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Exile
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1 Episode 21: The Heiress Who Helped End School Segregation 35:10
35:10
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Hilde Mosse comes from one of the wealthiest families in Berlin and stands to inherit an enormous fortune. But she longs for something more meaningful than the luxurious lifestyle her family provides. So Hilde decides to pursue her dream of becoming a doctor. As the Nazis take power in Germany and the Mosse family is forced to flee, Dr. Hilde Mosse lands in New York having nearly lost everything.. She finds her calling treating the mental health of Black youth – and the symptoms of a racist system. In addition to photographs, school records, and correspondence spanning Hilde Mosse’s entire lifetime, the Mosse Family Collection in the LBI Archives includes the diaries she kept between 1928 and 1934, from the ages of 16-22. Hilde’s papers are just part of the extensive holdings related to the Mosse Family at LBI. Learn more at lbi.org/hilde . Exile is a production of the Leo Baeck Institute, New York and Antica Productions. It’s narrated by Mandy Patinkin. This episode was written by Lauren Armstrong-Carter. Our executive producers are Laura Regehr, Rami Tzabar, Stuart Coxe, and Bernie Blum. Our producer is Emily Morantz. Research and translation by Isabella Kempf. Voice acting by Hannah Gelman. Sound design and audio mix by Philip Wilson. Theme music by Oliver Wickham. Please consider supporting the work of the Leo Baeck Institute with a tax-deductible contribution by visiting lbi.org/exile2025 . The entire team at Antica Productions and Leo Baeck Institute is deeply saddened by the passing of our Executive Producer, Bernie Blum. We would not have been able to tell these stories without Bernie's generous support. Bernie was also President Emeritus of LBI and Exile would not exist without his energetic and visionary leadership. We extend our condolences to his entire family. May his memory be a blessing. This episode of Exile is made possible in part by a grant from the Conference on Jewish Material Claims Against Germany, which is supported by the German Federal Ministry of Finance and the Foundation Remembrance, Responsibility and Future.…
🧬 Jason C. Foster - Part 1 | From Paper Routes to Pharma | Navigating the Dot-Com Bubble | Building a $1B Addiction Medicine Business in 4 Years
Manage episode 463389623 series 3461709
Content provided by Jon Chee. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Jon Chee or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success.
🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸
🔗 Get your unique referral link here: refer.excedr.com/ZTHETY.
Part 1 of 2: My guest today is Jason C. Foster, CEO and Executive Director of Ori Biotech. Ori is revolutionizing Cell and Gene Therapy manufacturing through the development of its proprietary platform, IRO®. By automating and standardizing Cell and Gene Therapy manufacturing, Ori and IRO® offer scientists the tools they need to streamline development and support widespread patient access to life-saving treatments.
Jason's experience prior to Ori includes more than 20 years of life science leadership in operations, sales, marketing, technology, and investing, during which he developed deep expertise in commercial strategy and a thorough understanding of healthcare markets across the UK, US, and EU.
In this episode, you'll hear about:
- Jason Foster's early entrepreneurship, from paper routes to creative ventures
- His transformative time at Columbia Business School, learning valuable lessons about decision-making and international perspectives
- Jason's entry into healthcare through Merck-Medco
- His experience growing a small pharmaceutical company from 5 to 400 employees, focusing on addiction medicine
- The decision to move his family to London to start the European branch of the business
If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!
Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Jason Foster, at these links:
Find Our Host, Jon Chee, at these links:
Excedr Socials & Website
LinkedIn: https://www.linkedin.com/company/excedr/
Youtube: https://www.youtube.com/@excedr
Instagram: https://www.instagram.com/excedr_inc
Twitter: https://twitter.com/ExcedrInc
Facebook: https://www.facebook.com/excedr
TikTok: https://www.tiktok.com/@excedr
Podcast Website: https://www.thebiotechstartupspodcast.com/
Enriched Notes:
Topics Mentioned:
University of Virginia https://www.virginia.edu/
Columbia University https://www.columbia.edu/
How to Spin Out of Academia https://www.excedr.com/resources/how-to-spin-out-of-academia-and-into-a-startup
How VC-Backed Startups Win When They Lease https://www.excedr.com/blog/how-vc-backed-startups-win-when-they-lease
Marketing & Sales Strategies for Startups https://www.excedr.com/blog/marketing-sales-strategies-for-biotechs
People Mentioned:
Larry Sabato https://en.wikipedia.org/wiki/Larry_Sabato
Timestamps:
00:00 Intro
04:51 Early years and entrepreneurial experiences
10:10 College decision process and time at the University of Virginia
18:05 Jason's experience in Washington D.C. and introduction to healthcare policy
20:57 Jason's decision to pursue an MBA at Columbia University
25:04 Memorable lessons from Columbia MBA program
30:47 Jason's transition to the private sector and joining Merck Medco
36:41 Insights on effective sales techniques in the pharmaceutical industry
43:19 Jason's career progression after Columbia and joining Medco Health Solutions
51:02 Jason's move to a small pharmaceutical company in Richmond, Virginia
54:59 Outro
The Biotech Startups Podcast is handcrafted by our friends over at: fame.so
122 episodes
Manage episode 463389623 series 3461709
Content provided by Jon Chee. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Jon Chee or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success.
🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸
🔗 Get your unique referral link here: refer.excedr.com/ZTHETY.
Part 1 of 2: My guest today is Jason C. Foster, CEO and Executive Director of Ori Biotech. Ori is revolutionizing Cell and Gene Therapy manufacturing through the development of its proprietary platform, IRO®. By automating and standardizing Cell and Gene Therapy manufacturing, Ori and IRO® offer scientists the tools they need to streamline development and support widespread patient access to life-saving treatments.
Jason's experience prior to Ori includes more than 20 years of life science leadership in operations, sales, marketing, technology, and investing, during which he developed deep expertise in commercial strategy and a thorough understanding of healthcare markets across the UK, US, and EU.
In this episode, you'll hear about:
- Jason Foster's early entrepreneurship, from paper routes to creative ventures
- His transformative time at Columbia Business School, learning valuable lessons about decision-making and international perspectives
- Jason's entry into healthcare through Merck-Medco
- His experience growing a small pharmaceutical company from 5 to 400 employees, focusing on addiction medicine
- The decision to move his family to London to start the European branch of the business
If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!
Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Jason Foster, at these links:
Find Our Host, Jon Chee, at these links:
Excedr Socials & Website
LinkedIn: https://www.linkedin.com/company/excedr/
Youtube: https://www.youtube.com/@excedr
Instagram: https://www.instagram.com/excedr_inc
Twitter: https://twitter.com/ExcedrInc
Facebook: https://www.facebook.com/excedr
TikTok: https://www.tiktok.com/@excedr
Podcast Website: https://www.thebiotechstartupspodcast.com/
Enriched Notes:
Topics Mentioned:
University of Virginia https://www.virginia.edu/
Columbia University https://www.columbia.edu/
How to Spin Out of Academia https://www.excedr.com/resources/how-to-spin-out-of-academia-and-into-a-startup
How VC-Backed Startups Win When They Lease https://www.excedr.com/blog/how-vc-backed-startups-win-when-they-lease
Marketing & Sales Strategies for Startups https://www.excedr.com/blog/marketing-sales-strategies-for-biotechs
People Mentioned:
Larry Sabato https://en.wikipedia.org/wiki/Larry_Sabato
Timestamps:
00:00 Intro
04:51 Early years and entrepreneurial experiences
10:10 College decision process and time at the University of Virginia
18:05 Jason's experience in Washington D.C. and introduction to healthcare policy
20:57 Jason's decision to pursue an MBA at Columbia University
25:04 Memorable lessons from Columbia MBA program
30:47 Jason's transition to the private sector and joining Merck Medco
36:41 Insights on effective sales techniques in the pharmaceutical industry
43:19 Jason's career progression after Columbia and joining Medco Health Solutions
51:02 Jason's move to a small pharmaceutical company in Richmond, Virginia
54:59 Outro
The Biotech Startups Podcast is handcrafted by our friends over at: fame.so
122 episodes
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The Biotech Startups Podcast
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1 🧬 Dr. Kate Yen: Scaling a Biotech, Running Lean, & Utilizing Translational Biology (Part 2) 51:30
51:30
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🧬 The Biotech Startups Podcast is powered by Excedr —helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science. As a TBSP listener, you get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners . “I didn’t set out to be an entrepreneur, but when I couldn’t find a company doing what I believed in, I built my own.” In part two of our conversation with Kate Yen , Founder and CEO of Auron Therapeutics, we explore her journey from leading a novel cancer therapy program at Agios to founding her own biotech company. Kate shares insights into drug development, clinical trials, and the business of biotech, highlighting the importance of translational biology, strategic partnerships, and lean operations in building a successful biotech startup. Kate earned her Ph.D. in Biological Chemistry from UCLA, where she also completed her postdoc. Before Auron, she held roles at Merck and as a UCLA professor before joining Agios Pharmaceuticals, where she led the IDH translational research team behind two FDA-approved IDH mutant inhibitors and co-led the discovery of vorasidenib, a promising glioma therapy now in clinical development. Key topics covered: Navigating clinical trials from discovery to FDA approval with a biomarker-driven approach The importance of translational biology and how Auron integrates it from day one Building a lean biotech startup , from early fundraising to assembling a high-impact team Securing big pharma partnerships in a challenging biotech market Leveraging AI and machine learning to map cancer biology and identify new drug targets If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening. Subscribe to the podcast: Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4 Youtube: https://www.youtube.com/@excedr Website: https://www.thebiotechstartupspodcast.com/ Find our guest, Kate Yen, at these links: LinkedIn: https://www.linkedin.com/in/kate-yen-448b22108/ Website: https://www.aurontx.com/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/jonchee Learn more about Excedr LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com Resources & articles mentioned: The Role of Translational Biology in Drug Development: https://www.sciencedirect.com/science/article/abs/pii/S1359644612004060 Navigating Clinical Trials: https://www.fda.gov/patients/learn-about-drug-and-device-approvals/drug-development-process Building & Running a Lean Biotech Startup: https://www.lablaunch.org/post/building-a-lean-biotech-startup Biotech Startup Fundraising Options: https://www.excedr.com/resources/biotech-startup-funding-options Biotech Partnerships - How Partnerships Support R&D: https://www.excedr.com/blog/how-biotech-partnerships-support-research How to Bootstrap Your Biotech Startup & Scale: https://www.excedr.com/resources/how-to-bootstrap-biotech-startup How to Choose the Right CRO for Biotech: https://www.excedr.com/blog/contract-research-organizations How Much Does Lab Space Cost? https://www.excedr.com/blog/how-much-does-lab-space-cost Top VC Firms for Biotech in 2024 - Supporting Innovation & Growth: https://www.excedr.com/blog/top-vc-firms-for-biotech 50 Biotech Seed & Angel Investors to Check Out in 2025: https://www.excedr.com/blog/biotech-seed-and-angel-investors Companies & people mentioned: Auron Therapeutics: https://www.aurontx.com/ Merck: https://www.merck.com/ Agios Pharmaceuticals: https://www.agios.com/ UCLA: https://www.ucla.edu/ Princeton University: https://www.princeton.edu/ Charles Sawyers: https://en.wikipedia.org/wiki/Charles_Sawyers Lew Cantley: https://en.wikipedia.org/wiki/Lewis_C._Cantley David Schenkein: https://www.linkedin.com/in/david-schenkein-md-45342476/ Mike Carey: https://www.uclahealth.org/cancer/members/michael-carey Ruben Shaw: https://www.linkedin.com/in/reuben-shaw-1b8611109/ Timestamps: 00:00 Intro 02:10 Kate Yen’s transition into leadership at Agios 05:39 Navigating clinical trials and biomarker-driven decision-making 10:29 The importance of translational biology in drug development 14:19 Taking the leap to start Auron Therapeutics 18:36 Raising early funding and building a lean biotech startup 26:41 Leveraging AI and machine learning in cancer drug discovery 30:58 Running a biotech startup with a sustainable and transparent culture 41:07 Fundraising strategies to expanding Auron’s platform beyond oncology 47:08 Closing questions for Kate 49:35 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Kate Yen - Part 1 | From Academia to Biotech Leader | Translating Research into Cancer Therapies | Early Days at Merck & Agios 51:27
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 1 of 2 : Our guest today is Kate Yen, Founder and CEO of Auron Therapeutics. Auron Therapeutics leverages cutting-edge science and AI-powered analysis to develop next-generation cancer therapies by mapping key drivers of tumorigenesis. Kate earned her Ph.D. in Biological Chemistry from UCLA, where she also completed her postdoc. She held roles at Merck and as a UCLA professor before joining Agios Pharmaceuticals, where she led the IDH translational research team behind two FDA-approved IDH mutant inhibitors and co-led the discovery of vorasidenib, a promising glioma therapy now in clinical development. With deep expertise in preclinical and clinical research, a proven track record in advancing breakthrough therapies, and a passion for oncology, Kate’s journey and insights are invaluable. In this episode, you'll hear about: Kate Yen’s journey from aspiring physician to PhD researcher at UCLA How her postdoc in Charles Sawyers’ lab sparked her passion for translational research Transitioning from academia to industry and learning drug discovery at Merck Taking the leap to join Agios Pharmaceuticals and leading the IDH program The role of collaboration in biotech, from academia to CRO partnerships If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening. Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4 Find Our Guest, Kate Yen, at these links: https://www.linkedin.com/in/kate-yen-448b22108/ https://www.aurontx.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: Auron Therapeutics: https://www.aurontx.com/ Merck: https://www.merck.com/ Agios Pharmaceuticals: https://www.agios.com/ UCLA: https://www.ucla.edu/ Princeton University: https://www.princeton.edu/ Biotech Startup Fundraising: https://www.excedr.com/resources/biotech-startup-funding-options Biotech Accelerators: https://www.excedr.com/resources/biotech-accelerators Biotech Incubators: https://www.excedr.com/resources/biotech-incubators Top VC Firms for Biotech: https://www.excedr.com/blog/top-vc-firms-for-biotech 50 Biotech Seed & Angel Investors: https://www.excedr.com/blog/biotech-seed-and-angel-investors Guide to Choosing a CRO: https://www.excedr.com/blog/contract-research-organizations Guide to Choosing a CMO: https://www.excedr.com/blog/contract-manufacturing-organizations People Mentioned: Charles Sawyers: https://en.wikipedia.org/wiki/Charles_Sawyers Lew Cantley: https://en.wikipedia.org/wiki/Lewis_C._Cantley David Schenkein: https://www.linkedin.com/in/david-schenkein-md-45342476/ Mike Carey: https://www.uclahealth.org/cancer/members/michael-carey Timestamps: 00:00 Intro 03:01 Kate Yen’s background and Auron Therapeutics’ mission 04:40 Early influences and passion for research 06:27 Choosing academia over medicine, attending UCLA grad school 13:11 Postdoc with Charles Sawyers and translational research 16:58 Transitioning to industry and joining Merck 24:44 Learning drug discovery and pharma culture at Merck 32:32 Taking the leap to Agios Pharmaceuticals 37:42 Leading the IDH program and cancer research 44:43 Collaborating with academic labs and CROs 50:28 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Oguzhan Atay - Part 2 | From Immigrant to Biotech Innovator | Battling Deportation with Nobel Laureate Support | Building a $140M Prenatal Testing Empire 1:04:48
1:04:48
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 2 of 2 : Our guest today is Oguzhan Atay, Co-founder & CEO of BillionToOne. BillionToOne is a precision diagnostics company that quantifies biology to create powerful molecular diagnostics. They work to improve disease detection by counting molecules with their proprietary molecular counting platform. They place patients at the forefront of everything they do and are currently applying their proprietary technology to non-invasive prenatal screening and liquid biopsy. Oguzhan holds a Ph.D. from Stanford in Systems Biology, where he implemented machine learning algorithms and mathematical models to solve specific problems in cellular biology and developed a data-driven mathematical framework to simplify the analysis of complex biological networks. He also has a degree in Molecular Biology from Princeton, as well as minors in Computer Science, Physics, and Applied Mathematics. Oguzhan not only combines deep technical expertise with visionary leadership, but he also has an incredibly inspirational immigrant journey, which makes this series a must-listen for first-time founders, scientists, and industry leaders alike. In this episode, you'll hear about: Oguzhan's journey from Turkey to Stanford BillionToOne's origin, including Y Combinator's role and initial funding challenges The company's innovative prenatal testing approach Expansion into oncology with blood tests for therapy selection and monitoring Oguzhan's personal struggles with immigration issues while starting the company and the support of his mentors If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4 Find Our Guest, Oguzhan Atay, at these links: https://www.linkedin.com/in/oatay/ https://billiontoone.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: BillionToOne https://billiontoone.com/ Y Combinator https://www.ycombinator.com/ Common Mistakes Biotechs Make & How to Avoid Them https://www.excedr.com/blog/common-business-mistakes How to Fund an R&D Startup https://www.excedr.com/resources/rd-startup-funding-first-steps Guide to the Venture Capitalist Decision https://www.excedr.com/resources/guide-to-the-venture-capitalist-decision-making-process People Mentioned: David Tsao https://www.linkedin.com/in/davidtsao/ Jim Collins https://en.wikipedia.org/wiki/James_C._Collins Timestamps: 00:00 - Intro 02:28 - The origin of BillionToOne and early challenges 06:48 - Y Combinator's role and initial funding struggles 12:24 - Meeting co-founders and pivoting based on market needs 17:17 - Realizing the importance of the problem in the United States 24:11 - Building physical infrastructure and scaling operations 32:04 - Company culture, hiring philosophy, and growth strategy 38:55 - Expanding into oncology and future product lines 46:40 - Plans for going public and becoming a generational company 53:42 - Shoutouts to supporters and overcoming immigration challenges 59:34 - Advice to his 21-year-old self: keeping an open mind 01:02:51 - Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Oguzhan Atay - Part 1 | From Small-Town Turkey to Stanford PhD | Solving Cell Cycle Mysteries | Building a Biotech During a Global Pandemic 1:00:39
1:00:39
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 1 of 2 : Our guest today is Oguzhan Atay, Co-founder & CEO of BillionToOne. BillionToOne is a precision diagnostics company that quantifies biology to create powerful molecular diagnostics. They work to improve disease detection by counting molecules with their proprietary molecular counting platform. They place patients at the forefront of everything they do and are currently applying their proprietary technology to non-invasive prenatal screening and liquid biopsy. Oguzhan holds a Ph.D. from Stanford in Systems Biology, where he implemented machine learning algorithms and mathematical models to solve specific problems in cellular biology and developed a data-driven mathematical framework to simplify the analysis of complex biological networks. He also has a degree in Molecular Biology from Princeton, as well as minors in Computer Science, Physics, and Applied Mathematics. Oguzhan not only combines deep technical expertise with visionary leadership, but he also has an incredibly inspirational immigrant journey, which makes this series a must-listen for first-time founders, scientists, and industry leaders alike. In this episode, you'll hear about: Oguzhan's upbringing in a small Turkish town His early passion for science, deciding to become a scientist at just 10 years old Oguzhan's experience in Turkey's rigorous education system His transition to studying at Princeton Oguzhan's PhD journey at Stanford If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4 Find Our Guest, Oguzhan Atay, at these links: https://www.linkedin.com/in/oatay/ https://billiontoone.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: Princeton https://www.princeton.edu/ Stanford https://www.stanford.edu/ BillionToOne https://billiontoone.com/ Common Mistakes Biotechs Make & How to Avoid Them https://www.excedr.com/blog/common-business-mistakes How to Fund an R&D Startup https://www.excedr.com/resources/rd-startup-funding-first-steps Guide to the Venture Capitalist Decision https://www.excedr.com/resources/guide-to-the-venture-capitalist-decision-making-process People Mentioned: Jan Skotheim https://www.linkedin.com/in/jan-skotheim-5157a426a/ Daniel Fisher https://www.linkedin.com/in/daniel-fisher-5466812a/ Jacques Fresco https://www.asbmb.org/asbmb-today/people/082222/in-memoriam-jacques-fresco Max Delbruck https://en.wikipedia.org/wiki/Max_Delbr%C3%BCck Linus Pauling https://en.wikipedia.org/wiki/Linus_Pauling J. Robert Oppenheimer https://en.wikipedia.org/wiki/J._Robert_Oppenheimer Timestamps: 00:00 - Intro 05:41 - Oguzhan's upbringing in Turkey and his parents' emphasis on education 10:22 - Competitive nature of the Turkish education system 15:18 - Oguzhan's decision to attend Princeton for undergraduate studies 21:28 - Integrated science program at Princeton and interdisciplinary approach 26:57 - Oguzhan's experience at the University of Oxford 32:20 - Choosing Stanford for PhD studies 38:21 - Oguzhan's PhD research at Stanford in cell cycle control 43:24 - The importance of resilience in scientific research and entrepreneurship 48:54 - BillionToOne's challenges and creative solutions during the COVID-19 pandemic 55:47 - How overcoming challenges led to unprecedented growth for BillionToOne 59:41 - Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Parag Shah - Part 2 | Scaling a Multi-Billion Dollar Life Sciences Fund | Culture, Capital & Entrepreneurship | The K2 HealthVentures Story 1:04:20
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 2 of 2 : Our guest today is Parag Shah, CEO and Founding Managing Director of K2 HealthVentures. K2 HealthVentures is an alternative investment firm that provides flexible, long-term financing solutions to innovative private and public companies in the life sciences and healthcare industries. Committed to making a broader impact, K2 also donates a percentage of its profits to support underserved areas in healthcare. Before founding K2, Parag was Senior Managing Director & Group Head of the Life Sciences practice at Hercules Capital, where he led the fund’s public offering and managed over $2 billion in investments. His deep expertise in life science and healthcare financing was further shaped through key leadership roles at Comerica, Imperial Bank, and BankBoston.Parag’s academic background includes a Masters in Environmental Policy & Planning and a Bachelors in Molecular Biology from MIT, where he conducted research at the Whitehead Institute. With 25+ years of experience at the intersection of science and finance, Parag brings invaluable insights for first-time founders, investors, scientists, and industry leaders navigating the complexities of biotech funding. In this episode, you'll hear about: How Parag scaled Hercules Capital into a multi-billion-dollar life sciences fund The challenges of building a strong company culture in investment firms Why evergreen capital structures can be a game-changer for biotech startups The founding story of K2 HealthVentures and its mission-driven approach How balancing work, family, and entrepreneurship leads to long-term success If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4 Find Our Guest, Parag Shah, at these links: https://www.linkedin.com/in/paragshah333/ https://k2hv.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: K2 HealthVentures: https://www.k2healthventures.com/ Hercules Capital: https://www.htgc.com/ Cooley LLP: https://www.cooley.com/ Life Science Cares: https://lifesciencecares.org/ Debt vs. Equity Financing for Biotech Startups: https://www.excedr.com/resources/debt-equity-options-funding-startup Biotech Startup Fundraising: https://www.excedr.com/resources/biotech-startup-funding-options Biotech Startup Support: https://www.excedr.com/resources-category/biotech-startup-support People Mentioned: Roy Liu: https://www.linkedin.com/in/roy-liu-36a35/ Anup Arora: https://www.linkedin.com/in/anup-arora-368ba81/ Meghan FitzGerald: https://www.linkedin.com/in/meghanmfitzgerald/ John Hale: https://www.linkedin.com/in/john-hale-770158b/ Timestamps: 00:00 Intro 01:54 Early days at Hercules and the challenge of biotech debt 06:14 Scaling Hercules, taking it public, and leadership lessons 11:34 Public vs. private investment funds: Key trade-offs and pressures 19:18 Leaving Hercules, taking a break, and redefining priorities 25:35 Avoiding burnout: Balancing work, family, and entrepreneurship 29:04 How time and capital constraints drive better decision-making 33:52 Founding K2 HealthVentures and reshaping biotech venture debt 39:01 Evergreen investment structure and why it benefits startups 46:59 The importance of co-founders, team culture, and shared vision 53:32 Scaling K2, launching a foundation, and investing with purpose 01:02:24 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Parag Shah - Part 1 | Rethinking Biotech Startup Funding | Building Smarter Capital Strategies | Risk, Reward & Leadership in Investing 47:04
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 1 of 2 : Our guest today is Parag Shah, CEO and Founding Managing Director of K2 HealthVentures. K2 HealthVentures is an alternative investment firm that provides flexible, long-term financing solutions to innovative private and public companies in the life sciences and healthcare industries. Committed to making a broader impact, K2 also donates a percentage of its profits to support underserved areas in healthcare. Before founding K2, Parag was Senior Managing Director & Group Head of the Life Sciences practice at Hercules Capital, where he led the fund’s public offering and managed over $2 billion in investments. His deep expertise in life science and healthcare financing was further shaped through key leadership roles at Comerica, Imperial Bank, and BankBoston.Parag’s academic background includes a Masters in Environmental Policy & Planning and a Bachelors in Molecular Biology from MIT, where he conducted research at the Whitehead Institute. With 25+ years of experience at the intersection of science and finance, Parag brings invaluable insights for first-time founders, investors, scientists, and industry leaders navigating the complexities of biotech funding. In this episode, you'll hear about: How Parag’s NYC upbringing shaped his leadership and risk-taking mindset His transition from molecular biology to finance and investing Key lessons from his early career in credit and venture lending How he helped shape biotech venture credit and redefine startup financing When to use debt vs. equity in life sciences fundraising If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4 Find Our Guest, Parag Shah, at these links: https://www.linkedin.com/in/paragshah333/ https://k2hv.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: K2 HealthVentures: https://www.k2healthventures.com/ Hercules Capital: https://www.htgc.com/ BankBoston (now part of Bank of America): https://en.wikipedia.org/wiki/BankBoston Imperial Bank (acquired by Comerica): https://www.comerica.com/ Venture Debt in Biotech: https://www.fiercebiotech.com/biotech/rise-venture-debt-and-when-biotechs-should-and-shouldnt-use-it Equity vs. Debt Financing: https://www.excedr.com/resources/debt-equity-options-funding-startup Biotech Startup Fundraising: https://www.excedr.com/resources/biotech-startup-funding-options Risk-Taking & Leadership in Startups: Biotech Startup Support: https://www.excedr.com/resources-category/biotech-startup-support Scaling Biotech Companies: https://www.linkedin.com/pulse/scaling-up-overcoming-multifaceted-challenges-growing-rami-levin-njoqe/ People Mentioned: Larry Suskind: https://dusp.mit.edu/people/lawrence-susskind John Ehrenfeld: https://www.linkedin.com/in/johnehrenfeld/ Timestamps: 00:00 Intro 02:59 Parag’s background and early career in finance 06:24 Growing up in NYC and how his parents influenced his mindset 09:42 The impact of education and key mentors in shaping his path 15:11 Transitioning from science to finance, why he left the lab 19:56 Lessons from Bank Boston and entering the world of credit investing 24:32 Moving to Argentina and unexpected entry into banking 29:56 Joining Imperial Bank and the challenges of building biotech venture credit 36:37 Understanding risk-taking and decision-making in biotech financing 42:52 When startups should use debt vs. equity and how venture debt fits into biotech funding 46:02 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Jason C. Foster - Part 2 | Manufacturing Brighter Futures | From Richmond to London: Building a Biotech Empire | Culture Eats Strategy for Breakfast 1:04:51
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 2 of 2 : My guest today is Jason C. Foster, CEO and Executive Director of Ori Biotech. Ori is revolutionizing Cell and Gene Therapy manufacturing through the development of its proprietary platform, IRO®. By automating and standardizing Cell and Gene Therapy manufacturing, Ori and IRO® offer scientists the tools they need to streamline development and support widespread patient access to life-saving treatments. Jason's experience prior to Ori includes more than 20 years of life science leadership in operations, sales, marketing, technology, and investing, during which he developed deep expertise in commercial strategy and a thorough understanding of healthcare markets across the UK, US, and EU. In this episode, you'll hear about: Jason Foster's journey from Virginia to London The critical role of culture in company success Ori Biotech's mission to increase accessibility of cell therapies by developing scalable manufacturing solutions Challenges in commercializing cell therapies and the need to consider commercial viability alongside safety and efficacy Jason's leadership insights, including the concept of being a "trusted advisor" and the importance of transparency in team building If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Find Our Guest, Jason C. Foster, at these links: https://www.linkedin.com/in/jasoncfoster/ https://oribiotech.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: Ori Biotech https://oribiotech.com/ How to Spin Out of Academia https://www.excedr.com/resources/how-to-spin-out-of-academia-and-into-a-startup How VC-Backed Startups Win When They Lease https://www.excedr.com/blog/how-vc-backed-startups-win-when-they-lease Marketing & Sales Strategies for Startups https://www.excedr.com/blog/marketing-sales-strategies-for-biotechs People Mentioned: Farlan Veraitch https://www.linkedin.com/in/farlan-singh-veraitch-a677112/ Reed Hastings https://www.linkedin.com/in/reedhastings/ Dan Pink https://www.linkedin.com/in/danielpink/ Timestamps: 00:00 - Intro 05:21 - Early days of expanding the business in Europe 10:37 - Reflections on entrepreneurship within a large organization 15:44 - The importance of culture in building a successful company 20:35 - Jason's journey to founding Ori Biotech 27:22 - Building Ori Biotech from the ground up 33:35 - The challenges and potential of cell therapy 39:51 - Ori Biotech's approach to go-to-market strategy 46:09 - The importance of being a trusted advisor to clients 51:10 - Hiring for cultural fit and building a strong team 55:17 - Future plans for Ori Biotech 57:59 - Shoutouts to mentors and supporters 1:00:05 - Advice to his 21-year-old self 1:02:48 - Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Jason C. Foster - Part 1 | From Paper Routes to Pharma | Navigating the Dot-Com Bubble | Building a $1B Addiction Medicine Business in 4 Years 53:22
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 1 of 2 : My guest today is Jason C. Foster, CEO and Executive Director of Ori Biotech. Ori is revolutionizing Cell and Gene Therapy manufacturing through the development of its proprietary platform, IRO®. By automating and standardizing Cell and Gene Therapy manufacturing, Ori and IRO® offer scientists the tools they need to streamline development and support widespread patient access to life-saving treatments. Jason's experience prior to Ori includes more than 20 years of life science leadership in operations, sales, marketing, technology, and investing, during which he developed deep expertise in commercial strategy and a thorough understanding of healthcare markets across the UK, US, and EU. In this episode, you'll hear about: Jason Foster's early entrepreneurship, from paper routes to creative ventures His transformative time at Columbia Business School, learning valuable lessons about decision-making and international perspectives Jason's entry into healthcare through Merck-Medco His experience growing a small pharmaceutical company from 5 to 400 employees, focusing on addiction medicine The decision to move his family to London to start the European branch of the business If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Find Our Guest, Jason Foster, at these links: https://www.linkedin.com/in/jasoncfoster/ https://oribiotech.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: University of Virginia https://www.virginia.edu/ Columbia University https://www.columbia.edu/ Merck https://en.wikipedia.org/wiki/Merck_%26_Co . Medco https://en.wikipedia.org/wiki/Medco_Health_Solutions How to Spin Out of Academia https://www.excedr.com/resources/how-to-spin-out-of-academia-and-into-a-startup How VC-Backed Startups Win When They Lease https://www.excedr.com/blog/how-vc-backed-startups-win-when-they-lease Marketing & Sales Strategies for Startups https://www.excedr.com/blog/marketing-sales-strategies-for-biotechs People Mentioned: Larry Sabato https://en.wikipedia.org/wiki/Larry_Sabato Emma Walmsley https://www.linkedin.com/in/emmawalmsleygsk/?originalSubdomain=uk Timestamps: 00:00 Intro 04:51 Early years and entrepreneurial experiences 10:10 College decision process and time at the University of Virginia 18:05 Jason's experience in Washington D.C. and introduction to healthcare policy 20:57 Jason's decision to pursue an MBA at Columbia University 25:04 Memorable lessons from Columbia MBA program 30:47 Jason's transition to the private sector and joining Merck Medco 36:41 Insights on effective sales techniques in the pharmaceutical industry 43:19 Jason's career progression after Columbia and joining Medco Health Solutions 51:02 Jason's move to a small pharmaceutical company in Richmond, Virginia 54:59 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Rafael Rosengarten - Part 4 | Lessons in Scaling a Biotech Startup | Using AI to Transform Cancer Diagnostics | The Genialis Supermodel & krasID 40:45
40:45
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 4 of 4 : My guest today is Rafael Rosengarten, CEO and Co-Founder of Genialis, the RNA biomarker company. Genialis is reimagining biomarkers for every target, drug, and patient using a combination of precision oncology, RNA, and AI. Rafael, a biomedical research veteran, combines academic excellence with industry innovation. A Dartmouth graduate with a Yale doctorate, he conducted postdoctoral research at Lawrence Berkeley National Laboratory, where he co-invented the j5 DNA assembly tool. As co-founder of the Alliance for AI in Healthcare, he advocates for responsible AI integration in medicine, drawing from his extensive background in evolution, immunology, bioengineering, and genetics. In this episode, you'll hear about: Scaling Genialis during COVID-19 and refining the company’s mission The importance of company culture and building a motivated, cohesive team Developing krasID and the Genialis supermodel to advance cancer diagnostics Raising Series A funding amid biotech market challenges The role of leadership and innovation in driving biotech success and shaping the future of precision oncology. If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Find Our Guest, Rafael Rosengarten, at these links: https://www.linkedin.com/in/rrosengarten/ https://www.genialis.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: Genialis: https://www.genialis.com/ Taiwania Capital: https://www.taiwaniacapital.com/ Debiopharm Innovation Fund: https://www.debiopharm.com/innovation-fund/ Genialis krasID: https://www.genialis.com/krasid/ Genialis Supermodel: https://www.genialis.com/supermodel/ How to Bootstrap a Biotech: https://www.excedr.com/resources/how-to-bootstrap-biotech-startup Biotech Funding Options: https://www.excedr.com/resources/biotech-startup-funding-options Top VCs in Biotech: https://www.excedr.com/blog/top-vc-firms-for-biotech AI in Cancer Diagnostics: https://www.frontiersin.org/articles/10.3389/fonc.2020.588221/full Predictive Biomarkers in Oncology: https://oncologypro.esmo.org/education-library/esmo-books/esmo-handbooks/translational-research/predictive-biomarkers How Biotech Partnerships Support Research: https://www.excedr.com/blog/how-biotech-partnerships-support-research People Mentioned: Cheng Wu (Founding Partner, Taiwania Capital): https://www.linkedin.com/in/cheng-wu-4614a8a/ Tiasha Stanković (COO, Head of People at Genialis): https://www.linkedin.com/in/tjasakk/?originalSubdomain=si Luka Ausec (Chief Discovery Officer at Genialis): https://www.linkedin.com/in/luka-ausec-378009150/ Miha Štajdohar (Co-founder, CTO at Genialis): https://www.linkedin.com/in/mstajdohar/ Marinka Zitnik (AI Researcher, Associate Professor of Bioinformatics): https://dbmi.hms.harvard.edu/people/marinka-zitnik Timestamps: 00:00 Intro 02:04 Scaling Genialis during COVID-19 and adapting as CEO 04:27 How pivotal clients influence a startup’s growth path 07:15 Addressing critical mistakes in clinical data pipelines 09:43 Redefining Genialis’ mission and fostering strong culture 12:19 Adapting to remote work while reinforcing team values 14:57 Raising Series A funding amid challenging market conditions 20:50 The importance of team culture and resilience 25:37 The Genialis supermodel and its impact on oncology AI 29:12 Two-year vision for Genialis and its three pillars 32:59 Closing questions and advice for entrepreneurs 38:59 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Rafael Rosengarten - Part 3 | Leveraging AI in Precision Medicine | How Predictive Biomarkers Transform Oncology | Lessons from Scaling a Startup 32:09
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 3 of 4 : My guest today is Rafael Rosengarten, CEO and Co-Founder of Genialis, the RNA biomarker company. Genialis is reimagining biomarkers for every target, drug, and patient using a combination of precision oncology, RNA, and AI. Rafael, a biomedical research veteran, combines academic excellence with industry innovation. A Dartmouth graduate with a Yale doctorate, he conducted postdoctoral research at Lawrence Berkeley National Laboratory, where he co-invented the j5 DNA assembly tool. As co-founder of the Alliance for AI in Healthcare, he advocates for responsible AI integration in medicine, drawing from his extensive background in evolution, immunology, bioengineering, and genetics. In this episode, you'll hear about: Rafael’s move to Baylor College of Medicine and Houston’s vibrant medical community Innovations in molecular cloning and synthetic biology tools at Baylor Bridging biology and AI through collaborations with University of Ljubljana researchers Founding Genialis and shifting its focus to predictive biomarker development Lessons from biotech pivots that shaped Genialis as a leader in precision oncology If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Find Our Guest, Rafael Rosengarten, at these links: https://www.linkedin.com/in/rrosengarten/ https://www.genialis.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: Baylor College of Medicine: https://www.bcm.edu/ University of Ljubljana: https://www.uni-lj.si/en/university Genialis: https://www.genialis.com/ Lab Equipment List, Synthetic Biology Research: https://www.excedr.com/blog/lab-equipment-list-for-synthetic-biology-research How to Bootstrap Your Biotech Startup & Scale: https://www.excedr.com/resources/how-to-bootstrap-biotech-startup When & How to Pivot a Biotech Startup: https://www.excedr.com/blog/when-how-to-pivot-a-biotech-startup Biotech Startup Support Resources: https://www.excedr.com/resources-category/biotech-startup-support The Role of Machine Learning in Biotech: https://www.linkedin.com/pulse/machine-learning-biotech-fundamentals-divya-ramamoorthy-blhte/ Predictive Biomarkers in Oncology: https://oncologypro.esmo.org/education-library/esmo-books/esmo-handbooks/translational-research/predictive-biomarkers AI and Omics Analysis in Cancer Research: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.588221/full Collaborative Biotech Partnerships: https://www.excedr.com/blog/how-biotech-partnerships-support-research People Mentioned: Gad Shaulsky: https://www.bcm.edu/people-search/gad-shaulsky-30425 Adam Kuspa: https://www.linkedin.com/in/adam-kuspa-23bab836/ Blaž Zupan: https://www.bcm.edu/people-search/blaz-zupan-33768 Marinka Zitnik: https://www.linkedin.com/in/marinkaz/ Miha Štajdohar: https://www.linkedin.com/in/mstajdohar/?originalSubdomain=si Laura Benjamin: https://www.linkedin.com/in/laura-e-benjamin-04299b34/ Timestamps: 00:00 Intro 02:11 Rafael’s move to Houston and postdoc at Baylor College of Medicine 04:09 Collaborating with mentors and early breakthroughs in molecular cloning 07:01 Joining the Gulf Coast Consortium and blending bench science with computational tools 09:44 Transformative partnership with AI pioneers from the University of Ljubljana 13:30 How early machine learning tools shaped Rafael’s career and perspective 17:04 Founding Genialis and the early challenges of pivoting its focus 19:59 Learning from failures and how they shaped Genialis’ mission 23:21 The role of predictive biomarkers in oncology and their real-world impact 27:59 Lessons learned from biotech pivots and navigating the startup world 31:16 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Rafael Rosengarten - Part 2 | From Marine Biology to Synthetic Biology | Building Biofuel Tools at JBEI | When Academic Labs Embrace Entrepreneurship 34:40
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 2 of 4 : My guest today is Rafael Rosengarten, CEO and Co-Founder of Genialis, the RNA biomarker company. Genialis is reimagining biomarkers for every target, drug, and patient using a combination of precision oncology, RNA, and AI. Rafael, a biomedical research veteran, combines academic excellence with industry innovation. A Dartmouth graduate with a Yale doctorate, he conducted postdoctoral research at Lawrence Berkeley National Laboratory, where he co-invented the j5 DNA assembly tool. As co-founder of the Alliance for AI in Healthcare, he advocates for responsible AI integration in medicine, drawing from his extensive background in evolution, immunology, bioengineering, and genetics. In this episode, you'll hear about: Rafael's graduate studies at Yale, where mentors fostered his independent research approach His diverse marine biology and genomics projects, preparing him for synthetic biology Rafael's transition to the Joint BioEnergy Institute (JBEI) for synthetic biology and biofuels research The collaborative environment at JBEI, including access to cutting-edge technology and bioinformatics tool development Rafael's insights on choosing the right lab environment and the growing acceptance of entrepreneurship in academia If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Find Our Guest, Rafael Rosengarten, at these links: https://www.linkedin.com/in/rrosengarten/ https://www.genialis.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: Yale https://www.yale.edu/ Joint BioEnergy Institute (JBEI) https://www.jbei.org/ Next-Generation Sequencing https://www.excedr.com/blog/next-generation-sequencing-101 How to Spin Out of Academia & Into a Startup https://www.excedr.com/resources/how-to-spin-out-of-academia-and-into-a-startup What Should Investors & Founders Expect From Each Other https://www.excedr.com/resources/investor-founder-expectations How to Fund an R&D Startup https://www.excedr.com/resources/rd-startup-funding-first-steps People Mentioned: Stephen Dellaporta https://www.linkedin.com/in/stephen-dellaporta-442aa611/ Leo Buss https://eeb.yale.edu/people/faculty/leo-buss Barbara McClintock https://en.wikipedia.org/wiki/Barbara_McClintock Christopher Mason https://www.linkedin.com/in/christopher-mason-4972a119/ Jonathan Rothberg https://www.linkedin.com/in/jonathanrothberg/ Jay Keasling https://www.linkedin.com/in/jay-keasling-6783754/ Nathan Hillson https://www.linkedin.com/in/nathan-hillson-73702915/ Timestamps: 00:00 - Intro 02:56 - Rafael's experience with his graduate advisors and diverse research projects 07:45 - Comparison of grad school experience to company building and board members 08:59 - Discussion about Jonathan Rothberg and sequencing developments at Yale 10:06 - Rafael's transition from Yale to the Joint BioEnergy Institute (JBEI) 12:46 - The importance of showing up and making connections in person 16:39 - The value of face-to-face interactions in business and collaboration 20:19 - Challenges in the biotech market and the need for in-person networking 23:11 - Rafael's work at JBEI in synthetic biology and tool development 28:22 - Key takeaways from Rafael's experience at JBEI 30:25 - The importance of entrepreneurship in academia and industry 33:55 - Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Rafael Rosengarten - Part 1 | From Salt Marsh to Biotech CEO | Snorkeling into Science | Choosing Marine Biology Over Cooking on a Mediterranean Yacht 30:30
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Part 1 of 4 : My guest today is Rafael Rosengarten, CEO and Co-Founder of Genialis, the RNA biomarker company. Genialis is reimagining biomarkers for every target, drug, and patient using a combination of precision oncology, RNA, and AI. Rafael, a biomedical research veteran, combines academic excellence with industry innovation. A Dartmouth graduate with a Yale doctorate, he conducted postdoctoral research at Lawrence Berkeley National Laboratory, where he co-invented the j5 DNA assembly tool. As co-founder of the Alliance for AI in Healthcare, he advocates for responsible AI integration in medicine, drawing from his extensive background in evolution, immunology, bioengineering, and genetics. In this episode, you'll hear about: Rafael's upbringing in rural South Carolina, influenced by his parents' intellectual hippie activist background and nature How his French cell biologist uncle sparked his love for science through snorkeling Rafael's journey at Dartmouth, initially pursuing chemistry but ultimately finding his passion in evolutionary biology and ecology His post-college experiences alternating between scientific research and culinary pursuits The pivotal decision to attend a marine biology program at Friday Harbor instead of accepting an offer to cook on a private yacht If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Find Our Guest, Rafael Rosengarten, at these links: https://www.linkedin.com/in/rrosengarten/ https://www.genialis.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: Dartmouth https://home.dartmouth.edu/ Bay Wolf https://www.berkeleyside.org/2015/07/01/oaklands-bay-wolf-restaurant-closing-after-40-years Yale https://www.yale.edu/ Chez Panisse https://www.chezpanisse.com/1/ Friday Harbor Laboratories https://fhl.uw.edu/ People Mentioned: Jay Keasling https://www.linkedin.com/in/jay-keasling-6783754/ Mark McPeak https://biology.dartmouth.edu/people/mark-alan-mcpeek David Peart https://www.linkedin.com/in/david-peart-251787302/ Carol Folt https://biology.dartmouth.edu/people/carol-l-folt Leo Buss https://eeb.yale.edu/people/faculty/leo-buss Alice Waters https://en.wikipedia.org/wiki/Alice_Waters Fanny Singer (Waters) https://thefoldmag.com/arts-culture/a-conversation-with-fanny-singer-about-her-mother-daughter-memoir-always-home Jeremiah Tower https://www.linkedin.com/in/jeremiah-tower/ Dan Barber https://en.wikipedia.org/wiki/Dan_Barber Thomas Keller https://en.wikipedia.org/wiki/Thomas_Keller Timestamps: 00:49 Intro 02:48 Rafael's upbringing in rural South Carolina and early influences 05:50 Discussing the impact of Rafael's upbringing on his business philosophy 07:44 Rafael's decision to attend Dartmouth College 10:27 Family influence on Rafael's academic pursuits 12:04 Rafael's experiences at Dartmouth and choosing his major 14:30 Summer internship at Bay Wolf restaurant in Oakland 16:55 Influential professors and classmates at Dartmouth 18:22 Post-graduation experiences and working at Yale 23:20 Comparing cooking experiences on the West Coast and East Coast 26:38 Entering Yale's biomedical program and the Friday Harbor experience 29:48 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Cyriac Roeding - Part 4 | Revolutionizing Cancer Detection & Therapy | Harnessing Synthetic Biology to Reshape Diagnostics | Solving Biotech’s Toughest Problems 37:38
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Part 4 of 4 : My guest today is Cyriac Roeding, founder, investor, and CEO of Earli, a company on a mission to transform cancer into a manageable condition. Using innovative gene therapy approaches, Earli’s technology forces cancer cells to produce a synthetic, non-human biomarker—overcoming the limitations of relying on naturally occurring biomarkers that cancer may or may not provide. Cyriac is a serial entrepreneur and investor who has created ventures at the intersection of physical and digital worlds. He has invested in startups like OpenAI and served as CEO of Shopkick, which was acquired for $250 million. His current focus, Earli, has raised nearly $60 million from top investors. Cyriac's journey from launching his first startup at 15 to being named a World Economic Forum Tech Pioneer showcases his valuable insights into building successful startups. In this episode, you’ll hear about: How a Thanksgiving article about Dr. Sam Gambhir inspired the founding of Earli Earli’s groundbreaking approach to revolutionizing cancer detection using synthetic biology The challenges of translating scientific discoveries into real-world clinical applications Overcoming obstacles and achieving breakthroughs in diagnostics and therapeutics Cyriac’s unwavering commitment to transforming cancer into a manageable condition If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Find Our Guest, Cyriac Roeding, at these links: https://www.linkedin.com/in/cyriacroeding/ https://www.earli.com/ https://www.joinrewind.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: Earli: https://www.earli.com/ Stanford University: https://www.stanford.edu/ Andreessen Horowitz: https://a16z.com/ Marc Benioff: https://www.linkedin.com/in/marcbenioff/ Khosla Ventures: https://www.khoslaventures.com/ Lab Equipment List, Synthetic Biology Research: https://www.excedr.com/blog/lab-equipment-list-for-synthetic-biology-research How to Bootstrap Your Biotech Startup & Scale: https://www.excedr.com/resources/how-to-bootstrap-biotech-startup When & How to Pivot a Biotech Startup: https://www.excedr.com/blog/when-how-to-pivot-a-biotech-startup How to Craft a Pitch Deck for Biotech Investors: https://www.excedr.com/resources/how-to-craft-a-pitch-deck-for-biotech-investors Top VC Firms for Biotech in 2024: https://www.excedr.com/blog/top-vc-firms-for-biotech Biotech Startup Support Resources: https://www.excedr.com/resources-category/biotech-startup-support People Mentioned: Dr. Sam Gambhir: https://en.wikipedia.org/wiki/Sanjiv_Sam_Gambhir David Suhy: https://www.linkedin.com/in/davidsuhy/ Jorge Conde: https://www.linkedin.com/in/jorge-conde-4099225/ Jim Allison: https://faculty.mdanderson.org/profiles/james_allison.html Pam Sharma: https://faculty.mdanderson.org/profiles/padmanee_sharma.html Phil Greenberg: https://www.fredhutch.org/en/faculty-lab-directory/greenberg-philip.html Timestamps: 00:00 Intro 02:08 How a Thanksgiving article about Dr. Sam Gambhir inspired Earli’s founding 05:43 Meeting Dr. Gambhir and learning biology as a non-scientist entrepreneur 09:02 Discovering the “one idea” that led to Earli’s revolutionary synthetic biology approach 12:54 Earli’s mission to transform cancer detection and diagnostics 17:30 Overcoming major challenges and achieving breakthroughs in diagnostics accuracy 21:54 The emotional and scientific legacy of Dr. Gambhir and its impact on Earli’s vision 26:28 Earli’s innovative approach to bridging diagnostics and therapeutics 30:05 The business potential of Earli’s platform for cancer and other diseases 33:04 Cyriac’s advice on taking the road less traveled as an entrepreneur 35:41 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬Cyriac Roeding - Part 3 | Founding Shopkick During the 2008 Financial Crisis | Transforming Retail with Mobile Tech | Exploring AI’s Use in Clinical Trials & Reshaping Drug Development 32:18
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Part 3 of 4 : My guest today is Cyriac Roeding, founder, investor, and CEO of Earli, a company on a mission to transform cancer into a manageable condition. Using innovative gene therapy approaches, Earli’s technology forces cancer cells to produce a synthetic, non-human biomarker—overcoming the limitations of relying on naturally occurring biomarkers that cancer may or may not provide. Cyriac is a serial entrepreneur and investor who has created ventures at the intersection of physical and digital worlds. He has invested in startups like OpenAI and served as CEO of Shopkick, which was acquired for $250 million. His current focus, Earli, has raised nearly $60 million from top investors. Cyriac's journey from launching his first startup at 15 to being named a World Economic Forum Tech Pioneer showcases his valuable insights into building successful startups. In this episode, you’ll hear about: Launching Shopkick during the 2008 financial crisis and securing funding against the odds Partnering with Best Buy, Macy’s, and Target to pioneer in-store rewards using ultrasound technology Overcoming GPS limitations with innovative hardware solutions Switching from retail tech to life sciences, with a focus on AI and engineering Cyriac’s vision for digital clinical trials to accelerate drug development If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Find Our Guest, Cyriac Roeding, at these links: https://www.linkedin.com/in/cyriacroeding/ https://www.earli.com/ https://www.joinrewind.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: Earli: https://www.earli.com/ Kleiner Perkins: https://en.wikipedia.org/wiki/Kleiner_Perkins Shopkick: https://en.wikipedia.org/wiki/Shopkick AI in Drug Development & Clinical Trials: https://www.earli.com/post/how-ai-is-powering-earlis-mission Biotech Startup Support: https://www.excedr.com/resources-category/biotech-startup-support People Mentioned: John Doerr: https://www.linkedin.com/in/john-doerr-03248211/ Steve Jobs: https://en.wikipedia.org/wiki/Steve_Jobs Reid Hoffman: https://www.linkedin.com/in/reidhoffman/ Aaron Emigh: https://www.linkedin.com/in/aaronemigh/ Alexis Rask: https://www.linkedin.com/in/aleinoff/ Timestamps: 00:00 Intro 01:58 Joining Kleiner Perkins as an entrepreneur-in-residence 05:43 Developing the idea for Shopkick 08:20 Securing Best Buy as a partner and navigating retailer challenges 11:11 Using ultrasound technology to solve GPS limitations for in-store tracking 13:25 Partnering with major brands and scaling Shopkick to profitability 16:25 Transitioning to life sciences and shifting focus to biology and AI 20:18 Exploring the potential of digital clinical trials 24:05 The intersection of biology, engineering, and software as the next frontier 27:57 Cyriac’s vision for the future of drug development 31:30 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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The Biotech Startups Podcast
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1 🧬 Cyriac Roeding - Part 2 | From Digital Clocks to Global Mobile Marketing | Cracking Coca-Cola's 160 Million Bottle Code | Silicon Valley's Pine-Scented Entrepreneurship | Leapfrogging Technology… 30:44
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🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success. 🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸 🔗 Get your unique referral link here : refer.excedr.com/ZTHETY . Part 2 of 4 : My guest today is Cyriac Roeding, founder, investor, and CEO of Earli, a company on a mission to transform cancer into a manageable condition. Using innovative gene therapy approaches, Earli’s technology forces cancer cells to produce a synthetic, non-human biomarker—overcoming the limitations of relying on naturally occurring biomarkers that cancer may or may not provide. Cyriac is a serial entrepreneur and investor who has created ventures at the intersection of physical and digital worlds. He has invested in startups like OpenAI and served as CEO of Shopkick, which was acquired for $250 million. His current focus, Earli, has raised nearly $60 million from top investors. Cyriac's journey from launching his first startup at 15 to being named a World Economic Forum Tech Pioneer showcases his valuable insights into building successful startups. In this episode, you’ll hear about: How Cyriac's early fascination with technology manifested through building a digital clock from scratch The transformative experience in Tokyo that served as a "reset button," exposing him to radical cultural differences His strategic career progression from Roland Berger to McKinsey The pivotal move from a failing mobile auction business to pioneering "mobile marketing" The challenging transition to CBS Mobile, where starting from zero employees allowed him to leapfrog competitors by implementing innovative features If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening! Links Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Find Our Guest, Cyriac Roeding, at these links: https://www.linkedin.com/in/cyriacroeding/ https://www.earli.com/ https://www.joinrewind.com/ Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/jonchee https://www.excedr.com Excedr Socials & Website LinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ Enriched Notes: Topics Mentioned: Earli Inc https://www.earli.com/ Roland Berger https://en.wikipedia.org/wiki/Roland_Berger_(company) McKinsey https://en.wikipedia.org/wiki/McKinsey_%26_Company CBS https://en.wikipedia.org/wiki/CBS People Mentioned: Chris Burggraeve https://www.linkedin.com/in/chrisburggraeve/ David Katz https://www.linkedin.com/in/davidakatz1/ Nancy Tellem https://www.linkedin.com/in/nancy-tellem-5a3b8311/ Timestamps: 00:00 Introduction and recap of previous episode with Cyriac Roeding 02:06 Cyriac's experience moving to Japan and cultural observations 03:58 Early technology interests: building digital clocks and programming robots 07:44 Discussion on trial and error in business and innovation 09:21 First job experiences at Roland Berger consulting in Tokyo and Munich 12:14 Journey to McKinsey and writing "The Secrets of Software Success" 14:09 First visit to Silicon Valley and falling in love with the entrepreneurial spirit 16:20 Starting a mobile technology company during the dot-com era 20:26 Success with Coca-Cola mobile marketing campaign and company profitability 22:01 Moving to CBS and initial challenges in Los Angeles 25:06 Building CBS Mobile strategy and innovative mobile initiatives 27:06 World travels observing mobile phone usage across different cultures 29:52 Outro The Biotech Startups Podcast is handcrafted by our friends over at: fame.so…
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