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CRISPR-Cas9
Manage episode 466979325 series 3637125
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By Dr. Alfred Granite
Dr. Granite's newsletter explores the CRISPR-Cas9 technology, tracing its accidental discovery in bacteria to its potential for revolutionizing healthcare. It emphasizes the rigorous scientific process behind CRISPR's development, contrasting it with politically motivated endeavors. The newsletter highlights the FDA's approval of Casgevy and Lyfgenia, the first CRISPR-based treatments for sickle cell disease, while also acknowledging challenges like chemotherapy requirements and high costs. Dr. Granite points to resources that help explain the complex technology, emphasizing its role in future genetic medicine, using videos and podcasts for easier understanding. The article also explores LUCA, the Last Universal Common Ancestor, as a way to highlight genetics and the fundamental building blocks of life and the possibilities for AI to discover new uses.
Newsletter: https://the-human-condition.beehiiv.com
26 episodes
ShareManage episode 466979325 series 3637125
Content provided by ADG. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by ADG or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
By Dr. Alfred Granite
Dr. Granite's newsletter explores the CRISPR-Cas9 technology, tracing its accidental discovery in bacteria to its potential for revolutionizing healthcare. It emphasizes the rigorous scientific process behind CRISPR's development, contrasting it with politically motivated endeavors. The newsletter highlights the FDA's approval of Casgevy and Lyfgenia, the first CRISPR-based treatments for sickle cell disease, while also acknowledging challenges like chemotherapy requirements and high costs. Dr. Granite points to resources that help explain the complex technology, emphasizing its role in future genetic medicine, using videos and podcasts for easier understanding. The article also explores LUCA, the Last Universal Common Ancestor, as a way to highlight genetics and the fundamental building blocks of life and the possibilities for AI to discover new uses.
Newsletter: https://the-human-condition.beehiiv.com
26 episodes
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by Dr. Alfred Granite This Poscast discusses the evolution of human health and the factors, largely emerging since 1980, contributing to its decline, driven by the author's recent hospitalization. Dr. Granite stresses the profit-driven nature of modern healthcare, pharmaceuticals, and the food industry , which he argues prioritize management and palatability over health. He highlights the disconnect between our evolutionary diet and modern food practices , including the consumption of ultra-processed foods and the unnatural diets of livestock, and suggests several online apps for healthier food choices . The author also recommends a video podcast by Dr. Nathan S. Bryan on nitric oxide , and offers access to past articles on related topics through his website, while also requesting reader support to continue his work. Newsletter: https://the-human-condition.beehiiv.com/p/chronic-disease…
1 Mitochondria: The Masters of Cellular Life and Health 12:44
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Play Later Play Later Lists Like Likedby: Dr. Alfred Granite This podcast created by Dr. Granite emphasizes the pivotal role of mitochondria in eukaryotic cells as the primary sites of energy production and their likely origin through endosymbiosis. He argues that these organelles are fundamental to advanced life and highlights how modern dietary habits, characterized by processed foods, and a lack of physical activity significantly impair mitochondrial function, contributing to widespread chronic diseases. Newsletter: https://the-human-condition. beehiiv.com…
By Dr. Alfred Granite Dr. Granite's newsletter examines why the U.S., despite its wealth and medical advancements, has a lower life expectancy than other educated wealthy nations. It attributes this issue to poor dietary habits shaped by a "melting pot" culinary culture heavily influenced by the processed food industry. Key contributors to this problem include added sugars, refined carbohydrates, trans fats, and seed oils, which drive metabolic dysfunction contributing to Metabolic Syndrome. The newsletter promotes solutions such as adopting nutrient-dense, whole food-based diets, including the Mediterranean diet, and exploring low-carbohydrate or carnivore approaches. Practical guidance is provided through food lists, tips for avoiding hidden sugars, healthy drink alternatives, and nutritional tracking tools. The emphasis is on gradual, sustainable dietary changes to enhance metabolic health and overall well-being. https://the-human-condition.beehiiv.com/p/the-diet-we-evolved-to-eat-c9fc…
By Dr. Alfred Granite Dr. Granite's introduces the concept that while humans evolved to survive food scarcity, modern food abundance, particularly processed options, now contributes to chronic diseases. He highlights the evolutionary basis of ketogenesis and its potential therapeutic uses. Contrasting the detrimental effects of ultra-processed foods and industrially produced fats like trans-fats, exemplified by Crisco's history. The author advocates for a return to more natural, whole foods, providing guidance on selecting healthy animal products, seafood, fruits, vegetables (noting lectin content), and grains, while criticizing the impact of modern hybridized wheat. Website: https://the-human-condition.beehiiv.com…
1 Autophagy: Cellular Renewal and the Science of Antiaging 18:33
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Play Later Play Later Lists Like LikedBy Dr. Alfred Granite This podcast explores the cellular mechanisms underlying aging and potential strategies to counteract them, emphasizing the growing scientific interest in life extension. It identifies key processes that deteriorate with age , such as DNA damage, telomere shortening, and loss of Proteostasis, ultimately leading to cellular dysfunction and age-related diseases. Additionally, it highlights autophagy, a crucial cellular "self-eating" process, as vital for removing damaged components, recycling energy, and preventing disease. It also details various dietary, supplemental, and lifestyle methods to boost autophagy , suggesting these interventions as promising avenues for promoting cellular health, longevity, and disease resistance, potentially revolutionizing our understanding and management of aging. Newsletter: https://the-human-condition. beehiiv.com/p/autophagy-and-antiaging…
1 Expanding Monitored Health Data: A New Healthcare Paradigm 14:43
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Play Later Play Later Lists Like LikedBy Dr. Alfred Granite The document outlines a shift in healthcare toward preventative medicine, emphasizing remote patient monitoring (RPM) and wearable technology to lower chronic disease costs through early detection and patient engagement. It highlights challenges such as data security and access, addresses poor dietary habits' role in metabolic dysfunction, and advocates advanced biomarkers and functional medicine for personalized prevention. Emerging technologies, including implantable medical devices, are also discussed as transformative for the future of healthcare. Newsletter: https://the-human-condition.beehiiv.com…
By Dr. Alfred Granite Dr. Granite's "Little Secrets" shares valuable, yet often overlooked, information regarding health and well-being. The document emphasizes that by understanding our inherent human flaws, such as pleasure-seeking, we can make informed choices for a healthier life. The author advocates for embracing a natural lifestyle , including sunlight exposure, clean water, nasal breathing, and avoiding excessive sterilization, as these align with our evolutionary biology. The text stresses the importance of mitochondrial health and posits that lifestyle and diet modifications can manage and prevent common chronic diseases. Finally, the document advocates for easily achievable steps to improve metabolism such as increasing one's frequency of movement in daily life, and key supplements like Magnesium, Zinc, Vitamin D, DHEA, Ashwagandha, Creatine, Tongkat Ali, and Fadogia Agrestis, to promote long-term health and vitality. Read the Newsletter: https://the-human-condition.beehiiv.com/p/little-secrets/health-and-longevity…
1 Red and Near-Infrared Light Therapy: An Overview of Benefits 15:55
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Play Later Play Later Lists Like LikedBy Dr. Alfred Granite Doctor Granite explains red and near-infrared (NIR) light therapy , detailing its historical origins, from ancient practices to modern scientific validation through laser and LED technology. He outlines the mechanisms of action , emphasizing how specific light wavelengths stimulate cellular functions, such as mitochondrial activity, and reduce inflammation. This podcast and the newsletter text discuss various applications of this therapy, including skin health, pain management, neurological conditions, metabolic health, hormonal balance, eye health, and general wellness. Furthermore, he mentions the benefits of sunlight as a source of red and NIR light while also advocating for the efficiency and intensity control offered by dedicated therapeutic devices. Finally, he provides recommendations and discounts for specific product brands. Newsletter: https://the-human-condition.beehiiv.com/p/red-and near-infrared- light-therapy…
By Dr. Alfred Granite Dr. Granite's newsletter explores the CRISPR-Cas9 technology , tracing its accidental discovery in bacteria to its potential for revolutionizing healthcare. It emphasizes the rigorous scientific process behind CRISPR's development , contrasting it with politically motivated endeavors. The newsletter highlights the FDA's approval of Casgevy and Lyfgenia , the first CRISPR-based treatments for sickle cell disease, while also acknowledging challenges like chemotherapy requirements and high costs. Dr. Granite points to resources that help explain the complex technology , emphasizing its role in future genetic medicine, using videos and podcasts for easier understanding. The article also explores LUCA, the Last Universal Common Ancestor, as a way to highlight genetics and the fundamental building blocks of life and the possibilities for AI to discover new uses. Newsletter: https://the-human-condition.beehiiv.com…
By Dr. Alfred Granite This document highlights the dangers of ultra-processed foods (UPFs) and their correlation with the rise of chronic illnesses. UPFs are factory-made products with extracted ingredients and additives, and examples include packaged snacks, sugary drinks, and processed meats. The document emphasizes that UPFs are calorie-dense, lack essential nutrients, and are designed to be addictive, leading to overconsumption and weight gain. It cites studies linking high UPF consumption to increased mortality, type 2 diabetes, cardiovascular disease, and other health issues. The author suggests strategies for reducing UPF intake, such as cooking at home, choosing whole foods, and reading nutrition labels. The document then proposes legislative solutions like regulating the promotion of unhealthy foods and setting strong dietary guidelines. Newsletter: https://the-human-condition.beehiiv.com…
By Dr. Alfred Granite Dr. Granite explores the evolution of healthcare, tracing it from ancient agricultural societies to the present. He introduces hyper-personalized medicine, a revolutionary approach tailoring treatments to individuals based on their genetics, lifestyle, and environment. This approach utilizes advanced technologies like CRISPR and wearable devices to provide more effective and precise care. The article also discusses the application of personalized medicine in elite sports, focusing on training optimization, injury prevention, and nutrition. Finally, it highlights the importance of integrating lifestyle and environmental factors for achieving optimal health outcomes, emphasizing the role of diet, exercise, sleep, and environmental pollutants. Newsletter: https://the-human-condition.beehiiv.com…
By Dr. Alfred Granite Dr. Granite's analysis reveals significant flaws in the American healthcare system, contrasting it unfavorably with systems in other developed nations. Key issues highlighted include exorbitant costs, limited access, poor health outcomes, and excessive administrative complexity. The text also explores the problematic influence of Big Pharma and the FDA's reliance on industry funding, hindering the approval of potentially beneficial, yet non-patentable, treatments. Proposed solutions range from immediate measures like increased price transparency and expanded coverage to more sweeping reforms, including government oversight of the FDA and Big Pharma, to improve affordability and equity. Ultimately, the author advocates for systemic change to achieve better health outcomes and reduce the financial burden on American citizens. Newsletter: https://the-human-condition.beehiiv.com…
By Dr. Alfred Granite This edition of The Human Condition explores the shift from symptom-based medicine (Medicine 2.0) to root-cause-focused, preventative care (Medicine 3.0). It highlights plasmapheresis as a promising longevity treatment and delves into emerging therapies like hyperbaric oxygen, ozone, hormone, and peptide therapies, emphasizing their potential in anti-aging and healthspan improvement. Advocating for these advances, the author predicts greater future accessibility and encourages readers to prioritize understanding and addressing the root causes of illness. https://the-human-condition.beehiiv.com/p/plasmapheresis-and-new-wellness-therapies…
By Dr. Alfred Granite This podcast that discusses the alarming rise in chronic diseases among American older adults and now children, attributing it primarily to poor diet and a lack of physical activity. The author connects this to the widespread consumption of ultra-processed foods and the historical shift in human diets from hunter-gatherer patterns to an abundance of readily available, often unhealthy, options. The piece also touches upon the controversial views of Robert F. Kennedy Jr. on vaccines and fluoride, while emphasizing the importance of a balanced diet like the Mediterranean or ketogenic diets, and the need to understand the nutritional value of food sources, particularly emphasizing the importance of natural, unprocessed foods . https://the-human-condition.beehiiv.com/p/where-are-we-going…
By Dr. Alfred Granite Peripheral Neuropathy (PN) : Explanation of the condition, its symptoms, causes, and stages. Personal Experience : The author's personal account of living with PN and the impact it had on their life. Treatment and Management : Discussion on various treatments and lifestyle changes that can help manage PN, including diet, supplements, and physical therapies. Diet and Nutrition : Emphasis on the importance of consuming high-quality fats and avoiding trans fats for nerve health. Peptides and Supplements : Information on specific peptides and supplements that can aid in nerve regeneration. Red/Near-Red Light Therapy : Recommendation of red light therapy for stimulating nerve regeneration and details on a specific product. Misconceptions about Fats : Clarification on the misconceptions about saturated fats and the dangers of trans fats. Link: https://the-human-condition.beehiiv.com/p/peripheripheral-neuropathy…
By Dr. Alfred Granite This podcast discusses the link between metabolic dysfunction and chronic diseases, arguing that poor diet and environmental toxins stemming from technological advancements are major contributing factors. Dr. Granite highlights the detrimental effects of trans fats and the role of mitochondrial dysfunction in various illnesses. He advocates for the use of artificial intelligence to address both healthcare challenges and environmental problems caused by human activity, suggesting AI can improve diagnostics, treatment, and efficiency while mitigating the negative consequences of technological progress. This chapter also includes a podcast featuring Professor Thomas Seyfried on a new treatment for cancer without chemotherapy or radiation and another one featuring Dr. Loyd Minor , dean of Stanford Medical School on AI’s future role in healthcare and medical education. Ultimately, he promotes a proactive and holistic approach to health and wellness, incorporating both lifestyle modifications and technological solutions. Read THE HUMAN CONDITION newsletter : https://the-human-condition.beehiiv.com/the-big-picture…
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THE HUMAN CONDITION
1 Understanding and Treating Alzheimer's Disease 18:17
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Play Later Play Later Lists Like LikedBy Dr. Alfred Granite This chapter provides a comprehensive overview of Alzheimer's disease, exploring its history, underlying biology, and current and emerging treatments. Key features discussed include the role of amyloid plaques and neurofibrillary tangles, genetic factors like the APOE gene, and the development of new blood tests for diagnosis. The text also emphasizes nutritional approaches , advocating for low-carbohydrate diets and the use of ketones, coconut oil, and MCT oil to combat insulin resistance and improve brain function. There is also an important video featuring Dr. Dale Bredesen , one of today's leadinding authorities on Alzheimer's who advocates a NEW individualized functional approach that has slowed and even reversed progression in hundreds of people. Newsletter: https://the-human-condition.beehiiv.com…
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1 Diabetes, Insulin Resistance, and the Evolutionary Diet 22:26
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Play Later Play Later Lists Like LikedBy Dr. Alfred Granite This podcast delves into the escalating global diabetes epidemic, clarifying the differences between type 1 and type 2 diabetes. Type 2 diabetes, the most common form, arises primarily from insulin resistance, driven by modern diet and lifestyle factors. This episode explores the connection between insulin resistance and various age-related diseases, including neurodegenerative conditions, and highlights the potential role of an evolutionary dietary mismatch in their development. Practical dietary recommendations to combat insulin resistance are discussed, focusing on the benefits of whole foods while minimizing processed carbohydrates, sugar, and unhealthy fats. Finally, the Sardinian lifestyle is presented as a model for longevity, emphasizing a diet rich in healthy fats and an active, community-centered way of life. Newsletter: https://the-human-condition.beehiiv.com…
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THE HUMAN CONDITION
By Dr. Alfred Granite Welcome to The Human Condition podcast… “Nitric Oxide: a key signaling molecule” Its crucial role is hlighted in various bodily functions, including vascular health, brain function, and immune response. This podcast traces the history of NO's discovery, detailing its impact on blood vessel dilation and blood pressure regulation. Furthermore, it examines NO's connection to erectile dysfunction (ED). it dicusses both dietary methods to increase NO levels and pharmaceutical interventions like Viagra and Cialis. Newsletter: https://the-human-condition.beehiiv.com/p/nitric-oxide…
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THE HUMAN CONDITION
By Dr. Alfred Granite Dr. Granite's article emphasizes the crucial role of gut health in overall well-being, highlighting the gut microbiome's influence on various bodily systems, including the brain, liver, immune system, and skin. Dysbiosis , an imbalance in gut microbiota, is linked to numerous health issues. The article advocates for improving gut health through dietary changes, probiotics, prebiotics, stress management, and sufficient sleep. It also explores fecal microbiota transplantation (FMT) as a treatment for certain conditions and introduces recent research on the gut microbiome's complexity and potential for antibiotic discovery. Finally, the article discusses "leaky gut". Newsletter: https://-the-human-condition.beehiiv.com…
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THE HUMAN CONDITION
By Dr. Alfred Granite Dr. Granite's text explores the link between metabolic dysfunction, specifically "Type 3 diabetes," and cognitive decline, particularly Alzheimer's disease. He advocates for a functional medicine approach focusing on root causes rather than symptoms. The text also introduces several nootropics , natural substances purported to enhance cognitive function, such as Bacopa Monnieri, Huperzine A, Phosphatidylserine, Ginkgo Biloba, Panax Ginseng, and Semax, describing their purported benefits and mechanisms of action. Finally, he emphasizes the importance of maintaining normal metabolic function to preserve cognitive health. Newsletter : https://the-human-condition,beehiiv.com/cognition-and-nootropics…
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THE HUMAN CONDITION
1 Hypochlorous Acid, the NATURAL skincare miricle... 13:08
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Play Later Play Later Lists Like LikedBy Dr, Alfred Granite CTO, Curativa Bay, Inc Discovered in 1834 hypochlorous acid, HOCl is now available as a sprayable mist that can be applied directly to the skin, eyes, nose, or mouth. This remarkable substance will effectively kill every known virus, bacteria, fungus and prion in existence . At the same time, it is completely safe and non-toxic. It can even be used to wash fruit and vegetables, cutting boards, and food services without the need for rinsing. It is naturally produced by our blood cells, specifically the neutrophils whenever our body is cut or burned. It instantly prevents infection and begins the healing process as it is released. Unlike antibiotics it does not encourage the growth of resistant strains of dangerous microbes. SAVE 20% ON OUUR BEST HOCl TRAVEL KIT https://www.curativabay.com/product/safe-travels-kit/…
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1 Innovations in Medical Technology for 2024 and Beyond 16:41
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Play Later Play Later Lists Like LikedBy Dr. Alfred Granite The author highlights several key innovations, including AI-powered diagnostics , personalized treatment plans , bioprinting and regenerative medicine , mRNA-based therapies , and surgical robots . These advancements , built upon earlier breakthroughs like the mapping of the human genome and CRISPR technology, are presented as a significant shift from the "dark ages" of medicine toward a future where data-driven, personalized care is enabled by artificial intelligence and quantum computing. The author emphasizes the transformative potential of these technologies to improve healthcare and wellness. Read the Newsletter: https://the -human-condition.beehiiv.com/…
By Dr. Alfred Granite This podcast analyzes the proposed healthcare agenda of Robert F. Kennedy Jr., highlighting the immense financial interests intertwined with the pharmaceutical, food, and water industries. The author expresses concern over Kennedy's unsubstantiated claims and radical approaches, proposing a more gradual, legislative approach focused on dietary improvements and FDA reform to address public health issues. Specific legislative actions are suggested to curb the influence of corporate interests and improve food quality. Finally, the author emphasizes the need for global cooperation and long-term solutions to improve both human and planetary health, acknowledging the slow pace of significant societal change. Newsletter: https://the-human-condition.Beehive.com/the-shape-of things-to-come/…
By Dr. Alfred Granite The text explores the history and resurgence of psychedelic drug therapy. It details the long history of psychedelic use by indigenous cultures and their recent re-emergence in treating mental health conditions like depression, anxiety, PTSD, and addiction. The document also examines the CIA's past interest in psychedelics for mind control, contrasting this with current scientific research exploring their therapeutic potential. Emphasis is placed on the potential benefits of psychedelic therapy, including its rapid and long-lasting effects and ability to promote neuroplasticity. Finally, the text notes the importance of responsible and guided use within a therapeutic context. Newsletter: https://the-human-condition.beehiiv.com…
By: Dr. Alfred Granite Zoonotic Diseases , illnesses transmitted from animals to humans, are the central focus, highlighting the current threat of avian flu (H5N1) spreading among various animal species and potentially evolving to facilitate human-to-human transmission. The text emphasizes the need for a "One Health Approach," a multidisciplinary strategy promoting collaboration between human and animal health experts and environmental scientists to prevent future outbreaks. It stresses the critical role of public awareness and collective action in addressing the issue, acknowledging the economic barriers to implementing necessary changes and the importance of honesty and transparency in public health communication. The piece underscores the link between human activities, environmental changes, and the emergence of zoonotic diseases , advocating for preventative measures to safeguard global health. Newsletter: https://the-human-condition.beehiiv.com/zoonotic-diseases…
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The BMJ brings you interviews with the people who are shaping medicine and science around the world.
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Sleep meditations created for women or anyone who feels called to listen 💗. Can’t sleep? Insomnia? Mind racing with worries and a never-ending to-do list? Tune in to the Sleep Meditation for Women podcast and let these guided meditations help you ease into sleep peacefully. Brought to you by the Women’s Meditation Network and hosted by Katie Krimitsos. Get comfy, press play and let yourself be guided into dreamland. Get more meditation resources at https://WomensMeditationNetwork.com
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What does exercise do to your brain? Can psychedelics treat depression? From smart daily habits to new medical breakthroughs, welcome to TED Health, with host Dr. Shoshana Ungerleider. TED speakers answer questions you never even knew you had, and share ideas you won't hear anywhere else, all around how we can live healthier lives. Follow Dr. Shoshana Ungerleider on Instagram at @shoshanamd and LinkedIn at @shoshanaungerleidermd Hosted on Acast. See acast.com/privacy for more information.
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We’ve all had a moment where we arrived at the grocery store and can’t remember passing any of the stoplights along the way. We’re halfway down an aisle and scrambling to remember what we even needed. Our mind is in overdrive trying to sort through our ever-growing to-do list. We’ve been there when just making it through the next task is hard. But the normal stresses of life aren’t the only thing YOU have to deal with. Nora McInerny hosts The Head Start: Embracing the Journey, a new podcast ...
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