Emergency Medicine Cases – Where the Experts Keep You in the Know. For show notes, quizzes, videos and more learning tools please visit emergencymedicinecases.com
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Pediheart Podcast #287: Fontan Associated Liver Disease And Intrahepatic Transcriptomics
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Manage episode 403937428 series 2087001
Content provided by Robert Pass. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Robert Pass or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
This week we enter the world of the adult congenital heart patient when we discuss Fontan associated liver disease with an ACHD expert, Dr. Katia Bravo-Jaimes of the Mayo Clinic. In this episode we discuss the role of intrahepatic transcriptomics and how genetic analysis of liver biopsy tissue may provide new insights into the pathophysiology of this disease process. How can differential gene expression in the liver of Fontan patients help to explain why some patients have mild versus others severe fibrosis or even frank cirrhosis? Can these insights provide hope for improved surveillance or therapy for this problem? Dr. Bravo-Jaimes provides the answers this week.
https://doi.org/10.1016/j.jacc.2023.12.005
…
continue reading
https://doi.org/10.1016/j.jacc.2023.12.005
466 episodes
MP3•Episode home
Manage episode 403937428 series 2087001
Content provided by Robert Pass. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Robert Pass or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
This week we enter the world of the adult congenital heart patient when we discuss Fontan associated liver disease with an ACHD expert, Dr. Katia Bravo-Jaimes of the Mayo Clinic. In this episode we discuss the role of intrahepatic transcriptomics and how genetic analysis of liver biopsy tissue may provide new insights into the pathophysiology of this disease process. How can differential gene expression in the liver of Fontan patients help to explain why some patients have mild versus others severe fibrosis or even frank cirrhosis? Can these insights provide hope for improved surveillance or therapy for this problem? Dr. Bravo-Jaimes provides the answers this week.
https://doi.org/10.1016/j.jacc.2023.12.005
…
continue reading
https://doi.org/10.1016/j.jacc.2023.12.005
466 episodes
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