An award-winning podcast from the Watson Institute for International and Public Affairs at Brown University, exploring today's biggest global challenges with the world's leading experts. Listen every other week by subscribing wherever you listen to podcasts.
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Mark Blyth, political economist at Brown's Watson Institute, and Carrie Nordlund, political scientist and associate director of Brown's Master of Public Affairs program, share their take on the week's news.
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A podcast from the Rhodes Center for International Finance and Economics at the Watson Institute at Brown University. Hosted by political economist and director of the Rhodes Center, Mark Blyth.
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US immigration laws are one of the biggest challenges for startups establishing in the US market. The Startup Visa® podcast is all about US immigration issues for startup founders and international entrepreneurs. US-based startups/employers struggle to hire talented minds who often need work visas. International entrepreneurs and founders need to navigate the US immigration maze to understand how to enter the US market legally. Tahmina Watson, author of the bestselling book series "The Start ...
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Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com
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With all of these great ideas growing all over Manila, it’s only fair to give all of that talent and potential an avenue to learn, network and eventually, find an opportunity to grow. International Start Up Meetings (ISUM) aims to do just that. ISUM has been bringing together startups, professionals, business-owners, mentors and investors since 2011. From the launch in Paris and through other exciting destinations such as Vienna, Lima and Mexico, ISUM has been a platform for entrepreneurs fr ...
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EP 148: Advancing veteran health through the Million Veteran Program with Dr. Mike Gaziano, professor of medicine at Harvard Medical School
35:13
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0:00 Intro 2:00 Mike’s career prior to the Million Veteran Program (MVP), how Mike got to work on MVP, and important milestones in the project's evolution 8:30 Future goals for the Million Veteran Program in expanding and diversifying the research cohort 11:00 The roles of various omics in advancing the project's development 14:30 The most meaningf…
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EP 147: From research to delivering precision medicine in the clinic with Scott Weiss, Professor of Medicine at Harvard University
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37:19
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Scott 01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD) 04:56 How and why Scott decided to transition into genetics 06:30 The advances in our understanding of the genetics of asthma and COPD over the past 2…
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South Africa’s elections, 30 years after apartheid: part 2
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This is the second part in our two-part series on South Africa’s politics 30 years after the election of Nelson Mandela, and with it, the end of apartheid. Around the same time as that anniversary this past spring, there was another momentous event in the country: South Africans went to the polls in May, and for the first time in 30 years, the Afri…
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EP 146: The biology of aging with Austin Argentieri, Research Fellow at Harvard Medical School, Affiliate Member of the Broad Institute, and Research Fellow at Massachusetts General Hospital
43:05
43:05
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Austin 01:42 What is aging and how should we think about it? 03:50 Discussion of Austin’s recent breakthrough paper on aging, including the questions he set out to answer, and the outcomes of the research 06:32 How Austin’s work focuses on using large-scale population proteomics data to create acc…
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EP 145: Navigating rare disease drug development regulations with Daniel O’Connor
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39:12
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Daniel 02:04 Defining rare disease in the age of personalized medicine 04:57 Key touchpoints with the Medicines and Healthcare products Regulatory Agency (MHRA) when developing a new medicine 09:27 Improvements over the course of Daniel’s career when it comes to incentivizing and making the path t…
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This summer’s UK and French elections explained, with Mark Blyth
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32:56
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Over the course of 2024, roughly half of the world’s population will participate in national elections. On this episode, we take a closer look at two of them: this summer’s elections in the United Kingdom and France. In the U.K., the center-left Labour Party won in a landslide in July, ending 14 years of Conservative Party rule. In France, an allia…
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EP 144: Research Roundup with Dr. Veera: breakthroughs in developmental disorders, Parkinson's, SLE, and Alzheimer's
56:48
56:48
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0:00 Introduction 1:40 A recurrent de novo mutation in a noncoding region of a small nucleolar RNA gene that has been identified as one of the most common causes of neurodevelopmental disorders This pathogenic variant escaped notice for years because it was not located in a protein coding region of the genome It now shows potential as a target for …
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EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Scientific Officer at Pheiron
36:17
36:17
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …
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South Africa, 30 years after apartheid: part 1
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This spring marked the thirtieth anniversary of the election of Nelson Mandela as South Africa’s president and the end of apartheid, the system of legalized racial segregation that had existed in South Africa for decades. Around the same time as that anniversary, there was another momentous event in the country: South Africans went to the polls in …
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EP 142: From genome to bedside: How genetics is transforming modern medical practice with Dr. Andrea Gropman
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42:45
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0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…
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EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University
43:24
43:24
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…
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EP 140: The future of Electronic Health Records and data analysis with Ben Goldacre
52:51
52:51
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0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…
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EP 139: Rare disease breakthroughs using tRNA with Michelle Werner, CEO of Alltrna and CEO-Partner of Flagship Pioneering
44:42
44:42
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0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…
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The surprising results of India’s election
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On June 4, results came in from the largest democratic election in history. Over 640 million people voted in India’s election, which took place at over one million polling places across the country over the course of six weeks. Many predicted that India’s prime minister Nerandra Modi and his party, the Bharatiya Janata Party (BJP) would dominate th…
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The expulsion of politics? What the UK’s Office of Budget Responsibility tells us about the limits of technocracy
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When it comes to governing our economy, estimates rule the day. We want to know what effect a policy might have on the government’s budget, on economic growth, on employment…in the next 1 year, 5 years, 10 years…you get the idea. If you want to make (or critique) public policy, you better have numbers to back it up. To get those types of estimates,…
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EP 138: Personalised medicine using microbiome models with Dr. Almut Heinken
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40:22
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0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…
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EP 137: Mavis Machirori on promoting equity, diversity, and social justice in genomics research
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41:40
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0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…
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A former police officer (and public health expert) on the opioid crisis and public safety
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17:57
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For this week’s show, we’re sharing an episode of “Humans in Public Health,” a podcast from The Brown School of Public Health. It makes a great follow-up to our episode earlier this month about Rhode Island’s first-in-the-nation legally approved proposal for a safe injection site (also known as an overdose prevention center) and how such programs w…
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What should the Supreme Court’s role in our politics be?
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At the Watson Institute, the beginning of summer means commencement festivities, moving trucks, and bittersweet goodbyes. In American politics, the beginning of summer means something very different: the approach of the Supreme Court's summer recess and, with it, the handing down of the Court’s final decisions from this term. This year’s cases will…
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EP 136: Developments in ring chromosome 20 research and advocacy with Allison Watson
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40:57
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0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…
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EP 135: Integration of newborn sequencing programs into healthcare systems with Dr. Ingrid Holm
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41:16
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0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…
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How American firearms fuel violence in Mexico
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Mexico, like the United States, has a gun violence problem. It has one of the highest murder rates in the world, and most of those murders come from firearms. In 2019, for example, almost 70% of the country's 35,000 murders involved firearms. But unlike the U.S., Mexico doesn’t have tens of thousands of licensed firearms dealers. It has two. So how…
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EP 134: Prenatal genetic testing and the future of AI in genetic counselling with Kira Dineen, host of DNA Today
40:44
40:44
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0:00 Introduction 1:00 The backstory of how Kira first started DNA Today in 2012, when she was still in high school! 3:30 Some of Kira’s favourite topics she has discussed on DNA Today, including the legacy of Henrietta Lacks, and the story of a Glee actress with down syndrome 10:00 Kira’s best practices for podcasting, from over 10 years of experi…
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EP 133: Insights into pharmacogenomics and increasing diversity in genomics research with Dr. Emma Magavern
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39:17
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0:00 Introduction 2:00 The value of an English Literature degree in designing and analysing research studies in medicine 3:45 Emma’s entrance to pharmacogenomics and her transition from practising physician to genetics research 6:00 How the East London Genes and Health program is increasing representation of diverse populations, namely South Asians…
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Harm reduction, overdose prevention, and the future of treating America’s overdose epidemic
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In February of this year, Providence became the first city in America to approve opening a state-sanctioned overdose prevention center. Sometimes known as safe injection sites, these are facilities where people can bring illegal drugs and consume them under the supervision of trained volunteers and health professionals. It’s one of the boldest expe…
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Money can’t buy happiness, but it can buy citizenship abroad
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When you think of high-end luxury commodities, you might imagine yachts, private jets, or even whole islands. But in the last few years, another commodity has started to receive a lot of attention from the world’s wealthiest people: citizenship. With enough money, people can buy their way into becoming a citizen of a growing list of countries aroun…
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EP 132: From mammoths to genome editing, trailblazing genetics with Dr. George Church
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47:41
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0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…
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EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens
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44:57
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0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…
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A new history of the Sandinista Revolution
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In the 1970s in Nicaragua, left-wing rebels, calling themselves the Sandinista National Liberation Front, fought to overthrow their country’s dictator. It worked. The Sandinistas led a coalition that took over the government in July 1979, in what became known as the Sandinista Revolution. However, within a few years, the Sandinistas faced a violent…
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EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal
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51:56
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Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…
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EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy
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38:44
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0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…
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Here’s a depressing fact: it takes longer to travel from Boston to Los Angeles today than it did 50 years ago. Getting to the airport, getting through the airport, the flight itself — just about every part of the process takes longer than it once did. According to New York Times senior writer David Leonhardt, this is just one example of the stagnat…
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EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata
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50:18
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0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…
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How asset managers came to own everything and you failed to notice
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53:11
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Listeners of the Rhodes Center Podcast have probably heard of companies like Black Rock, State Street and Vanguard. You’ve also probably heard how, through ETFs and other investment products, these types of investment firms own a staggering share of the world’s biggest companies (20-25% of the S&P 500 by some estimates). But in this episode, you’ll…
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EP 127: Insights into precision medicine, fatty liver disease, and minimally invasive diagnostic tools with Dr. Mazen Noureddin
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39:10
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0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…
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From Black Lives Matter to January 6, how ‘Black grief’ and ‘white grievance’ shape our politics
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The last decade has seen the growth of two political movements that appear diametrically opposed: the Black Lives Matter movement and the rise of Donald Trump. But as our guest on this episode explains, these two movements are linked, and can only be understood together. On this episode, Dan Richards talks with political scientist Juliet Hooker abo…
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