Episode 003 - Dr Morgan Langille – microbiome bioinformatics, DNA sequencing, metagenomics

Inside Matters

Dr Morgan Langille, an expert in bioinformatics, talks about developing novel technologies and techniques that enable a better understanding of human-microbial interactions. Dr Langille discusses advances in the microbiome field as well as combining computer science and microbiology to lead to new therapeutics and diagnostics. Episode Time Stamps

• 00:00 Intro
• 00:30, How Dr Langille got into the field of the microbiome
• 04:30, Gene duplication and reverse transcription
• 05:48, What is bioinformatics?
• 06:34, The evolution of bioinformatics
• 09:30, Genomic islands
• 1:04 - Phages
• 14:30 Dr Langille’s first bioinformatics tool
• 16:00 Bacterial genome libraries
• 18:20 Extremeophilic bacteria
• 19:00 Will there be bugs in space
• 21:42 Bacteria on Mars
• 22:15 Human microbiome diversity
• 23:30 Number of human cells vs microbes in the body
• 25:00 Genomic diversity within the microbiome
• 28:00 Perfect bioinformatics
• 33:40 Bioinformatics and microbiome research
• 34:37 Short read vs long read sequencing
• 45:30 Shotgun metagenomics
• 48:00 Bioinformatic tool development
• 1:01:00 Differences in bioinformatic tools and impact on research
• 1:06:00 Solutions to current technology challenges in bioinformatics
• 1:10:06 Tools that Morgan has developed
• 1:08:05 PICRUSt - bioinformatic tool
• 1:18:35 Jarvis - bioinformatic tool
• 1:24:00 Talent wars for bioinformatics
• 1:26:36 Machine learning and AI
• 1:32:51 Colorectal cancer and AI
• 1:36:35 Is blood sterile?
• 1:38:00 What does the future of medicine look like
• 1:40:51 DIY FMT