Martini is continuously improved and reparameterized. Paulo describes how a user-centric approach helps refine and troubleshoot the model through its widescale adopti…

1
Episode 14 - Syma Khalid: New ways to fight bacteria, the bacterial envelope, and kindness & openness in academia 23:00

3M ago23:00

23:00

Send us a text In the fourteenth episode, Syma Khalid and I talk about the challenges we're faced with when trying to understand the environment of the bacterial cell envelope, and the outer membrane in particular. We discuss how the lessons taken from the computational study of these structures can inform the design of future antibacterial agents.…

1
Episode 13 - Daniel Zuckerman: Trajectory ensembles, writing books, and learning biology through physics 29:45

3M ago29:45

29:45

Send us a text In the thirteenth episode, Daniel Zuckerman and I talk about textbooks on statistical biophysics and a physics-based vision of biology, a few of which he himself authored. Daniel reveals that his passion for clarity in writing comes from his early humanities background, and makes a case for how well-thought and physically motivated n…

1
Scientific marketing in the century of the biotech revolution 32:37

3M ago32:37

32:37

Most scientists start their education and careers with a vision of working in the lab to discover great things and drive innovation. However, we don’t all end up loving the actual lab work portion of science. What non-lab career options exist to utilize molecular biology knowledge and skills? Well, according to our guest, Jason Amsbaugh, Founder an…

1
Episode 12 - Vlad Cojocaru: Simulating transcriptional regulation, returning to our home countries, and the scales of the genome 27:12

3M ago27:12

27:12

Send us a text In the twelfth episode, Vlad Cojocaru and I discuss how the simulation field can integrate further layers of complexity in modeling transcription control and genome organization in humans. Vlad shares his insights on the computational biology of transcription factors, including DNA-mediated allostery and pioneer transcription factors…

1
Episode 11 - Justin Lemkul: Providing technical help online, sharing expertise, and polarization in nucleic acids 29:38

4M ago29:38

29:38

Send us a text In the eleventh episode, Justin Lemkul and I talk about the motivations and challenges behind providing technical help on online forums and mailing lists. Justin shares his story of becoming a prolific technical advisor for the Gromacs community, which evolves into a discussion about automatability, the role of expertise in running a…

1
Episode 10 - Ariane Nunes-Alves: Kinetics in drug design, molecular crowding, and the social life of a PI 19:13

4M ago19:13

19:13

Send us a text In the tenth episode, Ariane Nunes-Alves and I talk about a kinetics-centric view of drug design, making the case that modeling kinetics in atomistic simulation is an important frontier that, despite clear biomedical relevance, is rarely explicitly addressed either in model parameterization or with the latest AI methods. We discuss t…

1
Cheers to molecular Biology 34:47

4M ago34:47

34:47

While the end product is quite different, brewing beer is not all that different than many other bioproduction processes used in the lab and industry. Both require skills, experience, and the right QC/QA methods to control and monitor the starting materials and the entire process, all the way to that bottle of suds you might be thirsty for. Steve a…

1
Episode 9 - Michele Vendruscolo: Preventing protein misfolding, fostering public engagement of scientists, and AI tools in drug design 31:21

4M ago31:21

31:21

Send us a text In the ninth episode, Michele Vendruscolo and I discuss the current state of research on misfolding diseases, typically associated with excessive protein aggregation and formation of insoluble amyloids. Michele presents an optimistic perspective in which the convergence of recent clinical and software developments opens up new avenue…

1
Episode 8½ - My commentary: Wrapping up the first season 20:15

5M ago20:15

20:15

Send us a text In this episode, I'm attempting to string together the most common threads brought up by my guests in the first eight interviews on the podcast. Reflecting on these conversations, I'm suggesting some grand challenges for the field in the years to come.By Miłosz Wieczór

1
Unsung heroes of food health and safety 32:10

5M ago32:10

32:10

When you buy chicken or turkey from the grocery store, you might not give it much thought, but there is an entire network of people working to ensure the health of the animals in our food supply chain and your health. In this episode, we talk with an unsung hero, Beverly Wood, supervisor of the molecular diagnostics lab at the North Carolina Depart…

1
Episode 8 - Rossen Apostolov: Managing scientific collaboration, the biggest project of European biophysics, and seeding schools of thought 27:13

5M ago27:13

27:13

Send us a text In the eight episode, Rossen Apostolov and I depart from the standard format to talk about the core concepts behind BioExcel, the European Center of Excellence for computational biology. We discuss their main objectives and challenges, from working with code to organizing schools and webinars, talk about the challenges of sustaining …

1
Episode 7 - Aleksei Aksimentiev: Nanobiotechnology, the importance of mentoring, and engineering serendipity 37:38

6M ago37:38

37:38

Send us a text In the seventh episode, Aleksei Aksimentiev and I delve into the intersection of physics, biology, and nanotechnology, exploring the innovative world of nanopores and biomolecular sequencing. Aleksei shares his journey from particle physics in Ukraine to leading-edge research in the US, and underscores how on the unpredictable path o…

1
Episode 6 - Giulia Palermo: Reimagining scientific creativity, the RNA revolution, and truly multiscale systems 24:24

6M ago24:24

24:24

Send us a text In the sixth episode, Giulia Palermo and I discuss the challenges of studying truly multiscale biomolecular systems, such as the CRISPR/Cas9 complex she famously got involved with. While such problems can take us way out of our comfort zones, they also provide us with clear pathways to innovative and transformative science, something…

1
Episode 5 - Paul Robustelli: The dissolving barrier between industry and academia, embracing our artistic side, and new models of funding 30:04

6M ago30:04

30:04

Send us a text In the fifth episode, Paul Robustelli and I discuss how the once very sharp boundary between academia and industry has been becoming increasingly porous, and what implications it will have for future careers in science. Paul shares his experiences and observations about the competing models of funding scientific research, and makes a…

1
Molecular Biology for hire – the CRO experience 31:53

6M ago31:53

31:53

Contract Research Organizations (CROs) are a resource that most scientists know about but relatively few have first-hand, internal experience with. In this episode our hosts speak with Saboor Hekmaty, Director of Laboratory Operations at Avrok Biosciences, who pulls back the curtain to illuminate what CROs do, and the skills required for them to be…

1
Episode 4 - Modesto Orozco: Computations driving experiments, opening simulation data, and integrating knowledge across sources and scales 24:18

6M ago24:18

24:18

Send us a text In the fourth episode, Modesto Orozco and I talk about the rough path to the predictive power modern computational science has achieved in biology, and the immense possibilities it opens to today's computational biologists working across the scales of space and time. Modesto also reflects on why sharing simulation data is crucial to …

1
Episode 3 - Wojtek Kopeć: Science as a social endeavor, learning from industry, and the experience of starting a new lab 35:51

7M ago35:51

35:51

Send us a text In the third episode, Wojtek Kopeć and I discuss the overlooked yet exciting social aspect of scientific collaboration, and what the world of academia could learn from the industry and statisticians to avoid falling behind. Wojtek also shares his personal experience of starting a lab as a new PI, and we reflect on the role of honesty…

1
Episode 2 - Max Bonomi: Interoperability, AI-generated ensembles, and recognizing all contributions to science 24:24

7M ago24:24

24:24

Send us a text In the second episode, Max Bonomi and I discuss efforts to achieve interoperability and portability in the computational community, and how the AI structural revolution will unfold to bring us realistic molecular ensembles. We then move on to ask how the entire range of contributions to science can be recognized, particularly at the …

1
Episode 1 - Pilar Cossio: Modeling experimental setups, overpublishing, and maintaining code 27:00

7M ago27:00

27:00

Send us a text In the first episode, Pilar Cossio and I discuss the radical progress in integrating simulations with experiments, and the excitement about recent progress in modeling cryo-EM tomography data. We share thoughts on the sustainability of our publishing practices, and comment on the challenges of funding the maintenance of scientific co…

1
High-throughput transcriptomics and AI for drug discovery 31:56

7M ago31:56

31:56

Doing something complex and meaningful in a new way requires thinking and acting a bit differently. This is the case with how Dr. Joey Azofeifa, from Arpeggio Bio, is using systems biology to discover new drug candidates. Join us in this Season 2 kickoff episode where we dive headlong into transcriptomics, systems biology, machine learning, and lea…

1
Introduction: Do we really need another podcast? 6:39

7M ago6:39

6:39

Send us a text What is this all about? Does the computational community need a podcast? Along with the first interview, I'm sharing the idea behind PSI, and explaining why the time is ripe for a new marketplace of ideas to drive the changes in how we do science. Everyone is invited, from ambitious undergraduates to seasoned veterans!…

1
Season 2 Teaser 2:40

7M ago2:40

2:40

We start the second season of this series with an update on what you can expect from new episodes, which start to drop soon. Your host, Steve Lewis, shares details on changes you can expect as the series evolves. One change will be a broadening of application topics to be covered, as this season will include episodes discussing transcriptomics in b…

1
A look into the fruit bowl of biology 30:56

1y ago30:56

30:56

In this episode of Speaking of Mol Bio, we speak with Dr. Mandovi Chatterjee about single cell analysis. Dr. Chatterjee is the Director of Single Cell Core at Harvard University Medical School. She has spent her career at the exploring and mastering a wide variety of single cell methods . In conversation with Dr. Chatterjee, our hosts dive into the…

1
The intersection of biology and technology 38:45

1y ago38:45

38:45

In this episode, the hosts have an intriguing discussion with Dr. Ben Sun, Head of Biomarker Genetics at Biogen. Dr. Sun holds an MD/PhD from the University of Cambridge, providing a view and perspective on data from both research and clinical perspectives. The advantage of his unique background is that it provides a balanced perspective on large-s…

1
Multi-omics | The molecular biology of plants in space 31:59

1y ago31:59

31:59

Dr. Stan Roux, Professor of Molecular Biosciences at the University of Texas – Austin, has had a long and successful career based on his fascination with plants and his desire to understand plant biology. He’s spent his career exploring the effect of apyrase on root systems, crop yields, and plant nutrient uptake. We get into Stan’s unlikely career…

1
CRISPR | An insider’s perspective on CRISPR 31:39

1+ y ago31:39

31:39

In this episode, Gabriel and Steve welcome a colleague of theirs, Dr. Doris Beylkin, to share her depth of knowledge and perspective on the CRISPR cell engineering topic. While Doris is a Global Market Development Manager today, she has over 10 years of experience supporting customers in planning, troubleshooting, and analyzing gene modulation and …

1
Exosomes | The early realization of the exosome’s potential 32:11

1+ y ago32:11

32:11

This discussion with Dr. Johan Skog covers a lot of ground while staying super approachable. The Founder and Chief Scientific Officer of Exosome Diagnostics, starts by sharing basics about exosomes and tells us about how he’s translated his curiosity for the vesicles from tumor stem cells into his current role where he’s helped develop the world’s …

1
Lighting the touch paper for next generation nucleic acid therapies 32:06

1+ y ago32:06

32:06

In this episode Mike Ward, Clarivate’s Head of Thought Leadership for Life sciences and healthcare, spoke to Johnny Ohlson, Founder of Touchlight, a company who has developed a novel synthetic DNA vector. In recent years, we've seen that by harnessing the power of DNA, it has been possible to achieve success in treating previously incurable heredit…

1
Exosomes | Exploring the body’s extracellular delivery system 32:09

1+ y ago32:09

32:09

It’s been 40 years since extracellular vesicles, or exosomes, were first connected to the way cells communicate and transfer information. Since then, researchers have studied what part they play in the normal physiology of a cell. There has also been an expanding amount of work in the role that exosomes can play in therapeutics and diagnostics of a…

1
Multi-omics | Investigating the body’s internet 33:01

1+ y ago33:01

33:01

Multi-omics is a great example of how the scientific community is thinking larger and using complementary methods to gather deeper information to understand biology and inform medicine. Proteomics is just one of the -omes of multi-omics but it’s the one that Steve Williams, Chief Medical Officer at SomaLogic, has over 30 years’ experience in. Steve…

1
Multi-omics | The importance of science in data science 33:21

1+ y ago33:21

33:21

In this episode, we talk with Chris Whelan about the data behind science. Chris is the Director of Neuroscience, Data Science & Digital Health for Research and Development at The Janssen Pharmaceutical Companies of Johnson & Johnson, as well as the Chair of the UK Biobank Pharma Proteomics project. He connects the dots between genomics and proteomi…

1
CRISPR | Making the world better 29:57

1+ y ago29:57

29:57

Since it’s discovery, CRISPR Cas9 gene editing technology has blossomed and boomed. It’s moved from a highly technical niche technique to one that is arguably mainstream and being applied to countless challenges in applied biology. In this episode we talk with Travis Hardcastle, who previously worked in R&D to develop gene editing products and is n…

1
Season I Trailer 3:02

1+ y ago3:02

3:02

Experience the Speaking of Mol Bio podcast in its extended video format for a more immersive journey, while also ensuring accessibility with downloadable transcripts for each episode. Watch now at thermofisher.com/podcast-video A short trailer to introduce the Speaking of Mol Bio co-hosts and get their take on what the series is all about. You'll h…

1
Realizing the patient-friendly future of clinical trials 23:02

2y ago23:02

23:02

In this episode of Conversations in Healthcare, Ergomed founder Dr. Miroslav Reljanović talks to Mike Ward about how the COVID-19 pandemic has nudged clinical trials towards greater efficiency and inclusivity – and what’s needed to make good on this promising trend. Hosted on Acast. See acast.com/privacy for more information.…

1
How Patient Connect addresses unmet needs at the point of care 22:32

2+ y ago22:32

22:32

In this episode of Conversations in Healthcare, Mike Ward speaks with Dr. Grace Lomax, Clinical Director at Patient Connect, a part of Clarivate. Grace’s experience as a physician highlighted numerous unmet needs beyond just clinical issues – especially around healthcare literacy, education at the point of care, adherence and more. She discusses ho…

1
Social determinants: barriers to healthcare impacting racial and ethnic minorities 45:59

2+ y ago45:59

45:59

In this episode of Conversations in Healthcare, Matthew Arnold, Principal Analyst at Clarivate speaks with Dr. Kenton Johnston, Associate Professor of Health Management and Policy at Saint Louis University about disparities in the US health system. Matthew and Ken discuss both the historical context as well as the evolution of the system since the …

1
How Novo Ventures prioritized their investment strategy during the pandemic 25:50

3y ago25:50

25:50

In this episode of Conversations in Healthcare, Mike Ward speaks with Naveed Saddiqi, Senior Partner at Novo Ventures, one of the largest venture capital groups in the life sciences sector. Naveed shares about the firm’s mandate to generate funds for the Novo Nordisk Foundation, how the pandemic impacted their investment strategy and what excites h…

1
How Healx uses AI to transform rare disease drug discovery 27:52

3y ago27:52

27:52

In this episode of Conversations in Healthcare, Mike Ward speaks with Dr. Tim Guilliams, the co-founder and CEO of Healx. Healx is an artificial intelligence-powered technology company that's dedicated to helping rare disease patients access life improving treatments. Mike and Tim discuss the company’s innovative approach to drug discovery, choosin…

1
How the pandemic shifted Roche’s priorities and R&D investments 31:20

3y ago31:20

31:20

In this episode of Conversations in Healthcare, Mike Ward speaks with Richard Erwin, general manager and managing director of Roche Products Limited (UK), which was recorded in collaboration with One Nucleus's ON Helix conference (June 2021). Richard shares how the pandemic has shifted Roche’s priorities and why the organization has heavily increas…

1
Optimizing patient-first clinical trials with advanced site intelligence 40:56

3y ago40:56

40:56

In this episode of Conversations in Healthcare, Mike Ward speaks with Oriol Serra, former Head of Site Intelligence and Selection at Pfizer and Simon Andrews, Vice President of RWD Engagements and Innovations at Clarivate about optimizing patient-first clinical trial design and ensuring trial groups align to real-life populations and needs. The gro…

1
Showing the value of regulatory intelligence in pharma 31:32

3y ago31:32

31:32

In this episode of Conversations in Healthcare, Mike Ward speaks with Carolyn Hynes, Director of Regulatory Intelligence at AstraZeneca, and Céline Rodier, Senior Health Policy Manager at Clarivate, about strategies and tools to gather and assess regulatory intelligence, as well as KPIs and approaches to demonstrating ROI within your organization. …

Podcasts Worth a Listen

Nucleic Podcasts

Podcasts Worth a Listen

Quick Reference Guide